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Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Primary Purpose

Venous Thrombosis

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Apixaban

Placebo

About this trial

This is an interventional treatment trial for Venous Thrombosis

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Men and women ≥ 18 years of age;
Clinical diagnosis of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE);
Anticoagulant treatment completed
No recurrence of Venous Thromboembolism (VTE)

Exclusion Criteria:

Subjects with indications for long-term treatment with a vitamin K antagonist
Active bleeding or high risk for serious bleeding
Short life expectancy
Uncontrolled high blood pressure
Impaired kidney or liver function

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Active Comparator

Arm Label

Arm Description

2.5 mg

5.0 mg

0 mg

Outcomes

Primary Outcome Measures

Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or All-Cause Death During the Intended Treatment Period - Randomized Population With Imputation

VTE included: nonfatal deep vein thrombosis (DVT) or nonfatal pulmonary embolism (PE). All index events, DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate (proportion of participants with event) calculated as n/N (n=number of events; N=number of participants). Intended treatment period: longer of the dosing period plus 2 days (completed treatment) or 355 days (discontinued early). Composite endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. For missing endpoint data, participants were imputed as having had a primary efficacy outcome event.

Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or All-Cause Death During the Intended Treatment Period - Randomized Population Without Imputation

VTE included: nonfatal DVT or nonfatal PE. Event rate (proportion of participants with event) calculated as n/N (n=number of events; N=number of participants). Intended treatment period: longer of the dosing period plus 2 days (completed treatment) or 355 days (discontinued early). Composite endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for these endpoints; participants who had an event during the intended treatment period were counted. Confidence interval (CI) for single event rate was calculated based on the Wald asymptotic confidence limits.

Secondary Outcome Measures

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or VTE-related Death During the Intended Treatment Period - Randomized Population With Imputation

VTE includes nonfatal DVT or nonfatal PE. All index events, DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate (proportion of participants with event) calculated as n/N (n=number of events; N=number of participants). Intended treatment period: longer of the dosing period plus 2 days (completed treatment) or 355 days (discontinued early). Composite endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. For missing endpoint data, participants were imputed as having had a primary efficacy outcome event.

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Cardio Vascular (CV) -Related Death During the Intended Treatment Period - Randomized Population With Imputation

VTE includes nonfatal DVT or nonfatal PE. All index events, DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Composite endpoint included events that occurred any time from randomization until end of the intended treatment period, regardless of whether the participants were receiving drug treatment. Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. If there were missing endpoint data, participants were imputed as having had an efficacy outcome event.

Adjudicated Nonfatal Deep Vein Thrombosis (DVT) During the Intended Treatment Period - Randomized Population With Imputation

DVT was adjudicated/confirmed by a central independent adjudication committee blinded to treatment and assessed by compression ultrasound and/or venography. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period: longer of the dosing period plus 2 days (completed treatment) or 355 days (discontinued early). Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. Participants with missing endpoint information were classified as having had the efficacy event (imputation). Confidence interval (CI) for single event rate was calculated based on the Wald asymptotic confidence limits.

Adjudicated Nonfatal Pulmonary Embolism (PE) During the Intended Treatment Period - Randomized Population With Imputation

PE was adjudicated/confirmed by a central independent adjudication committee blinded to treatment and was assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. Participants with missing endpoint information were classified as having had the efficacy event (imputation). CI for single event rate was calculated based on the Wald asymptotic confidence limits.

Adjudicated Venous Thromboembolism (VTE) - Related Death During the Intended Treatment Period - Randomized Population With Imputation

VTE-related death defined as: PE (based on objective diagnostic testing, autopsy), unexplained death (and VTE cannot be ruled out), sudden death (and VTE cannot be ruled out). DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE, death, venous/arterial thromboembolic events, bleeding, thrombocytopenia, acute myocardial infarction and stroke were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Participants with missing endpoint information were classified as having had the efficacy event (imputation).

Adjudicated Cardiovascular (CV)-Related Death During the Intended Treatment Period - Randomized Population With Imputation

CV-related death was defined as myocardial infarction, stroke, or other specified cardiovascular event and were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. Participants with missing endpoint information were classified as having had the efficacy event (imputation). CI for single event rate was calculated based on the Wald asymptotic confidence limits.

Adjudicated All-Cause Death During the Intended Treatment Period - Randomized Population With Imputation

DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE, death, venous/arterial thromboembolic events, bleeding, thrombocytopenia, acute myocardial infarction and stroke were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Participants with missing endpoint information were classified as having had the efficacy event (imputation). CI for single event rate was calculated based on the Wald asymptotic confidence limits.

Number of Participants With an Adjudicated Symptomatic Nonfatal Venous Thromboembolism (VTE) Recurrence or Death (All Cause) During the Intended Treatment Period - Randomized Participants Without Imputation

All index events, DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. First event category was the first primary event for each participant and each participant was counted once. CV-related death was presented excluding VTE-related death. In participants with event category, each participant was counted once in each event category but could have been counted in multiple categories. No imputation was done for these endpoints; participants who had an event during the intended treatment period were counted.

Adjudicated Major Bleeding During the Treatment Period - Treated Population

Major bleeding was adjudicated/confirmed by a central independent adjudication committee blinded to treatment and was defined as acute clinically overt bleeding: associated with a fall in hemoglobin of 2 grams per deciliter (g/dL) or more, or leading to a transfusion of 2 or more units of packed red blood cells or 1000 milliliters (mL) or more of whole blood, or in a critical site: intracranial, intraspinal, intraocular, pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal, or another critical organ; or is fatal. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Confidence interval (CI) for event rate was calculated based on the Wald asymptotic confidence limits. Treated population includes randomized participants who received at least one dose of study drug.

Adjudicated Composite of Major/Clinically Relevant Non-major Bleeding During the Treatment Period - Treated Participants

Major bleeding and clinically relevant non-major bleeding were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. Major bleeding was defined as acute clinically overt bleeding: associated with a fall in hemoglobin of 2 g/dL or more, or leading to a transfusion of 2 or more units of packed red blood cells or 1000 mL or more of whole blood, or in a critical site: intracranial, intraspinal, intraocular, pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal, or another critical organ or is fatal. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). CI for single event rate was calculated based on the Wald asymptotic confidence limits. Treated population includes randomized participants who received at least one dose of study drug.

Adjudicated Clinically Relevant Non-major Bleeding During the Treatment Period - Treated Participants

Non-major clinically relevant bleeding was adjudicated/confirmed by a central independent adjudication committee blinded to treatment and defined as: acute clinically overt bleeding compromising hemodynamics; leading to hospitalization; traumatic subcutaneous hematoma; intramuscular hematoma; epistaxis that lasted for more than 5 minutes, was repetitive or led to an intervention; spontaneous gingival bleeding (or lasting more than 5 minutes); spontaneous hematuria (macroscopic or lasted more than 24 hours after instrumentation of the urogenital tract); macroscopic gastrointestinal hemorrhage (including at least 1 episode of melena or hematemesis (if clinically apparent with positive results on a fecal occult-blood test); rectal blood loss. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). CI for single event rate was calculated based on the Wald asymptotic confidence limits.

Adjudicated Clinically Relevant Minor Bleeding During the Treatment Period - Treated Participants

All bleeding events were reviewed by the central independent adjudication committee blinded to treatment and classified as major bleeding, clinically relevant non-major bleeding, minor bleeding or no bleeding. If event was not major or clinically relevant non-major, it was judged to be minor. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Confidence interval (CI) for single event rate was calculated based on the Wald asymptotic confidence limits. Treated population includes randomized participants who received at least one dose of study drug.

Adjudicated Total Bleeding During the Treatment Period - Treated Participants

All bleeding events were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. Total bleeding was defined as any major, clinically relevant non-major, or minor bleeding. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). CI for single event rate was calculated based on the Wald asymptotic confidence limits. Treated population includes randomized participants who received at least one dose of study drug.

