Back to resultsA Study of Avastin (Bevacizumab) in Combination With Platinum-Containing Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
Primary Purpose
Non-Squamous Non-Small Cell Lung Cancer
Status
Completed
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Platinum-based chemotherapy
Bevacizumab [Avastin]
Sponsored by
About this trial
This is an interventional treatment trial for Non-Squamous Non-Small Cell Lung Cancer
Eligibility Criteria
Inclusion Criteria:
- adult patients, >=18 years of age;
- histologically or cytologically documented inoperable, locally advanced ( stage III), metastatic (stage IV) or recurrent NSCLC other than squamous cell (tumors of mixed histology should be categorized by the predominant cell type);
- ECOG PS status 0-2;
- life expectancy >= 12weeks;
- adequate renal, liver and hematological function.
Exclusion Criteria:
- mixed, non-small and small cell tumors, or mixed adenosquamous carcinomas with a predominant squamous component;
- hemoptysis (>=1/2 teaspoon of bright red blood) in previous 3 months;
- evidence of tumor invading major blood vessels on imaging;
- evidence of CNS metastases, even if previously treated.
- major surgery (including open biopsy), significant traumatic injury within 28 days prior to enrolment, or anticipation of need for major surgery during study treatment;
- prior chemotherapy for stage IIIb/IV disease.
Sites / Locations
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Bevacizumab + Chemotherapy
Arm Description
Participants with advanced or recurrent NSCLC will be administered bevacizumab infusions at a dose of 7.5 milligram per kilogram (mg/kg) or 15 mg/kg (investigator's choice) on Day 1 and then every 3 weeks, intravenously (IV) for a maximum of 6 cycles in combination with the standard of care NSCLC first-line chemotherapy in line with the licensed national prescribing information, during the treatment period. The initial dose of bevacizumab will be administered following chemotherapy; all subsequent doses could be given before or after chemotherapy.
Outcomes
Primary Outcome Measures
Number of Participants With Adverse Events of Special Interest
Participants with adverse events (AEs) of special interest (hypertension, proteinuria, wound healing complications, gastrointestinal perforation, arterial and venous thromboembolic events, hemoptysis, Central Nervous System (CNS) bleeding, other hemorrhage events and congestive heart failure) were reported.
Number of Participants With Serious Adverse Events Related to Bevacizumab
Participants with serious adverse events (SAEs) related to bevacizumab were reported for the duration of the study.
Secondary Outcome Measures
Duration of Overall Survival
Overall survival time was defined as time between first bevacizumab administration and date of death, irrespective of the cause of death. Participants for whom no death was captured on the clinical database were censored at the most recent date they were known to be alive.
Time to Disease Progression
Time to disease progression was defined as time between first bevacizumab administration and date of first occurrence of progressive disease. Participants who had not progressed at the time of study completion (including participants who died before progressive disease) or who were lost to follow-up were censored at the last bevacizumab administration date. Progressive disease is defined as at least a 20% increase in the sum of the longest diameter (LD) of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions. Time to disease progression was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0.
Number of Participants With Central Nervous System Bleeding
The incidence of central nervous system (CNS) bleeding was reported for participants who developed CNS metastases during the study period and who did not have Computed Tomography (CT) or magnetic resonance imaging (MRI) techniques of the head performed at baseline.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00451906
Brief Title
A Study of Avastin (Bevacizumab) in Combination With Platinum-Containing Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
Official Title
Open-label Study of Bevacizumab (AVASTIN®) in Combination With Platinum-containing Chemotherapy as First-line Treatment of Patients With Advanced or Recurrent Non-squamous Non-small Cell Lung Cancer
Study Type
Interventional
2. Study Status
Record Verification Date
April 2016
Overall Recruitment Status
Completed
Study Start Date
August 2006 (undefined)
Primary Completion Date
June 2009 (Actual)
Study Completion Date
June 2009 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hoffmann-La Roche
4. Oversight
5. Study Description
Brief Summary
This single arm study will assess the safety and efficacy of Avastin combined with platinum-containing chemotherapy regimens in patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC). Avastin will be given as first-line treatment in combination with platinum-based chemotherapy or in combination with any standard of care NSCLC first-line chemotherapy used in line with the licensed national prescribing information. Eligible patients will receive Avastin (15mg/kg iv on day 1 of each 3 week cycle) concomitantly with chemotherapy. Avastin treatment will continue after completion of chemotherapy cycles until disease progression, and the target sample size is 500+ individuals.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-Squamous Non-Small Cell Lung Cancer
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
2252 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Bevacizumab + Chemotherapy
Arm Type
Experimental
Arm Description
Participants with advanced or recurrent NSCLC will be administered bevacizumab infusions at a dose of 7.5 milligram per kilogram (mg/kg) or 15 mg/kg (investigator's choice) on Day 1 and then every 3 weeks, intravenously (IV) for a maximum of 6 cycles in combination with the standard of care NSCLC first-line chemotherapy in line with the licensed national prescribing information, during the treatment period. The initial dose of bevacizumab will be administered following chemotherapy; all subsequent doses could be given before or after chemotherapy.
