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A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis

Primary Purpose

Plaque Psoriasis

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Placebo
ABT-874
ABT-874
Sponsored by
AbbVie (prior sponsor, Abbott)
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Plaque Psoriasis focused on measuring Plaque Psoriasis

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Subject is >= 18 years of age
  • Subject had a clinical diagnosis of psoriasis for at least 6 months, and had moderate to severe plaque psoriasis
  • Subject is judged to be in generally good health as determined by the principal investigator

Exclusion Criteria:

  • Subject has previous exposure to systemic anti-IL 12 therapy
  • Subject cannot discontinue systemic therapies and/or topical therapies for the treatment of psoriasis and cannot avoid UVB or PUVA phototherapy
  • Subject is taking or requires oral or injectible corticosteroids
  • Subject diagnosed with erythrodermic psoriasis, pustular psoriasis, medication-induced or medication-exacerbated psoriasis or new onset guttate psoriasis
  • Subject considered by the investigator, for any reason, to be an unsuitable candidate
  • Female subject who is pregnant or breast-feeding or considering becoming pregnant

Sites / Locations

  • Site Reference ID/Investigator# 6579
  • Site Reference ID/Investigator# 6697
  • Site Reference ID/Investigator# 7015
  • Site Reference ID/Investigator# 6728
  • Site Reference ID/Investigator# 6584
  • Site Reference ID/Investigator# 6696
  • Site Reference ID/Investigator# 6591
  • Site Reference ID/Investigator# 6710
  • Site Reference ID/Investigator# 7885
  • Site Reference ID/Investigator# 6872
  • Site Reference ID/Investigator# 7669
  • Site Reference ID/Investigator# 6821
  • Site Reference ID/Investigator# 6832
  • Site Reference ID/Investigator# 7305
  • Site Reference ID/Investigator# 7990
  • Site Reference ID/Investigator# 6711
  • Site Reference ID/Investigator# 8139
  • Site Reference ID/Investigator# 7167
  • Site Reference ID/Investigator# 7302
  • Site Reference ID/Investigator# 6921
  • Site Reference ID/Investigator# 6917
  • Site Reference ID/Investigator# 6707
  • Site Reference ID/Investigator# 7301
  • Site Reference ID/Investigator# 7012
  • Site Reference ID/Investigator# 6831
  • Site Reference ID/Investigator# 7016
  • Site Reference ID/Investigator# 6590
  • Site Reference ID/Investigator# 6582
  • Site Reference ID/Investigator# 7450
  • Site Reference ID/Investigator# 6714
  • Site Reference ID/Investigator# 6717
  • Site Reference ID/Investigator# 7017
  • Site Reference ID/Investigator# 7877
  • Site Reference ID/Investigator# 6704
  • Site Reference ID/Investigator# 7292
  • Site Reference ID/Investigator# 6706
  • Site Reference ID/Investigator# 7646
  • Site Reference ID/Investigator# 7014
  • Site Reference ID/Investigator# 6873
  • Site Reference ID/Investigator# 7523
  • Site Reference ID/Investigator# 6597
  • Site Reference ID/Investigator# 6703
