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Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome (EXAMINE)

Primary Purpose

Diabetes Mellitus, Type 2, Acute Coronary Syndrome

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Alogliptin
Placebo
Sponsored by
Takeda
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Diabetes Mellitus, Type 2 focused on measuring Diabetes Mellitus - Type 2, Diabetes Mellitus, cardiovascular outcomes, heart attack, stroke, dipeptidyl-peptidase IV inhibitors, metabolic disorders, metabolic diseases, glucose metabolism disorders

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Diagnosis of type 2 diabetes mellitus
  • Is receiving monotherapy or combination antidiabetic therapy with a glycosylated hemoglobin level between 6.5% and 11.0%, inclusive, at Screening (between 7.0 and 11.0%, inclusive, if the participant's antidiabetic regimen includes insulin)
  • Diagnosis of acute coronary syndrome within 15 to 90 days prior to randomization.

Exclusion Criteria:

  • Signs of type 1 diabetes mellitus
  • Currently receiving a glucagon-like peptide-1 analogue for glycemic control of type 2 diabetes mellitus at Screening
  • Received a dipeptidyl peptidase-4 inhibitor for either more than 14 days total or within the 3 months prior to Screening.

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Placebo

Alogliptin

Arm Description

Alogliptin placebo matching tablets, orally, once daily. Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Alogliptin 25 mg, tablets, orally, once daily for participants with normal or mildly impaired renal function as defined by estimated glomerular filtration rate (eGFR) ≥ 60 mL/min). Alogliptin 12.5 mg, tablets, orally, once daily for participants with moderately impaired renal function (eGFR ≥30 and <60 mL/min). Alogliptin 6.25 mg, tablets, orally, once daily for participants with severely impaired renal function or end stage renal disease (eGFR <30 mL/min). Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Outcomes

Primary Outcome Measures

Percentage of Participants With Primary Major Adverse Cardiac Events (MACE)
Primary Major Adverse Cardiac Events were defined as a composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke; these events were adjudicated by an independent cardiovascular endpoints committee.

Secondary Outcome Measures

Percentage of Participants With Secondary Major Adverse Cardiac Events (MACE)
Secondary MACE composite consisted of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or urgent revascularization due to unstable angina; these events were adjudicated by an independent cardiovascular endpoint committee.

Full Information

First Posted
August 28, 2009
Last Updated
April 15, 2014
Sponsor
Takeda
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1. Study Identification

Unique Protocol Identification Number
NCT00968708
Brief Title
Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome
Acronym
EXAMINE
Official Title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Cardiovascular Outcomes Following Treatment With Alogliptin in Addition to Standard of Care in Subjects With Type 2 Diabetes and Acute Coronary Syndrome
Study Type
Interventional

2. Study Status

Record Verification Date
April 2014
Overall Recruitment Status
Completed
Study Start Date
September 2009 (undefined)
Primary Completion Date
April 2013 (Actual)
Study Completion Date
June 2013 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Takeda

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to evaluate the cardiovascular outcomes of alogliptin, once daily (QD), compared with placebo, in addition to standard of care, in patients with type 2 diabetes mellitus and acute coronary syndrome.
Detailed Description
Alogliptin is a selective and potent dipeptidyl peptidase-4 inhibitor developed by Takeda for use in patients with type 2 diabetes mellitus. Cardiovascular outcomes is of special interest in the type 2 diabetes mellitus population, particularly in type 2 diabetes mellitus patients who have cardiovascular disease and are at high risk for major adverse cardiac events, such as those patients who have had recent acute coronary syndrome. This study has been designed to evaluate the cardiovascular safety of alogliptin versus placebo in addition to Standard of Care in adults with type 2 diabetes mellitus and acute coronary syndrome.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Diabetes Mellitus, Type 2, Acute Coronary Syndrome
Keywords
Diabetes Mellitus - Type 2, Diabetes Mellitus, cardiovascular outcomes, heart attack, stroke, dipeptidyl-peptidase IV inhibitors, metabolic disorders, metabolic diseases, glucose metabolism disorders

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
5380 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Placebo
Arm Type
Experimental
Arm Description
Alogliptin placebo matching tablets, orally, once daily. Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.
Arm Title
Alogliptin
Arm Type
Experimental
Arm Description
Alogliptin 25 mg, tablets, orally, once daily for participants with normal or mildly impaired renal function as defined by estimated glomerular filtration rate (eGFR) ≥ 60 mL/min). Alogliptin 12.5 mg, tablets, orally, once daily for participants with moderately impaired renal function (eGFR ≥30 and <60 mL/min). Alogliptin 6.25 mg, tablets, orally, once daily for participants with severely impaired renal function or end stage renal disease (eGFR <30 mL/min). Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.
Intervention Type
Drug
Intervention Name(s)
Alogliptin
Other Intervention Name(s)
Nesina®, SYR-322, SYR110322
Intervention Description
Alogliptin tablets
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Alogliptin placebo matching tablets
Primary Outcome Measure Information:
Title
Percentage of Participants With Primary Major Adverse Cardiac Events (MACE)
Description
Primary Major Adverse Cardiac Events were defined as a composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke; these events were adjudicated by an independent cardiovascular endpoints committee.
Time Frame
From randomization until the adjudication cut-off date of May 31 2013 (maximum time on study was 41 months).
Secondary Outcome Measure Information:
Title
Percentage of Participants With Secondary Major Adverse Cardiac Events (MACE)
Description
Secondary MACE composite consisted of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or urgent revascularization due to unstable angina; these events were adjudicated by an independent cardiovascular endpoint committee.
Time Frame
From randomization until the adjudication cut-of date of May 31 2013 (maximum time on study was 41 months).