Intervention Type
Drug
Intervention Name(s)
Platinum-based chemotherapy
Intervention Description
As prescribed
Intervention Type
Drug
Intervention Name(s)
Bevacizumab [Avastin]
Intervention Description
15 mg/kg IV on Day 1 of each 3 week cycle
Primary Outcome Measure Information:
Title
Number of Participants With Adverse Events of Special Interest
Description
Participants with adverse events (AEs) of special interest (hypertension, proteinuria, wound healing complications, gastrointestinal perforation, arterial and venous thromboembolic events, hemoptysis, Central Nervous System (CNS) bleeding, other hemorrhage events and congestive heart failure) were reported.
Time Frame
Up to 3 years
Title
Number of Participants With Serious Adverse Events Related to Bevacizumab
Description
Participants with serious adverse events (SAEs) related to bevacizumab were reported for the duration of the study.
Time Frame
Up to 3 years
Secondary Outcome Measure Information:
Title
Duration of Overall Survival
Description
Overall survival time was defined as time between first bevacizumab administration and date of death, irrespective of the cause of death. Participants for whom no death was captured on the clinical database were censored at the most recent date they were known to be alive.
Time Frame
Up to 3 years
Title
Time to Disease Progression
Description
Time to disease progression was defined as time between first bevacizumab administration and date of first occurrence of progressive disease. Participants who had not progressed at the time of study completion (including participants who died before progressive disease) or who were lost to follow-up were censored at the last bevacizumab administration date. Progressive disease is defined as at least a 20% increase in the sum of the longest diameter (LD) of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions. Time to disease progression was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0.
Time Frame
Up to 3 years
Title
Number of Participants With Central Nervous System Bleeding
Description
The incidence of central nervous system (CNS) bleeding was reported for participants who developed CNS metastases during the study period and who did not have Computed Tomography (CT) or magnetic resonance imaging (MRI) techniques of the head performed at baseline.
Time Frame
Up to 3 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
adult patients, >=18 years of age;
histologically or cytologically documented inoperable, locally advanced ( stage III), metastatic (stage IV) or recurrent NSCLC other than squamous cell (tumors of mixed histology should be categorized by the predominant cell type);
ECOG PS status 0-2;
life expectancy >= 12weeks;
adequate renal, liver and hematological function.
Exclusion Criteria:
mixed, non-small and small cell tumors, or mixed adenosquamous carcinomas with a predominant squamous component;
hemoptysis (>=1/2 teaspoon of bright red blood) in previous 3 months;
evidence of tumor invading major blood vessels on imaging;
evidence of CNS metastases, even if previously treated.
