Early Prediction of Fluoxetine Response

Model for Early Prediction of Clinical Response in Patients With Major Depression Receiving Fluoxetine

The purpose of this study is to identify what degree of symptom changes during the early weeks could be used to predict eventual nonresponse at week 6 among depressive inpatients taking fluoxetine.

Patients with major depressive disorder will receive 20 mg/day of fluoxetine for six weeks. Symptom severity was assessed by the 17-item Hamilton Depression Rating Scale (HAMD-17) at weeks 0, 1, 2, 3, 4 and 6. Stable response is defined as a reduction of 50% or more of the HAMD-17 score at week 4 and week 6 of treatment. Receiver operating characteristic curve will be used to determine the cutoff point of the percentage of HAMD-17 score reduction between stable responders and nonresponders at weeks 1, 2, 3 and 4.

Stable response was defined as a reduction of 50% or more of the HAMD-17 score at week 4 and week 6 of treatment

Inclusion Criteria: diagnosis of major depressive disorder HAM-D-17 ≧17 written informed consent Exclusion Criteria: Comorbid of substance abuse/dependence Comorbid with mental disorders due to general medical conditions Past history of treatment-resistant depression Severe physical problems pregnant women lactation

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