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Diagnosis of type 2 diabetes mellitus Is receiving monotherapy or combination antidiabetic therapy with a glycosylated hemoglobin level between 6.5% and 11.0%, inclusive, at Screening (between 7.0 and 11.0%, inclusive, if the participant's antidiabetic regimen includes insulin) Diagnosis of acute coronary syndrome within 15 to 90 days prior to randomization. Exclusion Criteria: Signs of type 1 diabetes mellitus Currently receiving a glucagon-like peptide-1 analogue for glycemic control of type 2 diabetes mellitus at Screening Received a dipeptidyl peptidase-4 inhibitor for either more than 14 days total or within the 3 months prior to Screening.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Medical Director Clinical Science
Organizational Affiliation
Takeda
Official's Role
Study Director
Facility Information:
City
Birmingham
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Alabama
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Dothan
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Mobile
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Muscle Shoals
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Cottonwood
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Goodyear
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Mesa
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Phoenix
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Tucson
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Little Rock
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Malvern
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Searcy
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White Hall
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Alameda
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Aliso Viejo
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Anaheim
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Bell Gardens
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Beverly Hills
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Chula Vista
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Corona
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Downey
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Escondido
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Fullerton
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Huntington Beach
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Huntington Park
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Inglewood
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La Mirada
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Lakewood
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Lancaster
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Lomita
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Merced
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Newport Beach
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Northridge
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Oakland
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Pomona
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Davie
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Daytona Beach
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DelRay Beach
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Doral
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Fleming Island
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Hollywood
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Ocala
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Orlando
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Palm Harbor
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Panama City
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Pembroke Pines
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Pensacola
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Stuart
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Tampa
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Vero Beach
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Atlanta
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Georgia
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Cartersville
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Conyers
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Dunwoody
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Marietta
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Savannah
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Tucker
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Lexington
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Madisonville
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Owensboro
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Alexandria
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Houma
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Lafayette
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Natchitoches
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New Orleans
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Slidell
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Biddeford
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Rockport
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Annapolis
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Baltimore
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Oxon Hill
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Rockville
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Boston
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Brockton
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Fall River
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Alpena
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Bridgman
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Dearborn
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Detroit
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Kalamazoo
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Lapeer
