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Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients (ACST-2)

Primary Purpose

Carotid Stenosis

Status
Unknown status
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
CEA, CAS
Sponsored by
University of Oxford
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Carotid Stenosis focused on measuring Carotid stenosis, CEA, CAS, Stenting

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Carotid artery stenosis detectable by duplex ultrasound, with no ipsilateral carotid territory symptoms(or none for some months) and no previous procedure done on it, which might well need procedural treatment now with CEA or CAS.
  • Already started any appropriate medical treatment (eg, statin, aspirin etc), and already recovered from any necessary coronary procedures (eg, CABG)
  • Patient seems fit and willing for follow-up in person (at 1 month) and by annual letter (for at least 5 years)
  • Investigations show that both procedures (CEA and CAS) appear to be practicable and appropriate
  • Some type of angiography (eg, MRA or CTA) has already been done that has shown that CEA and CAS would both be anatomically practicable.
  • Doctor and patient both substantially uncertain about whether to treat with CEA or CAS, and the doctor sees no clear indication/contra-indication for either procedure

Exclusion Criteria:

  • Small likelihood of worthwhile benefit (eg, very low risk of stroke because stenosis is very minor, or major co-morbidity or life-threatening disease, such as advanced cancer)
  • Unsuitable for one or other procedure (eg, stenosis at carotid siphon that is inaccessible for CEA, or complex vasculature below the stenosis that would hinder CAS, or patient unfit for major surgery)

