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VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome (VISTA-16)

Primary Purpose

Acute Coronary Syndrome

Status
Terminated
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
A-002, varespladib methyl
Placebo
Sponsored by
Anthera Pharmaceuticals
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acute Coronary Syndrome

Eligibility Criteria

40 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Men and women ≥40 years of age
  2. Written informed consent from the subject

  3. A diagnosis of unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI)

    Unstable angina is defined as:

    • Chest pain symptomatic of ischemia or angina occurring at rest or on minimal exertion with a pattern of increasing frequency or severity, lasting >10 minutes and consistent with myocardial ischemia within 24 hours prior to hospitalization and
    • New or dynamic ST-segment depression or prominent T-wave inversion changes in at least 2 contiguous leads and
    • In addition subjects meeting the above criteria for unstable angina must also have either troponin I, troponin T or CKMB above the LLD but below the 99th percentile of the upper reference limit (URL) and not due to cardioversion or underlying cardiovascular (CHF, cardiomyopathy) or renal disease

    NSTEMI is defined as:

    • Chest pain symptomatic of ischemia
    • No electrocardiogram (ECG) changes, or ST-depression, or T wave changes(i.e., no new Q waves on serial ECGs)and
    • Increase in cardiac troponin > local limit for the definition of myocardial infarction or increase in CK-MB isoenzyme > URL

    STEMI is defined as:

    • Chest pain symptomatic of ischemia
    • ST segment elevation and associated T wave changes or ST-segment elevation of at least 2 mm in 2 contiguous leads, either of which persisting for longer than 15 minutes and
    • Increase in cardiac troponin > local limit for the definition of myocardial infarction or increase in CK-MB >URL

  4. All subjects must have the presence of at least one of the following risk factors:

    • Diabetes Mellitus or

    • Presence of any 3 of the following characteristics of metabolic syndrome

      • Waist circumference >102 cm in males, >88 cm in females
      • Serum triglycerides ≥150 mg/dL (≥1.7 mmol/L)
      • HDL-C <40 mg/dL (<1 mmol/L) in males, <50 mg/dL (<1.3 mmol/L) in females
      • Blood pressure ≥130/85 mmHg
      • Plasma glucose ≥110 mg/dL (≥6.1 mmol/L) or
    • history of cerebrovascular disease (stroke or TIA) or
    • history of peripheral vascular disease or
    • previous CABG or
    • previous documented myocardial infarction or
    • previous coronary revascularization
  5. Subjects must be randomized within ≤96 hours of hospital admission for the index event, or if already hospitalized, within ≤96 hours of index event diagnosis
  6. Revascularization, if required or planned, must occur prior to randomization

Exclusion Criteria:

