The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Ischaemic Heart Diseases
About this trial
This is an interventional basic science trial for Ischaemic Heart Diseases focused on measuring Ischaemia reperfusion, t-PA, Fibrinolysis, Endothelial function, Local and remote ischaemic preconditioning
Eligibility Criteria
Inclusion Criteria:
- Healthy males between 18-65 years of ages, non-smokers.
Exclusion Criteria:
- Any concurrent illness or chronic medical condition. Concurrent use of vasoactive medication. Smoking history.
Sites / Locations
- University of Edinburgh, 49 Little France Crescent
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
1
2
3
Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, local ischaemic preconditioning will be induced by inflating a cuff around the non-dominant arm to 200 mmHg for 5 mins followed by 5 mins of reperfusion. This cycle will be repeated 3 times.
Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, remote ischaemic preconditioning will be induced by inflating a cuff around the dominant arm to 200 mmHg for 5 mins followed by 5 mins of reperfusion. This cycle will be repeated 3 times.
Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, sham will be performed by inflating a cuff to 10 mmHg for 5 mins followed by 5 mins of deflation. This cycle will be repeated 3 times.