major surgery (including open biopsy), significant traumatic injury within 28 days prior to enrolment, or anticipation of need for major surgery during study treatment;
prior chemotherapy for stage IIIb/IV disease.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Trials
Organizational Affiliation
Hoffmann-La Roche
Official's Role
Study Director
Facility Information:
City
Buenos Aires
ZIP/Postal Code
1272
Country
Argentina
City
Chaco-resistencia
ZIP/Postal Code
3400
Country
Argentina
City
Cordoba
ZIP/Postal Code
5000
Country
Argentina
City
Córdoba
ZIP/Postal Code
5016
Country
Argentina
City
Tucuman
ZIP/Postal Code
T400IAK
Country
Argentina
City
St. Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
City
Waratah
State/Province
New South Wales
ZIP/Postal Code
2298
Country
Australia
City
Auchenflower
State/Province
Queensland
ZIP/Postal Code
4066
Country
Australia
City
Chermside
State/Province
Queensland
ZIP/Postal Code
4032
Country
Australia
City
Tugun
State/Province
Queensland
ZIP/Postal Code
4224
Country
Australia
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
City
Malvern
State/Province
Victoria
ZIP/Postal Code
3144
Country
Australia
City
Wodonga
State/Province
Victoria
ZIP/Postal Code
3690
Country
Australia
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6008
Country
Australia
City
Sydney, New South Wales
ZIP/Postal Code
2077
Country
Australia
City
Bludesch
ZIP/Postal Code
6712
Country
Austria
City
Bregenz
ZIP/Postal Code
6900
Country
Austria
City
Feldkirch
ZIP/Postal Code
6807
Country
Austria
City
Graz
ZIP/Postal Code
8036
Country
Austria
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
City
Knittelfeld
ZIP/Postal Code
8720
Country
Austria
City
Kufstein
ZIP/Postal Code
6330
Country
Austria
City
Linz
ZIP/Postal Code
4010
Country
Austria
City
Linz
ZIP/Postal Code
4020
Country
Austria
City
Natters
ZIP/Postal Code
6161
Country
Austria
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
City
St Veit An Der Glan
ZIP/Postal Code
9300
Country
Austria
City
Vöcklabruck
ZIP/Postal Code
4840
Country
Austria
City
Wels
ZIP/Postal Code
4600
Country
Austria
City
Wien
ZIP/Postal Code
1030
Country
Austria
City
Wien
ZIP/Postal Code
1090
Country
Austria
City
Wien
ZIP/Postal Code
1130
Country
Austria
City
Wien
ZIP/Postal Code
1140
Country
Austria
City
Wien
ZIP/Postal Code
1145
Country
Austria
City
Zams
ZIP/Postal Code
6511
Country
Austria
City
Banja Luka
ZIP/Postal Code
78000
Country
Bosnia and Herzegovina
City
Sarajevo
ZIP/Postal Code
71000
Country
Bosnia and Herzegovina
City
Salvador, Bahia
State/Province
BA
ZIP/Postal Code
40170-110
Country
Brazil
City
Fortaleza
State/Province
CE
ZIP/Postal Code
60430-230
Country
Brazil
City
Vitoria
State/Province
ES
ZIP/Postal Code
29055-270
Country
Brazil
City
Goiania
State/Province
GO
ZIP/Postal Code
74075-040
Country
Brazil
City
Belo Horizonte
State/Province
MG
ZIP/Postal Code
30110-090
Country
Brazil
City
Belo Horizonte
State/Province
MG
ZIP/Postal Code
30150-320
Country
Brazil
City
Recife
State/Province
PE
ZIP/Postal Code
52012-220
Country
Brazil
City
Rio De Janeiro
State/Province
RJ
ZIP/Postal Code
20520-100
Country
Brazil
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
22260-020
Country
Brazil
City
Rio de Janeiro
State/Province
RJ
ZIP/Postal Code
22631-004
Country
Brazil
City
Ijui
State/Province
RS
ZIP/Postal Code
98700-000
Country
Brazil
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90050-170
Country
Brazil
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90110-270
Country
Brazil
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90430-090
Country
Brazil
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90610-000
Country
Brazil
City
Campinas
State/Province
SP
ZIP/Postal Code
13059-900
Country
