Effect of Intermittent Pedicle Clamping on Hepatocellular Injury During Liver Surgery
Hepatocellular Injury, Blood Loss

About this trial
This is an interventional basic science trial for Hepatocellular Injury focused on measuring liver surgery, pringle manoeuvre, hepatocellular damage, surgical complications, patients requiring liver surgery
Eligibility Criteria
Inclusion Criteria:
- patients > 18 years of age and < 100 years of age
- primary or secondary liver tumours requiring liver surgery
Exclusion Criteria:
- pre-existent liver disease (e.g. inflammatory liver disease, cirrhosis, inborn errors of metabolism)
- cholangiocarcinoma requiring biliary tract reconstruction during surgery
- steroid hormone medication
- tumours deemed irresectable during liver surgery
- laparoscopic liver surgery
Sites / Locations
- Maastricht University Medical Centre
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Pringle manoeuvre 15 minutes
Pringle manoeuvre 30 minutes
When intermittent pedicle occlusion during parenchymal transection is necessary, 2 cycles of 15 minutes of hepatic inflow occlusion will be applied each followed by 5 minutes of reperfusion. During inflow occlusion, the complete portal triad was clamped using a rubber sling.
When intermittent pedicle occlusion during parenchymal transection is necessary, 1 cycle of 30 minutes of hepatic inflow occlusion will be applied followed by 5 minutes of reperfusion. During inflow occlusion, the complete portal triad was clamped using a rubber sling.