Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis (CHASE)
Arthritis
About this trial
This is an interventional other trial for Arthritis focused on measuring JIA, SEA syndrome, AS, psoriatic arthritis, HPV vaccine
Eligibility Criteria
Inclusion Criteria:
- Female patients, age 9-26 years, with polyarticular JIA, pauciarticular JIA, and sero-negative arthritis.
Exclusion Criteria:
- Pregnancy
- Known allergy/sensitivity or any hypersensitivity to yeast or components of study drug or their formulation
- Systemic onset JIA with active systemic symptoms (systemic onset JIA with polyarticular features but no fever or rash may be included).
- Prior vaccination against HPV
- Known HPV infection
- Current or history of cervical cancer or cervical intraepithelial neoplasia (CIN).
Males are excluded from this study because Gardasil® is currently approved only for females.
Sites / Locations
- University of Chicago
- University Hospitals Case Medical Center
- MetroHealth
- Cleveland Clinic
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
Group A pauciarticular JIA
Group B polyarticular JIA
Group C seronegative arthritis
Females age 9-26 with pauciarticular JIA. All study subjects are receiving the Gardasil vaccine as part of their clinical care. The study observes outcomes related to this clinical care. Study intervention consists of some Blood Draws for serum titres taken to measure antibody and RNA titers.
Females age 9-26 with polyarticular JIA. All study subjects are receiving the Gardasil vaccine as part of their clinical care. The study observes outcomes related to this clinical care. Study intervention consists of some Blood Draws for Serum Titers taken to measure antibody and RNA titers.
Females age 9-26 with seronegative arthritis (including ankylosing spondylitis and psoriatic arthritis). All study subjects are receiving the Gardasil vaccine as part of their clinical care. The study observes outcomes related to this clinical care. Study intervention consists of some blood samples taken to measure antibody and RNA titers.