Sites / Locations

  • University of Toledo Medical Centre
  • Medical University of InnsbruckRecruiting
  • University Hospital AntwerpRecruiting
  • University St Lucas
  • Az St Blasius
  • University Hospital GentRecruiting
  • Centre Hospitalier Régional de la Citadelle
  • Centre Hospitalier De Mouscron
  • University of Sao PauloRecruiting
  • HCFM Ribeirao Preto da Universidade de Sao PauloRecruiting
  • Sveta Marina HospitalRecruiting
  • Foothills Medical CentreRecruiting
  • China-Japan Friendship HospitalRecruiting
  • Peking Union Medical College HospitalRecruiting
  • University Hospital Centre ZagrebRecruiting
  • University Hospital of MerkurRecruiting
  • St Anne's University Hospital BrnoRecruiting
  • Regional Hospital LiberecRecruiting
  • University Hospital Ostrava PorubaRecruiting
  • Central Military HospitalRecruiting
  • Hospital Ceské BudejoviceRecruiting
  • Kasr Alaini University Hospital
  • East Tallinn general HospitalRecruiting
  • Henri Mondor University HospitalRecruiting
  • University of Dresden 'Carl-Gustav-Carus'Recruiting
  • Universitätsklinikum Hamburg-EppendorfRecruiting
  • Universitätsklinik JenaRecruiting
  • Städtisches Klinikum KarlsruheRecruiting
  • University of LeipzigRecruiting
  • Universitätsmedizin MannheimRecruiting
  • Klinikum rechts der Isar derTechnischen Universität MuenchenRecruiting
  • St Franziskus-Hospital Münster GmbHRecruiting
  • Hegau-Bodensee-KlinikumRecruiting
  • Democritus University of ThraceRecruiting
  • Dept. of Vascular Surgery, Attikon University HospitalRecruiting
  • University Hospital of LarissaRecruiting
  • Semmelweis Medical UniversityRecruiting
  • Albert Szent-Györgyi Medical CentreRecruiting
  • St. James' Hospital
  • Rambam HospitalRecruiting
  • Cefalu Fondazione Istituto G.GiglioRecruiting
  • Azienda Ospedaliera S.G MoscatiRecruiting
  • University of BariRecruiting
  • University of BolognaRecruiting
  • Policlinico CataniaRecruiting
  • Azienda Ospedaliero-Universitaria S.AnnaRecruiting
  • San Giovanni Di DioRecruiting
  • Opsedale Villa Scassi
  • IRCCS San MartinoRecruiting
  • Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico di MilanoRecruiting
  • IRCCS Policlinico San DonatoRecruiting
  • Istituto Auxologico ItalianoRecruiting
  • San Paolo Hospital
  • Mirano HospitalRecruiting
  • Nuovo Ospedale Civile Sant' Agostino Estense
  • Policlinico di MonzaRecruiting
  • Ospedale San Francesco di Nuoro
  • University of Palermo
  • Foundation IRCCS Policlinico San Matteo
  • Vascular Endovascular Unit of PerugiaRecruiting
  • Santa Maria Hospital - ReggioRecruiting
  • Policlinico Universitario Campus Bio-medico di RomaRecruiting
  • A.C.O. San Fillippo NeriRecruiting
  • Fondazione Policlinico U. Agostino Gemeli IRCCS
  • San Camillo ForlaniniRecruiting
  • University La SapienzaRecruiting
  • IRCCS Clinico HumanitasRecruiting
  • Santa Maria alle ScotteRecruiting
  • Ospedali Riuniti di TriesteRecruiting
  • Umberto I- ASO MaurizianoRecruiting
  • Circolo University HospitalRecruiting
  • San Giacomo HospitalRecruiting
  • Sendai Medical CentreRecruiting
  • National Scientific Centre of SurgeryRecruiting
  • Rijnstate Hospital
  • MCL LeeuwardenRecruiting
  • University Hospital UtrechtRecruiting
  • Rikshospitalet
  • Poznan University of Medical SciencesRecruiting
  • Bielanski HospitalRecruiting
  • Central Hospital Internal Aff.
  • Mazovian Brodnowski HospitalRecruiting
  • University of Warsaw/ Institute of PsychiatryRecruiting
  • Regional Specialist Hospital (Wroclaw)Recruiting
  • Hospital Santa Marta
  • Novosibirsk Research Institute of Circulation PathologyRecruiting
  • Saint Petersburg Scientific Research Institute for Emergency CareRecruiting
  • V.A. Almazov National Medical Research CentreRecruiting
  • Dedinje Cardiovascular UnitRecruiting
  • Serbian Clinical CentreRecruiting
  • Khoo Teck Puat Hospital
  • Institute of Medical Sciences
  • Izola General HospitalRecruiting
  • Teaching Hospital MariborRecruiting
  • Hospital Clinic 1 Provinical de BarcelonaRecruiting
  • Guadalajara HospitalRecruiting
  • Hospital Universitari I Politecnic La FeRecruiting
  • Lasarettet HelsingborgRecruiting
  • Malmo University HospitalRecruiting
  • SodersjukhusetRecruiting
  • Cantonal Hospital AarauRecruiting
  • University of BaselRecruiting
  • Southend University HospitalRecruiting
  • East Kent Hospitals University NHS Foundation TrustRecruiting
  • Walton Centre
  • Cheltenham General HospitalRecruiting
  • Bishop Auckland Hospital
  • University Hospital of North Durham
  • Hull Royal InfirmaryRecruiting
  • St George's Hospital
  • The Royal LondonRecruiting
  • Luton & Dunstable HospitalRecruiting
  • Manchester Royal InfirmaryRecruiting
  • Wythenshawe HospitalRecruiting
  • James Cook Hospital
  • Freeman HospitalRecruiting
  • Royal Victoria Infirmary
  • Nottingham University HospitalRecruiting
  • John Radcliffe HospitalRecruiting
  • Derriford Hospital
  • The Royal Preston HospitalRecruiting
  • Royal BerkshireRecruiting
  • Sheffield Vascular InstituteRecruiting
  • Sunderland Royal HospitalRecruiting
  • Great Western HospitalRecruiting
  • North Cumbria University Hospital
  • York Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

CEA

CAS

Arm Description

Carotid endarterectomy

Carotid Artery Stenting

Outcomes

Primary Outcome Measures

To compare peri-procedural risks (MI, stroke and death) within the first month after the allocated CEA or CAS and long-term (up to 5 or more years) prevention of stroke, particularly disabling or fatal stroke, in subsequent years.

Secondary Outcome Measures

To identify types of patients to be identified in which one or other procedure is clearly preferable as well as economic evaluation; procedural costs and stroke-related healthcare costs and quality of life.

