Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects
Healthy Subjects
About this trial
This is an interventional basic science trial for Healthy Subjects focused on measuring ketamine, nicotine, schizophrenia, cognitive deficits, P300 oddball paradigm, Mismatch Negativity, P50 gating
Eligibility Criteria
Inclusion Criteria:
- 18-50 years old
- Smokers
Sites / Locations
- Veterans Administration Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Placebo Comparator
Active Comparator
Active Comparator
Ketamine and Nicotine
Placebo Comparator
Ketamine and Placebo
Nicotine and Placebo
0.23 mg/kg of ketamine bolus IV (in the arm) over one minute followed by maintenance infusion at 0.58mg/kg/hour x 30 minutes, followed by 0.29 mg/kg/hour x 64 minutes. 13.5 µg/kg of nicotine IV (in the arm) given over 10 min (1.35 µg/min/kg), followed by a constant infusion of 31.02 µg/kg given over 85 min (0.365 µg/min/kg)
-Placebo administration: Normal saline (sodium chloride 0.9%)over 95 minutes
Ketamine administration: 0.23 mg/kg bolus over one minute followed by maintenance infusion at 0.58mg/kg/hour x 30 minutes, followed by 0.29 mg/kg/hour x 64 minutes Placebo administration: Normal saline (sodium chloride 0.9%)over 94 minutes
Nicotine: 13.5 µg/kg given over 10 min (1.35 µg/min/kg)IV (in the arm), followed by a constant infusion of 31.02 µg/kg given over 85 min (0.365 µg/min/kg) Placebo: Normal saline (sodium chloride 0.9%)IV (in the arm)