Back to resultsY402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
Primary Purpose
Age-Related Macular Degeneration
Status
Unknown status
Phase
Not Applicable
Locations
Austria
Study Type
Interventional
Intervention
drawing blood
Sponsored by
About this trial
This is an interventional basic science trial for Age-Related Macular Degeneration focused on measuring age-related macular degeneration, genetics
Eligibility Criteria
Inclusion Criteria:
- man and women over 18 years old
- Filled out informed consentBereitschaft zur Teilnahme
- Diagnosis of non-exudative/ exudative age related macular dgeneneration
Exclusion Criteria:
- inherited retinal diseases
- other aquired retinal/ macular
- missing informed consent
Sites / Locations
- Rudoulf foundation Clinic
Outcomes
Primary Outcome Measures
higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals
Secondary Outcome Measures
a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD
Full Information
NCT ID
NCT00533754
First Posted
September 20, 2007
Last Updated
September 20, 2007
Sponsor
Rudolf Foundation Clinic
1. Study Identification
Unique Protocol Identification Number
NCT00533754
Brief Title
Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
Official Title
Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
Study Type
Interventional
2. Study Status
Record Verification Date
September 2007
Overall Recruitment Status
Unknown status
Study Start Date
July 2006 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
November 2007 (Anticipated)
3. Sponsor/Collaborators
Name of the Sponsor
Rudolf Foundation Clinic
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.
Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Age-Related Macular Degeneration
Keywords
age-related macular degeneration, genetics
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
Outcomes Assessor
Allocation
N/A
8. Arms, Groups, and Interventions
Intervention Type
Procedure
Intervention Name(s)
drawing blood
Primary Outcome Measure Information:
Title
higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals
Secondary Outcome Measure Information:
Title
a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD
10. Eligibility
Sex
All
Minimum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
man and women over 18 years old
Filled out informed consentBereitschaft zur Teilnahme
Diagnosis of non-exudative/ exudative age related macular dgeneneration
Exclusion Criteria:
inherited retinal diseases
other aquired retinal/ macular
missing informed consent
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Susanne Binder, M.D.
Organizational Affiliation
Rudoulf Foundation Clinic
Official's Role
Study Chair
Facility Information:
Facility Name
Rudoulf foundation Clinic
City
Vienna
ZIP/Postal Code
1030
Country
Austria
12. IPD Sharing Statement
Learn more about this trial
Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
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