  1. Subjects enrolled in another experimental (interventional)protocol within the past 30 days prior to Screening.
  2. Subjects treated for cancer within the previous 5 years except for skin basal cell carcinoma or carcinoma in situ of the cervix, with measures other than a minor, complete surgical excision or radiation therapy (e.g. chemotherapy)
  3. The presence of any severe liver disease with cirrhosis, active hepatitis, active chronic hepatitis, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3 x ULN, biliary obstruction with hyperbilirubinemia (total bilirubin >2 x ULN)
  4. Active cholecystitis, gall bladder symptoms, or any hepatobiliary abnormalities
  5. The presence of severe renal impairment (creatinine clearance [CrCl] <30 mL/min or creatinine >3 x ULN),nephrotic syndrome, or subjects undergoing dialysis
  6. Uncontrolled diabetes mellitus (known hemoglobin A1c [HbA1c] >11% within the last 1 month prior to Screening)
  7. Females who are nursing, pregnant, or intend to become pregnant during the time of the study, or females of childbearing potential who have a positive pregnancy test during screening evaluation. Women of child-bearing potential must also use a reliable method of birth control during the study and for 1 month following completion of therapy. A reliable method for this study is defined as one of the following: oral or injectable contraceptives, intrauterine device (IUD), contraceptive implants, tubal ligation, hysterectomy, a double barrier method (diaphragm with spermicidal foam or jelly, or a condom).
  8. Subjects who have a history of alcohol or drug abuse within 1 year of study entry
  9. Subjects living too far from participating center or unable to return for follow-up visits
  10. Subjects who in the opinion of the Investigator are a poor medical or psychiatric risk for therapy with an investigational drug, are unreliable, or have an incomplete understanding of the study which may affect their ability to take drugs as prescribed or comply with instructions
  11. Known human immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), or tuberculosis infection
  12. Acute bacterial, fungal or viral infection
  13. Subjects currently taking drugs that are potent inhibitors of cytochrome P450 unless they can be withdrawn
  14. Subjects with New York Heart Association (NYHA) Class III or IV heart failure, or if known, left ventricular ejection fraction (LVEF) <30
  15. Subjects with moderate or severe aortic stenosis, aortic regurgitation, mitral stenosis or mitral regurgitation
  16. Ventricular arrhythmias requiring chronic drug treatment or implantable cardioverter-defibrillator (ICD)
  17. Subjects with no stenosis or stenosis <50% on angiography, if known
  18. Subjects with a pacemaker or persistent left bundle branch block (LBBB)
  19. Fasting triglyceride levels of ≥400 mg/dL (4.5 mmol/L)
  20. Subjects who have a history of statin intolerance or a significant myopathy or rhabdomyolysis with any lipid altering drugs
  21. Subjects currently treated with the maximum labeled dose of a statin and not at LDL-C target for their level of risk as defined by NCEP ATP III

Sites / Locations

  • Investigator Site 1064
  • Investigator Site 1063
  • Investigator Site 1065
  • Investigator Site 1020
  • Investigator Site 1133
  • Investigator Site 1019
  • Investigator Site 1132
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  • Investigator Site 1079
  • Investigator Site 1006
  • Investigator Site 1050
  • Investigator Site 1045
  • Investigator Site 1061
  • Investigator Site 1054
  • Investigator Site 1140
  • Investigator Site 1111
  • Investigator Site 1028
  • Inevestigator Site 1074
  • Investigator Site 1030
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  • Investigator Site 1143
  • Investigator 1141
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  • Investigator Site 1026
  • Investigator Site 1122
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  • Investigator Site 1134
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  • Investigator Site 1138
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  • Investigator Site
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  • Investigator Site 3805
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Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

A-002 500 mg

Matched Placebo

Arm Description

Once daily oral administration

Once daily oral administration

Outcomes

Primary Outcome Measures

Primary Objective of the Study
To determine whether 16 weeks of treatment with A-002 plus atorvastatin and standard of care is superior to placebo plus atorvastatin and standard of care for reducing the hazard of the first occurrence of the combined endpoint of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or documented unstable angina with objective evidence of ischemia requiring hospitalization.

Secondary Outcome Measures

Secondary Objective of the Study
To determine whether A-002 plus atorvastatin and standard of care is superior to placebo plus atorvastatin and standard of care for reducing the occurrence of the hazard of the combined endpoint of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke or documented unstable angina with objective evidence of ischemia requiring hospitalization or multiple occurrences of the non-fatal components of the composite primary endpoint.

Full Information

First Posted
April 19, 2010
Last Updated
October 30, 2012
Sponsor
Anthera Pharmaceuticals
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1. Study Identification

Unique Protocol Identification Number
NCT01130246
Brief Title
VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome
Acronym
VISTA-16
Official Title
VISTA-16 Trial: Evaluation of the Safety and Efficacy of Short-Term A-002 Treatment in Subjects With Acute Coronary Syndromes
Study Type
Interventional

2. Study Status

Record Verification Date
October 2012
Overall Recruitment Status
Terminated
Why Stopped
Lack of efficacy
Study Start Date
May 2010 (undefined)
Primary Completion Date
March 2012 (Actual)
Study Completion Date
March 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Anthera Pharmaceuticals

