Treatment Trial for Psychogenic Nonepileptic Seizures (NEST-T_1)
Convulsion, Non-Epileptic, Conversion Disorder, Depression
About this trial
This is an interventional treatment trial for Convulsion, Non-Epileptic focused on measuring Treatment, Cognitive Behavior Therapy, pharmacotherapy, psychogenic nonepileptic seizures, pseudoseizures, dissociative seizures, conversion disorder
Eligibility Criteria
Inclusion Criteria:
- Video electroencephalogram (EEG) confirmed diagnosis of NES
- Have at least one nonepileptic seizure per month
- Able to complete self report symptom scales
- Not receiving optimized sertraline
Exclusion Criteria:
- Equivocal EEG findings
- using monoamine oxidase inhibitors (MAOIs), pimozide, or sumatriptan
- allergy/sensitivity to sertraline
- current alcohol/drug dependence
- serious medical illness requiring current hospitalization
Sites / Locations
- Stanford University
- University of Cincinnati
- Rhode Island Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
sertraline
CBT-ip
Combined (sertraline + CBT-ip)
Standard care
flexible dose sertraline
cognitive behavioral therapy-informed psychotherapy for nonepileptic seizures: 12 individual, 1 hour therapy sessions
flexible dose sertraline and cognitive behavioral therapy-informed psychotherapy for nonepileptic seizures: flexible dose sertraline and 12 individual, 1 hour therapy sessions
community care / treatment as usual: routine follow up with existing providers