Full Information

First Posted
April 15, 2009
Last Updated
March 23, 2020
Sponsor
University of Oxford
Collaborators
NHS Health Technology Assessment Programme, BUPA Foundation
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1. Study Identification

Unique Protocol Identification Number
NCT00883402
Brief Title
Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients
Acronym
ACST-2
Official Title
Asymptomatic Carotid Surgery Trial-2 (ACST-2): an International Randomised Trial to Compare Carotid Endarterectomy With Carotid Artery Stenting to Prevent Stroke
Study Type
Interventional

2. Study Status

Record Verification Date
April 2019
Overall Recruitment Status
Unknown status
Study Start Date
January 2008 (undefined)
Primary Completion Date
December 2020 (Anticipated)
Study Completion Date
December 2020 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Oxford
Collaborators
NHS Health Technology Assessment Programme, BUPA Foundation

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The trial randomise patients with asymptomatic carotid artery narrowing in whom prompt physical intervention is thought to be needed, but there there is still substantial uncertainty shared by patient and doctor about whether surgery or stenting is the more appropriate choice. The study is looking at immediate risks (within one month)and at long term benefits

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Carotid Stenosis
Keywords
Carotid stenosis, CEA, CAS, Stenting

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
3600 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
CEA
Arm Type
Active Comparator
Arm Description
Carotid endarterectomy
Arm Title
CAS
Arm Type
Active Comparator
Arm Description
Carotid Artery Stenting
Intervention Type
Procedure
Intervention Name(s)
CEA, CAS
Intervention Description
Carotid Artery Stenting (CAS) Carotid endarterectomy (CEA)
Primary Outcome Measure Information:
Title
To compare peri-procedural risks (MI, stroke and death) within the first month after the allocated CEA or CAS and long-term (up to 5 or more years) prevention of stroke, particularly disabling or fatal stroke, in subsequent years.
Time Frame
10 years
Secondary Outcome Measure Information:
Title
To identify types of patients to be identified in which one or other procedure is clearly preferable as well as economic evaluation; procedural costs and stroke-related healthcare costs and quality of life.
Time Frame
10 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Carotid artery stenosis detectable by duplex ultrasound, with no ipsilateral carotid territory symptoms(or none for some months) and no previous procedure done on it, which might well need procedural treatment now with CEA or CAS. Already started any appropriate medical treatment (eg, statin, aspirin etc), and already recovered from any necessary coronary procedures (eg, CABG) Patient seems fit and willing for follow-up in person (at 1 month) and by annual letter (for at least 5 years) Investigations show that both procedures (CEA and CAS) appear to be practicable and appropriate Some type of angiography (eg, MRA or CTA) has already been done that has shown that CEA and CAS would both be anatomically practicable. Doctor and patient both substantially uncertain about whether to treat with CEA or CAS, and the doctor sees no clear indication/contra-indication for either procedure Exclusion Criteria: Small likelihood of worthwhile benefit (eg, very low risk of stroke because stenosis is very minor, or major co-morbidity or life-threatening disease, such as advanced cancer) Unsuitable for one or other procedure (eg, stenosis at carotid siphon that is inaccessible for CEA, or complex vasculature below the stenosis that would hinder CAS, or patient unfit for major surgery)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Alison Halliday
Phone
+ 44 1865 617975
Email
acst@nds.ox.ac.uk
First Name & Middle Initial & Last Name or Official Title & Degree
Richard Bulbulia
Phone
+44 1865 743891
Email
acst@nds.ox.ac.uk
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Alison Halliday
Organizational Affiliation
University of Oxford
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Toledo Medical Centre
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43614
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Medical University of Innsbruck
City
Innsbruck
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gustav Fraedrich, Prof
Facility Name
University Hospital Antwerp
City
Antwerp
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prof Hendriks
Facility Name
University St Lucas
City
Brussels
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
Az St Blasius
City
Dendermonde
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
University Hospital Gent
City
Gent
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Frank Vermassen, Professor
Facility Name
Centre Hospitalier Régional de la Citadelle
City
Liege
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
Centre Hospitalier De Mouscron
City
Mouscron
Country
Belgium
Individual Site Status
Active, not recruiting
Facility Name
University of Sao Paulo
City
Sao Paulo
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Erasmo Da Silva, Dr
