Back to resultsDalteparin in Preventing Blood Clots in Patients With Lung Cancer
Primary Purpose
Lung Cancer, Thromboembolism
Status
Unknown status
Phase
Phase 3
Locations
United Kingdom
Study Type
Interventional
Intervention
dalteparin
quality-of-life assessment
Sponsored by
About this trial
This is an interventional supportive care trial for Lung Cancer focused on measuring thromboembolism, extensive stage small cell lung cancer, limited stage small cell lung cancer, stage IV non-small cell lung cancer, stage II non-small cell lung cancer, stage IIIA non-small cell lung cancer, stage IIIB non-small cell lung cancer, stage I non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Histopathological or cytological diagnosis of primary bronchial carcinoma (small cell or non-small cell lung cancer) within the past 6 weeks
- No other intrathoracic tumors (e.g., carcinoid tumor, mesothelioma, lymphoma, or lung metastases from another primary site)
- No clinically apparent brain metastases
PATIENT CHARACTERISTICS:
- ECOG performance status 0-3
- Platelet count ≥ 100,000/mm³
- Serum creatinine ≤ 150 µmol/L
- Willing and able to self-administer dalteparin by daily subcutaneous injection or have it administered by a caregiver
- Not pregnant or nursing
- Fertile female patients must use effective contraception (if sexually active)
- No hemorrhagic stroke within the past 3 months
- No known bleeding disorder
- No hemoptysis of CTC ≥ grade 2 (i.e., symptomatic hemoptysis requiring medical intervention)
- No central venous catheter requiring the use of thromboprophylaxis
- No known hypersensitivity to dalteparin, heparin, or other low molecular weight heparins (e.g., history of confirmed or suspected immunologically mediated heparin-induced thrombocytopenia; acute gastroduodenal ulcer; or subacute endocarditis)
- No prior illness likely to interfere with study treatment or comparisons
PRIOR CONCURRENT THERAPY:
- No prior treatment likely to interfere with study treatment or comparisons
- More than 12 months since prior and no concurrent therapeutic anticoagulation
- No concurrent ketorolac (Toradol®)
Sites / Locations
- Stoke Mandeville HospitalRecruiting
- Furness General HospitalRecruiting
- Royal Blackburn HospitalRecruiting
- Blackpool Victoria HospitalRecruiting
- Royal Bournemouth HospitalRecruiting
- Bristol Haematology and Oncology CentreRecruiting
- Burnley General HospitalRecruiting
- Queen's HospitalRecruiting
- West Suffolk HospitalRecruiting
- Walsgrave HospitalRecruiting
- Darlington MemorialRecruiting
- Derbyshire Royal InfirmaryRecruiting
- Doncaster Royal InfirmaryRecruiting
- Dorset County HospitalRecruiting
- Russells Hall HospitalRecruiting
- Queen Elizabeth HospitalRecruiting
- Wycombe General HospitalRecruiting
- Kidderminster HospitalRecruiting
- Royal Lancaster InfirmaryRecruiting
- Whipps Cross HospitalRecruiting
- Saint Bartholomew's HospitalRecruiting
- Helen Rollason Cancer Care Centre at North Middlesex HospitalRecruiting
- Whittington HospitalRecruiting
- University College HospitalRecruiting
- UCL Cancer InstituteRecruiting
- Luton and Dunstable HospitalRecruiting
- James Cook University HospitalRecruiting
- Milton Keynes General HospitalRecruiting
- Newcastle Upon Tyne Hospitals NHS TrustRecruiting
- James Paget HospitalRecruiting
- North Tyneside HospitalRecruiting
- Friarage HospitalRecruiting
- Northampton General HospitalRecruiting
- Mount Vernon Cancer Centre at Mount Vernon HospitalRecruiting
- Norfolk and Norwich University HospitalRecruiting
- Nottingham City HospitalRecruiting
- George Eliot HospitalRecruiting
- Derriford HospitalRecruiting
- Dorset Cancer CentreRecruiting
- Rosemere Cancer Centre at Royal Preston HospitalRecruiting
- Berkshire Cancer Centre at Royal Berkshire HospitalRecruiting
- Alexandra Healthcare NHSRecruiting
- Scarborough General HospitalRecruiting
- Cancer Research Centre at Weston Park HospitalRecruiting
- Wexham Park HospitalRecruiting
- South Tyneside District HospitalRecruiting
- Staffordshire General HospitalRecruiting
- University Hospital of North StaffordshireRecruiting
- Royal Marsden - SurreyRecruiting
- South Warwickshire HospitalRecruiting
- Weston General HospitalRecruiting
- New Cross HospitalRecruiting
- Yeovil District HospitalRecruiting
- Ysbyty GwyneddRecruiting
- Velindre Cancer Center at Velindre HospitalRecruiting
- Llandough HospitalRecruiting
- Royal Glamorgan HospitalRecruiting