  • Site Reference ID/Investigator# 7644
  • Site Reference ID/Investigator# 6826
  • Site Reference ID/Investigator# 7989
  • Site Reference ID/Investigator# 6581
  • Site Reference ID/Investigator# 7890
  • Site Reference ID/Investigator# 6709
  • Site Reference ID/Investigator# 7451
  • Site Reference ID/Investigator# 7299
  • Site Reference ID/Investigator# 6924
  • Site Reference ID/Investigator# 6577
  • Site Reference ID/Investigator# 7030
  • Site Reference ID/Investigator# 7878
  • Site Reference ID/Investigator# 7876
  • Site Reference ID/Investigator# 6599
  • Site Reference ID/Investigator# 6895
  • Site Reference ID/Investigator# 7637
  • Site Reference ID/Investigator# 7504
  • Site Reference ID/Investigator# 7018
  • Site Reference ID/Investigator# 6926
  • Site Reference ID/Investigator# 7293
  • Site Reference ID/Investigator# 8251
  • Site Reference ID/Investigator# 6598
  • Site Reference ID/Investigator# 8082
  • Site Reference ID/Investigator# 7165
  • Site Reference ID/Investigator# 7659
  • Site Reference ID/Investigator# 6727
  • Site Reference ID/Investigator# 6894
  • Site Reference ID/Investigator# 6578
  • Site Reference ID/Investigator# 7295
  • Site Reference ID/Investigator# 7879
  • Site Reference ID/Investigator# 6712
  • Site Reference ID/Investigator# 6580
  • Site Reference ID/Investigator# 6576
  • Site Reference ID/Investigator# 6589
  • Site Reference ID/Investigator# 6586
  • Site Reference ID/Investigator# 7668
  • Site Reference ID/Investigator# 6915
  • Site Reference ID/Investigator# 6825
  • Site Reference ID/Investigator# 6762
  • Site Reference ID/Investigator# 6822
  • Site Reference ID/Investigator# 7671
  • Site Reference ID/Investigator# 6705
  • Site Reference ID/Investigator# 6708
  • Site Reference ID/Investigator# 7081
  • Site Reference ID/Investigator# 6912
  • Site Reference ID/Investigator# 7306
  • Site Reference ID/Investigator# 8101
  • Site Reference ID/Investigator# 6807
  • Site Reference ID/Investigator# 6801
  • Site Reference ID/Investigator# 7519
  • Site Reference ID/Investigator# 7080
  • Site Reference ID/Investigator# 7314
  • Site Reference ID/Investigator# 7452
  • Site Reference ID/Investigator# 6702
  • Site Reference ID/Investigator# 6716
  • Site Reference ID/Investigator# 7309
  • Site Reference ID/Investigator# 6588
  • Site Reference ID/Investigator# 6715
  • Site Reference ID/Investigator# 7315
  • Site Reference ID/Investigator# 7636
  • Site Reference ID/Investigator# 6699
  • Site Reference ID/Investigator# 7316
  • Site Reference ID/Investigator# 7088
  • Site Reference ID/Investigator# 7310
  • Site Reference ID/Investigator# 7311
  • Site Reference ID/Investigator# 7313
  • Site Reference ID/Investigator# 7317
  • Site Reference ID/Investigator# 7308
  • Site Reference ID/Investigator# 6713
  • Site Reference ID/Investigator# 7067
  • Site Reference ID/Investigator# 7312
  • Site Reference ID/Investigator# 7087
  • Site Reference ID/Investigator# 6805
  • Site Reference ID/Investigator# 7638