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Venous Thromboembolism-related Death During the Intended Treatment Period - Randomized Population Without Imputation

VTE related death defined as PE (based on objective diagnostic testing, autopsy), unexplained death (and VTE cannot be ruled out), sudden death (and VTE cannot be ruled out). DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE and death, were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for these endpoints.

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Cardio Vascular (CV) - Related Death During the Intended Treatment Period - Randomized Population Without Imputation

CV-related death was defined as myocardial infarction, stroke, or other specified cardiovascular event. Index events of DVT and/or PE, along with myocardial infarction and stroke were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Composite endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for these endpoints; participants who had an event during the intended treatment period were counted.

Adjudicated Nonfatal Deep Vein Thrombosis (DVT) During the Intended Treatment Period - Randomized Population Without Imputation

DVT was adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint; participants who had an event during the intended treatment period were counted.

Adjudicated Nonfatal Pulmonary Embolism (PE) During the Intended Treatment Period - Randomized Population Without Imputation

PE was adjudicated/confirmed by a central independent adjudication committee blinded to treatment: PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint; participants who had an event during the intended treatment period were counted.

Adjudicated Venous Thromboembolism (VTE)- Related Death During the Intended Treatment Period - Randomized Population Without Imputation

VTE related death defined as PE (based on objective diagnostic testing, autopsy), unexplained death (and VTE cannot be ruled out), sudden death (and VTE cannot be ruled out). DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE, and death, were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint.

Adjudicated Cardio Vascular (CV)-Related Death During the Intended Treatment Period - Randomized Population Without Imputation

CV-related death was defined as myocardial infarction, stroke, or other specified cardiovascular event and these were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint; participants who had an event during the intended treatment period were counted.

Adjudicated All-Cause Death During the Intended Treatment Period - Randomized Population Without Imputation

DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE, death, venous/arterial thromboembolic events, bleeding, thrombocytopenia, acute myocardial infarction and stroke were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint; participants who had an event during the intended treatment period were counted.

Full Information

NCT ID

NCT00633893

First Posted

March 5, 2008

Last Updated

October 30, 2013

Sponsor

Bristol-Myers Squibb

Collaborators

Pfizer

1. Study Identification

Unique Protocol Identification Number

NCT00633893

Brief Title

Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Official Title

A Safety and Efficacy Trial Evaluating the Use of Apixaban for the Extended Treatment of Deep Vein Thrombosis and Pulmonary Embolism

Study Type

Interventional

2. Study Status

Record Verification Date

October 2013

Overall Recruitment Status

Completed

Study Start Date

May 2008 (undefined)

Primary Completion Date

August 2012 (Actual)

Study Completion Date

August 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Bristol-Myers Squibb

Collaborators

Pfizer

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The purpose is to evaluate the effects of an investigational blood thinner, apixaban, in preventing venous thromboembolic (VTE) recurrence or death in patients who have completed their intended treatment for deep vein thrombosis (DVT) or pulmonary embolism (PE)

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Venous Thrombosis

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantInvestigator

Allocation

Randomized

Enrollment

2711 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm Type

Experimental

Arm Description

2.5 mg

Arm Title

Arm Type

Experimental

Arm Description

5.0 mg

Arm Title

Arm Type

Active Comparator

Arm Description

0 mg

Intervention Type

Drug

Intervention Name(s)

Apixaban

Other Intervention Name(s)

BMS-562247

Intervention Description

Tablets, Oral, twice daily, 12 months

Intervention Type

Drug

Intervention Name(s)

Placebo

Intervention Description

Tablets, Oral, twice daily, 12 months

Primary Outcome Measure Information:

Title

Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or All-Cause Death During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or All-Cause Death During the Intended Treatment Period - Randomized Population Without Imputation

Description

Time Frame

Day 1 up to 12 months

Secondary Outcome Measure Information:

Title

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or VTE-related Death During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Cardio Vascular (CV) -Related Death During the Intended Treatment Period - Randomized Population With Imputation

Description

VTE includes nonfatal DVT or nonfatal PE. All index events, DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment. DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Composite endpoint included events that occurred any time from randomization until end of the intended treatment period, regardless of whether the participants were receiving drug treatment. Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. If there were missing endpoint data, participants were imputed as having had an efficacy outcome event.

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Nonfatal Deep Vein Thrombosis (DVT) During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Nonfatal Pulmonary Embolism (PE) During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Venous Thromboembolism (VTE) - Related Death During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Cardiovascular (CV)-Related Death During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated All-Cause Death During the Intended Treatment Period - Randomized Population With Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Major Bleeding During the Treatment Period - Treated Population

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Composite of Major/Clinically Relevant Non-major Bleeding During the Treatment Period - Treated Participants

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Clinically Relevant Non-major Bleeding During the Treatment Period - Treated Participants

Description

Time Frame

Day 1 up to 12 months

Title

Adjudicated Clinically Relevant Minor Bleeding During the Treatment Period - Treated Participants

Description

Time Frame

Day 1 up to 12 months

Title

Adjudicated Total Bleeding During the Treatment Period - Treated Participants

Description

Time Frame

Day 1 up to 12 months

Title

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Venous Thromboembolism-related Death During the Intended Treatment Period - Randomized Population Without Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Cardio Vascular (CV) - Related Death During the Intended Treatment Period - Randomized Population Without Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Nonfatal Deep Vein Thrombosis (DVT) During the Intended Treatment Period - Randomized Population Without Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Nonfatal Pulmonary Embolism (PE) During the Intended Treatment Period - Randomized Population Without Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Venous Thromboembolism (VTE)- Related Death During the Intended Treatment Period - Randomized Population Without Imputation

Description

VTE related death defined as PE (based on objective diagnostic testing, autopsy), unexplained death (and VTE cannot be ruled out), sudden death (and VTE cannot be ruled out). DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE, and death, were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint.

Time Frame

Day 1 up to 12 Months

Title

Adjudicated Cardio Vascular (CV)-Related Death During the Intended Treatment Period - Randomized Population Without Imputation

Description

Time Frame

Day 1 up to 12 Months

Title

Adjudicated All-Cause Death During the Intended Treatment Period - Randomized Population Without Imputation

Description

DVT and/or PE were adjudicated/confirmed by a central independent adjudication committee blinded to treatment: DVT assessed by compression ultrasound and/or venography; PE assessed by spiral computed tomography scanning, pulmonary angiography, and/or ventilation/perfusion lung scan. New/recurrent VTE, death, venous/arterial thromboembolic events, bleeding, thrombocytopenia, acute myocardial infarction and stroke were also adjudicated. Event rate is proportion of participants with event; calculated as n/N (n=number of events; N=number of participants). Intended treatment period was defined as the longer of the dosing period plus 2 days or 355 days. Endpoint included events at any time from randomization until end of the intended treatment period, regardless whether drug treatment was received. No imputation was done for this endpoint; participants who had an event during the intended treatment period were counted.

Time Frame

Day 1 up to 12 Months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Men and women ≥ 18 years of age; Clinical diagnosis of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE); Anticoagulant treatment completed No recurrence of Venous Thromboembolism (VTE) Exclusion Criteria: Subjects with indications for long-term treatment with a vitamin K antagonist Active bleeding or high risk for serious bleeding Short life expectancy Uncontrolled high blood pressure Impaired kidney or liver function

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Bristol-Myers Squibb

Organizational Affiliation

Bristol-Myers Squibb

Official's Role

Study Director

Facility Information:

Facility Name

Alabama Clinical Therapeutics, Llc

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35235

Country

United States

Facility Name

Cardiovascular Consultants, Ltd.

