Treatment of Tumors of the Choroid Plexus Epithelium
Choroid Plexus Tumors
About this trial
This is an interventional treatment trial for Choroid Plexus Tumors focused on measuring Choroid Plexus Tumors, Carboplatin, Cyclophosphamide, Etoposide, Vincristine, Paraplatin, Cytoxan, Neosar
Eligibility Criteria
Inclusion Criteria:
- The reference center has confirmed the receipt of slides sent (For randomization only = form 2)
- The postoperative imaging has been done and the result is available (for randomization only = for form 2 only)
- Indication criteria: Choroid plexus papilloma (Gr I) with histologically confirmed metastases. (For randomization only = use form 2).
- Indication criteria: Atypical choroid plexus papilloma or anaplastic choroid plexus papilloma histology with either metastases or postoperative residual tumor. (For randomization only = use form 2).
- Indication criteria: Choroid plexus carcinoma, regardless of histologically confirmed metastases or residual tumor. (For randomization only = use form 2).
- Informed consent signed (required for registration = form 1, and for randomization = form 2)
- Patients must have the following: WBC > 2000/ul, platelets >85 000/ul, serum creatinine in normal range, pregnancy test negative, hearing loss less than 30dB at 3000 Hz.
Exclusion Criteria:
- Previous irradiation or chemotherapy. (Exclusion from randomization only)
- The protocol did not pass the local centre required approvals, such as the Ethics Committee or the scientific review.
- Previous immunotherapy or antiangiogenic therapy (Exclusion from randomization only)
Sites / Locations
- University of Texas MD Anderson Cancer Center
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Carboplatin + Etoposide + Vincristine
Cyclophosphamide + Etoposide + Vincristine
Carboplatin 350 mg/m^2 by vein, Over 2 Hours x 2 Days. Etoposide 100 mg/m^2 by vein, Over 1 Hour x 5 Days. Vincristine 1.5 mg/m^2 (by vein)IV Push Over 15 Minutes On Day 5. Radiation treatment over a period of about 6 weeks.
Cyclophosphamide 1 g/m^2 by vein, Over 1 Hour x 2 Days. Etoposide 100 mg/m^2 by vein, Over 1 Hour x 5 Days. Vincristine 1.5 mg/m^2 (by vein)IV Push Over 15 Minutes On Day 5. Radiation treatment over a period of about 6 weeks.