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Placebo Comparator

Active Comparator

Active Comparator

Arm Label

1

2

3

Arm Description

Arm #1 is used for entire study. At week 12, arm is rerandomized.

Arm #2 is used for entire study. At week 12, arm is rerandomized.

Arm #3 is not used for weeks 0-11. At week 12, arm is rerandomized.

Outcomes

Primary Outcome Measures

PGA
PASI
PGA

Secondary Outcome Measures

DLQI
NAPSI
PASI
Safety parameters

Full Information

First Posted
December 7, 2007
Last Updated
February 6, 2013
Sponsor
AbbVie (prior sponsor, Abbott)
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1. Study Identification

Unique Protocol Identification Number
NCT00570986
Brief Title
A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis
Official Title
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis
Study Type
Interventional

2. Study Status

Record Verification Date
January 2013
Overall Recruitment Status
Completed
Study Start Date
November 2007 (undefined)
Primary Completion Date
June 2009 (Actual)
Study Completion Date
June 2009 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AbbVie (prior sponsor, Abbott)

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to determine the safety and efficacy of 2 doses of ABT-874 versus placebo in the treatment of subjects with moderate to severe plaque psoriasis.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Plaque Psoriasis
Keywords
Plaque Psoriasis

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
1465 (Actual)

8. Arms, Groups, and Interventions

Arm Title
1
Arm Type
Placebo Comparator
Arm Description
Arm #1 is used for entire study. At week 12, arm is rerandomized.
Arm Title
2
Arm Type
Active Comparator
Arm Description
Arm #2 is used for entire study. At week 12, arm is rerandomized.
Arm Title
3
Arm Type
Active Comparator
Arm Description
Arm #3 is not used for weeks 0-11. At week 12, arm is rerandomized.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Two injections at weeks 0 and 4. One injection at week 8. At week 12, arm is rerandomized to placebo every 4 weeks.
Intervention Type
Biological
Intervention Name(s)
ABT-874
Intervention Description
200mg at week 0 and week 4. 100mg at week 8. On week 12, arm is rerandomized to 100mg every 4 weeks.
Intervention Type
Biological
Intervention Name(s)
ABT-874
Intervention Description
100mg every 12 weeks.
Primary Outcome Measure Information:
Title
PGA
Time Frame
Proportion of subjects achieving a PGA 0/1 (Clear or minimal) at Week 12
Title
PASI
Time Frame
Subjects achieving a PASI 75 response defined as a 75% reduction in the PASI score from baseline at Week 12
Title
PGA
Time Frame
Proportion of subjects maintaining a PGA 0/1 response at Week 52
Secondary Outcome Measure Information:
Title
DLQI
Time Frame
Change from Baseline in DLQI total score vs. placebo at Week 12
Title
NAPSI
Time Frame
% change in NAPSI score at Week 12 vs placebo in subjects with nail psoriasis
Title
PASI
Time Frame
Subjects who achieve PASI 90 and 100 at Week 12
Title
Safety parameters
Time Frame
Throughout study