Brazil
City
Campinas
State/Province
SP
ZIP/Postal Code
13073-400
Country
Brazil
City
Jau
State/Province
SP
ZIP/Postal Code
17210-120
Country
Brazil
City
Ribeirao Preto
State/Province
SP
ZIP/Postal Code
14025-270
Country
Brazil
City
Santos
State/Province
SP
ZIP/Postal Code
11075-350
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01246-000
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01308-505
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01323-020
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01323-903
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01509-900
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
05401-400
Country
Brazil
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
08270-070
Country
Brazil
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 4E6
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2L 4M1
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3A 1A1
Country
Canada
City
Beijing
ZIP/Postal Code
100021
Country
China
City
Beijing
ZIP/Postal Code
100730
Country
China
City
Beijing
ZIP/Postal Code
101149
Country
China
City
Guangzhou
ZIP/Postal Code
510060
Country
China
City
Guangzhou
ZIP/Postal Code
510080
Country
China
City
Hangzhou
ZIP/Postal Code
310022
Country
China
City
Shanghai
ZIP/Postal Code
200032
Country
China
City
Shanghai
ZIP/Postal Code
200433
Country
China
City
Bogota
Country
Colombia
City
Cali
Country
Colombia
City
Manizales
Country
Colombia
City
Brno
ZIP/Postal Code
626 91
Country
Czech Republic
City
Plzen
ZIP/Postal Code
305 99
Country
Czech Republic
City
Praha
ZIP/Postal Code
150 06
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Czech Republic
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
City
Hillerod
ZIP/Postal Code
3400
Country
Denmark
City
Naestved
ZIP/Postal Code
4700
Country
Denmark
City
Århus
ZIP/Postal Code
8000
Country
Denmark
City
Guayaquil
ZIP/Postal Code
3623
Country
Ecuador
City
Quito
ZIP/Postal Code
17114965
Country
Ecuador
City
Cairo
ZIP/Postal Code
11737
Country
Egypt
City
Cairo
ZIP/Postal Code
11796
Country
Egypt
City
Tallinn
ZIP/Postal Code
11619
Country
Estonia
City
Tartu
ZIP/Postal Code
51003
Country
Estonia
City
Helsinki
ZIP/Postal Code
00290
Country
Finland
City
Paimio
ZIP/Postal Code
21540
Country
Finland
City
Pori
ZIP/Postal Code
28500
Country
Finland
City
Tampere
ZIP/Postal Code
33520
Country
Finland
City
Aix En Provence
ZIP/Postal Code
13616
Country
France
City
Avignon
ZIP/Postal Code
84000
Country
France
City
Besancon
ZIP/Postal Code
75015
Country
France
City
Beziers
ZIP/Postal Code
34525
Country
France
City
Bordeaux
ZIP/Postal Code
33076
Country
France
City
Brest
ZIP/Postal Code
29200
Country
France
City
Caen
ZIP/Postal Code
14076
Country
France
City
Chalon Sur Saone
ZIP/Postal Code
71100
Country
France
City
Clermont-ferrand
ZIP/Postal Code
63003
Country
France
City
GAP
ZIP/Postal Code
5000
Country
France
City
Grenoble
ZIP/Postal Code
38100
Country
France
City
Le Chesnay
ZIP/Postal Code
33300
Country
France
City
Lille
ZIP/Postal Code
59020
Country
France
City
Lille
ZIP/Postal Code
59037
Country
France
City
Lille
ZIP/Postal Code
59042
Country
France
City
Lyon
ZIP/Postal Code
69004
Country
France
City
Marseille
ZIP/Postal Code
13008
Country
France
City
Marseille
ZIP/Postal Code
13273
Country
France
City
Marseille
ZIP/Postal Code
13274
Country
France
City
Meaux
ZIP/Postal Code
77104
Country
France
City
Nancy
ZIP/Postal Code
54100
Country
France
City
Neuilly Sur Seine
ZIP/Postal Code
92200
Country
France
City
Paris
ZIP/Postal Code
75248
Country
France
City
Paris
ZIP/Postal Code
75571
Country
France
City
Perpignan
ZIP/Postal Code
66000
Country
France
City
Reims
ZIP/Postal Code
51100
Country
France
City
St Julien En Genevois
ZIP/Postal Code
74160
Country
