Comparative Study of Ceftaroline vs. Ceftriaxone in Adults With Community-Acquired Pneumonia (CAP)
Bacterial Pneumonia
About this trial
This is an interventional treatment trial for Bacterial Pneumonia focused on measuring ceftaroline, Community-acquired pneumonia, CAP, Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila spp, Legionella ssp, multi-drug resistant Streptococcus pneumoniae (MDRSP), antimicrobial resistance, pneumococci, beta-lactam, ceftaroline fosamil, ceftriaxone, antibiotic
Eligibility Criteria
Inclusion Criteria:
Subjects with community-acquired pneumonia requiring:
- initial hospitalization or treatment in an emergency room or urgent care setting
- infection requiring initial treatment with IV antimicrobial
Exclusion Criteria:
- Community-acquired pneumonia suitable for outpatient therapy with an oral antimicrobial agent
- Respiratory tract infections not due to community-acquired bacterial pathogens
- Infections resistant to ceftriaxone
- Any condition requiring concomitant systemic corticosteroids
- History of any hypersensitivity or allergic reaction to any ß-lactam antimicrobial
Sites / Locations
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Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Ceftaroline fosamil for injection
IV Ceftriaxone
Ceftaroline fosamil was administered in two consecutive 300 mg IV infusions over 30 minutes, every 12 hours (q12h).
Ceftriaxone was administered as a 1-g IV infusion over 30 minutes followed by IV saline placebo infused over 30 minutes, every 24 hours (q24h).