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85032

Country

United States

Facility Name

Robert J. Bloomberg, Md, Pc

City

Tempe

State/Province

Arizona

ZIP/Postal Code

85283

Country

United States

Facility Name

Fort Smith Lung Center

City

Fort Smith

State/Province

Arkansas

ZIP/Postal Code

72901

Country

United States

Facility Name

Beaver Medical Group

City

Banning

State/Province

California

ZIP/Postal Code

92220

Country

United States

Facility Name

Scripps Clinic/Scripps Health And Green Hospital

City

La Jolla

State/Province

California

ZIP/Postal Code

92037

Country

United States

Facility Name

Healthcare Partners Medical Group

City

Los Angeles

State/Province

California

ZIP/Postal Code

90015

Country

United States

Facility Name

Mission Internal Medical Group

City

Mission Viejo

State/Province

California

ZIP/Postal Code

92691

Country

United States

Facility Name

Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Facility Name

Indus Clinical Research Institute, Inc.

City

Pomona

State/Province

California

ZIP/Postal Code

91767

Country

United States

Facility Name

Kaiser Permanente Medical Center

City

San Francisco

State/Province

California

ZIP/Postal Code

94118

Country

United States

Facility Name

Stanford University Medical Center

City

Stanford

State/Province

California

ZIP/Postal Code

94305

Country

United States

Facility Name

Harbor Ucla Medical Center

City

Torrance

State/Province

California

ZIP/Postal Code

90509

Country

United States

Facility Name

Progressive Clinical Research

City

Vista

State/Province

California

ZIP/Postal Code

92083

Country

United States

Facility Name

Rocky Mountain Internal Medicine

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80012

Country

United States

Facility Name

New West Physicians

City

Golden

State/Province

Colorado

ZIP/Postal Code

80401

Country

United States

Facility Name

Alfieri Cardiology

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Bay Pines Va Healthcare Systems

City

Bay Pines

State/Province

Florida

ZIP/Postal Code

33744

Country

United States

Facility Name

Research Alliance, Inc.

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33756

Country

United States

Facility Name

St. Francis Sleep Allergy & Lung Institute

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33765

Country

United States

Facility Name

Berma Research Group

City

Fort Lauderdale

State/Province

Florida

ZIP/Postal Code

33316

Country

United States

Facility Name

Healthworx

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33021

Country

United States

Facility Name

Hematology Oncology Associates

City

Loxahatchee

State/Province

Florida

ZIP/Postal Code

33470

Country

United States

Facility Name

South Miami Heart Center

City

Miami

State/Province

Florida

ZIP/Postal Code

33143

Country

United States

Facility Name

Physicians Regional Medical Group

City

Naples

State/Province

Florida

ZIP/Postal Code

34119

Country

United States

Facility Name

Richard A. Mclean M.D., P.A.

City

Plantation

State/Province

Florida

ZIP/Postal Code

33317

Country

United States

Facility Name

Tampa Clinical Research

City

Tampa

State/Province

Florida

ZIP/Postal Code

33624

Country

United States

Facility Name

Primary Care Of The Treasure Coast, Inc.

City

Vero Beach

State/Province

Florida

ZIP/Postal Code

32960

Country

United States

Facility Name

Cleveland Clinic Florida

City

Weston

State/Province

Florida

ZIP/Postal Code

33331

Country

United States

Facility Name

Vascular Surgical Associates, Pc

City

Austell

State/Province

Georgia

ZIP/Postal Code

30106

Country

United States

Facility Name

Atlanta Institute For Medical Research, Inc

City

Decatur

State/Province

Georgia

ZIP/Postal Code

30030

Country

United States

Facility Name

Gwinnett Biomedical Research

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30046

Country

United States

Facility Name

Boise Orthopedic Clinic

City

Boise

State/Province

Idaho

ZIP/Postal Code

83706

Country

United States

Facility Name

Saltzer Medical Group

City

Nampa

State/Province

Idaho

ZIP/Postal Code

83686

Country

United States

Facility Name

Infectious Disease Of Indiana Psc

City

Carmel

State/Province

Indiana

ZIP/Postal Code

46032

Country

United States

Facility Name

Office Of:Eugene C. Fletcher, Md

City

New Albany

State/Province

Indiana

ZIP/Postal Code

47150

Country

United States

Facility Name

Heartland Vascular Medicine And Surgery

City

Windsor Heights

State/Province

Iowa

ZIP/Postal Code

50324

Country

United States

Facility Name

Kentucky Lung Clinic

City

Hazard

State/Province

Kentucky

ZIP/Postal Code

41701

Country

United States

Facility Name

Owensboro Heart & Vascular

City

Owensboro

State/Province

Kentucky

ZIP/Postal Code

42303

Country

United States

Facility Name

Pen Bay Medical Center

City

Rockport

State/Province

Maine

ZIP/Postal Code

04856

Country

United States

Facility Name

Anne Arundel Health System Research Institute, Inc.

City

Annapolis

State/Province

Maryland

ZIP/Postal Code

21401

Country

United States

Facility Name

Cape Cod Research Institute

City

Hyannis

State/Province

Massachusetts

ZIP/Postal Code

02601

Country

United States

Facility Name

Henry Ford Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

William Beaumont Hospital

City

Royal Oak

State/Province

Michigan

ZIP/Postal Code

48073

Country

United States

Facility Name

Veterans Affairs Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64128

Country

United States

Facility Name

Mercury Street Medical Group, Pllc

City

Butte

State/Province

Montana

ZIP/Postal Code

59701

Country

United States

Facility Name

Great Falls Clinic, Llp

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Internal Medical Associates Of Grand Island, P.C

City

Grand Island

State/Province

Nebraska

ZIP/Postal Code

68803

Country

United States

Facility Name

Creighton University Medical Center

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68131

Country

United States

Facility Name

Kaleida Health System

City

Buffalo

State/Province

New York

ZIP/Postal Code

14209

Country

United States

Facility Name

Goshen Medical Associates

City

Goshen

State/Province

New York

ZIP/Postal Code

10924

Country

United States

Facility Name

Sjh Cardiology Associates

City

Liverpool

State/Province

New York

ZIP/Postal Code

13088

Country

United States

Facility Name

Richmond University Medical Center

City

Staten Island

State/Province

New York

ZIP/Postal Code

10310

Country

United States

Facility Name

New York Medical College

City

Valhalla

State/Province

New York

ZIP/Postal Code

10595

Country

United States

Facility Name

Thomas L. Ortel, Md, Phd

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Facility Name

Valley Internal Medicine

City

Fayetteville

State/Province

North Carolina

ZIP/Postal Code

28304

Country

United States

Facility Name

Rex Healthcare

City

Raleigh

State/Province

North Carolina

ZIP/Postal Code

27607

Country

United States

Facility Name

Piedmont Healthcare/Research

City

Statesville

State/Province

North Carolina

ZIP/Postal Code

28625

Country

United States

Facility Name

Whiteville Medical Associates, P.A.

City

Whiteville

State/Province

North Carolina

ZIP/Postal Code

28472

Country

United States

Facility Name

Wilmington Medical Research

City

Wilmington

State/Province

North Carolina

ZIP/Postal Code

28401

Country

United States

Facility Name

Akron General Medical Center

City

Akron

State/Province

Ohio

ZIP/Postal Code

44307

Country

United States

Facility Name

Community Health Care, Inc.

City

Canal Fulton

State/Province

Ohio

ZIP/Postal Code

44614

Country

United States

Facility Name

Valley Medical Research

City

Centerville

State/Province

Ohio

ZIP/Postal Code

45459

Country

United States

Facility Name

Ohio State University Medical Center

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43210

Country

United States

Facility Name

Remington Davis Inc.

