Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana
Marijuana Smoking
About this trial
This is an interventional basic science trial for Marijuana Smoking focused on measuring naltrexone, smoked marijuana, marijuana use
Eligibility Criteria
Inclusion Criteria:
- Current marijuana use
- Able to perform study procedures
- Women practicing an effective form of birth control
Exclusion Criteria:
- Current repeated illicit drug use (other than marijuana)
- Presence of significant medical illness (e.g., diabetes, cardiovascular disease,hypertension, hepatitis, clinically significant laboratory abnormalities, LFTs > 3x upper limit of normal, blood pressure > 140/90
Sites / Locations
- New York State Psychiatric Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Placebo Comparator
Placebo Comparator
Placebo Comparator
Experimental
Experimental
Placebo Comparator
Placebo naltrexone + Inactive marijuana
Placebo naltrexone + Active marijuana (5.5% THC)
Placebo naltrexone + Active marijuana (6.2% THC)
Naltrexone + Active marijuana (5.5% THC)
Naltrexone + Active marijuana (6.2% THC)
Naltrexone + Inactive marijuana
Placebo naltrexone capsules (0mg), inactive marijuana (0% THC). Each study participant underwent 8 conditions in a randomized order.
Placebo naltrexone capsules (0mg), active marijuana (5.5% THC). Each study participant underwent 8 conditions in a randomized order.
Placebo naltrexone capsules (0mg), active marijuana (6.2% THC). Each study participant underwent 8 conditions in a randomized order.
Naltrexone capsules (12mg), active marijuana (5.5% THC). Each study participant underwent 8 conditions in a randomized order.
Naltrexone capsules (0mg), active marijuana (6.2% THC). Each study participant underwent 8 conditions in a randomized order.
Naltrexone capsules (12mg), inactive marijuana (0% THC). Each study participant underwent 8 conditions in a randomized order.