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Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction (EPISOD)

Primary Purpose

Sphincter of Oddi Dysfunction

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
ERCP with sphincterotomy
ERCP without sphincterotomy
Sponsored by
Medical University of South Carolina
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Sphincter of Oddi Dysfunction focused on measuring Sphincter of Oddi Dysfunction, Pancreatitis, Sphincterotomy

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Patients diagnosed with the clinical syndrome of SOD, as defined by the Modified Functional Biliary Disorders Module of the Rome III criteria
  2. Pain burden of Grade 3 or higher on RAPID Questionnaire.
  3. Cholecystectomy more than 90 days before enrollment.
  4. Laboratory Tests: Results of blood tests taken within 1 week preceding the baseline visit and any others available from the preceding 6 months (post-cholecystectomy):Direct bilirubin, alkaline phosphatase, amylase and lipase results must be no greater than 2 X the upper level of normal.Transaminase levels can be no more than 3 X upper limit of normal. If the transaminases are elevated (<2X ULN) in association with a pain attack, they cannot have returned to normal within 3 days.
  5. Normal abdominal imaging by CT or MR/MRCP with bile duct reported at ≤9mm.
  6. Upper endoscopy examination without findings to explain the pain.
  7. Pain persisting despite a one trial of acid suppressant medications for one month (if tolerated).
  8. Pain persisting despite a trial of antispasmodics.
  9. Subjects on antidepressants for pain control (not required) should be taking them for a minimum of one month prior to the baseline assessment.

9.Patients with SOD with depressive and/or anxiety disorders who receive psychopharmacologic treatment must be on stable medication dose for at least 6 weeks.

10.Access to a telephone. 11.Must be able to speak, read, and write English. 12.Signed and dated informed consent.

Exclusion Criteria:

  1. Prior ERCP treatment.
  2. Age < 18 or Age > 65.
  3. Pregnancy: Women who are pregnant at the time of Screening* will be excluded from the study. (*Note: Women who become pregnant AFTER the Baseline Visit/ERCP will be allowed to remain in the study for telephone follow-up visits).
  4. Prior gastric resection or surgery involving biliary diversion.
  5. Prior diagnosis of acute pancreatitis (lipase >3 x ULN) including post-ERCP pancreatitis, or of chronic pancreatitis by radiological imaging, EUS 5 or more criteria, or Cambridge criteria moderate or more on ERCP.
  6. Daily use of prescription analgesics over the previous month.
  7. Abdominal discomfort every day for the past month at level of 3 or more on a scale of 1-10.
  8. Presence of significant psychiatric disorders:

    1. Lifetime psychotic disorders, bipolar disorder;
    2. Substance use disorders within 6 months;
    3. Eating disorders within 2 years
    4. Moderate & severe depression defined by BDI-II (Beck Depression Inventory) cutoff scores >22 (unless receiving stable psychiatric therapy for six weeks); and/or,
    5. Suicidal risk (equal to or greater than "low") using MINI suicide section or a score of greater than 0 on question 9 of the BDI.
  9. The total number of days in the previous 3 months that the subject has taken prescription analgesics due to episodes of abdominal pain is greater than the total number of days the subject had episodes of abdominal pain.
  10. Any condition that, in the investigator's opinion, makes the subject unsuitable for study participation.

ERCP Criteria:

  1. Pancreas divisum (complete or partial) (known or discovered at study ERCP).
  2. Any pathology found at ERCP (except sphincter hypertension).
  3. Failed pancreatic manometry.

Sites / Locations

  • Yale University
  • Indiana University
  • University of Minnesota
  • Midwest Therapeutic Endoscopy Consultants
  • Medical University of South Carolina Digestive Disease Center
  • Methodist Dallas Medical Center
  • Virginia Mason Medical Center

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

1.ERCP with sphincterotomy

2.ERCP without sphincterotomy

Arm Description

ERCP with sphincterotomy: cutting the biliary sphincter muscle (sphincterotomy)

ERCP without cutting the biliary sphincter muscle (sphincterotomy)

Outcomes

Primary Outcome Measures

Percentage of Participants With Success
The primary outcome was a dichotomous (success/failure) variable. Success was defined as patients having a RAPID score of <6 days at months 9 and 12 post-procedure, without re-intervention and without use of prescription analgesics during months 10, 11 and 12 unless used for non-abdominal pain for no more than 14 days. The subject was considered a failure if the 12-month RAPID score was missing or collected outside the acceptable window. If the 9-month RAPID was missing, or outside of the window, then the 6-month value was used when available.

Secondary Outcome Measures

Percentage of Patients With a Successful Primary Outcome, Out of Those With Abnormal Sphincter Manometry.
Successful outcome was defined using the primary outcome definition of success at 12 months post randomization. Abnormal sphincter manometry was determined as a basal pressure of more than 40mm Hg in both leads.