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Jobst Vascular Center At The Toledo Hospital

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43606

Country

United States

Facility Name

Cor Clinical Research, Llc

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73103

Country

United States

Facility Name

Pma Medical Specialists

City

Phoenixville

State/Province

Pennsylvania

ZIP/Postal Code

19460

Country

United States

Facility Name

Rhode Island Hospital

City

Providence

State/Province

Rhode Island

ZIP/Postal Code

02903

Country

United States

Facility Name

Charleston Hematology Oncology Associates, Pa

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29414

Country

United States

Facility Name

Greenville Hospital System

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29615

Country

United States

Facility Name

Three Rivers Medical Associates, Pa

City

Irmo

State/Province

South Carolina

ZIP/Postal Code

29063

Country

United States

Facility Name

Clinical Research Authority, Llc

City

Murrells Inlet

State/Province

South Carolina

ZIP/Postal Code

29576

Country

United States

Facility Name

Palmetto Clinical Research

City

Summerville

State/Province

South Carolina

ZIP/Postal Code

29485

Country

United States

Facility Name

Holston Medical Group

City

Bristol

State/Province

Tennessee

ZIP/Postal Code

37620

Country

United States

Facility Name

Holston Medical Group

City

Kingsport

State/Province

Tennessee

ZIP/Postal Code

37660

Country

United States

Facility Name

Amarillo Heart Clinical Research Institute Inc.

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79106

Country

United States

Facility Name

Corsicana Medical Research

City

Corsicana

State/Province

Texas

ZIP/Postal Code

75110

Country

United States

Facility Name

Ankur Doshi, Md

City

Houston

State/Province

Texas

ZIP/Postal Code

77024

Country

United States

Facility Name

Northwest Heart Center

City

Tomball

State/Province

Texas

ZIP/Postal Code

77375

Country

United States

Facility Name

Tanner Clinic

City

Layton

State/Province

Utah

ZIP/Postal Code

84041

Country

United States

Facility Name

University Of Utah Hospital

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84132

Country

United States

Facility Name

University Of Virginia Health System

City

Charlottesville

State/Province

Virginia

ZIP/Postal Code

22908

Country

United States

Facility Name

Sentara York Clinical Research

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23510

Country

United States

Facility Name

Lake Washington Vascular, Pllc

City

Bellevue

State/Province

Washington

ZIP/Postal Code

98004

Country

United States

Facility Name

Franciscan Research Center

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

Medical Assoicates Inc.

