Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)
About this trial
This is an interventional treatment trial for Tetralogy of Fallot (TOF) focused on measuring pediatric cardiac surgery, stress response, early extubation, Dexmedetomidine, TOF, VSD, AVSD
Eligibility Criteria
Inclusion Criteria:
- Childrens with the diagnosis of tetralogy of fallot, ventricular septal defect and atrioventricular septal defect who are under one year of age.
Exclusion Criteria:
- Patients who are having reoperation.
- Patients with comorbidities, such as heart failure.
- Patients receiving digoxin preoperatively.
Sites / Locations
- Nationwide Children's Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
Fentanyl (High Dose)
Fentanyl (Low Dose)
Fentanyl (Low Dose) + Dexmedetomidine
This arm will receive a total of 25 mcg/kg of Fentanyl (High Dose) in two divided doses. First half-dose given at induction and second half-dose given before incision.
This arm will receive a total of 10 mcg/kg of Fentanyl (Low Dose). First half-dose will be given at induction and second half -dose given before incision.
This arm will receive10 mcg/kg of Fentanyl (Low Dose) -2 divided doses. Dexmedetomidine (Dex) loading dose-1 mcg/kg over 10 min, then Dex infusion at 0.5mcg/kg/hr.