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The objective of this study is to evaluate the safety and efficacy of short-term A-002 treatment on morbidity and mortality when added to atorvastatin and standard of care in subjects with an acute coronary syndrome (ACS).
Detailed Description
A double-blind randomized parallel group placebo controlled study in subjects presenting with an ACS. Up to 6500 subjects will be randomized to receive either A-002 500 mg once daily (QD) or placebo tablets in addition to atorvastatin QD and standard of care. Treatment will be 16 weeks in duration. The dose of atorvastatin shall be adjusted after 8 weeks if subject's LDL-C is ≥100 mg/dL, but otherwise must remain stable throughout the16-week duration of study. The survival status for all enrolled subjects will be ascertained 6 months after they complete the study. Randomization must occur within ≤96 hours of hospitalization for the index ACS event, or if already hospitalized, within ≤96 hours of index event diagnosis. Follow-up visits will occur on Weeks 1, 2, 4, 8, and 16. A 6 month follow-up visit will also occur.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Coronary Syndrome

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
5189 (Actual)

8. Arms, Groups, and Interventions

Arm Title
A-002 500 mg
Arm Type
Experimental
Arm Description
Once daily oral administration
Arm Title
Matched Placebo
Arm Type
Placebo Comparator
Arm Description
Once daily oral administration
Intervention Type
Drug
Intervention Name(s)
A-002, varespladib methyl
Intervention Description
A-002 administered once daily in addition to atorvastatin and standard of care
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo administered once daily in addition to atorvastatin and standard of care
Primary Outcome Measure Information:
Title
Primary Objective of the Study
Description
To determine whether 16 weeks of treatment with A-002 plus atorvastatin and standard of care is superior to placebo plus atorvastatin and standard of care for reducing the hazard of the first occurrence of the combined endpoint of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or documented unstable angina with objective evidence of ischemia requiring hospitalization.
Time Frame
16 weeks
Secondary Outcome Measure Information:
Title
Secondary Objective of the Study
Description
To determine whether A-002 plus atorvastatin and standard of care is superior to placebo plus atorvastatin and standard of care for reducing the occurrence of the hazard of the combined endpoint of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke or documented unstable angina with objective evidence of ischemia requiring hospitalization or multiple occurrences of the non-fatal components of the composite primary endpoint.
Time Frame
2, 4, 8, 16 weeks and 6 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Men and women ≥40 years of age Written informed consent from the subject A diagnosis of unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI) Unstable angina is defined as: Chest pain symptomatic of ischemia or angina occurring at rest or on minimal exertion with a pattern of increasing frequency or severity, lasting >10 minutes and consistent with myocardial ischemia within 24 hours prior to hospitalization and New or dynamic ST-segment depression or prominent T-wave inversion changes in at least 2 contiguous leads and In addition subjects meeting the above criteria for unstable angina must also have either troponin I, troponin T or CKMB above the LLD but below the 99th percentile of the upper reference limit (URL) and not due to cardioversion or underlying cardiovascular (CHF, cardiomyopathy) or renal disease NSTEMI is defined as: Chest pain symptomatic of ischemia No electrocardiogram (ECG) changes, or ST-depression, or T wave changes(i.e., no new Q waves on serial ECGs)and Increase in cardiac troponin > local limit for the definition of myocardial infarction or increase in CK-MB isoenzyme > URL STEMI is defined as: Chest pain symptomatic of ischemia ST segment elevation and associated T wave changes or ST-segment elevation of at least 2 mm in 2 contiguous leads, either of which persisting for longer than 15 minutes and Increase in cardiac troponin > local limit for the definition of myocardial infarction or increase in CK-MB >URL All subjects must have the presence of at least one of the following risk factors: Diabetes Mellitus or Presence of any 3 of the following characteristics of metabolic syndrome Waist circumference >102 cm in males, >88 cm in females Serum triglycerides ≥150 mg/dL (≥1.7 mmol/L) HDL-C <40 mg/dL (<1 mmol/L) in males, <50 mg/dL (<1.3 mmol/L) in females Blood pressure ≥130/85 mmHg Plasma glucose ≥110 mg/dL (≥6.1 mmol/L) or history of cerebrovascular disease (stroke or TIA) or history of peripheral vascular disease or previous CABG or previous documented myocardial infarction or previous coronary revascularization Subjects must be randomized within ≤96 hours of hospital admission for the index event, or if already hospitalized, within ≤96 hours of index event diagnosis Revascularization, if required or planned, must occur prior to randomization Exclusion Criteria: Subjects enrolled in another experimental (interventional)protocol within the past 30 days prior to Screening. Subjects treated for cancer within the previous 5 years except for skin basal cell carcinoma or carcinoma in situ of the cervix, with measures other than a minor, complete surgical excision or radiation therapy (e.g. chemotherapy) The presence of any severe liver disease with cirrhosis, active hepatitis, active chronic hepatitis, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3 x ULN, biliary obstruction with hyperbilirubinemia (total bilirubin >2 x ULN) Active cholecystitis, gall bladder symptoms, or any hepatobiliary abnormalities The presence of severe renal impairment (creatinine clearance [CrCl] <30 mL/min or creatinine >3 x ULN),nephrotic syndrome, or subjects undergoing dialysis Uncontrolled diabetes mellitus (known hemoglobin A1c [HbA1c] >11% within the last 1 month prior to Screening) Females who are nursing, pregnant, or intend to become pregnant during the time of the study, or females of childbearing potential who have a positive pregnancy test during screening evaluation. Women of child-bearing potential must also use a reliable method of birth control during the study and for 1 month following completion of therapy. A reliable method for this study is defined as one of the following: oral or injectable contraceptives, intrauterine device (IUD), contraceptive implants, tubal ligation, hysterectomy, a double barrier method (diaphragm with spermicidal foam or jelly, or a condom). Subjects who have a history of alcohol or drug abuse within 1 year of study entry Subjects living too far from participating center or unable to return for follow-up visits Subjects who in the opinion of the Investigator are a poor medical or psychiatric risk for therapy with an investigational drug, are unreliable, or have an incomplete understanding of the study which may affect their ability to take drugs as prescribed or comply with instructions Known human immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), or tuberculosis infection Acute bacterial, fungal or viral infection Subjects currently taking drugs that are potent inhibitors of cytochrome P450 unless they can be withdrawn Subjects with New York Heart Association (NYHA) Class III or IV heart failure, or if known, left ventricular ejection fraction (LVEF) <30 Subjects with moderate or severe aortic stenosis, aortic regurgitation, mitral stenosis or mitral regurgitation Ventricular arrhythmias requiring chronic drug treatment or implantable cardioverter-defibrillator (ICD) Subjects with no stenosis or stenosis <50% on angiography, if known Subjects with a pacemaker or persistent left bundle branch block (LBBB) Fasting triglyceride levels of ≥400 mg/dL (4.5 mmol/L) Subjects who have a history of statin intolerance or a significant myopathy or rhabdomyolysis with any lipid altering drugs Subjects currently treated with the maximum labeled dose of a statin and not at LDL-C target for their level of risk as defined by NCEP ATP III
Facility Information:
Facility Name
Investigator Site 1064
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35205
Country
United States
Facility Name
Investigator Site 1063
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35235
Country
United States
Facility Name
Investigator Site 1065
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35243
Country
United States
Facility Name
Investigator Site 1020
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Investigator Site 1133
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Investigator Site 1019
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
Investigator Site 1132
City
Escondido
State/Province
California
ZIP/Postal Code
92025
Country
United States
Facility Name
Investigator Site 1087
City
Mission Viejo
State/Province
California
ZIP/Postal Code
92691
Country
United States
Facility Name
Investigator Site 1005
City
Torrance
State/Province
California
ZIP/Postal Code
90502
Country
United States
Facility Name
Investigator Site 1079
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80012
Country
United States
Facility Name
Investigator Site 1006