City

Menomonee Falls

State/Province

Wisconsin

ZIP/Postal Code

53051

Country

United States

Facility Name

Local Institution

City

Capital Federal

State/Province

Buenos Aires

ZIP/Postal Code

C1426ANZ

Country

Argentina

Facility Name

Local Institution

City

Ciudad Autonoma De Buenos Aire

State/Province

Buenos Aires

ZIP/Postal Code

1093 AAS

Country

Argentina

Facility Name

Local Institution

City

Ciudad Autonoma De Buenos Aire

State/Province

Buenos Aires

ZIP/Postal Code

C1180AAX

Country

Argentina

Facility Name

Local Institution

City

Ciudad Autonoma De Buenos Aire

State/Province

Buenos Aires

ZIP/Postal Code

C1437JCP

Country

Argentina

Facility Name

Local Institution

City

Ciudad De Buenos Aires

State/Province

Buenos Aires

ZIP/Postal Code

C1034ACO

Country

Argentina

Facility Name

Local Institution

City

Ciudad De Buenos Aires

State/Province

Buenos Aires

ZIP/Postal Code

C1181ACH

Country

Argentina

Facility Name

Local Institution

City

Coronel Suarez

State/Province

Buenos Aires

ZIP/Postal Code

B7540GHD

Country

Argentina

Facility Name

Local Institution

City

La Plata

State/Province

Buenos Aires

ZIP/Postal Code

1900

Country

Argentina

Facility Name

Local Institution

City

La Plata

State/Province

Buenos Aires

ZIP/Postal Code

B1902COI

Country

Argentina

Facility Name

Local Institution

City

Mar Del Plata

State/Province

Buenos Aires

ZIP/Postal Code

7600

Country

Argentina

Facility Name

Local Institution

City

San Martin

State/Province

Buenos Aires

ZIP/Postal Code

B1650CSQ

Country

Argentina

Facility Name

Local Institution

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000CVB

Country

Argentina

Facility Name

Local Institution

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000DSV

Country

Argentina

Facility Name

Local Institution

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2002KDS

Country

Argentina

Facility Name

Local Institution

City

Buenos Aires

ZIP/Postal Code

C1122AAL

Country

Argentina

Facility Name

Local Institution

City

Buenos Aires

ZIP/Postal Code

C1280AEB

Country

Argentina

Facility Name

Local Institution

City

Buenos Aires

ZIP/Postal Code

C1431FWO

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

5000

Country

Argentina

Facility Name

Local Institution

City

Cordoba

ZIP/Postal Code

X5000JHQ

Country

Argentina

Facility Name

Local Institution

City

Corrientes

ZIP/Postal Code

3400

Country

Argentina

Facility Name

Local Institution

City

Garran

State/Province

Australian Capital Territory

ZIP/Postal Code

2605

Country

Australia

Facility Name

Local Institution

City

Kogarah

State/Province

New South Wales

ZIP/Postal Code

2217

Country

Australia

Facility Name

Local Institution

City

Lismore

State/Province

New South Wales

ZIP/Postal Code

2480

Country

Australia

Facility Name

Local Institution

City

St Leonards

State/Province

New South Wales

ZIP/Postal Code

2065

Country

Australia

Facility Name

Local Institution

City

Herston

State/Province

Queensland

ZIP/Postal Code

4029

Country

Australia

Facility Name

Local Institution

City

Kippa Ring

State/Province

Queensland

ZIP/Postal Code

4021

Country

Australia

Facility Name

Local Institution

City

Woolloongabba

State/Province

Queensland

ZIP/Postal Code

4102

Country

Australia

Facility Name

Local Institution

City

Adelaide

State/Province

South Australia

ZIP/Postal Code

5000

Country

Australia

Facility Name

Local Institution

City

Bedford Park

State/Province

South Australia

ZIP/Postal Code

5042

Country

Australia

Facility Name

Local Institution

City

Launceston

State/Province

Tasmania

ZIP/Postal Code

7250

Country

Australia

Facility Name

Local Institution

City

Box Hill

State/Province

Victoria

ZIP/Postal Code

3128

Country

Australia

Facility Name

Local Institution

City

Clayton

State/Province

Victoria

ZIP/Postal Code

3168

Country

Australia

Facility Name

Local Institution

City

Footscray

State/Province

Victoria

ZIP/Postal Code

3011

Country

Australia

Facility Name

Local Institution

City

Parkville

State/Province

Victoria

ZIP/Postal Code

3050

Country

Australia

Facility Name

Local Institution

City

Richmond

State/Province

Victoria

ZIP/Postal Code

3121

Country

Australia

Facility Name

Local Institution

City

Ringwood East

State/Province

Victoria

ZIP/Postal Code

3135

Country

Australia

Facility Name

Local Institution

City

Windsor

State/Province

Victoria

ZIP/Postal Code

3181

Country

Australia

Facility Name

Local Institution

City

Perth

State/Province

Western Australia

ZIP/Postal Code

6000

Country

Australia

Facility Name

Local Institution

City

Graz

ZIP/Postal Code

8036

Country

Austria

Facility Name

Local Institution

City

Innsbruck

ZIP/Postal Code

A-6020

Country

Austria

Facility Name

Local Institution

City

Vienna

ZIP/Postal Code

1090

Country

Austria

Facility Name

Local Institution

City

Vienna

ZIP/Postal Code

1100

Country

Austria

Facility Name

Local Institution

City

Wien

ZIP/Postal Code

1090

Country

Austria

Facility Name

Local Institution

City

Wien

ZIP/Postal Code

1140

Country

Austria

Facility Name

Local Institution

City

Salvador

State/Province

Bahia

ZIP/Postal Code

40144 900

Country

Brazil

Facility Name

Local Institution

City

Brasilia

State/Province

Distrito Federal

ZIP/Postal Code

70335

Country

Brazil

Facility Name

Local Institution

City

Belo Horizonte - Mg

State/Province

Minas Gerais

ZIP/Postal Code

30130

Country

Brazil

Facility Name

Local Institution

City

Belo Horizonte - Mg

State/Province

Minas Gerais

ZIP/Postal Code

30150

Country

Brazil

Facility Name

Local Institution

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80030

Country

Brazil

Facility Name

Local Institution

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80050

Country

Brazil

Facility Name

Local Institution

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80810

Country

Brazil

Facility Name

Local Institution

City

Curitiba

State/Province

Parana

ZIP/Postal Code

81520

Country

Brazil

Facility Name

Local Institution

City

Rio Janeiro

State/Province

Rio De Janeiro

ZIP/Postal Code

22280

Country

Brazil

Facility Name

Local Institution

City

Port Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90020

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90035

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90610

Country

Brazil

Facility Name

Local Institution

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

9110270

Country

Brazil

Facility Name

Local Institution

City

Botucatu

State/Province

Sao Paulo

ZIP/Postal Code

18618

Country

Brazil

Facility Name

Local Institution

City

Campinas

State/Province

Sao Paulo

ZIP/Postal Code

13083

Country

Brazil

Facility Name

Local Institution

City

Santo Andre - Sp

State/Province

Sao Paulo

ZIP/Postal Code

09060

Country

Brazil

Facility Name

Local Institution

City

Sao Jose Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15015

Country

Brazil

Facility Name

Local Institution

City

Sao Jose Do Rio Preto

State/Province

Sao Paulo

ZIP/Postal Code

15090

Country

Brazil

Facility Name

Local Institution

City

Rio De Janeiro

ZIP/Postal Code

20551

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

01323

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

01509

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

04005

Country

Brazil

Facility Name

Local Institution

City

Sao Paulo

ZIP/Postal Code

05403

Country

Brazil

Facility Name

Local Institution

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T5H 4B9

Country

Canada

Facility Name

Local Institution

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T5X 3N5

Country

Canada

Facility Name

Local Institution

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

Tsa 4l8

Country

Canada

Facility Name

Local Institution

City

Kelowna

State/Province

British Columbia

ZIP/Postal Code

V1Y 9L8

Country

Canada

Facility Name

Local Institution

City

Victoria

State/Province

British Columbia

ZIP/Postal Code

V8R 4R2

Country

Canada

Facility Name

Local Institution

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8L 2X2

Country

Canada

Facility Name

Local Institution

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8S 4K1

Country

Canada

Facility Name

Local Institution

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 2C4

Country

Canada

Facility Name

Local Institution

City

Waterloo

State/Province

Ontario

ZIP/Postal Code

N2J 1C4

Country

Canada

Facility Name

Local Institution

City

Windsor

State/Province

Ontario

ZIP/Postal Code

N8X 5A6

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H1T 2M4

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3G 1A4

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3T 1M5

Country

Canada

Facility Name

Local Institution

City

Pointe- Claire

State/Province

Quebec

ZIP/Postal Code

H9R 3J1

Country

Canada

Facility Name

Local Institution

City

St. Jerome

State/Province

Quebec

ZIP/Postal Code

J7Z 5T3

Country

Canada

Facility Name

Local Institution

City

Quebec

ZIP/Postal Code

G1V 4G5

Country

Canada

Facility Name

Local Institution

City

Temuco

State/Province

Araucania

ZIP/Postal Code

4781173

Country

Chile

Facility Name

Local Institution

City

Punta Arenas

State/Province

Magallanes Antartica

ZIP/Postal Code

6212296

Country

Chile

Facility Name

Local Institution

City

Independencia

State/Province

Metropolitana

ZIP/Postal Code

XXXXX

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

7500520

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

7600448

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

7980378

Country

Chile

Facility Name

Local Institution

City

Santiago

State/Province

Metropolitana

ZIP/Postal Code

8330024

Country

Chile

Facility Name

Local Institution

City

Vina Del Mar

State/Province

Valparaiso

ZIP/Postal Code

2520000

Country

Chile

Facility Name

Local Institution

City

Kladno

ZIP/Postal Code

272 59

Country

Czech Republic

Facility Name

Local Institution

City

Litomysl