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Livonia
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MIdland
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Saginaw
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Waterford
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Duluth
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Rochester
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Chesterfield
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Jefferson City
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St. Joseph
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St. Louis
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Great Falls
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Omaha
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Las Vegas
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Pahrump
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Brick
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Bridgewater
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Camden
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Fort Lee
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Linden
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New Brunswick
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Newark
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Ridgewood
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Sewell
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Sicklerville
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South Plainfield
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Albuquerque
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Bronx
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Cortlandt Manor
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Freeport
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Huntington
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Kingston
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New York
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Rochester
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Williamsville
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Asheville
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Toledo
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Westlake
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Zanesville
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Bartlesville
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Oklahoma
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Oklahoma City
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Oklahoma
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Yukon
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Bend
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Corvallis
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Portland
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Altoona
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Bethlehem
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Clymer
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Langhorne
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Scotland
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Sellersville
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Yardley
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Rhode Island
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Beaufort
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Easley
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Florence
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Spartanburg
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Sioux Falls
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Bartlett
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Cleveland
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Franklin
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Tennessee
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Germantown
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Jackson
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Tennessee
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Johnson City
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Tennessee
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Kingsport
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Knoxville
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Memphis
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Country
United States
City
Murfreesboro
State/Province
Tennessee
Country
United States
City
Nashville
State/Province
Tennessee
Country
United States
City
Oak Ridge
State/Province
Tennessee
Country
United States
City
Austin
State/Province
Texas
Country
United States
City
Beaumont
State/Province
Texas
Country
United States
City
Carrollton
State/Province
Texas
Country
United States
City
Dallas
State/Province
Texas
Country
United States
City
Denton
State/Province
Texas
Country
United States
City
Edinburg
State/Province
Texas
Country
United States
City
Fort Worth
State/Province
Texas
Country
United States
City
Grapevine
State/Province
Texas
Country
United States
City
Houston
State/Province
Texas
Country
United States
City
McKinney
State/Province
Texas
Country
United States
City
North Richland Hills
State/Province
Texas
Country
United States
City
Plano
State/Province
Texas
Country
United States
City
Saginaw
State/Province
Texas
Country
United States
City
San Antonio
State/Province
Texas
Country
United States
City
Southlake
State/Province
Texas
Country
United States
City
Temple
State/Province
Texas
Country
United States
City
Tomball
State/Province
Texas
Country
United States
City
Bountiful
State/Province
Utah
Country
United States
City
Ogden
State/Province
Utah
Country
United States
City
Salt Lake City
State/Province
Utah
Country
United States
City
Bennington
State/Province
Vermont
Country
United States
City
South Burlington
State/Province
Vermont
Country
United States
City
Burke
State/Province
Virginia