Full Information

First Posted
May 30, 2008
Last Updated
March 20, 2018
Sponsor
Medical University of South Carolina
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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1. Study Identification

Unique Protocol Identification Number
NCT00688662
Brief Title
Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction
Acronym
EPISOD
Official Title
A Phase III Randomized Multicenter Clinical Trial of Sphincterotomy for the Treatment of SOD III Patients
Study Type
Interventional

2. Study Status

Record Verification Date
March 2018
Overall Recruitment Status
Completed
Study Start Date
July 2008 (undefined)
Primary Completion Date
December 2013 (Actual)
Study Completion Date
December 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Medical University of South Carolina
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction(SOD) study (EPISOD) is a randomized sham-controlled study of biliary and pancreatic sphincterotomy as treatment for patients with pain after cholecystectomy fitting the criteria for sphincter of Oddi dysfunction type III.
Detailed Description
Clinical Trial Phase: Phase III Study Sites Seven clinical centers in US Study Period Planned enrollment period - 3 years Planned duration of the study - 5 years Study Population SOD III Patients Primary Study Objective: To ascertain whether subjects with SOD III respond to sphincterotomy, Secondary Study Objectives To evaluate: the association between the results of Sphincter of Oddi Manometry (SOM) (abnormal/normal) and the primary outcome (success/failure); the success rate (as defined in the primary) of subjects who receive biliary sphincterotomy alone versus subjects who receive both biliary and pancreatic sphincterotomy in the subgroup of patients with manometrically proven hypertension of the pancreatic sphincter; the effects of pre-specified prognostic factors on the primary outcome; anxiety and depression scores over time and their relation to study outcomes; the economic impact of SOD III, and of endoscopic sphincterotomy in patients with SOD III; and, to, conduct a careful follow-up study (EPISOD2) of standard of care treatment (separate protocol). Study Design The EPISOD Trial is a parallel, randomized, double-blinded, sham-controlled, multicenter Phase III clinical trial of endoscopic sphincterotomy as treatment for adults 18 to 65 years of age diagnosed with SOD III. Sample Size A minimum of 214 subjects will be randomized using a 2:1 allocation in favor of sphincterotomy and will be followed for 12 months post-randomization.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sphincter of Oddi Dysfunction
Keywords
Sphincter of Oddi Dysfunction, Pancreatitis, Sphincterotomy

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
214 (Actual)

8. Arms, Groups, and Interventions

Arm Title
1.ERCP with sphincterotomy
Arm Type
Active Comparator
Arm Description
ERCP with sphincterotomy: cutting the biliary sphincter muscle (sphincterotomy)
Arm Title
2.ERCP without sphincterotomy
Arm Type
Placebo Comparator
Arm Description
ERCP without cutting the biliary sphincter muscle (sphincterotomy)
Intervention Type
Procedure
Intervention Name(s)
ERCP with sphincterotomy
Intervention Description
cutting the biliary sphincter muscle (sphincterotomy)
Intervention Type
Procedure
Intervention Name(s)
ERCP without sphincterotomy
Intervention Description
ERCP with sphincter manometry, but no sphincterotomy
Primary Outcome Measure Information:
Title
Percentage of Participants With Success
Description
The primary outcome was a dichotomous (success/failure) variable. Success was defined as patients having a RAPID score of <6 days at months 9 and 12 post-procedure, without re-intervention and without use of prescription analgesics during months 10, 11 and 12 unless used for non-abdominal pain for no more than 14 days. The subject was considered a failure if the 12-month RAPID score was missing or collected outside the acceptable window. If the 9-month RAPID was missing, or outside of the window, then the 6-month value was used when available.
Time Frame
1 year
Secondary Outcome Measure Information:
Title
Percentage of Patients With a Successful Primary Outcome, Out of Those With Abnormal Sphincter Manometry.
Description
Successful outcome was defined using the primary outcome definition of success at 12 months post randomization. Abnormal sphincter manometry was determined as a basal pressure of more than 40mm Hg in both leads.
Time Frame
1 year

