Safety and Effectiveness of 3 Doses of Crofelemer Compared to Placebo in the Treatment of HIV Associated Diarrhea (ADVENT)

This is an interventional treatment trial for HIV Associated Diarrhea focused on measuring HIV, AIDS, Diarrhea, HIV Associated Diarrhea Read More

Inclusion Criteria:

• History of HIV-1 infection confirmed by standard serological tests
• Stable medical regimen for treatment of HIV disease and associated conditions for at least 4 weeks prior to screening
• Patient-reported history of diarrhea, defined as either persistently loose stools despite regular ADM use, or one or more watery bowel movements per day without regular ADM use, of at least 1 month duration
• Colonoscopy within the past 5 years if ≥ 50 years of age.

Exclusion Criteria:

• Pregnancy or breast-feeding
• Current or past gastrointestinal (GI) medical or surgical conditions
• Use of certain opiate pain medication within 2 weeks of screening
• Use of an antibiotic within 2 weeks prior to screening, with the exception of stable antibiotic therapy for prophylactic treatment of infection or an HIV-associated condition
• CD4 counts < 100 cells/mm3
• Previous randomization into this study, or into any other crofelemer study