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Subject is >= 18 years of age Subject had a clinical diagnosis of psoriasis for at least 6 months, and had moderate to severe plaque psoriasis Subject is judged to be in generally good health as determined by the principal investigator Exclusion Criteria: Subject has previous exposure to systemic anti-IL 12 therapy Subject cannot discontinue systemic therapies and/or topical therapies for the treatment of psoriasis and cannot avoid UVB or PUVA phototherapy Subject is taking or requires oral or injectible corticosteroids Subject diagnosed with erythrodermic psoriasis, pustular psoriasis, medication-induced or medication-exacerbated psoriasis or new onset guttate psoriasis Subject considered by the investigator, for any reason, to be an unsuitable candidate Female subject who is pregnant or breast-feeding or considering becoming pregnant
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Martin Kaul, MD
Organizational Affiliation
AbbVie
Official's Role
Study Chair
Facility Information:
Facility Name
Site Reference ID/Investigator# 6579
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35205
Country
United States
Facility Name
Site Reference ID/Investigator# 6697
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35233
Country
United States
Facility Name
Site Reference ID/Investigator# 7015
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Site Reference ID/Investigator# 6728
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85251
Country
United States
Facility Name
Site Reference ID/Investigator# 6584
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85710
Country
United States
Facility Name
Site Reference ID/Investigator# 6696
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Site Reference ID/Investigator# 6591
City
Bakersfield
State/Province
California
ZIP/Postal Code
93309
Country
United States
Facility Name
Site Reference ID/Investigator# 6710
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
Site Reference ID/Investigator# 7885
City
Irvine
State/Province
California
ZIP/Postal Code
92697
Country
United States
Facility Name
Site Reference ID/Investigator# 6872
City
Los Angeles
State/Province
California
ZIP/Postal Code
90045
Country
United States
Facility Name
Site Reference ID/Investigator# 7669
City
Oceanside
State/Province
California
ZIP/Postal Code
92056
Country
United States
Facility Name
Site Reference ID/Investigator# 6821
City
San Diego
State/Province
California
ZIP/Postal Code
92103
Country
United States
Facility Name
Site Reference ID/Investigator# 6832
City
San Diego
State/Province
California
ZIP/Postal Code
92117
Country
United States
Facility Name
Site Reference ID/Investigator# 7305
City
San Diego
State/Province
California
ZIP/Postal Code
92123
Country
United States
Facility Name
Site Reference ID/Investigator# 7990
City
San Francisco
State/Province
California
ZIP/Postal Code
94118
Country
United States
Facility Name
Site Reference ID/Investigator# 6711
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Facility Name
Site Reference ID/Investigator# 8139
City
Torrance
State/Province
California
ZIP/Postal Code
90503
Country
United States
Facility Name
Site Reference ID/Investigator# 7167
City
Vallejo
State/Province
California
ZIP/Postal Code
94589
Country
United States
Facility Name
Site Reference ID/Investigator# 7302
City
Denver
State/Province
Colorado
ZIP/Postal Code
80209
Country
United States
Facility Name
Site Reference ID/Investigator# 6921
City
Longmont
State/Province
Colorado
ZIP/Postal Code
80501
Country
United States
Facility Name
Site Reference ID/Investigator# 6917
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06511
Country
United States
Facility Name
Site Reference ID/Investigator# 6707
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32204
Country
United States
Facility Name
Site Reference ID/Investigator# 7301
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Site Reference ID/Investigator# 7012
City
Miami
State/Province
Florida
ZIP/Postal Code
33144
Country
United States
Facility Name
Site Reference ID/Investigator# 6831
City
Miami
State/Province
Florida
ZIP/Postal Code
33173
Country
United States
Facility Name
Site Reference ID/Investigator# 7016
City
South Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Site Reference ID/Investigator# 6590
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33407
Country
United States
Facility Name
Site Reference ID/Investigator# 6582
City
Alpharetta
State/Province
Georgia
ZIP/Postal Code
30022
Country
United States
Facility Name
Site Reference ID/Investigator# 7450
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30327
Country
United States
Facility Name
Site Reference ID/Investigator# 6714
City
Newnan
State/Province
Georgia
ZIP/Postal Code
30263
Country
United States
Facility Name
Site Reference ID/Investigator# 6717
City
Snellville
State/Province
Georgia
ZIP/Postal Code
30078
Country
United States
