Effects Of Volume Control Guided by Body Composition Monitor (BCM) on Blood Pressure and Cardiac Condition in Hemodialysis Patients
Left Ventricular Hypertrophy
About this trial
This is an interventional diagnostic trial for Left Ventricular Hypertrophy focused on measuring Hemodialysis, Left Ventricular Hypertrophy, Body Composition Monitor
Eligibility Criteria
Inclusion Criteria:
- Age older than 18-year,
- Maintenance bicarbonate HD scheduled thrice weekly (12 hours/week),
- Willingness to participate in the study with a written informed consent.
Exclusion Criteria:
- Presence of a cardiac stent, pacemaker or defibrillator ,
- Artificial joints, pin or amputation
- Permanent or temporary catheters (may affect BCM measurement),
- Being scheduled for living donor renal transplantation,
- Presence of serious life-limiting co-morbid situations, like malignancy, uncontrollable infection, end-stage cardiac, pulmonary, or hepatic disease,
- Pregnancy or lactating,
- Current use of investigational drugs or participation in an interventional clinical trial that contradicts or interferes with the therapies or measured outcomes in this trial,
- Mental incompetence.
Sites / Locations
- Ege University Division of Nephrology
Arms of the Study
Arm 1
Arm 2
Active Comparator
Other
Study group
Control Group
Pre-dialytic overhydration(OH) will be estimated by Body Composition Monitor (BCM) at least once a month. If OH is positive, dry weight will be reached by ultrafiltration without regard to the level of blood pressure. If OH is negative and: Systolic blood pressure(SBP)< 100 mmHg with/or intradialytic hypotension episodes(IDHE) and/or clothing and/or erythrocytosis(htc>36%);dry weight will be increased. SBP normal(100-150 mmHg) w/o IDHE and clothing and erythrocytosis;dry weight will not be changed. SBP normal(100-150 mmHg) with IDHE and/or clothing and/or erythrocytosis;dry weight will be increased. SBP>150 mmHg captopril test(CT)will be done. If CT is positive, ACEI/ ARBs will be used and dry weight will be increased if IDHE and/or clothing and/or erythrocytosis(htc>36%) are present. If CT is negative, BCM measurement will be repeated and if same,ABPM will be performed for confirmation.
BCM results obtained at the beginning, at the 6th, and 12th months will not be given to the treating physicians. Dry weight estimation will be guided by clinical findings, telecardiography, and echocardiography as used to be.