The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery

The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery

The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery: A Randomized, Prospective, Double-Blinded Study

Sinus surgery is a common, day surgery procedure performed by general and subspecialty trained otolaryngologists. In most cases, this is a safe surgery with a low incidence of complications. When there is significant bleeding or enough bleeding to obscure important anatomical landmarks, there is a higher chance of complications. These complications can include blindness, meningitis or cerebrospinal fluid leak. Our hypothesis is that in patients taking oral tranexamic acid three days before surgery and six days after, there will be less intraoperative bleeding, better surgical visualization and less postoperative bleeding events.

This group will be the experimental group which will receive tranexamic acid in oral form three days before and six days after surgery.

This will be the control group which will take the placebo medication for 3 days before and six days after their functional endoscopic sinus surgery (FESS).

Inclusion Criteria: Chronic sinusitis requiring bilateral functional endoscopic sinus surgery Between the ages of 18-65 Willing to comply with standard followup No coagulopathy Not pregnant Exclusion Criteria: Pregnant On anticoagulants within 3 months of the surgery Coagulopathy <18 or >65 years of age

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