Country
United States
City
Charlottesville
State/Province
Virginia
Country
United States
City
Galax
State/Province
Virginia
Country
United States
City
Lakeridge
State/Province
Virginia
Country
United States
City
Manassas
State/Province
Virginia
Country
United States
City
Norfolk
State/Province
Virginia
Country
United States
City
Richmond
State/Province
Virginia
Country
United States
City
Roanoke
State/Province
Virginia
Country
United States
City
Suffolk
State/Province
Virginia
Country
United States
City
Virginia Beach
State/Province
Virginia
Country
United States
City
Everett
State/Province
Washington
Country
United States
City
Tacoma
State/Province
Washington
Country
United States
City
Beloit
State/Province
Wisconsin
Country
United States
City
Green Bay
State/Province
Wisconsin
Country
United States
City
Madison
State/Province
Wisconsin
Country
United States
City
Manitowoc
State/Province
Wisconsin
Country
United States
City
Milwaukee
State/Province
Wisconsin
Country
United States
City
Waukesha
State/Province
Wisconsin
Country
United States
City
Bahia Blanca
Country
Argentina
City
Buenos Aires
Country
Argentina
City
C0rdoba
Country
Argentina
City
Capital Federal, Buenos Aires
Country
Argentina
City
Capital Federal
Country
Argentina
City
Carlos Paz, C0rdoba
Country
Argentina
City
Ciudad Aut0noma de Buenos Aires
Country
Argentina
City
Ciudad Autonoma de Buenos Aires
Country
Argentina
City
Ciudad de C0rdoba
Country
Argentina
City
Cordoba - Cordoba
Country
Argentina
City
Cordoba
Country
Argentina
City
Corrientes
Country
Argentina
City
Derqui Pilar, Buenos Aires
Country
Argentina
City
Formosa
Country
Argentina
City
Haedo, Buenos Aires
Country
Argentina
City
La Plata, Buenos Aires
Country
Argentina
City
La Plata
Country
Argentina
City
Mar del Plata, Provincia de Buenos Aires
Country
Argentina
City
Mar del Plata
Country
Argentina
City
Mendoza
Country
Argentina
City
Moron, Buenos Aires
Country
Argentina
City
Olivos
Country
Argentina
City
Quilmes
Country
Argentina
City
Ramos Mejia, Buenos Aries
Country
Argentina
City
Ramos Mejia
Country
Argentina
City
Rosario - Santa Fe
Country
Argentina
City
Rosario, Provincia de Santa Fe
Country
Argentina
City
Rosario
Country
Argentina
City
Salta
Country
Argentina
City
San Isidro
Country
Argentina
City
San Juan, San Juan
Country
Argentina
City
San Justo
Country
Argentina
City
San Luis
Country
Argentina
City
San Miguel de Tucuman
Country
Argentina
City
San Salvador, de Jujuy
Country
Argentina
City
Santa Fe
Country
Argentina
City
Trelew, Chubut
Country
Argentina
City
Villa Maria
Country
Argentina
City
Broken Hill
State/Province
New South Wales
Country
Australia
City
Kogarah
State/Province
New South Wales
Country
Australia
City
Milton
State/Province
Queensland
Country
Australia
City
Nambour
State/Province
Queensland
Country
Australia
City
Hobart
State/Province
Tasmania
Country
Australia
City
Fitzroy
State/Province
Victoria
Country
Australia
City
Frankston
State/Province
Victoria
Country
Australia
City
Heidelberg
State/Province
Victoria
Country
Australia
City
Prahran
State/Province
Victoria
Country
Australia
City
Adelaide, SA
Country
Australia
City
Bruce
Country
Australia
City
Feldkirch
Country
Austria
City
Graz
Country
Austria
City
Salzburg
Country
Austria
City
Wien
Country
Austria
City
Antwerpen
Country
Belgium
City
Bonheiden
Country
Belgium
City
Brasschaat
Country
Belgium
City
Brussel
Country
Belgium
City
Bruxelles
Country
Belgium
City
Gent
Country
Belgium
City
La Louviere
Country
Belgium
City
Curitiba
State/Province
PR
Country
Brazil
City
Rio de Janeiro
State/Province
RJ
Country
Brazil
City
Sao Paulo
State/Province
SP
Country
Brazil
City
Tatui
State/Province
SP
Country
Brazil
City
Aracaju, Sergipe
Country
Brazil
City
Belem - PA
Country
Brazil
City
Belo Horizonte - MG
Country
Brazil
City
Belo Horizonte, Minas Gerais
Country
Brazil
City
Blumenau
Country
Brazil
City
Brasilia - DF
Country
Brazil
City
Brasilia, Distrito Federal
Country
Brazil
City
Campina Grande do Sul
Country
Brazil
City
Campinas, Sao Paulo
Country
Brazil
City
Campo Grande, Mato Grosso do Sul
Country
Brazil
City
Curitiba, Parana
Country
Brazil
City
Fortaleza - CE
Country
Brazil
City
Fortaleza, Ceara
Country
Brazil
City
Goiania, Goias
Country
Brazil
City
Goiania
Country
Brazil
City
Joinville
Country
Brazil
City
Londrina/PR
Country
Brazil
City
Macei0
Country
Brazil
City
Marilia, Sao Paulo
Country
Brazil
City
Marilia
Country
Brazil
City
Mogi das Cruzes
Country
Brazil
City
Natal, RN
Country
Brazil
City
Natal
Country
Brazil
City
Passo Fundo, Rio Grande do Sul
Country
Brazil
City
Porto Alegre - RS
Country
Brazil
City
Porto Alegre, Rio Grande do Sul
Country
Brazil
City
Porto Alegre
Country
Brazil
City
Recife, Pernambuco
Country
Brazil
City
Recife, PE
Country
Brazil
City
Recife
Country
Brazil
City
Rio de Janeiro - RJ
Country
Brazil
City
Rio de Janeiro
Country
Brazil
City
Salvador - BA
Country
Brazil
City
Salvador, Bahia
Country
Brazil
City
Santo Andre
Country
Brazil
City
Sao Jose do Rio Preto, Sao Paulo
Country
Brazil
City
Sao Jose do Rio Preto- SP
Country
Brazil
City
Sao Jose do Rio Preto
Country
Brazil
City
Sao Jose, Santa Catarina
Country
Brazil
City
Sao Paulo, Sao Paulo
Country
Brazil
City
Sao Paulo, SP
Country
Brazil
City
Sao Paulo
Country
Brazil
City
Sobral, CE
Country
Brazil
City
Taguatinga
Country
Brazil
City
Uberlandia, Minas Gerais
Country
Brazil
City
Votuporanga
Country
Brazil
City
Blagoevgrad
Country
Bulgaria
City
Dimitrovgrad
Country
Bulgaria
City
Kazanlak
Country
Bulgaria
City
Lovech
Country
Bulgaria
City
Pleven
Country
Bulgaria
City
Plovdiv
Country
Bulgaria
City
Sevlievo
Country
Bulgaria
City
Smolian
Country
Bulgaria
City
Sofia
Country
Bulgaria
City
Stara Zagora
Country
Bulgaria
City
Varna
Country
Bulgaria
City
Calgary
State/Province
Alberta
Country
Canada
City
Edmonton
State/Province
Alberta
Country
Canada
City
Abbotsford
State/Province
British Columbia
Country
Canada
City
Kelowna
State/Province
British Columbia
Country
Canada
City
Vancouver
State/Province
British Columbia
Country
Canada
City
Victoria
State/Province
British Columbia