- Prince Charles HospitalRecruiting
- Royal Gwent HospitalRecruiting
- Glan Clwyd HospitalRecruiting
Outcomes
Primary Outcome Measures
Overall survival
Secondary Outcome Measures
Venous thrombotic event-free survival
Serious adverse events
Metastasis-free survival
Toxicity
Quality of life as measured by EQ-5D
Breathlessness (dyspnea) as measured by the Cancer Dyspnea Scale
Anxiety and depression as measured by the Hospital Anxiety and Depression Scale
Cost effectiveness
Cost utility
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00519805
Brief Title
Dalteparin in Preventing Blood Clots in Patients With Lung Cancer
Official Title
FRAGMATIC - A Randomised Phase III Clinical Trial Investigating the Effect of FRAGMin Added to Standard Therapy In Patients With Lung Cancer
Study Type
Interventional
2. Study Status
Record Verification Date
March 2008
Overall Recruitment Status
Unknown status
Study Start Date
August 2007 (undefined)
Primary Completion Date
August 2012 (Anticipated)
Study Completion Date
undefined (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
Velindre NHS Trust
4. Oversight
5. Study Description
Brief Summary
RATIONALE: Anticoagulants, such as dalteparin, may help prevent blood clots from forming in patients with lung cancer. It is not yet known whether dalteparin is effective in preventing blood clots in patients with lung cancer.
PURPOSE: This randomized phase III trial is studying how well dalteparin works in preventing blood clots in patients with lung cancer.
Detailed Description
OBJECTIVES:
Primary
Determine whether the addition of dalteparin results in improved survival.
Secondary
Determine venous thrombotic event-free survival and metastasis-free survival.
Determine serious adverse events in patients treated with this drug.
Determine the toxicity of this drug in these patients.
Determine the quality of life, breathlessness, anxiety, and depression in patients treated with this drug.
Determine the cost effectiveness and cost utility of this drug.
OUTLINE: This is a multicenter study. Patients are randomized to 1 of 2 treatment arms.
Arm I (control): Patients receive anticancer treatment considered appropriate by the local medical team.
Arm II: Patients receive anticancer treatment considered appropriate by the local medical team. Beginning before the start of the first definitive anticancer treatment, patients receive dalteparin subcutaneously daily for up to 24 weeks.
Quality of life, anxiety, depression, and dyspnea are assessed at baseline, at 12 and 24 weeks, and then at 9 and 12 months.
After completion of therapy, patients are followed at 9 months, 1 year, and then every 6 months for at least 2 years.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lung Cancer, Thromboembolism
Keywords
thromboembolism, extensive stage small cell lung cancer, limited stage small cell lung cancer, stage IV non-small cell lung cancer, stage II non-small cell lung cancer, stage IIIA non-small cell lung cancer, stage IIIB non-small cell lung cancer, stage I non-small cell lung cancer
7. Study Design
Primary Purpose
Supportive Care
Study Phase
Phase 3
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2200 (Anticipated)
8. Arms, Groups, and Interventions
Intervention Type
Drug
Intervention Name(s)
dalteparin
Intervention Type
Procedure
Intervention Name(s)
quality-of-life assessment
Primary Outcome Measure Information:
Title
Overall survival
Secondary Outcome Measure Information:
Title
Venous thrombotic event-free survival
Title
Serious adverse events
Title
Metastasis-free survival
Title
Toxicity
Title
Quality of life as measured by EQ-5D
Title
Breathlessness (dyspnea) as measured by the Cancer Dyspnea Scale
Title
Anxiety and depression as measured by the Hospital Anxiety and Depression Scale
Title
Cost effectiveness
Title
Cost utility
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histopathological or cytological diagnosis of primary bronchial carcinoma (small cell or non-small cell lung cancer) within the past 6 weeks
No other intrathoracic tumors (e.g., carcinoid tumor, mesothelioma, lymphoma, or lung metastases from another primary site)
No clinically apparent brain metastases
PATIENT CHARACTERISTICS:
ECOG performance status 0-3
Platelet count ≥ 100,000/mm³
Serum creatinine ≤ 150 µmol/L
Willing and able to self-administer dalteparin by daily subcutaneous injection or have it administered by a caregiver
Not pregnant or nursing