France
City
Strasbourg
ZIP/Postal Code
67085
Country
France
City
Strasbourg
ZIP/Postal Code
69091
Country
France
City
Toulon
ZIP/Postal Code
83000
Country
France
City
Toulon
ZIP/Postal Code
83056
Country
France
City
Toulouse
ZIP/Postal Code
31052
Country
France
City
Toulouse
ZIP/Postal Code
31400
Country
France
City
Valenciennes
ZIP/Postal Code
59300
Country
France
City
Vandoeuvre Les Nancy
ZIP/Postal Code
54511
Country
France
City
Augsburg
ZIP/Postal Code
86150
Country
Germany
City
Bad Berka
ZIP/Postal Code
99437
Country
Germany
City
Bayreuth
ZIP/Postal Code
95455
Country
Germany
City
Berlin
ZIP/Postal Code
12167
Country
Germany
City
Berlin
ZIP/Postal Code
12200
Country
Germany
City
Berlin
ZIP/Postal Code
13353
Country
Germany
City
Bielefeld
ZIP/Postal Code
33604
Country
Germany
City
Bonn
ZIP/Postal Code
53113
Country
Germany
City
Coswig
ZIP/Postal Code
01640
Country
Germany
City
Donaustauf
ZIP/Postal Code
93093
Country
Germany
City
Düsseldorf
ZIP/Postal Code
40225
Country
Germany
City
Ebensfeld
ZIP/Postal Code
96250
Country
Germany
City
Erlangen
ZIP/Postal Code
91054
Country
Germany
City
Essen
ZIP/Postal Code
45147
Country
Germany
City
Frankfurt
ZIP/Postal Code
60488
Country
Germany
City
Freiburg
ZIP/Postal Code
79106
Country
Germany
City
Gauting
ZIP/Postal Code
82131
Country
Germany
City
Gerlingen
ZIP/Postal Code
70839
Country
Germany
City
Grosshansdorf
ZIP/Postal Code
22927
Country
Germany
City
Göttingen
ZIP/Postal Code
37075
Country
Germany
City
Halle (Saale)
ZIP/Postal Code
06120
Country
Germany
City
Hamburg
ZIP/Postal Code
21075
Country
Germany
City
Hamburg
ZIP/Postal Code
22081
Country
Germany
City
Hannover
ZIP/Postal Code
30169
Country
Germany
City
Hannover
ZIP/Postal Code
30625
Country
Germany
City
Karlsruhe
ZIP/Postal Code
76137
Country
Germany
City
Kiel
ZIP/Postal Code
24116
Country
Germany
City
Köln
ZIP/Postal Code
50677
Country
Germany
City
Leer
ZIP/Postal Code
26789
Country
Germany
City
Leipzig
ZIP/Postal Code
04207
Country
Germany
City
Leverkusen
ZIP/Postal Code
51375
Country
Germany
City
Löwenstein
ZIP/Postal Code
74245
Country
Germany
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
City
Mainz
ZIP/Postal Code
55131
Country
Germany
City
Minden
ZIP/Postal Code
32423
Country
Germany
City
Muenchen
ZIP/Postal Code
80336
Country
Germany
City
Neuruppin
ZIP/Postal Code
16816
Country
Germany
City
Nürnberg
ZIP/Postal Code
90419
Country
Germany
City
Oldenburg
ZIP/Postal Code
26121
Country
Germany
City
Rostock
ZIP/Postal Code
18057
Country
Germany
City
Treuenbrietzen
ZIP/Postal Code
14929
Country
Germany
City
Ulm
ZIP/Postal Code
89081
Country
Germany
City
Villingen-Schwenningen
ZIP/Postal Code
78045
Country
Germany
City
Wiesbaden
ZIP/Postal Code
65199
Country
Germany
City
Wolfsburg
ZIP/Postal Code
38440
Country
Germany
City
Wuerselen
ZIP/Postal Code
52146
Country
Germany
City
Hong Kong
ZIP/Postal Code
852
Country
Hong Kong
City
Hong Kong
Country
Hong Kong
City
Shatin
Country
Hong Kong
City
Budapest
ZIP/Postal Code
1529
Country
Hungary
City
Mátraháza
ZIP/Postal Code
3233
Country
Hungary
City
Pecs
ZIP/Postal Code
7635
Country
Hungary
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
City
Torokbalint
ZIP/Postal Code
2045
Country
Hungary
City
Reykjavik
ZIP/Postal Code
101
Country
Iceland
City
Beer Sheva
ZIP/Postal Code
84101
Country
Israel
City
Haifa
ZIP/Postal Code
31096
Country
Israel
City
Jerusalem
ZIP/Postal Code
12000
Country
Israel
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
City
Kfar-Saba
ZIP/Postal Code
44281
Country
Israel
City
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
City
Zerifin
ZIP/Postal Code
70300
Country
Israel
City
Avezzano
State/Province
Abruzzo
ZIP/Postal Code
67051
Country
Italy
City
Pescara
State/Province
Abruzzo