Facility Name
HCFM Ribeirao Preto da Universidade de Sao Paulo
City
São Paulo
Country
Brazil
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Edwaldo E Joviliano, Dr
Facility Name
Sveta Marina Hospital
City
Varna
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Foothills Medical Centre
City
Calgary
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Hill, Dr
Facility Name
China-Japan Friendship Hospital
City
Beijing
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ye Zhidong, Dr
Facility Name
Peking Union Medical College Hospital
City
Beijing
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liu Bao, Professor
Facility Name
University Hospital Centre Zagreb
City
Zagreb
Country
Croatia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mladen Petrunic, Prof
Facility Name
University Hospital of Merkur
City
Zagreb
Country
Croatia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ivan Cvjetko, Dr
Facility Name
St Anne's University Hospital Brno
City
Brno
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Staffa, Prof
Facility Name
Regional Hospital Liberec
City
Liberec
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vladimir Benes, Dr
Facility Name
University Hospital Ostrava Poruba
City
Ostrava Poruba
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dr Prochazka
Facility Name
Central Military Hospital
City
Prague
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Hospital Ceské Budejovice
City
České Budějovice
Country
Czechia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jiri Fiedler, Dr
Facility Name
Kasr Alaini University Hospital
City
Cairo
Country
Egypt
Individual Site Status
Active, not recruiting
Facility Name
East Tallinn general Hospital
City
Tallinn
Country
Estonia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Veronika Palmiste, Dr
Facility Name
Henri Mondor University Hospital
City
Paris
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean Pierre Becquemin, Prof
Facility Name
University of Dresden 'Carl-Gustav-Carus'
City
Dresden
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jessica Barlinn, Dr
Facility Name
Universitätsklinikum Hamburg-Eppendorf
City
Hamburg
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sebastian Debus, prof
Facility Name
Universitätsklinik Jena
City
Jena
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Albrecht Guenther, Prof
Facility Name
Städtisches Klinikum Karlsruhe
City
Karlsruhe
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Storck, Prof
Facility Name
University of Leipzig
City
Leipzig
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dierk Scheinert, Prof
Facility Name
Universitätsmedizin Mannheim
City
Mannheim
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angelika Alonso, Prof
Facility Name
Klinikum rechts der Isar derTechnischen Universität Muenchen
City
Munich
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hans Henning Eckstein, Prof
Facility Name
St Franziskus-Hospital Münster GmbH
City
Munster
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giovanni Torsello, Prof
Facility Name
Hegau-Bodensee-Klinikum
City
Singen
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tomas Pfeiffer, Prof
Facility Name
Democritus University of Thrace
City
Alexandroupolis
ZIP/Postal Code
68100
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Miltos Lazarides, Prof
Facility Name
Dept. of Vascular Surgery, Attikon University Hospital
City
Athens
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Spyros Vasdekis, Prof
Facility Name
University Hospital of Larissa
City
Larissa
Country
Greece
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Athanasious Giannoukas, Prof
Facility Name
Semmelweis Medical University
City
Budapest
Country
Hungary
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lazslo Entz, Prof
Facility Name
Albert Szent-Györgyi Medical Centre
City
Szeged
Country
Hungary
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pal Barzo, Prof
Facility Name
St. James' Hospital
City
Dublin
Country
Ireland
Individual Site Status
Active, not recruiting
Facility Name
Rambam Hospital
City
Haifa
Country
Israel
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prof Hoffman
Facility Name
Cefalu Fondazione Istituto G.Giglio
City
Cefalu
State/Province
PA
ZIP/Postal Code
90015
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pierfrancesco Veroux, Prof
Facility Name
Azienda Ospedaliera S.G Moscati
City
Avellino
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
giovanni Amatucci, Dr
Facility Name
University of Bari
City
Bari
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Raffaele Pulli, Prof
Facility Name
University of Bologna
City
Bologna
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
A Stella, Prof
Facility Name
Policlinico Catania
City
Catania
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
P Veroux, Prof
Facility Name
Azienda Ospedaliero-Universitaria S.Anna
City
Ferrera
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vincenzo Gasbarro, Prof
Facility Name
San Giovanni Di Dio
City
Florence
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
S Michelagnoli, Prof
Facility Name
Opsedale Villa Scassi
City
Genoa
ZIP/Postal Code
16149
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gianantonio Simoni, Dr
