Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers

This is an interventional basic science trial for Infectious Diseases focused on measuring Probiotic - Lactobacillus casei DN114-001, dairy product - infections - shiftworkers, Common infectious diseases,, occuring in healthy subjects,, including upper respiratory tract infections (defined as rhinopharyngitis, sore throat, sinusitis and otitis),, lower respiratory tract infections (defined as bronchitis,, pneumopathy and flu and flu-like syndromes), and, gastrointestinal tract infection defined as gastroenteritis. Read More

Inclusion criteria: male and female aged 18-65 years; working in 2- or 3-shift work patterns (including night work); same job position for at least 4.5 months; a 19 to 30 kg/m2 body mass index; no symptoms of CIDs during the 2 weeks before product consumption; agreeing to a written informed consent.

Exclusion criteria: part time work (<90%); allergy/hypersensitivity to components of the study product; severe respiratory allergy; a situation which, in the investigator's opinion, could interfere with optimal participation or constitute a special risk for the volunteer; a history of chronic metabolic/gastro-intestinal disease (except appendectomy); surgery/intervention requiring general anesthesia in the last 4 weeks; administration of systemic/topical treatments likely to interfere with the evaluation parameters in the last 4 weeks; chronic disease requiring antibiotics/antiseptics/anti-inflammatory medications; special medicated diet; chronic/iatrogenic immunodeficiency; cardiac/renal/respiratory insufficiency; severe evolutive/chronic pathology; pregnancy, breast feeding or lacking effective contraception in females; susceptibility not to comply with dietary recommendation during the study period.