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Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

Primary Purpose

Epilepsy

Status
Unknown status
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
genome analyzes (genetic defects and pathophysiological mechanisms )
Sponsored by
University Hospital, Strasbourg, France
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional trial for Epilepsy focused on measuring Benign childhood epilepsy

Eligibility Criteria

4 Years - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • iodiopathic focal epilepsy with cognitif deficit

Exclusion Criteria:

  • medical history of status epilepticus

Sites / Locations

  • Hôpital Femme Mère Enfant - Hospices Civils de Lyon, Service Epilepsie, Sommeil et Exploration fonctionnelle neurologique pédiatrique
  • American Memorial Hospital, CHU de Reims, Unité de Neurologie Pédiatrique - Service Pédiatrie A
  • Clinique neurologique, Hôpitaux Universitaires de Strasbourg
  • Hôpital de Hautepierre, Service de pédiatrie 1

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
February 24, 2009
Last Updated
February 24, 2009
Sponsor
University Hospital, Strasbourg, France
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1. Study Identification

Unique Protocol Identification Number
NCT00851331
Brief Title
Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits
Official Title
Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits
Study Type
Interventional

2. Study Status

Record Verification Date
February 2009
Overall Recruitment Status
Unknown status
Study Start Date
undefined (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
University Hospital, Strasbourg, France

4. Oversight

5. Study Description

Brief Summary
Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures and sometimes with major effects on social, behavioral and cognitive development. Childhood focal epilepsies particularly are age-related diseases mainly occurring during developmental critical period. A complex interplay between brain development and maturation processes and susceptibility genes may contribute to the development of various childhood epileptic syndromes associated with language and cognitive deficits. Indeed, the Landau-Kleffner syndrome (LKS), the continuous spike-and-waves during sleep syndrome (CSWS), and the benign childhood epilepsy with centrotemporal spikes (BCECTS) or benign rolandic epilepsy, are different syndromes that are considered as part of a single continuous spectrum of disorders. While genetic component in those three syndromes remains elusive, novel and high throughput genome analyzes could bring interesting insights into the possible genetic defects and pathophysiological mechanisms underlying and linking the various disorders associating epilepsy with speech and cognitive impairments.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Epilepsy
Keywords
Benign childhood epilepsy

7. Study Design

Study Phase
Not Applicable

8. Arms, Groups, and Interventions

Intervention Type
Genetic
Intervention Name(s)
genome analyzes (genetic defects and pathophysiological mechanisms )

10. Eligibility

Sex
All
Minimum Age & Unit of Time
4 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: iodiopathic focal epilepsy with cognitif deficit Exclusion Criteria: medical history of status epilepticus
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Gabrielle Rudolf, PhD, HDR
Phone
(33) 3.88.11.66.62
Ext
3207
Email
Gabrielle.Rudolf@chru-strasbourg.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Edouard HIRSCH, MD
Organizational Affiliation
University Hospital, Strasbourg, France
Official's Role
Principal Investigator
Facility Information:
Facility Name
Hôpital Femme Mère Enfant - Hospices Civils de Lyon, Service Epilepsie, Sommeil et Exploration fonctionnelle neurologique pédiatrique
City
Bron
State/Province
69500
Country
France
Facility Name
American Memorial Hospital, CHU de Reims, Unité de Neurologie Pédiatrique - Service Pédiatrie A
City
Reims
ZIP/Postal Code
51092
Country
France
Facility Name
Clinique neurologique, Hôpitaux Universitaires de Strasbourg
City
Strasbourg
ZIP/Postal Code
67091
Country
France
Facility Name
Hôpital de Hautepierre, Service de pédiatrie 1
City
Strasbourg
ZIP/Postal Code
67098
Country
France

12. IPD Sharing Statement

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Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

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