Phone
+39 010 8492870
Facility Name
IRCCS San Martino
City
Genoa
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
D Palombo, Prof
Facility Name
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico di Milano
City
Milan
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Livio Gabrielli, Prof
Facility Name
IRCCS Policlinico San Donato
City
Milan
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
G Nano, Prof
Facility Name
Istituto Auxologico Italiano
City
Milan
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Renato Casana, Dr
Facility Name
San Paolo Hospital
City
Milan
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Mirano Hospital
City
Mirano
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Salvatore Sacca, Dr
Facility Name
Nuovo Ospedale Civile Sant' Agostino Estense
City
Modena
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Policlinico di Monza
City
Monza
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Valerio S Tolva, Dr
Facility Name
Ospedale San Francesco di Nuoro
City
Nuoro
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
University of Palermo
City
Palermo
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Foundation IRCCS Policlinico San Matteo
City
Pavia
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Vascular Endovascular Unit of Perugia
City
Perugia
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gianbattista Parlani, Dr
Facility Name
Santa Maria Hospital - Reggio
City
Raggio
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dr Tusini
Facility Name
Policlinico Universitario Campus Bio-medico di Roma
City
Roma
ZIP/Postal Code
00128
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesco Spinelli, Prof
Phone
+39 06225411612
Facility Name
A.C.O. San Fillippo Neri
City
Rome
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sonia Ronchey, Dr
Facility Name
Fondazione Policlinico U. Agostino Gemeli IRCCS
City
Rome
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Y Tshomba
Facility Name
San Camillo Forlanini
City
Rome
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicola Mangialardi, Prof
Facility Name
University La Sapienza
City
Rome
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesco Speziale, Prof
Facility Name
IRCCS Clinico Humanitas
City
Rozzano
ZIP/Postal Code
20089
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Efram Civilini, Professor
Facility Name
Santa Maria alle Scotte
City
Siena
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prof Setacci
Facility Name
Ospedali Riuniti di Trieste
City
Trieste
ZIP/Postal Code
34142
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Barbara Ziani, Dr
Phone
+39 040 3994761
Facility Name
Umberto I- ASO Mauriziano
City
Turin
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
M Ferri, Prof
Facility Name
Circolo University Hospital
City
Varese
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
P Castelli, Prof
Facility Name
San Giacomo Hospital
City
Veneto
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlo Cernetti, Dr
Facility Name
Sendai Medical Centre
City
Sendai
Country
Japan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Inoue Takashi, Dr
Facility Name
National Scientific Centre of Surgery
City
Almaty
Country
Kazakhstan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
T Tajibayev, Dr
Facility Name
Rijnstate Hospital
City
Arnhem
Country
Netherlands
Individual Site Status
Active, not recruiting
Facility Name
MCL Leeuwarden
City
Leeuwarden
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
A. Khodadade Jahrome, Dr
Facility Name
University Hospital Utrecht
City
Utrecht
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
GJ de Borst, Dr
Facility Name
Rikshospitalet
City
Oslo
Country
Norway
Individual Site Status
Active, not recruiting
Facility Name
Poznan University of Medical Sciences
City
Poznan
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
G Oszkinis, Prof
Facility Name
Bielanski Hospital
City
Warsaw
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
G Madycki, Professor
Facility Name
Central Hospital Internal Aff.
City
Warsaw
Country
Poland
Individual Site Status
Active, not recruiting
Facility Name
Mazovian Brodnowski Hospital
City
Warsaw
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
P Myrcha, Ass. Prof
Facility Name
University of Warsaw/ Institute of Psychiatry
City
Warsaw
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dr Kobayashi
Facility Name
Regional Specialist Hospital (Wroclaw)
City
Wroclaw
Country
Poland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
W Iwanowski, Dr
Facility Name
Hospital Santa Marta
City
Lisbon
ZIP/Postal Code
1150
Country
Portugal
Individual Site Status
Active, not recruiting
Facility Name
Novosibirsk Research Institute of Circulation Pathology
City
Novosibirsk
Country
Russian Federation
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
V Starodubtsev, Dr
Facility Name
Saint Petersburg Scientific Research Institute for Emergency Care
City
Saint Petersburg
Country
Russian Federation
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pavel Chechulov, Dr
Facility Name
V.A. Almazov National Medical Research Centre
City
Saint Petersburg
Country
Russian Federation
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Boris Komakha, Dr