Facility Name
Site Reference ID/Investigator# 7017
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
Facility Name
Site Reference ID/Investigator# 7877
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
Site Reference ID/Investigator# 6704
City
Skokie
State/Province
Illinois
ZIP/Postal Code
60077
Country
United States
Facility Name
Site Reference ID/Investigator# 7292
City
West Dundee
State/Province
Illinois
ZIP/Postal Code
60118
Country
United States
Facility Name
Site Reference ID/Investigator# 6706
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46256
Country
United States
Facility Name
Site Reference ID/Investigator# 7646
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46260
Country
United States
Facility Name
Site Reference ID/Investigator# 7014
City
Overland Park
State/Province
Kansas
ZIP/Postal Code
66202
Country
United States
Facility Name
Site Reference ID/Investigator# 6873
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Site Reference ID/Investigator# 7523
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Site Reference ID/Investigator# 6597
City
Andover
State/Province
Massachusetts
ZIP/Postal Code
01810
Country
United States
Facility Name
Site Reference ID/Investigator# 6703
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Facility Name
Site Reference ID/Investigator# 7644
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Site Reference ID/Investigator# 6826
City
Fort Gratiot
State/Province
Michigan
ZIP/Postal Code
48059
Country
United States
Facility Name
Site Reference ID/Investigator# 7989
City
Grand Blanc
State/Province
Michigan
ZIP/Postal Code
48439
Country
United States
Facility Name
Site Reference ID/Investigator# 6581
City
Fridley
State/Province
Minnesota
ZIP/Postal Code
55432
Country
United States
Facility Name
Site Reference ID/Investigator# 7890
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Site Reference ID/Investigator# 6709
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63117
Country
United States
Facility Name
Site Reference ID/Investigator# 7451
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68144
Country
United States
Facility Name
Site Reference ID/Investigator# 7299
City
Berlin
State/Province
New Jersey
ZIP/Postal Code
08009
Country
United States
Facility Name
Site Reference ID/Investigator# 6924
City
East Windsor
State/Province
New Jersey
ZIP/Postal Code
08520
Country
United States
Facility Name
Site Reference ID/Investigator# 6577
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08903
Country
United States
Facility Name
Site Reference ID/Investigator# 7030
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87106
Country
United States
Facility Name
Site Reference ID/Investigator# 7878
City
Buffalo
State/Province
New York
ZIP/Postal Code
14221
Country
United States
Facility Name
Site Reference ID/Investigator# 7876
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Site Reference ID/Investigator# 6599
City
New York
State/Province
New York
ZIP/Postal Code
10025
Country
United States
Facility Name
Site Reference ID/Investigator# 6895
City
New York
State/Province
New York
ZIP/Postal Code
10029-6501
Country
United States
Facility Name
Site Reference ID/Investigator# 7637
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
Site Reference ID/Investigator# 7504
City
Rochester
State/Province
New York
ZIP/Postal Code
14623
Country
United States
Facility Name
Site Reference ID/Investigator# 7018
City
Stoney Brook
State/Province
New York
ZIP/Postal Code
11790
Country
United States
Facility Name
Site Reference ID/Investigator# 6926
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28601
Country
United States
Facility Name
Site Reference ID/Investigator# 7293
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
Site Reference ID/Investigator# 8251
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Facility Name
Site Reference ID/Investigator# 6598
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Site Reference ID/Investigator# 8082
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Site Reference ID/Investigator# 7165
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43212
Country
United States
Facility Name
Site Reference ID/Investigator# 7659
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45408
Country
United States
Facility Name
Site Reference ID/Investigator# 6727
City
Lake Oswego
State/Province
Oregon
ZIP/Postal Code
97035
Country
United States
Facility Name
Site Reference ID/Investigator# 6894
City
Portland
State/Province
Oregon
ZIP/Postal Code
97210
Country
United States
Facility Name
Site Reference ID/Investigator# 6578
City
Portland
State/Province
Oregon
ZIP/Postal Code
97223
Country
United States
Facility Name
Site Reference ID/Investigator# 7295
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Site Reference ID/Investigator# 7879
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Site Reference ID/Investigator# 6712
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19103