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Investigator Site 1050
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
Investigator Site 1045
City
Denver
State/Province
Colorado
ZIP/Postal Code
80220
Country
United States
Facility Name
Investigator Site 1061
City
Fort Collins
State/Province
Colorado
ZIP/Postal Code
80528
Country
United States
Facility Name
Investigator Site 1054
City
Littleton
State/Province
Colorado
ZIP/Postal Code
80120
Country
United States
Facility Name
Investigator Site 1140
City
Wheat Ridge
State/Province
Colorado
ZIP/Postal Code
80033
Country
United States
Facility Name
Investigator Site 1111
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06102
Country
United States
Facility Name
Investigator Site 1028
City
Newark
State/Province
Delaware
ZIP/Postal Code
19718
Country
United States
Facility Name
Inevestigator Site 1074
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010
Country
United States
Facility Name
Investigator Site 1030
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20037
Country
United States
Facility Name
Investigator Site 1117
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20422
Country
United States
Facility Name
Investigator Site 1022
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Investigator Site 1051
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Investigator Site 1112
City
Ft. Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Investigator Site 1049
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33805
Country
United States
Facility Name
Investigator Site 1124
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Facility Name
Investigator Site 1095
City
Tallahassee
State/Province
Florida
ZIP/Postal Code
32308
Country
United States
Facility Name
Investigator Site 1058
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
Investigator Site1110
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Facility Name
Investigator Site 1011
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30901
Country
United States
Facility Name
Investigator Site 1114
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Investigator Site 1086
City
Naperville
State/Province
Illinois
ZIP/Postal Code
60540
Country
United States
Facility Name
Investigator Site 1125
City
Oak Lawn
State/Province
Illinois
ZIP/Postal Code
60453
Country
United States
Facility Name
Investigator Site 1044
City
Covington
State/Province
Louisiana
ZIP/Postal Code
70433
Country
United States
Facility Name
Investigator Site 1069
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Investigator Site 1066
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70115
Country
United States
Facility Name
Investigator Site 1144
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71101
Country
United States
Facility Name
Investigator Site 1060
City
Flint
State/Province
Michigan
ZIP/Postal Code
48532
Country
United States
Facility Name
Investigator Site 1136
City
Novi
State/Province
Michigan
ZIP/Postal Code
48374
Country
United States
Facility Name
Investigator Site 1137
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
Investigator Site 1048
City
Traverse City
State/Province
Michigan
ZIP/Postal Code
49684
Country
United States
Facility Name
Investigator Site 1034
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55807
Country
United States
Facility Name
Investigator Site 1046
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55407
Country
United States
Facility Name
Investigator Site 1033
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55417
Country
United States
Facility Name
Investigator Site 1016
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Facility Name
Investigator Site 1027
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
Facility Name
Investigator Site 1092
City
Missoula
State/Province
Montana
ZIP/Postal Code
59802
Country
United States
Facility Name
Investigator Site 1032
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68131
Country
United States
Facility Name
Investigator Site 1031
City
Ridgewood
State/Province
New Jersey
ZIP/Postal Code
07450
Country
United States
Facility Name
Investigator Site 1057
City
Johnson City
State/Province
New York
ZIP/Postal Code
13790
Country
United States
Facility Name
Investigator Site 1101
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Investigator Site 1100
City
Gastonia
State/Province
North Carolina
ZIP/Postal Code
28054
Country
United States
Facility Name
Investigator Site 1121
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27609
Country
United States
Facility Name
Investigator Site 1088
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27610
Country
United States
Facility Name
Investigator Site 1123
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