ZIP/Postal Code
65100
Country
Italy
City
Potenza
State/Province
Basilicata
ZIP/Postal Code
85100
Country
Italy
City
Rionero in Vulture
State/Province
Basilicata
ZIP/Postal Code
85029
Country
Italy
City
Catanzaro
State/Province
Calabria
ZIP/Postal Code
88100
Country
Italy
City
Avellino
State/Province
Campania
ZIP/Postal Code
83100
Country
Italy
City
Napoli
State/Province
Campania
ZIP/Postal Code
80131
Country
Italy
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40138
Country
Italy
City
Carpi
State/Province
Emilia-Romagna
ZIP/Postal Code
41012
Country
Italy
City
Modena
State/Province
Emilia-Romagna
ZIP/Postal Code
41100
Country
Italy
City
Rimini
State/Province
Emilia-Romagna
ZIP/Postal Code
47900
Country
Italy
City
Aviano
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33081
Country
Italy
City
Udine
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33100
Country
Italy
City
Roma
State/Province
Lazio
ZIP/Postal Code
00100
Country
Italy
City
Roma
State/Province
Lazio
ZIP/Postal Code
00144
Country
Italy
City
Roma
State/Province
Lazio
ZIP/Postal Code
00161
Country
Italy
City
Sora
State/Province
Lazio
ZIP/Postal Code
03039
Country
Italy
City
Viterbo
State/Province
Lazio
ZIP/Postal Code
01100
Country
Italy
City
Genova
State/Province
Liguria
ZIP/Postal Code
16132
Country
Italy
City
Genova
State/Province
Liguria
ZIP/Postal Code
16149
Country
Italy
City
La Spezia
State/Province
Liguria
ZIP/Postal Code
19100
Country
Italy
City
Bergamo
State/Province
Lombardia
ZIP/Postal Code
24128
Country
Italy
City
Cremona
State/Province
Lombardia
ZIP/Postal Code
26100
Country
Italy
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20132
Country
Italy
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20162
Country
Italy
City
Pavia
State/Province
Lombardia
ZIP/Postal Code
27100
Country
Italy
City
S Fermo Della Battaglia
State/Province
Lombardia
ZIP/Postal Code
22100
Country
Italy
City
Sondrio
State/Province
Lombardia
ZIP/Postal Code
23100
Country
Italy
City
Ancona
State/Province
Marche
Country
Italy
City
Novara
State/Province
Piemonte
ZIP/Postal Code
28100
Country
Italy
City
Bari
State/Province
Puglia
ZIP/Postal Code
70126
Country
Italy
City
Brindisi
State/Province
Puglia
ZIP/Postal Code
72100
Country
Italy
City
San Giovanni Rotondo
State/Province
Puglia
ZIP/Postal Code
71013
Country
Italy
City
Cagliari
State/Province
Sardegna
ZIP/Postal Code
09121
Country
Italy
City
Sassari
State/Province
Sardegna
ZIP/Postal Code
07100
Country
Italy
City
Catania
State/Province
Sicilia
ZIP/Postal Code
95100
Country
Italy
City
Catania
State/Province
Sicilia
ZIP/Postal Code
95122
Country
Italy
City
Palermo
State/Province
Sicilia
ZIP/Postal Code
90127
Country
Italy
City
Taormina
State/Province
Sicilia
ZIP/Postal Code
98039
Country
Italy
City
Arezzo
State/Province
Toscana
ZIP/Postal Code
52100
Country
Italy
City
Lido Di Camaiore
State/Province
Toscana
ZIP/Postal Code
55043
Country
Italy
City
Pisa
State/Province
Toscana
ZIP/Postal Code
56100
Country
Italy
City
Camposampiero
State/Province
Veneto
ZIP/Postal Code
35012
Country
Italy
City
Feltre - Bl
State/Province
Veneto
ZIP/Postal Code
32032
Country
Italy
City
Negrar
State/Province
Veneto
ZIP/Postal Code
37024
Country
Italy
City
Bologna, Umbria
ZIP/Postal Code
6132
Country
Italy
City
Forli, Emilia-Romagna
ZIP/Postal Code
47100
Country
Italy
City
Riga
ZIP/Postal Code
LV 1079
Country
Latvia
City
Riga
ZIP/Postal Code
LV-1002
Country
Latvia
City
Beirut
ZIP/Postal Code
99999
Country
Lebanon
City
Kaunas
ZIP/Postal Code
50009
Country
Lithuania
City
Klaipeda
ZIP/Postal Code
5808
Country
Lithuania
City
Vilnius
ZIP/Postal Code
08660
Country
Lithuania
City
Chihuahua
ZIP/Postal Code
31000
Country
Mexico
City
Leon
ZIP/Postal Code
37150
Country
Mexico
City