Fertile female patients must use effective contraception (if sexually active)
No hemorrhagic stroke within the past 3 months
No known bleeding disorder
No hemoptysis of CTC ≥ grade 2 (i.e., symptomatic hemoptysis requiring medical intervention)
No central venous catheter requiring the use of thromboprophylaxis
No known hypersensitivity to dalteparin, heparin, or other low molecular weight heparins (e.g., history of confirmed or suspected immunologically mediated heparin-induced thrombocytopenia; acute gastroduodenal ulcer; or subacute endocarditis)
No prior illness likely to interfere with study treatment or comparisons
PRIOR CONCURRENT THERAPY:
No prior treatment likely to interfere with study treatment or comparisons
More than 12 months since prior and no concurrent therapeutic anticoagulation
No concurrent ketorolac (Toradol®)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Fergus Macbeth, MD
Organizational Affiliation
Velindre NHS Trust
Official's Role
Study Chair
Facility Information:
Facility Name
Stoke Mandeville Hospital
City
Aylesbury-Buckinghamshire
State/Province
England
ZIP/Postal Code
HP21 8AL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicholas Bates, MD
Phone
44-1296-316-555
Facility Name
Furness General Hospital
City
Barrow in Furness
State/Province
England
ZIP/Postal Code
LA14 4LF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Fyfe, MD
Phone
44-1524-583-510
Facility Name
Royal Blackburn Hospital
City
Blackburn
State/Province
England
ZIP/Postal Code
BB2 3HH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wiebke Appel, MD, FRCR, MRCP
Phone
44-1772-522-792
Facility Name
Blackpool Victoria Hospital
City
Blackpool
State/Province
England
ZIP/Postal Code
FY3 8NR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew C. Hindley, MD
Phone
44-177-252-2908
Email
andrew.hindley@lthtr.nhs.uk
Facility Name
Royal Bournemouth Hospital
City
Bournemouth
State/Province
England
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tom Geldart
Phone
44-1202-726-088
Facility Name
Bristol Haematology and Oncology Centre
City
Bristol
State/Province
England
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen J. Falk, MD
Phone
44-1935-384-559
Email
stephen.falk@ubht.nhs.uk
Facility Name
Burnley General Hospital
City
Burnley
State/Province
England
ZIP/Postal Code
BB10 2PQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wiebke Appel, MD, FRCR, MRCP
Phone
44-772-522-792
Facility Name
Queen's Hospital
City
Burton-upon-Trent
State/Province
England
ZIP/Postal Code
DE13 0RB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
A.D. Chetiyawardana, MD
Phone
44-283-566-333
Facility Name
West Suffolk Hospital
City
Bury St. Edmunds
State/Province
England
ZIP/Postal Code
IP33 2QZ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1284-713-195
Facility Name
Walsgrave Hospital
City
Coventry
State/Province
England
ZIP/Postal Code
CV2 2DX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caroline Humber, MD
Phone
44-2476-967-478
Facility Name
Darlington Memorial
City
Darlington
State/Province
England
ZIP/Postal Code
DL3 6HX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clive Peedell, MD
Phone
44-1643-850-850
Facility Name
Derbyshire Royal Infirmary
City
Derby
State/Province
England
ZIP/Postal Code
DE1 2QY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Muthu Kumar, MD
Phone
44-1332-347-141 ext. 2437
Email
muthu.kumar@derbyhospitals.nhs.uk
Facility Name
Doncaster Royal Infirmary
City
Doncaster
State/Province
England
ZIP/Postal Code
DN2 5LT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-130-236-6666
Facility Name
Dorset County Hospital
City
Dorchester
State/Province
England
ZIP/Postal Code
DT1 2JY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mike Bayne, MD
Phone
44-1202-448-648
Facility Name
Russells Hall Hospital
City
Dudley
State/Province
England
ZIP/Postal Code
DY1 2HQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Simon Grumett, MD
Phone
44-384-456-111
Facility Name
Queen Elizabeth Hospital
City
Gateshead
State/Province
England
ZIP/Postal Code
NE9 6SX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fiona McDonald, MD
Phone
44-191-256-3567
Facility Name
Wycombe General Hospital
City
High Wycombe
State/Province
England
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicholas Bates, MD
Phone
44-865-225-601
Facility Name
Kidderminster Hospital
City
Kidderminster Worcestershire
State/Province
England
ZIP/Postal Code
