Hexetidine and Chlorobutanol for Lesions Due to Prostheses
Oral Mucositis
About this trial
This is an interventional supportive care trial for Oral Mucositis
Eligibility Criteria
Inclusion Criteria:
- Use of removable partial or complete dentures;
- Presence of lesions of oral mucosae due to dentures;
- Absence of any concomitant local or systemic pathology;
- Absence of pregnancy or breastfeeding;
- Negative allergic anamnesis;
- Negative anamnesis for recurrent aphthous stomatitis;
- No taking medicines with potential pharmacologic interactions with molecules to be tested;
- No taking antibiotics and/or painkillers for at least 6 months before entering the experimentation;
- Good oral hygiene with a full-mouth plaque score ≤25%;
- Non smoking or light smoking (≤10 cigarettes/day) status.
Exclusion Criteria:
Missing one or more of the above described conditions automatically excluded a subject from the study.
Sites / Locations
- University "Federico II", Department of Prosthodontics
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Experimental mouthwash
Chlorexidine-based mouthwash
The experimental mouthwash (Buccagel®, Curaden Healthcare, Saronno, Italy) was made up of: purified water, dicaprylyl-ether, coco-caprylate caprate, xylitol, glyceryl-stearate, ceteareth-20, ceteareth-12, cetyl-palmitate, cetearyl-alcohol, chlorobutanol, aroma, hexetidine, methylparaben, propylparaben, sodium saccharin, citric acid and colorant C.I. 16255.
A conventional commercial mouthwash (Curasept® ADS 0.20%, Curaden Healthcare, Saronno, Italy) made up of: water, xylitol, propylenglycol, Peg-40 of hydrogenated ricin oil, ascorbic acid, chlorhexidine digluconate, aroma, poloxamer 407, sodium metabisulfite, sodium citrate and colorant C.I. 42090.