Bioactive Plant Foods: Effects on Functional Bioavailability and Genomic Stability (Biogreen)

This is an interventional basic science trial for Metabolic Syndrome focused on measuring Angelica keiskei, Glycine max, metabolic syndrome Read More

Inclusion Criteria: healthy control group (n=20)

1. Age: over 50 years old
2. Female subjects must be post-menopausal
3. BMI: 18.5 - 30, waist/hip ratio < 0.9 for men, < 0.85 for women
4. TG<150 mg/dL (1.7 mmol/L) and no medication for TG
5. Total cholesterol < 200 mg /dL (5.18 mmol/L) and no medication for cholesterol
6. Blood pressure: SBP < 130 mmHg and DBP < 85 mmHg and no hypertensive medication
7. Plasma glucose: fasting blood glucose < 100 mg/dL (5.6 mmol/L) and no diabetes medication

Inclusion Criteria: Metabolic syndrome (n=40)

1. Age: over 50 years old
2. BMI: > 30 or waist/hip ratio > 0.9 for men, > 0.85 for women

3. Plus any two of the following four factors:

   • TG: 150-400 mg/dL (1.7 - 4.52 mmol/L) and/or medication for TG
   • HDL cholesterol: <40 mg /dL (1.03 mmol/L) for men, <50 mg/dL (1.29 mmol/L) for women and/or medication for cholesterol
   • Blood pressure: SBP, 130-160 mmHg and/or DBP 85-95 mmHg and/or antihypertensive medication
   • Plasma glucose: fasting blood glucose 100-125 mg/dL (5.55- 6.94 mmol/L) and no diabetes medication

Exclusion Criteria:

1. Study participants will be screened for normal hematologic parameters, normal serum albumin, normal liver function, normal kidney function, absence of fat malabsorption.
2. Subjects with a history of kidney stones, active small bowel disease or resection, atrophic gastritis, insulin-requiring diabetes, alcoholism, pancreatic disease, or bleeding disorders will be excluded from the study.
3. Exogenous hormone users will be excluded from the study.
4. Moreover, subjects will be non-smokers and will not have taken vitamin or carotenoid supplements for at least 6 weeks prior to the study and throughout the study for both healthy subjects and subjects with metabolic syndrome.