Country
Canada
City
Grand Falls-Windsor
State/Province
Newfoundland and Labrador
Country
Canada
City
St. John's
State/Province
Newfoundland and Labrador
Country
Canada
City
Halifax
State/Province
Nova Scotia
Country
Canada
City
Ajax
State/Province
Ontario
Country
Canada
City
Cambridge
State/Province
Ontario
Country
Canada
City
Hamilton
State/Province
Ontario
Country
Canada
City
Newmarket
State/Province
Ontario
Country
Canada
City
Niagara Falls
State/Province
Ontario
Country
Canada
City
Oshawa
State/Province
Ontario
Country
Canada
City
Pickering
State/Province
Ontario
Country
Canada
City
Smiths Falls
State/Province
Ontario
Country
Canada
City
Sudbury
State/Province
Ontario
Country
Canada
City
Toronto
State/Province
Ontario
Country
Canada
City
Greenfield Park
State/Province
Quebec
Country
Canada
City
Greenfield
State/Province
Quebec
Country
Canada
City
Lachine
State/Province
Quebec
Country
Canada
City
Mont-Royal
State/Province
Quebec
Country
Canada
City
Pointe Claire
State/Province
Quebec
Country
Canada
City
Pointe-Claire
State/Province
Quebec
Country
Canada
City
Sainte-Foy
State/Province
Quebec
Country
Canada
City
Sherbrooke
State/Province
Quebec
Country
Canada
City
St. Jerome
State/Province
Quebec
Country
Canada
City
Terrebonne
State/Province
Quebec
Country
Canada
City
Ontario
Country
Canada
City
Quebec
Country
Canada
City
Antofagasta, Region II
Country
Chile
City
Antofagasta
Country
Chile
City
Iquique, Region I
Country
Chile
City
Osorno
Country
Chile
City
Rancagua
Country
Chile
City
Santiago
Country
Chile
City
Talcahuano
Country
Chile
City
Temuco, Region de la Araucania
Country
Chile
City
Temuco
Country
Chile
City
Vina del Mar
Country
Chile
City
Barranquilla
Country
Colombia
City
Bogota
Country
Colombia
City
Bucaramanga
Country
Colombia
City
Medellin
Country
Colombia
City
Cakovec
Country
Croatia
City
Krapinske Toplice
Country
Croatia
City
Osijek
Country
Croatia
City
Rijeka
Country
Croatia
City
Sisak
Country
Croatia
City
Split
Country
Croatia
City
Virovitica
Country
Croatia
City
Zadar
Country
Croatia
City
Zagreb
Country
Croatia
City
Caslav
Country
Czech Republic
City
Hradec Kralove
Country
Czech Republic
City
Olomouc
Country
Czech Republic
City
Ostrava - Vitkovice
Country
Czech Republic
City
Zlin
Country
Czech Republic
City
Znojmo
Country
Czech Republic
City
Herlev
Country
Denmark
City
Herning
Country
Denmark
City
Kobenhavn NV
Country
Denmark
City
Alexandria
Country
Egypt
City
Giza
Country
Egypt
City
Monofia
Country
Egypt
City
Helsinki
Country
Finland
City
Jyvaskyla
Country
Finland
City
Kokkola
Country
Finland
City
Kuopio
Country
Finland
City
Tampere
Country
Finland
City
Turku
Country
Finland
City
Bordeaux
Country
France
City
Corbeil Essonnes
Country
France
City
Corbeil-Essonnes
Country
France
City
Creteil
Country
France
City
Dijon
Country
France
City
La Rochelle
Country
France
City
Lille
Country
France
City
Montpellier
Country
France
City
Narbonne
Country
France
City
Paris
Country
France
City
Pau
Country
France
City
Pessac
Country
France
City
Rennes
Country
France
City
Toulouse
Country
France
City
Bad Nauheim
Country
Germany
City
Bensheim
Country
Germany
City
Berlin
Country
Germany
City
Dortmund
Country
Germany
City
Dresden
Country
Germany
City
Essen
Country
Germany
City
Halle (Saale)
Country
Germany
City
Jena
Country
Germany
City
Kassel
Country
Germany
City
Koln
Country
Germany
City
Leipzig
Country
Germany
City
Mainz
Country
Germany
City
Mannheim
Country
Germany
City
Muenchen
Country
Germany
City
Munster
Country
Germany
City
Neumuenster
Country
Germany
City
Neuwied
Country
Germany
City
Sankt Ingbert
Country
Germany
City
Siegen
Country
Germany
City
Wangen
Country
Germany
City
Marousi
Country
Greece
City
Guatemala City
Country
Guatemala
City
Guatemala
Country
Guatemala
City
Quetzaltenango
Country
Guatemala
City
Hong Kong
Country
Hong Kong
City
Kowloon
Country
Hong Kong
City
Shatin
Country
Hong Kong
City
Tsuen Wan
Country
Hong Kong
City
Budaors
Country
Hungary
City
Budapest
Country
Hungary
City
Debrecen
Country
Hungary
City
Dunaujvaros
Country
Hungary
City
Gyula
Country
Hungary
City
H0dmezovasarhely
Country
Hungary
City
Kaposvar
Country
Hungary
City
Kecskemet
Country
Hungary
City
Nagykanizsa
Country
Hungary
City
Pecs
Country
Hungary
City
Sopron
Country
Hungary
City
Szekesfehervar
Country
Hungary
City
Szentes
Country
Hungary
City
Szombathely
Country
Hungary
City
Zalaegerszeg
Country
Hungary
City
Hyderabad
State/Province
Andhra Pradesh
Country
India
City
Nellore
State/Province
Andhra Pradesh
Country
India
City
Vijayawada
State/Province
Andhra Pradesh
Country
India
City
Visakhapatnam
State/Province
Andhra Pradesh
Country
India
City
Perumbakkam
State/Province
Chennai
Country
India
City
New Delhi
State/Province
Delhi
Country
India
City
Ahmedabad
State/Province
Gujarat
Country
India
City
Anand
State/Province
Gujarat
Country
India
City
Surat
State/Province
Gujarat
Country
India
City
Vadodara
State/Province
Gujarat
Country
India
City
Bangalore
State/Province
Karnataka
Country
India
City
Belgaum
State/Province
Karnataka
Country
India
City
Mangalore
State/Province
Karnataka
Country
India
City
Manipal
State/Province
Karnataka
Country
India
City
Mysore
State/Province
Karnataka
Country
India
City
Cochin
State/Province
Kerala
Country
India
City
Kochi
State/Province
Kerala
Country
India
City
Thiruvananthapuram
State/Province
Kerala
Country
India
City
Thrissur
State/Province
Kerala
Country
India
City
Trivandrum
State/Province
Kerala
Country
India
City
Aurangabad
State/Province
Maharashtra
Country
India
City
Mumbai
State/Province
Maharashtra
Country
India
City
Nagpur
State/Province
Maharashtra
Country
India
City
Nashik
State/Province
Maharashtra
Country
India
City
Pune
State/Province
Maharashtra
Country
India
City
Jalandhar
State/Province
Punjab
Country
India
City
Ludhiana
State/Province
Punjab
Country
India
City
Jaipur
State/Province
Rajasthan
Country
India
City
Chennai
State/Province
Tamil Nadu
Country
India
City
Coimbatore
State/Province
Tamil Nadu
Country
India
City
Madurai
State/Province
Tamil Nadu
Country
India
City
Kolkatta