ZIP/Postal Code

570 14

Country

Czech Republic

Facility Name

Local Institution

City

Mestec Kralove

ZIP/Postal Code

289 03

Country

Czech Republic

Facility Name

Local Institution

City

Ostrava Vitkovice

ZIP/Postal Code

703 00

Country

Czech Republic

Facility Name

Local Institution

City

Plzen

ZIP/Postal Code

323 33

Country

Czech Republic

Facility Name

Local Institution

City

Praha 13

ZIP/Postal Code

158 00

Country

Czech Republic

Facility Name

Local Institution

City

Praha 1

ZIP/Postal Code

110 00

Country

Czech Republic

Facility Name

Local Institution

City

Praha 1

ZIP/Postal Code

118 33

Country

Czech Republic

Facility Name

Local Institution

City

Praha 2

ZIP/Postal Code

120 00

Country

Czech Republic

Facility Name

Local Institution

City

Praha 2

ZIP/Postal Code

121 11

Country

Czech Republic

Facility Name

Local Institution

City

Praha 2

ZIP/Postal Code

128 08

Country

Czech Republic

Facility Name

Local Institution

City

Praha 4

ZIP/Postal Code

140 21

Country

Czech Republic

Facility Name

Local Institution

City

Usti Nad Orlici

ZIP/Postal Code

562 18

Country

Czech Republic

Facility Name

Local Institution

City

Arhus C

ZIP/Postal Code

8000

Country

Denmark

Facility Name

Local Institution

City

Braedstrup

ZIP/Postal Code

8740

Country

Denmark

Facility Name

Local Institution

City

Esbjerg

ZIP/Postal Code

6700

Country

Denmark

Facility Name

Local Institution

City

Frederiksberg

ZIP/Postal Code

2000

Country

Denmark

Facility Name

Local Institution

City

Hellerup

ZIP/Postal Code

2900

Country

Denmark

Facility Name

Local Institution

City

Herning

ZIP/Postal Code

7400

Country

Denmark

Facility Name

Local Institution

City

Hilleroed

ZIP/Postal Code

3400

Country

Denmark

Facility Name

Local Institution

City

Naestved

ZIP/Postal Code

4700

Country

Denmark

Facility Name

Local Institution

City

Silkeborg

ZIP/Postal Code

8600

Country

Denmark

Facility Name

Local Institution

City

Arras

ZIP/Postal Code

62022

Country

France

Facility Name

Local Institution

City

Besancon

ZIP/Postal Code

25000

Country

France

Facility Name

Local Institution

City

Brest Cedex

ZIP/Postal Code

29609

Country

France

Facility Name

Local Institution

City

Clamart

ZIP/Postal Code

92141

Country

France

Facility Name

Local Institution

City

Clermont-Ferrand Cedex 01

ZIP/Postal Code

63003

Country

France

Facility Name

Local Institution

City

Dijon

ZIP/Postal Code

21079

Country

France

Facility Name

Local Institution

City

Grenoble

ZIP/Postal Code

38043

Country

France

Facility Name

Local Institution

City

Le Kremlin-Bicetre

ZIP/Postal Code

94275

Country

France

Facility Name

Local Institution

City

Lille Cedex

ZIP/Postal Code

59020

Country

France

Facility Name

Local Institution

City

Limoges Cedex

ZIP/Postal Code

87042

Country

France

Facility Name

Local Institution

City

Lyon Cedex 03

ZIP/Postal Code

69437

Country

France

Facility Name

Local Institution

City

Nantes

ZIP/Postal Code

44093

Country

France

Facility Name

Local Institution

City

Saint-Priest En Jarez

ZIP/Postal Code

42270

Country

France

Facility Name

Local Institution

City

Toulouse Cedex 9

ZIP/Postal Code

31059

Country

France

Facility Name

Local Institution

City

Vernon

ZIP/Postal Code

27200

Country

France

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

10117

Country

Germany

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

10787

Country

Germany

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

14050

Country

Germany

Facility Name

Local Institution

City

Bochum

ZIP/Postal Code

44791

Country

Germany

Facility Name

Local Institution

City

Bonn

ZIP/Postal Code

53115

Country

Germany

Facility Name

Local Institution

City

Cologne

ZIP/Postal Code

50937

Country

Germany

Facility Name

Local Institution

City

Dortmund

ZIP/Postal Code

44137

Country

Germany

Facility Name

Local Institution

City

Dresden

ZIP/Postal Code

01067

Country

Germany

Facility Name

Local Institution

City

Dresden

ZIP/Postal Code

01307

Country

Germany

Facility Name

Local Institution

City

Erfurt

ZIP/Postal Code

99089

Country

Germany

Facility Name

Local Institution

City

Frankfurt

ZIP/Postal Code

60596

Country

Germany

Facility Name

Local Institution

City

Gottingen

ZIP/Postal Code

37075

Country

Germany

Facility Name

Local Institution

City

Karlsbad

ZIP/Postal Code

76307

Country

Germany

Facility Name

Local Institution

City

Krefeld

ZIP/Postal Code

47805

Country

Germany

Facility Name

Local Institution

City

Ludwigshafen

ZIP/Postal Code

67063

Country

Germany

Facility Name

Local Institution

City

Mannheim

ZIP/Postal Code

68161

Country

Germany

Facility Name

Local Institution

City

Mannheim

ZIP/Postal Code

68165

Country

Germany

Facility Name

Local Institution

City

Mannheim

ZIP/Postal Code

68167

Country

Germany

Facility Name

Local Institution

City

Munchen

ZIP/Postal Code

80331

Country

Germany

Facility Name

Local Institution

City

Munich

ZIP/Postal Code

80336

Country

Germany

Facility Name

Local Institution

City

Hong Kong

Country

Hong Kong

Facility Name

Local Institution

City

Shatin, N.T

Country

Hong Kong

Facility Name

Local Institution

City

Hyderabad

State/Province

Andhra Pradesh

ZIP/Postal Code

500 082

Country

India

Facility Name

Local Institution

City

Hyderabad

State/Province

Andhra Pradesh

ZIP/Postal Code

500034

Country

India

Facility Name

Local Institution

City

Ahmedabad

State/Province

Gujarat

ZIP/Postal Code

380006

Country

India

Facility Name

Local Institution

City

Gurgaon

State/Province

Haryana

ZIP/Postal Code

122001

Country

India

Facility Name

Local Institution

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560054

Country

India

Facility Name

Local Institution

City

Bengaluru

State/Province

Karnataka

ZIP/Postal Code

560017

Country

India

Facility Name

Local Institution

City

Kochi

State/Province

Kerala

ZIP/Postal Code

682041

Country

India

Facility Name

Local Institution

City

Pune

State/Province

Maharashtra

ZIP/Postal Code

411001

Country

India

Facility Name

Local Institution

City

Mohali

State/Province

Punjab

ZIP/Postal Code

160062

Country

India

Facility Name

Local Institution

City

Ludhiana

State/Province

Tagore Nagar

ZIP/Postal Code

141001

Country

India

Facility Name

Local Institution

City

Chennai

State/Province

Tamil Nadu

ZIP/Postal Code

600 006

Country

India

Facility Name

Local Institution

City

Ahmedabad

ZIP/Postal Code

380015

Country

India

Facility Name

Local Institution

City

Bangalore, Karnataka

ZIP/Postal Code

560034

Country

India

Facility Name

Local Institution

City

Bangalore

ZIP/Postal Code

560052

Country

India

Facility Name

Local Institution

City

Chennai

ZIP/Postal Code

600 003

Country

India

Facility Name

Local Institution

City

Chennai

ZIP/Postal Code

600 006

Country

India

Facility Name

Local Institution

City

New Dehli

ZIP/Postal Code

110025

Country

India

Facility Name

Local Institution

City

Afula

ZIP/Postal Code

18101

Country

Israel

Facility Name

Local Institution

City

Givataim

ZIP/Postal Code

53488

Country

Israel

Facility Name

Local Institution

City

Hadera

ZIP/Postal Code

38101

Country

Israel

Facility Name

Local Institution

City

Haifa

ZIP/Postal Code

31048

Country

Israel

Facility Name

Local Institution

City

Haifa

ZIP/Postal Code

31096

Country

Israel

Facility Name

Local Institution

City

Holon

ZIP/Postal Code

58100

Country

Israel

Facility Name

Local Institution

City

Jerusalem

ZIP/Postal Code

91031

Country

Israel

Facility Name

Local Institution

City

Kfar Saba

ZIP/Postal Code

44281

Country

Israel

Facility Name

Local Institution

City

Kiryat Hadassah

ZIP/Postal Code

91120

Country

Israel

Facility Name

Local Institution

City

Nahariya

ZIP/Postal Code

22100

Country

Israel

Facility Name

Local Institution

City

Petach-Tikva

ZIP/Postal Code

49100

Country

Israel

Facility Name

Local Institution

City

Safed

ZIP/Postal Code

13100

Country

Israel

Facility Name

Local Institution

City

Tel Aviv

ZIP/Postal Code

64239

Country

Israel

Facility Name

Local Institution

City

Tel Hashomer

ZIP/Postal Code

52621

Country

Israel

Facility Name

Local Institution

City

Bollate

ZIP/Postal Code

20021

Country

Italy

Facility Name

Local Institution

City

Bologna

ZIP/Postal Code

40138

Country

Italy

Facility Name

Local Institution

City

Chieti Scalo

ZIP/Postal Code

66013

Country

Italy

Facility Name

Local Institution

City

Cosenza

ZIP/Postal Code

87100

Country

Italy

Facility Name

Local Institution

City

Ferrara

ZIP/Postal Code

44100

Country

Italy

Facility Name

Local Institution

City

Firenze

ZIP/Postal Code

50134

Country

Italy

Facility Name

Local Institution

City

Genova

ZIP/Postal Code

16128

Country

Italy

Facility Name

Local Institution

City

Milano

ZIP/Postal Code

20132

Country

Italy

Facility Name

Local Institution

City

Padova

ZIP/Postal Code

35128

Country

Italy

Facility Name

Local Institution

City

Palermo

ZIP/Postal Code

90127

Country

Italy

Facility Name

Local Institution

City

Pavia

ZIP/Postal Code

27100

Country

Italy

Facility Name

Local Institution

City

Perugia

ZIP/Postal Code

06132

Country

Italy

Facility Name

Local Institution

City

Piacenza

ZIP/Postal Code

29100

Country

Italy

Facility Name

Local Institution

City

Pisa

ZIP/Postal Code

56124

Country

Italy

Facility Name

Local Institution

City

Roma

ZIP/Postal Code

00168

Country

Italy

Facility Name

Local Institution

City

Rozzano (Mi)

ZIP/Postal Code

20089

Country

Italy

Facility Name

Local Institution

City

San Daniele Del Friuli (Ud)

ZIP/Postal Code

33038

Country

Italy

Facility Name

Local Institution

City

Udine

ZIP/Postal Code

33100

Country

Italy

Facility Name

Local Institution

City

Venezia

ZIP/Postal Code

30122

Country

Italy

Facility Name

Local Institution

City

Vicenza

ZIP/Postal Code

36100

Country

Italy

Facility Name

Local Institution

City

Vittorio Veneto (Tv)