DY11 6RJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1562-513-093
Facility Name
Royal Lancaster Infirmary
City
Lancaster
State/Province
England
ZIP/Postal Code
LA1 4RP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Fyfe, MD
Phone
44-1524-583-510
Facility Name
Whipps Cross Hospital
City
London
State/Province
England
ZIP/Postal Code
E11 1NR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paula Wells, MD
Phone
44-20-7601-8044
Facility Name
Saint Bartholomew's Hospital
City
London
State/Province
England
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paula Wells, MD
Phone
44-207-601-8044
Facility Name
Helen Rollason Cancer Care Centre at North Middlesex Hospital
City
London
State/Province
England
ZIP/Postal Code
N18 1QX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-20-7472-6115
Facility Name
Whittington Hospital
City
London
State/Province
England
ZIP/Postal Code
N19 5NF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Siow M. Lee, MD, PhD, FRCP
Phone
44-20-7288-5227
Facility Name
University College Hospital
City
London
State/Province
England
ZIP/Postal Code
NW1 2PG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Siow M. Lee, MD, PhD, FRCP
Phone
44-20-7288-5227
Email
sm.lee@uclh.org
Facility Name
UCL Cancer Institute
City
London
State/Province
England
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-20-7472-6115
Facility Name
Luton and Dunstable Hospital
City
Luton
State/Province
England
ZIP/Postal Code
LU4 0DZ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1582-497-513
Facility Name
James Cook University Hospital
City
Middlesbrough
State/Province
England
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clive Peedell, MD
Phone
44-643-850-850
Facility Name
Milton Keynes General Hospital
City
Milton Keynes
State/Province
England
ZIP/Postal Code
MK6 5LD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hany Eldeeb, MD
Phone
44-1604-523-815
Facility Name
Newcastle Upon Tyne Hospitals NHS Trust
City
Newcastle-Upon-Tyne
State/Province
England
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-191-256-3555
Facility Name
James Paget Hospital
City
Norfolk
State/Province
England
ZIP/Postal Code
NR31 6LA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1603-287-674
Facility Name
North Tyneside Hospital
City
North Shields
State/Province
England
ZIP/Postal Code
NE29 8NH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-191-256-3555
Facility Name
Friarage Hospital
City
North Yorkshire
State/Province
England
ZIP/Postal Code
DL6 1JG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clive Peedell, MD
Phone
44-643-850-850
Facility Name
Northampton General Hospital
City
Northampton
State/Province
England
ZIP/Postal Code
NN1 5BD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1604-543-789
Facility Name
Mount Vernon Cancer Centre at Mount Vernon Hospital
City
Northwood
State/Province
England
ZIP/Postal Code
HA6 2RN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeanette Dickson, MD
Phone
44-923-844-551
Email
jeanette.dickson@nhs.net
Facility Name
Norfolk and Norwich University Hospital
City
Norwich
State/Province
England
ZIP/Postal Code
NR4 7UY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tom W. Roques, MD
Phone
44-603-287-671
Email
tom.roques@nnuh.nhs.uk
Facility Name
Nottingham City Hospital
City
Nottingham
State/Province
England
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-115-969-1169
Facility Name
George Eliot Hospital
City
Nuneaton
State/Province
England
ZIP/Postal Code
CV10 7DJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mark Hocking, MD
Phone
44-2476-967-490
Facility Name
Derriford Hospital
City
Plymouth
State/Province
England
ZIP/Postal Code
PL6 8DH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dennis Yiannakis, MD
Phone
44-1752-439-103
Facility Name
Dorset Cancer Centre
City
Poole Dorset
State/Province
England
ZIP/Postal Code
BH15 2JB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Virginia Laurence, MD
Phone
44-1202-448-262
Facility Name
Rosemere Cancer Centre at Royal Preston Hospital
City
Preston
State/Province
England
ZIP/Postal Code
PR2 9HT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Geraldine Skailes, MD
Phone
44-1772-522-913
Facility Name
Berkshire Cancer Centre at Royal Berkshire Hospital
City
Reading
State/Province
England
ZIP/Postal Code
RG1 5AN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard Brown, MD
Phone
44-118-322-8343
Facility Name
