The Arthritis, Diet, and Activity Promotion Trial (ADAPT)
Knee Osteoarthritis
About this trial
This is an interventional treatment trial for Knee Osteoarthritis focused on measuring knee osteoarthritis, weight-loss, exercise, obesity, physical function, total mortality
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 60 years.
- BMI ≥ 28 kg/m2.
- Knee pain on most days of the month.
- Sedentary lifestyle pattern (<20 min exercise per week for last 6 months)
- Self-reported difficulty with at least one of the following: walking 1/4 mile, climbing stairs, kneeling, bending, stooping, shopping, lifting, self-care.
- Radiographic evidence of grade 1-3 knee osteoarthritis.
Exclusion Criteria:
- Serious medical condition that precludes safe participation in exercise such as heart disease (angina, congestive heart failure), severe hypertension, COPD, renal or liver disease, insulin-dependent diabetes.
- Mini-mental state exam score <24.
- Inability to walks without a cane.
- Reported alcohol consumption >14 drinks/week.
- Inability to complete protocol.
- ST segment depression.
- Participation in another research study.
Sites / Locations
- Wake Forest University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
No Intervention
Dietary weight-loss
Exercise
Dietary weight-loss & exercise
Health lifestyle control
The goal of the dietary weight-loss intervention was to produce and maintain a mean weight-loss of 5% initial body weight during the 18-month intervention, using dietary counseling and behavior modification.
Participants participated in resistance training (15 minutes) and aerobic exercise (30 minutes) 3d/week for 18-months. The first 4-months of the exercise training were facility-based. After 4-months, participants were allowed to transition to a home-based intervention if they chose to.
Participants received both the dietary weight-loss and exercise interventions for 18-months
The healthy-lifestyle control served as the usual care comparison group. For 3 months, participants met monthly with a health educator to discuss topics such as osteoarthritis, obesity, and exercise. Regular phone contact was maintained during months 4-18.