Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment, Alzheimer's Disease, Traumatic Brain Injury
About this trial
This is an interventional treatment trial for Mild Cognitive Impairment focused on measuring cognitive rehabilitation, explicit memory training, mild cognitive impairment, Alzheimer's disease, traumatic brain injury, veterans
Eligibility Criteria
Inclusion Criteria:
General inclusion criteria (all patients):
- A minimum of 12 years of education or attainment of a Graduation Equivalency Diploma;
- All medications stable for approximately 3 months;
- No history of severe mental illness;
- No current untreated alcohol or substance abuse/dependence;
- English as native and preferred language;
- MRI-compatible if taking part in fMRI studies 7) Able to give informed consent.
MCI Inclusion Criteria:
- Diagnosis of amnestic MCI based on criteria set forth by Petersen (2004). Additionally, other potential causes of cognitive deficit ruled out by the referring physician;
- 55 years of age or older.
TBI Inclusion criteria:
- History of a mild to moderate TBI;
- No history of other neurological disease or injury;
- A minimum of 6 months and maximum of 5 years post-onset of TBI;
- 18 - 45 years old.
Exclusion Criteria:
- History of neurological disease or injury (other than TBI)
- History of severe mental illness
- Current untreated alcohol or substance abuse
- Other conditions may exclude; please discuss with contact
Sites / Locations
- Atlanta VA Medical and Rehab Center, Decatur
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
MST healthy older adults Stage 1
MST MCI Stage 1
XP healthy older adults Stage 1
XP MCI Stage 1
MST healthy older adults Stage 2
SCT healthy older adults Stage 2
Mnemonic strategy training
Exposure training
XP healthy older adults Stage 1
XP MCI Stage 1
MST healthy older adults Stage 2
SCT healthy older adults Stage 2