Facility Name
Dedinje Cardiovascular Unit
City
Belgrade
Country
Serbia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
G Radak, Prof
Facility Name
Serbian Clinical Centre
City
Belgrade
Country
Serbia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
L Davidovic, Prof
Facility Name
Khoo Teck Puat Hospital
City
Singapore
Country
Singapore
Individual Site Status
Withdrawn
Facility Name
Institute of Medical Sciences
City
Ruzomberok
Country
Slovakia
Individual Site Status
Active, not recruiting
Facility Name
Izola General Hospital
City
Izola
Country
Slovenia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
M Gasparini, Prof
Facility Name
Teaching Hospital Maribor
City
Maribor
Country
Slovenia
Individual Site Status
Recruiting
Facility Name
Hospital Clinic 1 Provinical de Barcelona
City
Barcelona
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dr Riambau
Facility Name
Guadalajara Hospital
City
Guadalajara
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Estrella Blanco, Dr
Facility Name
Hospital Universitari I Politecnic La Fe
City
Valencia
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manuel Miralles, Dr
Facility Name
Lasarettet Helsingborg
City
Helsingborg
Country
Sweden
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
P Qvarfordt, Prof
Facility Name
Malmo University Hospital
City
Malmo
Country
Sweden
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dr Bjores
Facility Name
Sodersjukhuset
City
Stockholm
Country
Sweden
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dr Konrad
Facility Name
Cantonal Hospital Aarau
City
Aarau
ZIP/Postal Code
CH-5001
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Timo Kahles, Dr
Facility Name
University of Basel
City
Basel
Country
Switzerland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Leo Bonati, Dr
Facility Name
Southend University Hospital
City
Westcliff-on-Sea
State/Province
Essex
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
P Guyler, Dr
Facility Name
East Kent Hospitals University NHS Foundation Trust
City
Canterbury
State/Province
Kent
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Hargroves, Dr
Facility Name
Walton Centre
City
Aintree
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Cheltenham General Hospital
City
Cheltenham
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard Bulbulia, Mr
Facility Name
Bishop Auckland Hospital
City
Durham
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
University Hospital of North Durham
City
Durham
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Hull Royal Infirmary
City
Hull
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ian Chetter, Prof
Facility Name
St George's Hospital
City
London
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
The Royal London
City
London
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sageet Amlani, Dr
Facility Name
Luton & Dunstable Hospital
City
Luton
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
L Sekaran, Dr
Facility Name
Manchester Royal Infirmary
City
Manchester
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
JV Smyth, Mr
Facility Name
Wythenshawe Hospital
City
Manchester
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
C McCollum, Prof
Facility Name
James Cook Hospital
City
Middlesbrough
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Freeman Hospital
City
Newcastle
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gerry Stansby, Prof
Facility Name
Royal Victoria Infirmary
City
Newcastle
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Nottingham University Hospital
City
Nottingham
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
S Mac Sweeney, Mr
Facility Name
John Radcliffe Hospital
City
Oxford
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ursula Schulz, Dr
Facility Name
Derriford Hospital
City
Plymouth
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
The Royal Preston Hospital
City
Preston
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
George Thomas, Mr
Facility Name
Royal Berkshire
City
Reading
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
E Flossman, Dr
Facility Name
Sheffield Vascular Institute
City
Sheffield
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Trevor Cleveland, Dr
Facility Name
Sunderland Royal Hospital
City
Sunderland
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
P Dunlop, Mr
Facility Name
Great Western Hospital
City
Swindon
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gopi Ramadurai, Dr
Facility Name
North Cumbria University Hospital
City
Whitehaven
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
York Hospital
City
York
Country
United Kingdom
Individual Site Status
Withdrawn

12. IPD Sharing Statement

Citations:
PubMed Identifier
15135594
Citation
Halliday A, Mansfield A, Marro J, Peto C, Peto R, Potter J, Thomas D; MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet. 2004 May 8;363(9420):1491-502. doi: 10.1016/S0140-6736(04)16146-1. Erratum In: Lancet. 2004 Jul 31;364(9432):416.
Results Reference
background
Links:
URL
http://www.acst-2.org
Description
ACST-2 Website

Learn more about this trial

Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients

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