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Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Patients

Primary Purpose

Pulmonary Disease, Chronic Obstructive, Hyperoxia

Status

Completed

Phase

Not Applicable

Locations

Norway

Study Type

Interventional

Intervention

4 times 4 minutes high aerobic intensity one leg cycling

About this trial

This is an interventional treatment trial for Pulmonary Disease, Chronic Obstructive focused on measuring COPD, training, VO2peak, performance, ventilation, high aerobic intensity treadmill walking, one leg training by cycling

Eligibility Criteria

20 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

COPD

Exclusion Criteria:

Heart disease
Walking or cycling inabilities
Other diseases

Sites / Locations

Norwegian University of Science and Technology

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Active Comparator

Arm Label

Arm Description

High aerobic intensity treadmill walking. 4 by 4 minutes interval training on a 5% graded treadmill at a heart rate corresponding to 85-95% of maximal heart rate. 3 times per week for 10 weeks.

4 times 4 minutes interval training in hyperoxia - 100% oxygen

One leg at a time training 4 times 4 minutes interval training using cycling ergometer

Outcomes

Primary Outcome Measures

VO2peak

Ventilation

FEV1

Walking performance

Secondary Outcome Measures

Quality of life

SPSS

Full Information

NCT ID

NCT00658853

First Posted

April 10, 2008

Last Updated

July 15, 2016

Sponsor

Norwegian University of Science and Technology

1. Study Identification

Unique Protocol Identification Number

NCT00658853

Brief Title

Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Patients

Official Title

Effective High Aerobic Intensity Interval Training to Improve Maximal Oxygen Uptake in COPD Patients

Study Type

Interventional

2. Study Status

Record Verification Date

July 2016

Overall Recruitment Status

Completed

Study Start Date

January 2004 (undefined)

Primary Completion Date

February 2006 (Actual)

Study Completion Date

February 2006 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Norwegian University of Science and Technology

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

4 times 4 minutes interval training with and without hyperoxia is more effective than low intensity endurance training.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Pulmonary Disease, Chronic Obstructive, Hyperoxia

Keywords

COPD, training, VO2peak, performance, ventilation, high aerobic intensity treadmill walking, one leg training by cycling

7. Study Design

Primary Purpose

Treatment

Study Phase

Not Applicable

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

26 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm Type

Active Comparator

Arm Description

High aerobic intensity treadmill walking. 4 by 4 minutes interval training on a 5% graded treadmill at a heart rate corresponding to 85-95% of maximal heart rate. 3 times per week for 10 weeks.

Arm Title

Arm Type

Active Comparator

Arm Description

4 times 4 minutes interval training in hyperoxia - 100% oxygen

Arm Title

Arm Type

Active Comparator

Arm Description

One leg at a time training 4 times 4 minutes interval training using cycling ergometer

Intervention Type

Behavioral

Intervention Name(s)

4 times 4 minutes high aerobic intensity one leg cycling

Intervention Description

3 times per week for 10 weeks

Primary Outcome Measure Information:

Title

VO2peak

Time Frame

10 weeks

Title

Ventilation

Time Frame

10 weeks

Title

FEV1

Time Frame

10 weeks

Title

Walking performance

Time Frame

10 weeks

Secondary Outcome Measure Information:

Title

Quality of life

Time Frame

3 months

Title

SPSS

Time Frame

3 months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

20 Years

Maximum Age & Unit of Time

85 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: COPD Exclusion Criteria: Heart disease Walking or cycling inabilities Other diseases

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Jan Helgerud, PhD

Organizational Affiliation

Norwegian University of Science and Technology

Official's Role

Principal Investigator

Facility Information:

Facility Name

Norwegian University of Science and Technology

City

Trondheim

ZIP/Postal Code

NO-7489

Country

Norway

12. IPD Sharing Statement

Citations:

PubMed Identifier

19821224

Citation

Bjorgen S, Helgerud J, Husby V, Steinshamn S, Richadson RR, Hoff J. Aerobic high intensity one-legged interval cycling improves peak oxygen uptake in chronic obstructive pulmonary disease patients; no additional effect from hyperoxia. Int J Sports Med. 2009 Dec;30(12):872-8. doi: 10.1055/s-0029-1238292.

Results Reference

result

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Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Patients

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