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Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia

Primary Purpose

Osteopenia

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
resistance exercise
plyometric exercise
Sponsored by
University of Missouri-Columbia
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Osteopenia

Eligibility Criteria

25 Years - 60 Years (Adult)MaleDoes not accept healthy volunteers

Inclusion Criteria:

  • Male
  • Age 25-60 years
  • No symptoms of disease
  • Currently participating in cycling activities an average of 4 hr/wk for the previous 24 months
  • Osteopenia of the lumbar spine and/or hip (T score < -1.0 and > -2.5 )

Exclusion Criteria:

  • Medications or supplements that affect bone metabolism or prevent exercise
  • Previous or current medical condition affecting bone health
  • Osteoporosis of the lumbar spine and/or hip (T score > -1.0 or < -2.5)
  • Cardiovascular disease
  • Metallic implants
  • Current smoker
  • Current regular participation in high-intensity resistance training and/or plyometrics

Sites / Locations

  • University of Missouri-Columbia; McKee Gym

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

resistance exercise

plyometric exercise

Arm Description

12 month resistance exercise training

12 month plyometric exercise training

Outcomes

Primary Outcome Measures

Bone Mineral Density

Secondary Outcome Measures

Serum markers of bone turnover
Serum hormones regulating bone turnover

Full Information

First Posted
December 10, 2007
Last Updated
October 6, 2016
Sponsor
University of Missouri-Columbia
Collaborators
National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
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1. Study Identification

Unique Protocol Identification Number
NCT00572104
Brief Title
Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia
Official Title
Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia
Study Type
Interventional

2. Study Status

Record Verification Date
October 2016
Overall Recruitment Status
Completed
Study Start Date
January 2008 (undefined)
Primary Completion Date
November 2013 (Actual)
Study Completion Date
November 2013 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Missouri-Columbia
Collaborators
National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This study will compare the ability of two types of long term (12 months) weight-bearing exercise treatments (1. high-intensity jumping and 2. weight lifting) to increase bone mass of the total body, spine and hip in physically active men with osteopenia.
Detailed Description
The overall goal of this project is to determine the efficacy of chronic (12 months) plyometric jump training exercise on bone mineral density (BMD) and markers of bone turnover in physically active males cyclists diagnosed with osteopenia below normal bone mineral density of the lumbar spine or hip.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Osteopenia

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
38 (Actual)

8. Arms, Groups, and Interventions

Arm Title
resistance exercise
Arm Type
Experimental
Arm Description
12 month resistance exercise training
Arm Title
plyometric exercise
Arm Type
Experimental
Arm Description
12 month plyometric exercise training
Intervention Type
Other
Intervention Name(s)
resistance exercise
Intervention Description
12 month training intervention of weight resistance exercise. All participants receive a daily calcium and vitamin D supplement
Intervention Type
Other
Intervention Name(s)
plyometric exercise
Intervention Description
12 month training intervention of plyometric exercise. All participants receive a daily calcium and vitamin D supplement
Primary Outcome Measure Information:
Title
Bone Mineral Density
Time Frame
12 months
Secondary Outcome Measure Information:
Title
Serum markers of bone turnover
Time Frame
3 months
Title
Serum hormones regulating bone turnover
Time Frame
3 months

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
25 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male Age 25-60 years No symptoms of disease Currently participating in cycling activities an average of 4 hr/wk for the previous 24 months Osteopenia of the lumbar spine and/or hip (T score < -1.0 and > -2.5 ) Exclusion Criteria: Medications or supplements that affect bone metabolism or prevent exercise Previous or current medical condition affecting bone health Osteoporosis of the lumbar spine and/or hip (T score > -1.0 or < -2.5) Cardiovascular disease Metallic implants Current smoker Current regular participation in high-intensity resistance training and/or plyometrics
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Pamela S Hinton
Organizational Affiliation
University of Missouri-Columbia, Department of Nutritional Sciences
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Missouri-Columbia; McKee Gym
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65211
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No

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Efficacy of Plyometrics to Increase Bone Mass in Men With Osteopenia

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