State/Province
West Bengal
Country
India
City
Delhi
Country
India
City
Ashkelon
Country
Israel
City
Beer Sheva
Country
Israel
City
Haifa
Country
Israel
City
Holon
Country
Israel
City
Jerusalem
Country
Israel
City
Kfar-Saba
Country
Israel
City
Nahariya
Country
Israel
City
Nazareth
Country
Israel
City
Petach Tikva
Country
Israel
City
Rehovot
Country
Israel
City
Rishon Lezion
Country
Israel
City
Safed
Country
Israel
City
Tel Aviv
Country
Israel
City
Tiberias
Country
Israel
City
Cosenza
Country
Italy
City
Isernia
Country
Italy
City
Milano
Country
Italy
City
Napoli
Country
Italy
City
Palermo
Country
Italy
City
Pavia
Country
Italy
City
Ravenna
Country
Italy
City
Roma
Country
Italy
City
Sesto San Giovanni
Country
Italy
City
Aichi-gun
State/Province
Aichi
Country
Japan
City
Nagoya,
State/Province
Aichi
Country
Japan
City
Seto city
State/Province
Aichi
Country
Japan
City
Funabashi-city
State/Province
Chiba
Country
Japan
City
Kashiwa city
State/Province
Chiba
Country
Japan
City
Imabari
State/Province
Ehime
Country
Japan
City
Fukuoka-shi
State/Province
Fukuoka
Country
Japan
City
Kasuga-city
State/Province
Fukuoka
Country
Japan
City
Kitakyusyu
State/Province
Fukuoka
Country
Japan
City
Ohkawa-city
State/Province
Fukuoka
Country
Japan
City
Fukushima-shi
State/Province
Fukushima
Country
Japan
City
Gifu-city
State/Province
Gifu
Country
Japan
City
Shibukawa
State/Province
Gunma
Country
Japan
City
Takasaki
State/Province
Gunma
Country
Japan
City
Higashihiroshima-city
State/Province
Hiroshima
Country
Japan
City
Tomakomai-city
State/Province
Hokkaido
Country
Japan
City
Amagasaki-city
State/Province
Hyogo
Country
Japan
City
Kanazawa
State/Province
Ishikawa
Country
Japan
City
Sakaide City
State/Province
Kagawa
Country
Japan
City
Kawasaki
State/Province
Kanagawa
Country
Japan
City
Sagamihara-shi
State/Province
Kanagawa
Country
Japan
City
Nankoku-city
State/Province
Kochi
Country
Japan
City
Kumamoto-city
State/Province
Kumamoto
Country
Japan
City
Uji-shi
State/Province
Kyoto
Country
Japan
City
Matsusaka City
State/Province
Mie
Country
Japan
City
Nagasaki-city
State/Province
Nagasaki
Country
Japan
City
Nagasaki-shi
State/Province
Nagasaki
Country
Japan
City
Oita-city
State/Province
Oita
Country
Japan
City
Okayama-city
State/Province
Okayama
Country
Japan
City
Shimajiri-gun
State/Province
Okinawa
Country
Japan
City
Tomigusuku City
State/Province
Okinawa
Country
Japan
City
Kishiwada-city
State/Province
Osaka
Country
Japan
City
Matsubara-city
State/Province
Osaka
Country
Japan
City
Yao-shi
State/Province
Osaka
Country
Japan
City
Ageo
State/Province
Saitama
Country
Japan
City
Wako-city
State/Province
Saitama
Country
Japan
City
Hamada-city
State/Province
Shimane
Country
Japan
City
Suntou-gun
State/Province
Shizuoka
Country
Japan
City
Komatsushima-city
State/Province
Tokushima
Country
Japan
City
Tokushima-city
State/Province
Tokushima
Country
Japan
City
Hino
State/Province
Tokyo
Country
Japan
City
Tachikawa-city
State/Province
Tokyo
Country
Japan
City
Iwakuni-shi
State/Province
Yamaguchi
Country
Japan
City
Niigata
Country
Japan
City
Saga
Country
Japan
City
Tokyo
Country
Japan
City
Anyang
Country
Korea, Republic of
City
Busan
Country
Korea, Republic of
City
Daegu
Country
Korea, Republic of
City
Goyang-Si
Country
Korea, Republic of
City
Guri
Country
Korea, Republic of
City
Gyeonggi-do
Country
Korea, Republic of
City
Jeonju-si
Country
Korea, Republic of
City
Kangwon-do
Country
Korea, Republic of
City
Pusan
Country
Korea, Republic of
City
Seoul
Country
Korea, Republic of
City
Suwon
Country
Korea, Republic of
City
Yangsan
Country
Korea, Republic of
City
Dasman
Country
Kuwait
City
Daugavpils
Country
Latvia
City
Ogre
Country
Latvia
City
Riga
Country
Latvia
City
Tukums
Country
Latvia
City
Valmiera
Country
Latvia
City
Kaunas
Country
Lithuania
City
Kedainiai
Country
Lithuania
City
Klaipeda
Country
Lithuania
City
Palanga
Country
Lithuania
City
Panevezys
Country
Lithuania
City
Vilnius
Country
Lithuania
City
Alor Setar
Country
Malaysia
City
Batu Caves
Country
Malaysia
City
Georgetown
Country
Malaysia
City
Kuala Lumpur
Country
Malaysia
City
Kuantan
Country
Malaysia
City
Kubang Kerian
Country
Malaysia
City
Pulau Pinang
Country
Malaysia
City
Selangor
Country
Malaysia
City
Acapulco, Guerrero
Country
Mexico
City
Aguascalientes
Country
Mexico
City
Chihuahua
Country
Mexico
City
Chihuhua, Chihuhua
Country
Mexico
City
Ciudad Obregon, Sonora
Country
Mexico
City
Cuernavaca, Morelos
Country
Mexico
City
Cuernavaca
Country
Mexico
City
Culiacan
Country
Mexico
City
Durango
Country
Mexico
City
Guadalajara, Jalisco
Country
Mexico
City
Guadalajara
Country
Mexico
City
Merida, Yucatan
Country
Mexico
City
Metepec
Country
Mexico
City
Mexicali, Baja California
Country
Mexico
City
Mexico City, Mexico
Country
Mexico
City
Mexico City
Country
Mexico
City
Mexico
Country
Mexico
City
Monclova, Coahuila
Country
Mexico
City
Monterrey, NL
Country
Mexico
City
Monterrey, Nuevo Le0n
Country
Mexico
City
Monterrey, Nuevo Leon
Country
Mexico
City
Monterrey
Country
Mexico
City
Morelia, Michoacan
Country
Mexico
City
Pachuca
Country
Mexico
City
Saltillo, Coahuila
Country
Mexico
City
Saltillo
Country
Mexico
City
San Luis Potosi.SLP
Country
Mexico
City
San Luis Potosi
Country
Mexico
City
Tijuana, Baja California Norte
Country
Mexico
City
Tlalnepantla, Edo de Mexico
Country
Mexico
City
Tlalnepantla
Country
Mexico
City
Xalapa, Veracruz
Country
Mexico
City
Zapopan
Country
Mexico
City
Auckland
Country
New Zealand
City
Christchurch
Country
New Zealand
City
Otahuhu
Country
New Zealand
City
Palmerston North
Country
New Zealand
City
Takapuna
Country
New Zealand
City
Tauranga
Country
New Zealand
City
Arequipa
Country
Peru
City
Bellavista
Country
Peru
City
Callao
Country
Peru
City
Cusco
Country
Peru
City
Huacho
Country
Peru
City
Ica
Country
Peru
City
La Victoria, Lima
Country
Peru
City
Lima San Isidro
Country
Peru
City
Lima
Country
Peru
City
Los Olivos
Country
Peru
City
Miraflores, Lima
Country
Peru
City
Piura
Country
Peru
City
San Isidro, Lima
Country
Peru
City
San Miguel, Lima
Country
Peru
City
Trujillo, La Libertad