Alexandra Healthcare NHS
City
Redditch, Worcestershire
State/Province
England
ZIP/Postal Code
B98 7UB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joanna Hamilton, MD
Phone
44-2476-967-477
Facility Name
Scarborough General Hospital
City
Scarborough
State/Province
England
ZIP/Postal Code
YO12 6QL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1482-701-151
Facility Name
Cancer Research Centre at Weston Park Hospital
City
Sheffield
State/Province
England
ZIP/Postal Code
S1O 2SJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Penella J. Woll, MD, PhD
Phone
44-14-226-5235
Facility Name
Wexham Park Hospital
City
Slough, Berkshire
State/Province
England
ZIP/Postal Code
SL2 4HL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1753-634-191
Facility Name
South Tyneside District Hospital
City
South Shields
State/Province
England
ZIP/Postal Code
NE34 0PL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Goudarz Mazdai, MD, PhD
Phone
44-191-202-4010
Facility Name
Staffordshire General Hospital
City
Stafford
State/Province
England
ZIP/Postal Code
ST16 3SA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caroline Brammer, MD
Phone
44-902-695-201
Facility Name
University Hospital of North Staffordshire
City
Stoke-On-Trent
State/Province
England
ZIP/Postal Code
ST4 7LN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1782-554-974
Facility Name
Royal Marsden - Surrey
City
Sutton
State/Province
England
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-20-8661-3278
Facility Name
South Warwickshire Hospital
City
Warwick, Warwickshire
State/Province
England
ZIP/Postal Code
CV34 5BJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caroline Humber, MD
Phone
44-2476-967-478
Facility Name
Weston General Hospital
City
Weston-super-Mare
State/Province
England
ZIP/Postal Code
BS23 4TQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher J. Williams, DM, FRCP
Phone
44-1934-881-136
Facility Name
New Cross Hospital
City
Wolverhampton
State/Province
England
ZIP/Postal Code
WV10 0QP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Ferry, MD
Phone
44-1245-516-598
Facility Name
Yeovil District Hospital
City
Yeovil
State/Province
England
ZIP/Postal Code
BA21 4AT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen J. Falk, MD
Phone
44-932-384-559
Email
stephen.falk@swest.uhs.uk
Facility Name
Ysbyty Gwynedd
City
Bangor
State/Province
Wales
ZIP/Postal Code
LL57 2PW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nick Stuart, MD
Phone
44-1248-384-150
Email
nick.stuart@nww-tr.wales.nus.uk
Facility Name
Velindre Cancer Center at Velindre Hospital
City
Cardiff
State/Province
Wales
ZIP/Postal Code
CF14 2TL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fergus Macbeth, MD
Phone
44-292-031-6232
Facility Name
Llandough Hospital
City
Llandough
State/Province
Wales
ZIP/Postal Code
CF64 2XX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fergus Macbeth, MD
Phone
44-29-2061-5888
Facility Name
Royal Glamorgan Hospital
City
Llantrisant
State/Province
Wales
ZIP/Postal Code
CF72 8XR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-2920-615-888
Facility Name
Prince Charles Hospital
City
Mid Glamorgan
State/Province
Wales
ZIP/Postal Code
CF47 9DT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fergus Macbeth, MD
Phone
44-29-2061-5888
Facility Name
Royal Gwent Hospital
City
Newport Gwent
State/Province
Wales
ZIP/Postal Code
NP9 2UB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
44-1633-623-623
Facility Name
Glan Clwyd Hospital
City
Rhyl, Denbighshire
State/Province
Wales
ZIP/Postal Code
LL 18 5UJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angel Garcia-Alonso, MD
Phone
44-1745-583-910
12. IPD Sharing Statement
Citations:
PubMed Identifier
19807917
Citation
Griffiths GO, Burns S, Noble SI, Macbeth FR, Cohen D, Maughan TS. FRAGMATIC: a randomised phase III clinical trial investigating the effect of fragmin added to standard therapy in patients with lung cancer. BMC Cancer. 2009 Oct 6;9:355. doi: 10.1186/1471-2407-9-355.
Results Reference
result
PubMed Identifier
33337539
Citation
Rutjes AW, Porreca E, Candeloro M, Valeriani E, Di Nisio M. Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database Syst Rev. 2020 Dec 18;12(12):CD008500. doi: 10.1002/14651858.CD008500.pub5.
Results Reference
derived
Learn more about this trial
Dalteparin in Preventing Blood Clots in Patients With Lung Cancer
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