Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?
Primary Purpose
Metabolic Syndrome
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
aerobic exercise
strength training
Sponsored by
About this trial
This is an interventional treatment trial for Metabolic Syndrome focused on measuring Exercise therapy
Eligibility Criteria
Inclusion Criteria:
- Having metabolic syndrome according to international diabetes foundations definition (IDF).
Exclusion Criteria:
- Unstable angina pectoris
- Uncompensated heart failure
- Myocardial infarction during the past 4 weeks
- Complex ventricular arrhythmias
- Kidney failure
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Experimental
No Intervention
Arm Label
aerobic exercise
strength training
control group
Arm Description
Outcomes
Primary Outcome Measures
proinflammatory markers
circulating interleukin-18 and interleukin-6
Secondary Outcome Measures
Full Information
NCT ID
NCT00986024
First Posted
September 28, 2009
Last Updated
December 12, 2012
Sponsor
Norwegian University of Science and Technology
1. Study Identification
Unique Protocol Identification Number
NCT00986024
Brief Title
Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?
Official Title
Strength Training Versus Aerobic Interval Training to Modify Risk Factors of the Metabolic Syndrome
Study Type
Interventional
2. Study Status
Record Verification Date
December 2012
Overall Recruitment Status
Completed
Study Start Date
August 2006 (undefined)
Primary Completion Date
March 2007 (Actual)
Study Completion Date
March 2007 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Norwegian University of Science and Technology
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The aim of the present study was to evaluate the effects of aerobic interval training versus strength training or a combination of these regimes on factors comprising the metabolic syndrome in order to find the most effective exercise regime for patients with metabolic syndrome.
Detailed Description
In the Western world, approximately 25% of young to middle-aged adults have metabolic syndrome. There seem to be a strong age-dependence in the prevalence of the metabolic syndrome, but the incidence rises rapidly within adolescents and middle-aged groups and follows the development of obesity in the general population. Metabolic syndrome confers an increased risk of coronary heart disease, cardiovascular disease, and premature death; therefore, effective and affordable strategies to combat the syndrome would be of great individual and social importance.
Despite the general agreement that moderate-intensity physical activity for a minimum of 30 min five days per week or vigorous-intensity aerobic physical activity for a minimum of 20 min three days a week promote and maintain health, the optimal training regime to treat metabolic syndrome and its associated cardiovascular abnormalities remains uncertain.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Metabolic Syndrome
Keywords
Exercise therapy
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
31 (Actual)
8. Arms, Groups, and Interventions
Arm Title
aerobic exercise
Arm Type
Experimental
Arm Title
strength training
Arm Type
Experimental
Arm Title
control group
Arm Type
No Intervention
Intervention Type
Behavioral
Intervention Name(s)
aerobic exercise
Intervention Description
carried out 3 times per week for 12 weeks
Intervention Type
Behavioral
Intervention Name(s)
strength training
Intervention Description
carried out 3 times per week for 12 weeks
Primary Outcome Measure Information:
Title
proinflammatory markers
Description
circulating interleukin-18 and interleukin-6
Time Frame
12 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Having metabolic syndrome according to international diabetes foundations definition (IDF).
Exclusion Criteria:
Unstable angina pectoris
Uncompensated heart failure
Myocardial infarction during the past 4 weeks
Complex ventricular arrhythmias
Kidney failure
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ulrik Wisløff, md prof
Organizational Affiliation
Norwegian University of Science and Technology
Official's Role
Study Director
12. IPD Sharing Statement
Citations:
PubMed Identifier
22455564
Citation
Stensvold D, Slordahl SA, Wisloff U. Effect of exercise training on inflammation status among people with metabolic syndrome. Metab Syndr Relat Disord. 2012 Aug;10(4):267-72. doi: 10.1089/met.2011.0140. Epub 2012 Mar 28.
Results Reference
result
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Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?
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