Country
United States
Facility Name
Site Reference ID/Investigator# 6580
City
Johnston
State/Province
Rhode Island
ZIP/Postal Code
02919
Country
United States
Facility Name
Site Reference ID/Investigator# 6576
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Facility Name
Site Reference ID/Investigator# 6589
City
Greer
State/Province
South Carolina
ZIP/Postal Code
29651
Country
United States
Facility Name
Site Reference ID/Investigator# 6586
City
Goodlettsville
State/Province
Tennessee
ZIP/Postal Code
37072
Country
United States
Facility Name
Site Reference ID/Investigator# 7668
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37934
Country
United States
Facility Name
Site Reference ID/Investigator# 6915
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37215
Country
United States
Facility Name
Site Reference ID/Investigator# 6825
City
Arlington
State/Province
Texas
ZIP/Postal Code
76011
Country
United States
Facility Name
Site Reference ID/Investigator# 6762
City
Austin
State/Province
Texas
ZIP/Postal Code
78759
Country
United States
Facility Name
Site Reference ID/Investigator# 6822
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Site Reference ID/Investigator# 7671
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246-1613
Country
United States
Facility Name
Site Reference ID/Investigator# 6705
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Site Reference ID/Investigator# 6708
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Site Reference ID/Investigator# 7081
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Site Reference ID/Investigator# 6912
City
Tyler
State/Province
Texas
ZIP/Postal Code
75703
Country
United States
Facility Name
Site Reference ID/Investigator# 7306
City
Webster
State/Province
Texas
ZIP/Postal Code
77598
Country
United States
Facility Name
Site Reference ID/Investigator# 8101
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84132
Country
United States
Facility Name
Site Reference ID/Investigator# 6807
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Facility Name
Site Reference ID/Investigator# 6801
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States
Facility Name
Site Reference ID/Investigator# 7519
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Site Reference ID/Investigator# 7080
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53209
Country
United States
Facility Name
Site Reference ID/Investigator# 7314
City
Barrie
ZIP/Postal Code
L4M 6L2
Country
Canada
Facility Name
Site Reference ID/Investigator# 7452
City
Calgary
ZIP/Postal Code
T3A 2N1
Country
Canada
Facility Name
Site Reference ID/Investigator# 6702
City
Edmonton
ZIP/Postal Code
T5K 1X3
Country
Canada
Facility Name
Site Reference ID/Investigator# 6716
City
Halifax
ZIP/Postal Code
B3H 0A2
Country
Canada
Facility Name
Site Reference ID/Investigator# 7309
City
Hamilton
ZIP/Postal Code
L8N 1V6
Country
Canada
Facility Name
Site Reference ID/Investigator# 6588
City
Laval
ZIP/Postal Code
H7S 2C6
Country
Canada
Facility Name
Site Reference ID/Investigator# 6715
City
London
ZIP/Postal Code
N5X 2P1
Country
Canada
Facility Name
Site Reference ID/Investigator# 7315
City
London
ZIP/Postal Code
N6A 3H7
Country
Canada
Facility Name
Site Reference ID/Investigator# 7636
City
Markham
ZIP/Postal Code
L3P 1A8
Country
Canada
Facility Name
Site Reference ID/Investigator# 6699
City
Montreal
ZIP/Postal Code
H2K 4L5
Country
Canada
Facility Name
Site Reference ID/Investigator# 7316
City
Montreal
ZIP/Postal Code
H3H 1V4
Country
Canada
Facility Name
Site Reference ID/Investigator# 7088
City
North Bay
ZIP/Postal Code
P1B 3Z7
Country
Canada
Facility Name
Site Reference ID/Investigator# 7310
City
Ottawa
ZIP/Postal Code
K2G 6E2
Country
Canada
Facility Name
Site Reference ID/Investigator# 7311
City
Quebec City
ZIP/Postal Code
G1V 4X7
Country
Canada
Facility Name
Site Reference ID/Investigator# 7313
City
St. John's
ZIP/Postal Code
A1A 5E8
Country
Canada
Facility Name
Site Reference ID/Investigator# 7317
City
Surrey
ZIP/Postal Code
V3R 6A7
Country
Canada
Facility Name
Site Reference ID/Investigator# 7308
City
Vancouver
ZIP/Postal Code
V5Z 3Y1
Country
Canada
Facility Name
Site Reference ID/Investigator# 6713
City
Vancouver
ZIP/Postal Code
V5Z 4E8
Country
Canada
Facility Name
Site Reference ID/Investigator# 7067
City
Waterloo
ZIP/Postal Code
N2J 1C4
Country
Canada
Facility Name
Site Reference ID/Investigator# 7312
City
Westmount
ZIP/Postal Code
H3Z 2S6
Country
Canada
Facility Name
Site Reference ID/Investigator# 7087
City
Windsor
ZIP/Postal Code
N8W 1E6
Country
Canada
Facility Name
Site Reference ID/Investigator# 6805
City
Windsor
ZIP/Postal Code
N8W 5L7
Country
Canada
Facility Name
Site Reference ID/Investigator# 7638
City
Winnipeg
ZIP/Postal Code
R3C 1R4
Country
Canada

12. IPD Sharing Statement

Learn more about this trial

A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis

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