Mexico City
ZIP/Postal Code
14080
Country
Mexico
City
Mexico City
ZIP/Postal Code
16200
Country
Mexico
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
City
Den Haag
ZIP/Postal Code
2504 LN
Country
Netherlands
City
Eindhoven
ZIP/Postal Code
5623 EJ
Country
Netherlands
City
Groningen
ZIP/Postal Code
9728 NZ
Country
Netherlands
City
Haarlem
ZIP/Postal Code
2035 RC
Country
Netherlands
City
Helmond
ZIP/Postal Code
5700 AB
Country
Netherlands
City
Hoofddorp
ZIP/Postal Code
2134 TM
Country
Netherlands
City
Nieuwegein
ZIP/Postal Code
3430 CM
Country
Netherlands
City
Schiedam
ZIP/Postal Code
3116 BA
Country
Netherlands
City
Tiel
ZIP/Postal Code
4002 WP
Country
Netherlands
City
Zwolle
ZIP/Postal Code
8011 JW
Country
Netherlands
City
Bialystok
ZIP/Postal Code
15-540
Country
Poland
City
Krakow
ZIP/Postal Code
31-115
Country
Poland
City
Lublin
ZIP/Postal Code
20-950
Country
Poland
City
Poznan
ZIP/Postal Code
60-569
Country
Poland
City
Warszawa
ZIP/Postal Code
02-781
Country
Poland
City
Warszawa
ZIP/Postal Code
04-394
Country
Poland
City
Zabrze
ZIP/Postal Code
41-483
Country
Poland
City
Braga
ZIP/Postal Code
4719
Country
Portugal
City
Coimbra
ZIP/Postal Code
55643
Country
Portugal
City
Lisboa
ZIP/Postal Code
1070
Country
Portugal
City
Lisboa
ZIP/Postal Code
1600
Country
Portugal
City
Lisboa
ZIP/Postal Code
17769-001
Country
Portugal
City
Porto
ZIP/Postal Code
4200-072
Country
Portugal
City
Porto
ZIP/Postal Code
4200
Country
Portugal
City
Santa Maria Da Feira
ZIP/Postal Code
4520-211
Country
Portugal
City
Setubal
ZIP/Postal Code
2910-446
Country
Portugal
City
Vila Nova De Gaia
ZIP/Postal Code
4400-129
Country
Portugal
City
Bucharest
ZIP/Postal Code
010816
Country
Romania
City
Cluj Napoca
ZIP/Postal Code
3400
Country
Romania
City
Timisoara
ZIP/Postal Code
300223
Country
Romania
City
Balashikha
ZIP/Postal Code
143900
Country
Russian Federation
City
Engels
ZIP/Postal Code
413115
Country
Russian Federation
City
Irkutsk
ZIP/Postal Code
664035
Country
Russian Federation
City
Kislino, Kursk Region
ZIP/Postal Code
305035
Country
Russian Federation
City
Krasnodar
ZIP/Postal Code
350086
Country
Russian Federation
City
Moscow
ZIP/Postal Code
107005
Country
Russian Federation
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
City
Moscow
ZIP/Postal Code
143423
Country
Russian Federation
City
Samara
ZIP/Postal Code
443066
Country
Russian Federation
City
Smolensk
ZIP/Postal Code
214000
Country
Russian Federation
City
Stavropol
ZIP/Postal Code
355047
Country
Russian Federation
City
Tumen
ZIP/Postal Code
625047
Country
Russian Federation
City
Tver
ZIP/Postal Code
170008
Country
Russian Federation
City
Ulyanovsk
ZIP/Postal Code
ND
Country
Russian Federation
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
City
Bratislava
ZIP/Postal Code
825 56
Country
Slovakia
City
Kosice
ZIP/Postal Code
041 90
Country
Slovakia
City
Nitra
ZIP/Postal Code
949 88
Country
Slovakia
City
Poprad
ZIP/Postal Code
058 87
Country
Slovakia
City
Golnik
ZIP/Postal Code
4204
Country
Slovenia
City
Ljubljana
ZIP/Postal Code
1000
Country
Slovenia
City
Elche
State/Province
Alicante
ZIP/Postal Code
03202
Country
Spain
City
Manresa
State/Province
Barcelona
ZIP/Postal Code
08243
Country
Spain
City
Mataro
State/Province
Barcelona
ZIP/Postal Code
08304
Country
Spain
City
Sabadell
State/Province
Barcelona
ZIP/Postal Code
08208
Country
Spain
City
Terrassa
State/Province
Barcelona
ZIP/Postal Code
08221
Country
Spain
City
Santander
State/Province
Cantabria
ZIP/Postal Code
39008
Country
Spain
City
Palma De Mallorca
State/Province
Islas Baleares
ZIP/Postal Code
07014
Country
Spain
City
Alcorcon
State/Province
Madrid
ZIP/Postal Code
28922
Country
Spain
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
City
La Laguna
State/Province
