Assessment of the Functional Significance of Accessory Pudendal Arteries
Prostate Cancer
About this trial
This is an interventional treatment trial for Prostate Cancer
Eligibility Criteria
Inclusion Criteria:
- They have selected a LRP, with or without robotic assistance, by Jonathan Colelman, MD, Bertrand Guillonneau, MD, Vincent Laudone, MD, Raul Parra, MD, or Karim Touijer MD for definitive treatment of their prostate cancer after a full discussion of treatment options.
Exclusion Criteria:
- Patients undergoing Open Radical Prostatectomy
- Patients with prior history of insulin dependent diabetes mellitus
- Patient who have received prior radiation therapy to the pelvis or prostate
- Patients requiring anticoagulation postoperatively
- Known allergy to Phenylephrine, Alprostadil, Papaverine or Phentolamine
- Patients whose systolic blood pressure is below 90 mmHg at the time of evaluation despite routine measures taken by the anesthesiologist at his best criteria.
- Patients with labile hypertension or history of prior priapism
- Patients with penile scarring or penile prosthesis
- Patients with an International Index of Erectile Function score < 24
Sites / Locations
- Memorial Sloan-Kettering Cancer Center
Arms of the Study
Arm 1
Experimental
1
Day of Surgery:Patient is admitted through the Preoperative Surgical Center (PSC). If a large APA is identified, then subject will continue on study Dissect APA (without any changes from what is routinely done) with a penile injection of Trimix. Once the initial Doppler Ultrasound is completed, the accessory pudendal artery will be temporarily clamped to stop blood flow. After the artery is clamped, the Doppler Ultrasound will be repeated. We estimate an extension of the surgery no longer than 5 or 10 minutes in comparison to the usual operating time. Once the Doppler Ultrasound is completed, the clamp will be removed and the surgery continued in its usual fashion.