ZIP/Postal Code

31029

Country

Italy

Facility Name

Local Institution

City

Busan

ZIP/Postal Code

602-702

Country

Korea, Republic of

Facility Name

Local Institution

City

Jongno-Gu

ZIP/Postal Code

110-774

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

120752

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

135-710

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

137-040

Country

Korea, Republic of

Facility Name

Local Institution

City

Seoul

ZIP/Postal Code

138736

Country

Korea, Republic of

Facility Name

Local Institution

City

Tijuana

State/Province

Baja California

ZIP/Postal Code

22500

Country

Mexico

Facility Name

Local Institution

City

Mexico

State/Province

Distrito Federal

ZIP/Postal Code

06726

Country

Mexico

Facility Name

Local Institution

City

Leon

State/Province

Guanajuato

ZIP/Postal Code

37320

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44130

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44200

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44280

Country

Mexico

Facility Name

Local Institution

City

Zapopan

State/Province

Jalisco

ZIP/Postal Code

45200

Country

Mexico

Facility Name

Local Institution

City

Monterrey

State/Province

Nuevo Leon

ZIP/Postal Code

64000

Country

Mexico

Facility Name

Local Institution

City

Monterrey

State/Province

Nuevo Leon

ZIP/Postal Code

64710

Country

Mexico

Facility Name

Local Institution

City

Culiacan

State/Province

Sinaloa

ZIP/Postal Code

80020

Country

Mexico

Facility Name

Local Institution

City

Culiacan

State/Province

Sinaloa

ZIP/Postal Code

80230

Country

Mexico

Facility Name

Local Institution

City

Xalapa

State/Province

Veracruz

ZIP/Postal Code

91020

Country

Mexico

Facility Name

Local Institution

City

Aguascalientes

ZIP/Postal Code

20230

Country

Mexico

Facility Name

Local Institution

City

Chihuahua

ZIP/Postal Code

31203

Country

Mexico

Facility Name

Local Institution

City

Durango

ZIP/Postal Code

34080

Country

Mexico

Facility Name

Local Institution

City

Puebla

ZIP/Postal Code

72000

Country

Mexico

Facility Name

Local Institution

City

Queretaro

ZIP/Postal Code

76000

Country

Mexico

Facility Name

Local Institution

City

San Luis Potosi

ZIP/Postal Code

78200

Country

Mexico

Facility Name

Local Institution

City

San Luis Potosi

ZIP/Postal Code

78240

Country

Mexico

Facility Name

Local Institution

City

Alesund

ZIP/Postal Code

6026

Country

Norway

Facility Name

Local Institution

City

Fredrikstad

ZIP/Postal Code

1606

Country

Norway

Facility Name

Local Institution

City

Gjettum

ZIP/Postal Code

1346

Country

Norway

Facility Name

Local Institution

City

Gjovik

ZIP/Postal Code

2819

Country

Norway

Facility Name

Local Institution

City

Hamar

ZIP/Postal Code

2318

Country

Norway

Facility Name

Local Institution

City

Oslo

ZIP/Postal Code

0407

Country

Norway

Facility Name

Local Institution

City

Cavite

ZIP/Postal Code

4114

Country

Philippines

Facility Name

Local Institution

City

Davao City

ZIP/Postal Code

8000

Country

Philippines

Facility Name

Local Institution

City

Pasig City

ZIP/Postal Code

1600

Country

Philippines

Facility Name

Local Institution

City

Quezon City

ZIP/Postal Code

1102

Country

Philippines

Facility Name

Local Institution

City

Arkonska 4

ZIP/Postal Code

71455

Country

Poland

Facility Name

Local Institution

City

Bialystok

ZIP/Postal Code

15-276

Country

Poland

Facility Name

Local Institution

City

Bydgoszcz

ZIP/Postal Code

85-168

Country

Poland

Facility Name

Local Institution

City

Bydgoszcz

ZIP/Postal Code

85-650

Country

Poland

Facility Name

Local Institution

City

Bydgoszcz

ZIP/Postal Code

85-681

Country

Poland

Facility Name

Local Institution

City

Gdansk

ZIP/Postal Code

80-803

Country

Poland

Facility Name

Local Institution

City

Gdynia

ZIP/Postal Code

81-348

Country

Poland

Facility Name

Local Institution

City

Gdynia

ZIP/Postal Code

81-423

Country

Poland

Facility Name

Local Institution

City

Lodz

ZIP/Postal Code

90-153

Country

Poland

Facility Name

Local Institution

City

Lublin

ZIP/Postal Code

20-081

Country

Poland

Facility Name

Local Institution

City

Lublin

ZIP/Postal Code

20-718

Country

Poland

Facility Name

Local Institution

City

Poznan

ZIP/Postal Code

61-848

Country

Poland

Facility Name

Local Institution

City

Przeworsk

ZIP/Postal Code

37-200

Country

Poland

Facility Name

Local Institution

City

Szczecin

ZIP/Postal Code

70-111

Country

Poland

Facility Name

Local Institution

City

Tarnobrzeg

ZIP/Postal Code

39-400

Country

Poland

Facility Name

Local Institution

City

Warsawa

ZIP/Postal Code

02-776

Country

Poland

Facility Name

Local Institution

City

Warsaw

ZIP/Postal Code

01-809

Country

Poland

Facility Name

Local Institution

City

Warsaw

ZIP/Postal Code

02-005

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

01-138

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

02-018

Country

Poland

Facility Name

Local Institution

City

Wroclaw

ZIP/Postal Code

51-124

Country

Poland

Facility Name

Local Institution

City

Wroclaw

ZIP/Postal Code

53-114

Country

Poland

Facility Name

Local Institution

City

Guarda

ZIP/Postal Code

6301-857

Country

Portugal

Facility Name

Local Institution

City

Lisboa

ZIP/Postal Code

1769-001

Country

Portugal

Facility Name

Local Institution

City

San Juan

ZIP/Postal Code

00909

Country

Puerto Rico

Facility Name

Local Institution

City

San Juan

ZIP/Postal Code

00921

Country

Puerto Rico

Facility Name

Local Institution

City

Baia Mare

ZIP/Postal Code

430031

Country

Romania

Facility Name

Local Institution

City

Bucharest

ZIP/Postal Code

022328

Country

Romania

Facility Name

Local Institution

City

Bucharest

ZIP/Postal Code

030171

Country

Romania

Facility Name

Local Institution

City

Bucharest

ZIP/Postal Code

050098

Country

Romania

Facility Name

Local Institution

City

Targu Mures

ZIP/Postal Code

540136

Country

Romania

Facility Name

Local Institution

City

Arkhangelsk

ZIP/Postal Code

163045

Country

Russian Federation

Facility Name

Local Institution

City

Kemerovo

ZIP/Postal Code

650002

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

105077

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

111539

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

119049

Country

Russian Federation

Facility Name

Local Institution

City

Moscow

ZIP/Postal Code

127473

Country

Russian Federation

Facility Name

Local Institution

City

Novosibirsk

ZIP/Postal Code

630055

Country

Russian Federation

Facility Name

Local Institution

City

Novosibirsk

ZIP/Postal Code

630090

Country

Russian Federation

Facility Name

Local Institution

City

Rostov-On Don

ZIP/Postal Code

344022

Country

Russian Federation

Facility Name

Local Institution

City

Ryazan

ZIP/Postal Code

390026

Country

Russian Federation

Facility Name

Local Institution

City

Saint Petersburg

ZIP/Postal Code

192242

Country

Russian Federation

Facility Name

Local Institution

City

Saint-Petersburg

ZIP/Postal Code

196247

Country

Russian Federation

Facility Name

Local Institution

City

Saint-Petersburg

ZIP/Postal Code

199106

Country

Russian Federation

Facility Name

Local Institution

City

Samara

ZIP/Postal Code

443010

Country

Russian Federation