Country
Peru
City
Trujillo
Country
Peru
City
Baguio
Country
Philippines
City
Dasmarinas
Country
Philippines
City
Davao City
Country
Philippines
City
Iloilo City
Country
Philippines
City
Laoag City
Country
Philippines
City
Makati City
Country
Philippines
City
Manila
Country
Philippines
City
Marikina City
Country
Philippines
City
Pasig City
Country
Philippines
City
Quezon City
Country
Philippines
City
Bialystok
Country
Poland
City
Bydgoszcz
Country
Poland
City
Czestochowa
Country
Poland
City
Dabrowa Gornicza
Country
Poland
City
Elblag
Country
Poland
City
Gdansk
Country
Poland
City
Gdynia
Country
Poland
City
Grodzisk Mazowiecki
Country
Poland
City
Inowroclaw
Country
Poland
City
Katowice
Country
Poland
City
Kielce
Country
Poland
City
Krakow
Country
Poland
City
Legnica
Country
Poland
City
Lodz
Country
Poland
City
Lubartow
Country
Poland
City
Lublin
Country
Poland
City
Plock
Country
Poland
City
Pulawy
Country
Poland
City
Radom
Country
Poland
City
Ruda Slaska
Country
Poland
City
Skierniewice
Country
Poland
City
Slupsk
Country
Poland
City
Szczecin
Country
Poland
City
Torun
Country
Poland
City
Warsaw
Country
Poland
City
Warszawa
Country
Poland
City
Wroclaw
Country
Poland
City
Zabrze
Country
Poland
City
Zgierz
Country
Poland
City
Coimbra
Country
Portugal
City
Faro
Country
Portugal
City
Lisboa
Country
Portugal
City
Vila Real
Country
Portugal
City
Aibonito
Country
Puerto Rico
City
Carolina
Country
Puerto Rico
City
Cidra
Country
Puerto Rico
City
Halo Rey
Country
Puerto Rico
City
Levittown
Country
Puerto Rico
City
Manati
Country
Puerto Rico
City
Mayaguez
Country
Puerto Rico
City
Ponce
Country
Puerto Rico
City
Salinas
Country
Puerto Rico
City
San Juan
Country
Puerto Rico
City
Santurce
Country
Puerto Rico
City
Bacau
Country
Romania
City
Baia Mare
Country
Romania
City
Braila
Country
Romania
City
Brasov
Country
Romania
City
Bucharest
Country
Romania
City
Bucuresti
Country
Romania
City
Buzau
Country
Romania
City
Galati
Country
Romania
City
Iasi
Country
Romania
City
Oradea
Country
Romania
City
Ploiesti
Country
Romania
City
Satu Mare
Country
Romania
City
Targu Mures
Country
Romania
City
Timisoara
Country
Romania
City
Arkhangelsk
Country
Russian Federation
City
Barnaul
Country
Russian Federation
City
Ivanovo
Country
Russian Federation
City
Kazan
Country
Russian Federation
City
Kemerovo
Country
Russian Federation
City
Krasnodar
Country
Russian Federation
City
Krasnoyarsk
Country
Russian Federation
City
Kursk
Country
Russian Federation
City
Moscow
Country
Russian Federation
City
Nizhniy Novgorod
Country
Russian Federation
City
Novosibirsk
Country
Russian Federation
City
Rostov-on-Don
Country
Russian Federation
City
Saratov
Country
Russian Federation
City
St. Petersburg
Country
Russian Federation
City
Ufa
Country
Russian Federation
City
Volgograd
Country
Russian Federation
City
Vsevolozhsk
Country
Russian Federation
City
Belgrade
Country
Serbia
City
Beograd
Country
Serbia
City
Nis
Country
Serbia
City
Bardejov
Country
Slovakia
City
Bratislava
Country
Slovakia
City
Dolny Kubin
Country
Slovakia
City
Komarno
Country
Slovakia
City
Kosice - Saca
Country
Slovakia
City
Kosice
Country
Slovakia
City
Levice
Country
Slovakia
City
Liptovsky Hradok
Country
Slovakia
City
Nove Mesto nad Vahom
Country
Slovakia
City
Nove Zamky
Country
Slovakia
City
Povazska Bystrica
Country
Slovakia
City
Rimavska Sobota
Country
Slovakia
City
Ruzomberok
Country
Slovakia
City
Svidnik
Country
Slovakia
City
Zilina
Country
Slovakia
City
Port Elizabeth
State/Province
Eastern Cape
Country
South Africa
City
Johannesburg
State/Province
Gauteng
Country
South Africa
City
Pretoria
State/Province
Gauteng
Country
South Africa
City
Durban
State/Province
Kwazulu-Natal
Country
South Africa
City
Cape Town
State/Province
Western Cape
Country
South Africa
City
Paarl
State/Province
Western Cape
Country
South Africa
City
Somerset West
State/Province
Western Cape
Country
South Africa
City
Tygerberg
State/Province
Western Cape
Country
South Africa
City
Worcester
State/Province
Western Cape
Country
South Africa
City
Durban
Country
South Africa
City
Pretoria
Country
South Africa
City
Zaragoza
State/Province
Arag0n
Country
Spain
City
Oviedo
State/Province
Asturias
Country
Spain
City
Cuenca
State/Province
Castilla-La Mancha
Country
Spain
City
Barcelona
State/Province
Cataluna
Country
Spain
City
Figueres
State/Province
Cataluna
Country
Spain
City
Torrevieja
State/Province
Comunidad Valenciana
Country
Spain
City
A Coruna
State/Province
Galicia
Country
Spain
City
Santiago de Compostela
State/Province
Galicia
Country
Spain
City
Bacarot
Country
Spain
City
Merida
Country
Spain
City
Palma de Mallorca
Country
Spain
City
Dalby
Country
Sweden
City
Falkoping
Country
Sweden
City
Goteborg
Country
Sweden
City
Harnosand
Country
Sweden
City
Kristianstad
Country
Sweden
City
Malmo
Country
Sweden
City
Motala
Country
Sweden
City
Stockholm
Country
Sweden
City
Kaohsiung
Country
Taiwan
City
Taipei County
Country
Taiwan
City
Taoyuan
Country
Taiwan
City
Amphure Muang
Country
Thailand
City
Bangkojk
Country
Thailand
City
Bangkok
Country
Thailand
City
Chiang Rai
Country
Thailand
City
Chiangmai
Country
Thailand
City
Muang
Country
Thailand
City
Nakhon Ratchasima
Country
Thailand
City
Pathumwan
Country
Thailand
City
Patumthani
Country
Thailand
City
Phitsanulok
Country
Thailand
City
Phrae
Country
Thailand
City
Ankara, Balgat
Country
Turkey
City
Antalya
Country
Turkey
City
Istanbul
Country
Turkey
City
Kayseri
Country
Turkey
City
Konya
Country
Turkey
City
Donetsk
Country
Ukraine
City
Ivano-Frankivsk
Country
Ukraine
City
Kharkiv
Country
Ukraine
City
Kyiv
Country
Ukraine
City
Lviv
Country
Ukraine
City
Odesa
Country
Ukraine
City
Poltava
Country
Ukraine
City
Simferopol
Country
Ukraine
City
Vinnytsya
Country
Ukraine
City
Zaporizhzhya
Country
Ukraine
City
Abu Dhabi
Country
United Arab Emirates
City
Barnsley
Country
United Kingdom
City
Bath
Country
United Kingdom
City
Birmingham
Country
United Kingdom
City
Bournemouth
Country
United Kingdom
City
Carshalton
Country
United Kingdom
City
Chertsey
Country
United Kingdom
City
Chichester
Country
United Kingdom