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Patients diagnosed with the clinical syndrome of SOD, as defined by the Modified Functional Biliary Disorders Module of the Rome III criteria Pain burden of Grade 3 or higher on RAPID Questionnaire. Cholecystectomy more than 90 days before enrollment. Laboratory Tests: Results of blood tests taken within 1 week preceding the baseline visit and any others available from the preceding 6 months (post-cholecystectomy):Direct bilirubin, alkaline phosphatase, amylase and lipase results must be no greater than 2 X the upper level of normal.Transaminase levels can be no more than 3 X upper limit of normal. If the transaminases are elevated (<2X ULN) in association with a pain attack, they cannot have returned to normal within 3 days. Normal abdominal imaging by CT or MR/MRCP with bile duct reported at ≤9mm. Upper endoscopy examination without findings to explain the pain. Pain persisting despite a one trial of acid suppressant medications for one month (if tolerated). Pain persisting despite a trial of antispasmodics. Subjects on antidepressants for pain control (not required) should be taking them for a minimum of one month prior to the baseline assessment. 9.Patients with SOD with depressive and/or anxiety disorders who receive psychopharmacologic treatment must be on stable medication dose for at least 6 weeks. 10.Access to a telephone. 11.Must be able to speak, read, and write English. 12.Signed and dated informed consent. Exclusion Criteria: Prior ERCP treatment. Age < 18 or Age > 65. Pregnancy: Women who are pregnant at the time of Screening* will be excluded from the study. (*Note: Women who become pregnant AFTER the Baseline Visit/ERCP will be allowed to remain in the study for telephone follow-up visits). Prior gastric resection or surgery involving biliary diversion. Prior diagnosis of acute pancreatitis (lipase >3 x ULN) including post-ERCP pancreatitis, or of chronic pancreatitis by radiological imaging, EUS 5 or more criteria, or Cambridge criteria moderate or more on ERCP. Daily use of prescription analgesics over the previous month. Abdominal discomfort every day for the past month at level of 3 or more on a scale of 1-10. Presence of significant psychiatric disorders: Lifetime psychotic disorders, bipolar disorder; Substance use disorders within 6 months; Eating disorders within 2 years Moderate & severe depression defined by BDI-II (Beck Depression Inventory) cutoff scores >22 (unless receiving stable psychiatric therapy for six weeks); and/or, Suicidal risk (equal to or greater than "low") using MINI suicide section or a score of greater than 0 on question 9 of the BDI. The total number of days in the previous 3 months that the subject has taken prescription analgesics due to episodes of abdominal pain is greater than the total number of days the subject had episodes of abdominal pain. Any condition that, in the investigator's opinion, makes the subject unsuitable for study participation. ERCP Criteria: Pancreas divisum (complete or partial) (known or discovered at study ERCP). Any pathology found at ERCP (except sphincter hypertension). Failed pancreatic manometry.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Joseph Romagnuolo, MD
Organizational Affiliation
Medical Universtiy of South Carolina
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Martin Freeman, MD
Organizational Affiliation
University of Minnesota
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Richard Kozarek, MD
Organizational Affiliation
Virginia Mason Medical Center
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Evan Fogel, MD
Organizational Affiliation
Indiana University
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Peter Cotton, MD
Organizational Affiliation
MUSC Digestive Disease Center
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Paul Tarnasky, MD
Organizational Affiliation
Digestive Health Associates of Texas
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Giuseppe Aliperti, MD
Organizational Affiliation
Midwest Therapeutic Endoscopy Consultants
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Priya Jamidar, MD
Organizational Affiliation
Yale University
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Jose Serrano
Organizational Affiliation
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Official's Role
Study Director
Facility Information:
Facility Name
Yale University
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Indiana University
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
University of Minnesota
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55415
Country
United States
Facility Name
Midwest Therapeutic Endoscopy Consultants
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Medical University of South Carolina Digestive Disease Center
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Methodist Dallas Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75203
Country
United States
Facility Name
Virginia Mason Medical Center
City
Seattle
State/Province
Washington
ZIP/Postal Code
98101
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
26165739
Citation
Yaghoobi M, Pauls Q, Durkalski V, Romagnuolo J, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Elta GH, Hawes RH, Wood-Williams A, Cotton PB. Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study. Endoscopy. 2015 Oct;47(10):884-90. doi: 10.1055/s-0034-1392418. Epub 2015 Jul 10.
Results Reference
derived
PubMed Identifier
24867013
Citation
Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, Aliperti G, Freeman M, Kozarek R, Jamidar P, Wilcox M, Serrano J, Brawman-Mintzer O, Elta G, Mauldin P, Thornhill A, Hawes R, Wood-Williams A, Orrell K, Drossman D, Robuck P. Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the EPISOD randomized clinical trial. JAMA. 2014 May;311(20):2101-9. doi: 10.1001/jama.2014.5220.
Results Reference
derived
PubMed Identifier
24472759
Citation
Romagnuolo J, Cotton PB, Durkalski V, Pauls Q, Brawman-Mintzer O, Drossman DA, Mauldin P, Orrell K, Williams AW, Fogel EL, Tarnasky PR, Aliperti G, Freeman ML, Kozarek RA, Jamidar PA, Wilcox CM, Serrano J, Elta GH. Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction? Gastrointest Endosc. 2014 May;79(5):765-72. doi: 10.1016/j.gie.2013.11.037. Epub 2014 Jan 25.
Results Reference
derived
PubMed Identifier
21034899
Citation
Cotton PB, Durkalski V, Orrell KB, Brawman-Mintzer O, Drossman DA, Wilcox CM, Mauldin PD, Elta GH, Tarnasky PR, Fogel EL, Jagganath SB, Kozarek RA, Freeman ML, Romagnuolo J, Robuck PR. Challenges in planning and initiating a randomized clinical study of sphincter of Oddi dysfunction. Gastrointest Endosc. 2010 Nov;72(5):986-91. doi: 10.1016/j.gie.2010.08.022.
Results Reference
derived

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Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction

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