Effect of Duolac 7S Administration on Improving Symptom in Irritable Bowel Syndrome

Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS). The purpose of this study is to investigate the efficacy of Duolac7S in changing the colonic microflora and improve the symptoms in IBS sufferers. In all, 64 patients with Rome III positive diarrhea type IBS will complete a 6-week multiple centre controlled clinical trial. Patients will be randomized to receive either 2 capsules/day Duolac7S or 2 capsules/day placebo. IBS symptoms will be monitored and scored according to Likert scale. Changes in faecal microflora, stool frequency and form, quality of life (QOL) scores will be also monitored.

IBS symptoms were recorded on diary cards every evening during the treatment periods. Abdominal pain, discomfort,urgency and bloating were recorded (score 0-10); stool frequency as number of stools per day; stool consistency according to Bristol stool scale form (score 1-7).

Inclusion Criteria: age: 18~65 years diarrhea type irritable bowel syndrome (by ROME III criteria) no organic bowel disease (by colonoscopy or barium enema) Exclusion Criteria: pregnant women or nursing mothers hypersensitivity to probiotics congestive heart failure or ischemic heart disease systolic blood pressure : more than 160 mmHg or diastolic blood pressure: more than 100 mmHg uncontrolled diabetes mellitus, secondary dyslipidemia, hyperthyroidism, or hypothyroidism abdominal surgery (exception: appendectomy, hernia surgery) more than moderate alcohol drinking