City
Colchester
Country
United Kingdom
City
Coventry
Country
United Kingdom
City
Croydon
Country
United Kingdom
City
Doncaster
Country
United Kingdom
City
Glasgow
Country
United Kingdom
City
Hull
Country
United Kingdom
City
Inverness
Country
United Kingdom
City
Kirkcaldy
Country
United Kingdom
City
Liverpool
Country
United Kingdom
City
Livingston
Country
United Kingdom
City
London
Country
United Kingdom
City
Nuneaton
Country
United Kingdom
City
Stevenage
Country
United Kingdom
City
Sunderland
Country
United Kingdom
City
Torquay
Country
United Kingdom
City
Wakefield
Country
United Kingdom
City
West Midlands
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
34872085
Citation
Ferreira JP, Rossignol P, Bakris G, Mehta C, White WB, Zannad F. Blood and Urine Biomarkers Predicting Worsening Kidney Function in Patients with Type 2 Diabetes Post-Acute Coronary Syndrome: An Analysis from the EXAMINE Trial. Am J Nephrol. 2021;52(12):969-976. doi: 10.1159/000519436. Epub 2021 Dec 6.
Results Reference
derived
PubMed Identifier
32493335
Citation
Ferreira JP, Mehta C, Sharma A, Nissen SE, Rossignol P, Zannad F. Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial. BMC Med. 2020 Jun 4;18(1):165. doi: 10.1186/s12916-020-01616-8.
Results Reference
derived
PubMed Identifier
31902327
Citation
Sharma A, Vaduganathan M, Ferreira JP, Liu Y, Bakris GL, Cannon CP, White WB, Zannad F. Clinical and Biomarker Predictors of Expanded Heart Failure Outcomes in Patients With Type 2 Diabetes Mellitus After a Recent Acute Coronary Syndrome: Insights From the EXAMINE Trial. J Am Heart Assoc. 2020 Jan 7;9(1):e012797. doi: 10.1161/JAHA.119.012797. Epub 2020 Jan 4.
Results Reference
derived
PubMed Identifier
30371278
Citation
White WB, Jalil F, Cushman WC, Bakris GL, Bergenstal R, Heller SR, Liu Y, Mehta C, Zannad F, Cannon CP. Average Clinician-Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial. J Am Heart Assoc. 2018 Oct 16;7(20):e009114. doi: 10.1161/JAHA.118.009114.
Results Reference
derived
PubMed Identifier
29848776
Citation
Jarolim P, White WB, Cannon CP, Gao Q, Morrow DA. Serial Measurement of Natriuretic Peptides and Cardiovascular Outcomes in Patients With Type 2 Diabetes in the EXAMINE Trial. Diabetes Care. 2018 Jul;41(7):1510-1515. doi: 10.2337/dc18-0109. Epub 2018 May 30.
Results Reference
derived
PubMed Identifier
29769203
Citation
Sharma A, Cannon CP, White WB, Liu Y, Bakris GL, Cushman WC, Zannad F. Early and Chronic Dipeptidyl-Peptidase-IV Inhibition and Cardiovascular Events in Patients With Type 2 Diabetes Mellitus After an Acute Coronary Syndrome: A Landmark Analysis of the EXAMINE Trial. J Am Heart Assoc. 2018 May 16;7(11):e007649. doi: 10.1161/JAHA.117.007649.
Results Reference
derived
PubMed Identifier
29581078
Citation
White WB, Heller SR, Cannon CP, Howitt H, Khunti K, Bergenstal RM; EXAMINE Investigators. Alogliptin in Patients with Type 2 Diabetes Receiving Metformin and Sulfonylurea Therapies in the EXAMINE Trial. Am J Med. 2018 Jul;131(7):813-819.e5. doi: 10.1016/j.amjmed.2018.02.023. Epub 2018 Mar 23.
Results Reference
derived
PubMed Identifier
29064626
Citation
Hwang YC, Morrow DA, Cannon CP, Liu Y, Bergenstal R, Heller S, Mehta C, Cushman W, Bakris GL, Zannad F, White WB. High-sensitivity C-reactive protein, low-density lipoprotein cholesterol and cardiovascular outcomes in patients with type 2 diabetes in the EXAMINE (Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care) trial. Diabetes Obes Metab. 2018 Mar;20(3):654-659. doi: 10.1111/dom.13136. Epub 2017 Nov 21.
Results Reference
derived
PubMed Identifier
28275958
Citation
Kay S, Strickson A, Puelles J, Selby R, Benson E, Tolley K. Comparative Effectiveness of Adding Alogliptin to Metformin Plus Sulfonylurea with Other DPP-4 Inhibitors in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis. Diabetes Ther. 2017 Apr;8(2):251-273. doi: 10.1007/s13300-017-0245-8. Epub 2017 Mar 8.
Results Reference
derived
PubMed Identifier
28246236
Citation
Cavender MA, White WB, Jarolim P, Bakris GL, Cushman WC, Kupfer S, Gao Q, Mehta CR, Zannad F, Cannon CP, Morrow DA. Serial Measurement of High-Sensitivity Troponin I and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus in the EXAMINE Trial (Examination of Cardiovascular Outcomes With Alogliptin Versus Standard of Care). Circulation. 2017 May 16;135(20):1911-1921. doi: 10.1161/CIRCULATIONAHA.116.024632. Epub 2017 Feb 28.
Results Reference
derived
PubMed Identifier
27289121
Citation
White WB, Kupfer S, Zannad F, Mehta CR, Wilson CA, Lei L, Bakris GL, Nissen SE, Cushman WC, Heller SR, Bergenstal RM, Fleck PR, Cannon CP; EXAMINE Investigators. Cardiovascular Mortality in Patients With Type 2 Diabetes and Recent Acute Coronary Syndromes From the EXAMINE Trial. Diabetes Care. 2016 Jul;39(7):1267-73. doi: 10.2337/dc16-0303. Epub 2016 Jun 11.
Results Reference
derived
PubMed Identifier
25765696
Citation
Zannad F, Cannon CP, Cushman WC, Bakris GL, Menon V, Perez AT, Fleck PR, Mehta CR, Kupfer S, Wilson C, Lam H, White WB; EXAMINE Investigators. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet. 2015 May 23;385(9982):2067-76. doi: 10.1016/S0140-6736(14)62225-X. Epub 2015 Mar 10.
Results Reference
derived
PubMed Identifier
23992602
Citation
White WB, Cannon CP, Heller SR, Nissen SE, Bergenstal RM, Bakris GL, Perez AT, Fleck PR, Mehta CR, Kupfer S, Wilson C, Cushman WC, Zannad F; EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013 Oct 3;369(14):1327-35. doi: 10.1056/NEJMoa1305889. Epub 2013 Sep 2.
Results Reference
derived
PubMed Identifier
21982652
Citation
White WB, Bakris GL, Bergenstal RM, Cannon CP, Cushman WC, Fleck P, Heller S, Mehta C, Nissen SE, Perez A, Wilson C, Zannad F. EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome. Am Heart J. 2011 Oct;162(4):620-626.e1. doi: 10.1016/j.ahj.2011.08.004. Epub 2011 Sep 14.
Results Reference
derived

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Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome

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