Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement
Primary Purpose
Abnormal Aortic Valve
Status
Completed
Phase
Phase 4
Locations
Korea, Republic of
Study Type
Interventional
Intervention
ulinastatin
Sponsored by

About this trial
This is an interventional trial for Abnormal Aortic Valve
Eligibility Criteria
Inclusion Criteria:
- 40% below of output of left ventricle
- tricuspid valve failure from moderate to severe
- urgent surgery required
- infectious endocarditis
Sites / Locations
- Severance Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
ulinastatin
C group
Arm Description
Administer with 30,000U /ulinastatin
administer normal saline
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00944385
Brief Title
Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement
Official Title
Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement
Study Type
Interventional
2. Study Status
Record Verification Date
May 2011
Overall Recruitment Status
Completed
Study Start Date
June 2009 (undefined)
Primary Completion Date
April 2011 (Actual)
Study Completion Date
April 2011 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Yonsei University
4. Oversight
5. Study Description
Brief Summary
According to TEG (thromboelastography), as maximum amplitude is increased the amount of bleeding and transfusion and Cardiac enzyme is reduced by using ulinastatin.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Abnormal Aortic Valve
7. Study Design
Study Phase
Phase 4
8. Arms, Groups, and Interventions
Arm Title
ulinastatin
Arm Type
Experimental
Arm Description
Administer with 30,000U /ulinastatin
Arm Title
C group
Arm Type
Placebo Comparator
Arm Description
administer normal saline
Intervention Type
Drug
Intervention Name(s)
ulinastatin
Intervention Description
Administer 30000U/ulinastatin. Comparison of different dosages of drug.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
40% below of output of left ventricle
tricuspid valve failure from moderate to severe
urgent surgery required
infectious endocarditis
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Younglan Kwak, MD, PhD
Organizational Affiliation
Severance Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Severance Hospital
City
Seoul
ZIP/Postal Code
120-752
Country
Korea, Republic of
12. IPD Sharing Statement
Learn more about this trial
Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement
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