Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence
Opiate Dependence
About this trial
This is an interventional treatment trial for Opiate Dependence focused on measuring Buprenorphine, Buprenorphine/naloxone, Counseling, Primary care
Eligibility Criteria
Inclusion Criteria:
- opioid dependence
Exclusion Criteria:
- current dependence on alcohol, cocaine, benzodiazepines or sedatives
- current suicide or homicide risk
- current psychotic disorder or untreated major depression
- inability to read or understand English
- life-threatening or unstable medical problems
Sites / Locations
- The APT Foundation, Inc. -- Welch Building
- Yale University School of Medicine
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
1
2
Buprenorphine/naloxone maintenance (Mtn) is designed to reflect usual care by primary care physicians and includes weekly drug counseling (DC) and referral to ancillary services.
Buprenorphine/naloxone detoxification (Dtx) is identical to Mtn for the first 4 weeks (stabilization) following randomization. In Mtn, Bup will continue unchanged for the remainder of the study. In Dtx, the dosage of Bup will be tapered to zero over the next 3 weeks, and patients will not receive additional Bup for the remainder of the study. Dtx patients will be offered thrice-weekly DC beginning during the taper and naltrexone will be offered 7 days following the last dose of Buprenorphine/naloxone.