Back to resultsEffect of Stress on Heroin-Related Memory Retrieval
Primary Purpose
Heroin Dependence, Learning and Memory
Status
Completed
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
propranolol and cortisol
Sponsored by
About this trial
This is an interventional trial for Heroin Dependence
Eligibility Criteria
Inclusion Criteria:
- Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.
Exclusion Criteria:
- current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).
Sites / Locations
- National Institute on Drug Dependence
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
A, 4
Arm Description
Outcomes
Primary Outcome Measures
Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts
Secondary Outcome Measures
Full Information
NCT ID
NCT00759005
First Posted
September 23, 2008
Last Updated
September 23, 2008
Sponsor
National Institute on Drug Dependence, China
1. Study Identification
Unique Protocol Identification Number
NCT00759005
Brief Title
Effect of Stress on Heroin-Related Memory Retrieval
Study Type
Interventional
2. Study Status
Record Verification Date
September 2008
Overall Recruitment Status
Completed
Study Start Date
March 2007 (undefined)
Primary Completion Date
June 2008 (Actual)
Study Completion Date
September 2008 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
National Institute on Drug Dependence, China
4. Oversight
5. Study Description
Brief Summary
The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Heroin Dependence, Learning and Memory
7. Study Design
Study Phase
Not Applicable
8. Arms, Groups, and Interventions
Arm Title
A, 4
Arm Type
Experimental
Intervention Type
Drug
Intervention Name(s)
propranolol and cortisol
Primary Outcome Measure Information:
Title
Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts
10. Eligibility
Sex
Male
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.
Exclusion Criteria:
current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).
Facility Information:
Facility Name
National Institute on Drug Dependence
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100191
Country
China
12. IPD Sharing Statement
Learn more about this trial
Effect of Stress on Heroin-Related Memory Retrieval
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