Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity (BMRR3)
Primary Purpose
Osteoporosis, Excitability
Status
Completed
Phase
Not Applicable
Locations
Turkey
Study Type
Interventional
Intervention
Forearm vibration
Sponsored by
About this trial
This is an interventional basic science trial for Osteoporosis focused on measuring bone, motor neuron excitability, forearm vibration, mechanical loading, muscle electrical activity
Eligibility Criteria
Inclusion Criteria:
- Healthy subjects
- Right handed
- Young adult women and men
Exclusion Criteria:
- secondary osteoporosis
- neuropathy (central or peripheral)
- myopathy
- systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
- professional sportswoman/sportsman
- subjects doing regular sports activities
- tendinopathy
- amputee, endoprosthesis, metal implants
Sites / Locations
- Vakif Gureba Training & Research Hospital
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Healthy young adult subjects
Arm Description
Forearm vibration will be applied in healthy young adult subjects
Outcomes
Primary Outcome Measures
Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration
Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration
Secondary Outcome Measures
Full Information
NCT ID
NCT01097122
First Posted
March 27, 2010
Last Updated
February 24, 2012
Sponsor
Vakif Gureba Training and Research Hospital
1. Study Identification
Unique Protocol Identification Number
NCT01097122
Brief Title
Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity
Acronym
BMRR3
Official Title
Effects Of Unilateral Forearm Vibration On Electrical Activity Of Untrained Contralateral Forearm Muscle
Study Type
Interventional
2. Study Status
Record Verification Date
February 2012
Overall Recruitment Status
Completed
Study Start Date
March 2010 (undefined)
Primary Completion Date
June 2010 (Actual)
Study Completion Date
July 2010 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Vakif Gureba Training and Research Hospital
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density or bone mineral content.
A total of 80 voluntaries are planned to include in this study. Vibration will be applied the right forearm. Muscle electrical activity will be measured on ipsilateral and contralateral flexor carpi radialis (FCR) muscle at rest as EMGrms by surface electromyography (EMG). The rest-EMGrms will be measured at before and during vibration. An increase in muscle electrical activity at rest indicates an increase in motor neuron pool activation. The right distal radius bone mineral content (BMC) and density will be measured by dual energy X-ray absorptiometry (DXA).
The right radius bone mineral density (BMD) and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO).
Motor unit potentials will be measured by electromyography at left flexor carpi radialis. Neurotrac ETS device will be used.
Detailed Description
A functional cooperation exists between bones and skeletal muscles. Bones work together with muscles as a simple mechanical lever system to produce body movement. One of the important functions of bones is to exert resistance against gravity in order to carry the body. In order to carry out their mechanical functions, bones need to have considerable resistance to deformation under load. It is well-known that muscle activity (i.e., exercises) improves the resistance of bone to mechanical loading, and that it is also important for treating and preventing osteoporosis. Resistance and impact training have been shown to induce bone formation and/or prevent bone resorption. Skeletal muscles have positive effects on bone structure and function. Can bones have an effect on muscle activity? There is only one study about the effect of bones on muscles. In this study, it was shown that bones may affect muscle strength gain in healthy young adult males.
Vibration has a strong osteogenic effect. Vibration-induced bone formation is neuronally regulated. Vibration can also effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. But, it has not been reported whether bone has an effect on the increase in muscle EMG activity caused by vibration or not. The aim of this study was to determine whether radius bone exposed to cyclic mechanical loading affects muscle electrical activity of contralateral untrained m. flexor carpi radialis in healthy adult volunteers.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Osteoporosis, Excitability
Keywords
bone, motor neuron excitability, forearm vibration, mechanical loading, muscle electrical activity
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
ParticipantOutcomes Assessor
Allocation
N/A
Enrollment
90 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Healthy young adult subjects
Arm Type
Experimental
Arm Description
Forearm vibration will be applied in healthy young adult subjects
Intervention Type
Procedure
Intervention Name(s)
Forearm vibration
Other Intervention Name(s)
Cyclic mechanical loading
Intervention Description
Mechanical loading with forearm vibration will be applied right radius in all groups
Primary Outcome Measure Information:
Title
Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration
Description
Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration
Time Frame
2 or 3 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Healthy subjects
Right handed
Young adult women and men
Exclusion Criteria:
secondary osteoporosis
neuropathy (central or peripheral)
myopathy
systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
professional sportswoman/sportsman
subjects doing regular sports activities
tendinopathy
amputee, endoprosthesis, metal implants
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
ILHAN KARACAN, MD
Organizational Affiliation
Vakif Gureba Training & Research Hospital
Official's Role
Study Chair
Facility Information:
Facility Name
Vakif Gureba Training & Research Hospital
City
İstanbul
ZIP/Postal Code
34000
Country
Turkey
12. IPD Sharing Statement
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Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity
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