Open-label Study to Evaluate Safety of Multiple Courses of IM Alefacept During Treatment of Chronic Plaque Psoriasis

This is an interventional treatment trial for Psoriasis focused on measuring psoriasis, alefacept, intramuscular Read More

Inclusion Criteria:

• Must have received at least 8 injections in the C99-717 study and completed the final follow-up visit OR,
• Must have completed the C99-712 study and been in C99-717 interim visits at the time dosing in the C99-717 study was closed. A subject who completed C99-712 but did not participate in any part of C99-717, including interim visits, must have prior sponsor approval before admission into C-728

Exclusion Criteria:

• Nursing mothers, pregnant women, and women planning to become pregnant while on study are to be excluded. Female patients who are not postmenopausal for at least 1 year, surgically sterile, or willing to practice effective contraception during the study
• Clinically significant abnormal hematology values or history of an immunosuppressive disorder
• Serious local infection or systemic infection within 3 months prior to the first dose of alefacept
• A significant change in the subject's medical history from their previous alefacept study
• Any subject who initiated alternative systemic therapy, phototherapy, or disallowed therapy prior to visit 8 in study C99-712 or C99-717
• Current enrollment in any investigational study in which the subject is receiving any type of drug, biologic, or non-drug therapy (participation in registry-type studies is allowed)