Effect of Genotyping for CYP450 Polymorphisms Versus Intense Clinical Monitoring on Antipsychotic Drug Treatment
Schizophrenia
About this trial
This is an interventional diagnostic trial for Schizophrenia focused on measuring Pharmacogenetics, Compliance, Antipsychotic drugs, Schizophrenia
Eligibility Criteria
Inclusion Criteria:
- Diagnosed with schizophrenia
- Able to give written informed consent
Exclusion Criteria:
- Genotyped prior to inclusion
Sites / Locations
- Department of Clinical Pharmacology, Bispebjerg Hospital and Research Unit, Psychiatric Centre Bispebjerg
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
No Intervention
Genotyping for CYP4502D6 and 2C19 polymorphisms
(2) Intense clinical monitoring
(3) Control
In this study arm (1) the genotype information is given to the physician in charge of treatment and can be used to direct the pharmacological treatment in accordance with the current guidelines from Sct. Hans hospital. In the guidelines the genotype is translated to the clinical designation "normal", "slow" or "fast" metabolizer of CYP2D6 or "normal" or "slow" metabolizer of CYP2C19. Different treatment options for the different genotypes are described in the clinical guidelines.
In this study arm (2) the genotype information is not revealed. The intervention consists of an intensified clinical monitoring of treatment effect, side effects and patient perspective. Staffpersonnel is trained in the use of a clinical manual that builds on a selection of validated questions from the Scale for the Assessment of Positive Symptoms (SAPS), Side effect score (Udvalg af Kliniske Undersøgelser (UKU) and Rating of Medical Influences (ROMI). The manual has to be used at least once in a quarter (every third month), which is monitored by the study personnel. Data registered by the patients primary contact person are not used as outcome measures in the study but only as intervention tool for the optimisation of the medical antipsychotic treatment.
In this studyarm (3), (Control) treatment followed usual local practice. The genotype information was not revealed.