Tenerife
ZIP/Postal Code
38320
Country
Spain
City
Barakaldo
State/Province
Vizcaya
ZIP/Postal Code
48903
Country
Spain
City
Alicante
ZIP/Postal Code
3010
Country
Spain
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
City
Barcelona
ZIP/Postal Code
08907
Country
Spain
City
Barcelona
ZIP/Postal Code
08916
Country
Spain
City
Girona
ZIP/Postal Code
17007
Country
Spain
City
Huesca
ZIP/Postal Code
22004
Country
Spain
City
La Coruña
ZIP/Postal Code
15006
Country
Spain
City
Lugo
ZIP/Postal Code
27004
Country
Spain
City
Madrid
ZIP/Postal Code
28002
Country
Spain
City
Madrid
ZIP/Postal Code
28034
Country
Spain
City
Madrid
ZIP/Postal Code
28035
Country
Spain
City
Madrid
ZIP/Postal Code
28040
Country
Spain
City
Madrid
ZIP/Postal Code
28041
Country
Spain
City
Madrid
ZIP/Postal Code
28046
Country
Spain
City
Murcia
ZIP/Postal Code
30008
Country
Spain
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
City
Valencia
ZIP/Postal Code
41014
Country
Spain
City
Valencia
ZIP/Postal Code
46009
Country
Spain
City
Valencia
ZIP/Postal Code
46010
Country
Spain
City
Valencia
ZIP/Postal Code
46015
Country
Spain
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
City
Gothenburg
ZIP/Postal Code
41345
Country
Sweden
City
Lund
ZIP/Postal Code
22185
Country
Sweden
City
Malmoe
ZIP/Postal Code
20502
Country
Sweden
City
Oerebro
ZIP/Postal Code
70185
Country
Sweden
City
Stokholm, Solna
ZIP/Postal Code
01716
Country
Sweden
City
Umea
ZIP/Postal Code
90185
Country
Sweden
City
Uppsala
ZIP/Postal Code
751 85
Country
Sweden
City
Aarau
ZIP/Postal Code
5000
Country
Switzerland
City
Baden
ZIP/Postal Code
5404
Country
Switzerland
City
Genolier
ZIP/Postal Code
1272
Country
Switzerland
City
Locarno
ZIP/Postal Code
6601
Country
Switzerland
City
Taichung
ZIP/Postal Code
407
Country
Taiwan
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
City
Ankara
ZIP/Postal Code
06530
Country
Turkey
City
Gaziantep
ZIP/Postal Code
27310
Country
Turkey
City
Istanbul
ZIP/Postal Code
34300
Country
Turkey
City
Istanbul
ZIP/Postal Code
34383
Country
Turkey
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
City
Sıhhiye, ANKARA
ZIP/Postal Code
06100
Country
Turkey
City
Aberdeen
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
City
Belfast
ZIP/Postal Code
BT9 7AB
Country
United Kingdom
City
Birmingham
ZIP/Postal Code
B9 5SS
Country
United Kingdom
City
Cambridge
ZIP/Postal Code
PE3 6DA
Country
United Kingdom
City
Cardiff
ZIP/Postal Code
CF14 2TL
Country
United Kingdom
City
Manchester
ZIP/Postal Code
M23 9LT
Country
United Kingdom
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
City
Suffolk
ZIP/Postal Code
IP33 2QZ
Country
United Kingdom
City
Barcelona
ZIP/Postal Code
6001
Country
Venezuela
City
Barquisimeto
ZIP/Postal Code
3001
Country
Venezuela
City
Porlamar
ZIP/Postal Code
6301
Country
Venezuela
12. IPD Sharing Statement
Citations:
PubMed Identifier
23018280
Citation
Bearz A, Passalacqua R, Alabiso O, Cinieri S, Gridelli C, Cravesana C, Crino L. First-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer : analysis of the Italian patients enrolled in the SAiL study. Clin Drug Investig. 2012 Nov;32(11):755-60. doi: 10.1007/s40261-012-0001-9.
Results Reference
derived
PubMed Identifier
20650686
Citation
Crino L, Dansin E, Garrido P, Griesinger F, Laskin J, Pavlakis N, Stroiakovski D, Thatcher N, Tsai CM, Wu YL, Zhou C. Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study. Lancet Oncol. 2010 Aug;11(8):733-40. doi: 10.1016/S1470-2045(10)70151-0. Epub 2010 Jul 23.
Results Reference
derived
Learn more about this trial
A Study of Avastin (Bevacizumab) in Combination With Platinum-Containing Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Cell Lung Cancer.
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