Regadenoson Combined With Symptom-Limited Exercise in Patients Undergoing Myocardial Perfusion Imaging
Coronary Artery Disease, Myocardial Ischemia
About this trial
This is an interventional diagnostic trial for Coronary Artery Disease
Eligibility Criteria
Inclusion Criteria:
- Males and non-pregnant, non-nursing females clinically referred for vasodilator stress myocardial perfusion imaging with the addition of exercise
- Age >=30 years
Exclusion Criteria:
- Extremely limited functional capacity
- Age <30 years
- Unable or unwilling to provide informed consent
- Pregnant or nursing females
- Current use of methylxanthines within 12 hours of testing
- Current use of dipyridamole or aminophylline within 48 hours of testing
- Uncontrolled hypertension (>200 mmHg systolic/>120 mmHg diastolic)
- Known hypertrophic cardiomyopathy with obstruction or severe aortic stenosis
- Decompensated congestive heart failure
- History of sick sinus syndrome or > first degree atrioventricular block in the absence of a functioning pacemaker
- Asthma or other bronchospastic reactive airway disease
- History of percutaneous coronary intervention or coronary artery bypass grafting, or documented history of acute myocardial infarction or unstable angina within one week of testing
- Patients at risk for hypotensive reaction to regadenoson
Sites / Locations
- Hartford Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Vasodilator-exercise stress
Exercise-vasodilator stress
Four-minute infusion of dipyridamole (0.56 mg/kg) followed by symptom-limited exercise; injection of technetium-99m labeled radiopharmaceutical at peak hyperemia or peak exercise followed by SPECT myocardial perfusion imaging
Symptom-limited exercise followed by a bolus intravenous injection of regadenoson (0.4 mg/5 mL) in patients failing to achieve a standard clinical endpoint; injection of technetium-99m labeled radiopharmaceutical 15 seconds after administration of regadenoson (or at peak exercise if regadenoson not administered) followed by SPECT myocardial perfusion imaging.