Facility Name

Local Institution

City

Saratov

ZIP/Postal Code

410012

Country

Russian Federation

Facility Name

Local Institution

City

Saratov

ZIP/Postal Code

410028

Country

Russian Federation

Facility Name

Local Institution

City

St Petersburg

ZIP/Postal Code

194044

Country

Russian Federation

Facility Name

Local Institution

City

Tomsk

ZIP/Postal Code

634012

Country

Russian Federation

Facility Name

Local Institution

City

Yaroslavl

ZIP/Postal Code

150062

Country

Russian Federation

Facility Name

Local Institution

City

Singapore

ZIP/Postal Code

169608

Country

Singapore

Facility Name

Local Institution

City

Singapore

ZIP/Postal Code

308433

Country

Singapore

Facility Name

Local Institution

City

Bloemfontein

State/Province

Free State

ZIP/Postal Code

9301

Country

South Africa

Facility Name

Local Institution

City

Centurion

State/Province

Gauteng

ZIP/Postal Code

0157

Country

South Africa

Facility Name

Local Institution

City

Parktown

State/Province

Gauteng

ZIP/Postal Code

2193

Country

South Africa

Facility Name

Local Institution

City

Pretoria

State/Province

Gauteng

ZIP/Postal Code

0083

Country

South Africa

Facility Name

Local Institution

City

Pretoria

State/Province

Gauteng

ZIP/Postal Code

0084

Country

South Africa

Facility Name

Local Institution

City

Durban

State/Province

Kwa Zulu Natal

ZIP/Postal Code

4001

Country

South Africa

Facility Name

Local Institution

City

Pietermaritzburg

State/Province

Kwa Zulu Natal

ZIP/Postal Code

3201

Country

South Africa

Facility Name

Local Institution

City

Bellville

State/Province

Western Cape

ZIP/Postal Code

7530

Country

South Africa

Facility Name

Local Institution

City

George

State/Province

Western Cape

ZIP/Postal Code

6529

Country

South Africa

Facility Name

Local Institution

City

Somerset West

State/Province

Western Cape

ZIP/Postal Code

7130

Country

South Africa

Facility Name

Local Institution

City

Worcester

State/Province

Western Cape

ZIP/Postal Code

6850

Country

South Africa

Facility Name

Local Institution

City

Torrevieja

State/Province

Alicante

ZIP/Postal Code

03186

Country

Spain

Facility Name

Local Institution

City

Badalona

State/Province

Barcelona

ZIP/Postal Code

08916

Country

Spain

Facility Name

Local Institution

City

Majadahonda

State/Province

Madrid

ZIP/Postal Code

28222

Country

Spain

Facility Name

Local Institution

City

San Sebastian De Los Reyes

State/Province

Madrid

ZIP/Postal Code

28702

Country

Spain

Facility Name

Local Institution

City

Cadiz

ZIP/Postal Code

11009

Country

Spain

Facility Name

Local Institution

City

Getafe

ZIP/Postal Code

28905

Country

Spain

Facility Name

Local Institution

City

Girona

ZIP/Postal Code

17007

Country

Spain

Facility Name

Local Institution

City

L'Hospitalet De Llobregat

ZIP/Postal Code

08907

Country

Spain

Facility Name

Local Institution

City

Leon

ZIP/Postal Code

24008

Country

Spain

Facility Name

Local Institution

City

Madrid

ZIP/Postal Code

28007

Country

Spain

Facility Name

Local Institution

City

Madrid

ZIP/Postal Code

28029

Country

Spain

Facility Name

Local Institution

City

Madrid

ZIP/Postal Code

28040

Country

Spain

Facility Name

Local Institution

City

Madrid

ZIP/Postal Code

28041

Country

Spain

Facility Name

Local Institution

City

Mourente

ZIP/Postal Code

36071

Country

Spain

Facility Name

Local Institution

City

Pamplona

ZIP/Postal Code

31008

Country

Spain

Facility Name

Local Institution

City

Salamanca

ZIP/Postal Code

37007

Country

Spain

Facility Name

Local Institution

City

Sant Boi De Llobregat

ZIP/Postal Code

08830

Country

Spain

Facility Name

Local Institution

City

Tarragona

ZIP/Postal Code

43007

Country

Spain

Facility Name

Local Institution

City

Toledo

ZIP/Postal Code

45071

Country

Spain

Facility Name

Local Institution

City

Valencia

ZIP/Postal Code

46026

Country

Spain

Facility Name

Local Institution

City

Chernihiv

ZIP/Postal Code

14034

Country

Ukraine

Facility Name

Local Institution

City

Dnipropetrovsk

ZIP/Postal Code

49000

Country

Ukraine

Facility Name

Local Institution

City

Donetsk

ZIP/Postal Code

83045

Country

Ukraine

Facility Name

Local Institution

City

Ivano-Frankivsk

ZIP/Postal Code

76008

Country

Ukraine

Facility Name

Local Institution

City

Ivano-Frankivsk

ZIP/Postal Code

76018

Country

Ukraine

Facility Name

Local Institution

City

Kharkiv

ZIP/Postal Code

61018

Country

Ukraine

Facility Name

Local Institution

City

Kyiv

ZIP/Postal Code

03680

Country

Ukraine

Facility Name

Local Institution

City

Lviv

ZIP/Postal Code

79010

Country

Ukraine

Facility Name

Local Institution

City

Odesa

ZIP/Postal Code

65117

Country

Ukraine

Facility Name

Local Institution

City

Ternopil

ZIP/Postal Code

46000

Country

Ukraine

Facility Name

Local Institution

City

Vinnytsia

ZIP/Postal Code

21018

Country

Ukraine

Facility Name

Local Institution

City

Zaporizhzhia

ZIP/Postal Code

69035

Country

Ukraine

Facility Name

Local Institution

City

Aberdeen

State/Province

Aberdeenshire

ZIP/Postal Code

AB25 2ZN

Country

United Kingdom

Facility Name

Local Institution

City

Romford

State/Province

Essex

ZIP/Postal Code

RM7 0AG

Country

United Kingdom

Facility Name

Local Institution

City

London

State/Province

Greater London

ZIP/Postal Code

SE5 9RS

Country

United Kingdom

Facility Name

Local Institution

City

London

State/Province

Greater London

ZIP/Postal Code

SW17 0QT

Country

United Kingdom

Facility Name

Local Institution

City

Manchester

State/Province

Greater Manchester

ZIP/Postal Code

M23 9LT

Country

United Kingdom

Facility Name

Local Institution

City

Hull

State/Province

Humberside

ZIP/Postal Code

HU3 2JZ

Country

United Kingdom

Facility Name

Local Institution

City

Nottingham

State/Province

Nottinghamshire

ZIP/Postal Code

NG7 2UH

Country

United Kingdom

Facility Name

Local Institution

City

Bury St. Edmunds

State/Province

Suffolk

ZIP/Postal Code

IP30 9QU

Country

United Kingdom

Facility Name

Local Institution

City

Coventry

State/Province

West Midlands

ZIP/Postal Code

CV2 2DX

Country

United Kingdom

Facility Name

Local Institution

City

Dudley

State/Province

West Midlands

ZIP/Postal Code

DY1 2HQ

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

35570249

Citation

Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16.

Results Reference

derived

PubMed Identifier

26446706

Citation

Liu X, Thompson J, Phatak H, Mardekian J, Porcari A, Johnson M, Cohen AT. Extended anticoagulation with apixaban reduces hospitalisations in patients with venous thromboembolism. An analysis of the AMPLIFY-EXT trial. Thromb Haemost. 2016 Jan;115(1):161-8. doi: 10.1160/TH15-07-0606. Epub 2015 Oct 8.

Results Reference

derived

PubMed Identifier

23216615

Citation

Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Porcari A, Raskob GE, Weitz JI; AMPLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med. 2013 Feb 21;368(8):699-708. doi: 10.1056/NEJMoa1207541. Epub 2012 Dec 8.

Results Reference

derived

Learn more about this trial

Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism

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Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Venous Thrombosis

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial