Prevention of Gestational Diabetes

Feasibility of a Lifestyle Intervention in Early Risk Pregnancy in Preventing Deterioration in Glucose Tolerance?

Gestational diabetes mellitus (GDM)is a major health problem growing prevalence of obesity the older age of pregnant women A randomized controlled trial in 54 pregnant voluntary women at high risk for GDM. feasibility of an early intervention glucose tolerance at weeks 26-28

A 75-g oral glucose tolerance test (OGTT) was performed at weeks 8-12 voluntary women in early pregnancy (n=96) 54 high risk mothers were randomized lifestyle intervention group (n=27) close follow-up (n=27) An OGTT was performed again at weeks 26-28 the lifestyle intervention group (n=27) the close follow-up group (n=27) other high-risk women of the early care group (n=42)who were not randomized An OGTT was also performed at weeks 26-28 in two neighboring municipalities a standard care high-risk group(n=171)who did not undergo early intervention Primary outcomes number of at risk participants developing GDM during pregnancy in the two arms Secondary outcomes the effect of intervention on fetal growth

Gestational diabetes mellitus, Lifestyle intervention, Oral glucose tolerance test, Insulin treatment, Pregnancy outcomes

Lifestyle: The women received counseling by a clinical nutritionist six times and by a physiotherapist six times during pregnancy.

Follow-up: The women received information of the results of a glucose tolerance test (OGTT), reported food records three times during pregnancy, exercise history and exercise diaries monthly.

Lifestyle: The women received counseling by a clinical nutritionist six times and by a physiotherapist six times during pregnancy.

Follow-up: The women received information of the results of a glucose tolerance test (OGTT), reported food records three times during pregnancy, exercise history and exercise diaries monthly.

Inclusion Criteria: high risk for gestational diabetes fasting glucose 4.8-5.5 mmol/l and 2-hour glucose of OGTT <7.8 mmol/l Exclusion Criteria: normal glucose tolerance at weeks 8-12 gestational diabetes at weeks 8-12

Korpi-Hyovalti E, Heinonen S, Schwab U, Laaksonen DE, Niskanen L. Effect of intensive counselling on physical activity in pregnant women at high risk for gestational diabetes mellitus. A clinical study in primary care. Prim Care Diabetes. 2012 Dec;6(4):261-8. doi: 10.1016/j.pcd.2012.07.004. Epub 2012 Aug 13.

Korpi-Hyovalti EA, Laaksonen DE, Schwab US, Vanhapiha TH, Vihla KR, Heinonen ST, Niskanen LK. Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance. BMC Public Health. 2011 Mar 24;11:179. doi: 10.1186/1471-2458-11-179.