Investigator Site 1075
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Investigator Site 1108
City
Fargo
State/Province
North Dakota
ZIP/Postal Code
58122
Country
United States
Facility Name
Investigator Site 1024
City
Canton
State/Province
Ohio
ZIP/Postal Code
44710
Country
United States
Facility Name
Investigator Site 1143
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Investigator 1141
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44109
Country
United States
Facility Name
Investigator Site 1131
City
Mansfield
State/Province
Ohio
ZIP/Postal Code
44901
Country
United States
Facility Name
Investigator Site 1004
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Facility Name
Investigator Site 1026
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Investigator Site 1122
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Investigator Site 1107
City
Danville
State/Province
Pennsylvania
ZIP/Postal Code
17822
Country
United States
Facility Name
Investigator Site 1029
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
Facility Name
Investigator Site 1134
City
Lancaster
State/Province
Pennsylvania
ZIP/Postal Code
17602
Country
United States
Facility Name
Investigator Site 1018
City
York
State/Province
Pennsylvania
ZIP/Postal Code
17405
Country
United States
Facility Name
Investigator Site 1072
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02906
Country
United States
Facility Name
Investigator Site 1038
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
55701
Country
United States
Facility Name
Investigator Site 1138
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57104
Country
United States
Facility Name
Investigator Site 1014
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38305
Country
United States
Facility Name
Investigator Site 1047
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37917
Country
United States
Facility Name
Investigator Site 1115
City
Dallas
State/Province
Texas
ZIP/Postal Code
75216
Country
United States
Facility Name
Investigator Site 1040
City
Dallas
State/Province
Texas
ZIP/Postal Code
75226
Country
United States
Facility Name
Investigator Site 1037
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Investigator Site 1130
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Investigator Site 1025
City
Tyler
State/Province
Texas
ZIP/Postal Code
75501
Country
United States
Facility Name
Investigator Site 1139
City
Layton
State/Province
Utah
ZIP/Postal Code
84041
Country
United States
Facility Name
Investigator Site 1056
City
Harrisonburg
State/Province
Virginia
ZIP/Postal Code
22801
Country
United States
Facility Name
Investigator Site 1083
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Facility Name
Investigator Site 1043
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
Facility Name
Investigator Site 1042
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Facility Name
Investigator Site 6106
City
Canberra
State/Province
Australian Capital Territory
Country
Australia
Facility Name
Investigator Site 6114
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
Investigator Site 6120
City
Kingswood
State/Province
New South Wales
ZIP/Postal Code
2747
Country
Australia
Facility Name
Investigator Site 6113
City
Cairns
State/Province
Queensland
ZIP/Postal Code
4870
Country
Australia
Facility Name
Investigator Site 6112
City
Douglas
State/Province
Queensland
ZIP/Postal Code
4814
Country
Australia
Facility Name
Investigator Site 6123
City
Nambour
State/Province
Queensland
ZIP/Postal Code
4560
Country
Australia
Facility Name
Investigator Site 6111
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Investigator Site 6124
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
Investigator Site 6103
City
Elizabeth Vale
State/Province
South Australia
ZIP/Postal Code
5112
Country
Australia
Facility Name
Investigator Site 6122
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
Facility Name
Investigator Site 6129
City
Epping
State/Province
Victoria
ZIP/Postal Code
3076
Country
Australia
Facility Name
Investigator Site 6127
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Investigator Site 6125
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Investigator Site 6130
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
Investigator Site 6118
City
Brisbane
Country
Australia
Facility Name
Investigator Site 6126
City
Geelong
Country
Australia
Facility Name
Investigator Site 6101
City
Kogarah
ZIP/Postal Code
NSW2217
Country
Australia
Facility Name
Investigator Site 6105
City
Melbourne
ZIP/Postal Code
3004
Country
Australia
Facility Name
Investigator Site 6110
City
Nedlands
ZIP/Postal Code
6009
Country
Australia
Facility Name
Investigator Site 6121
City
New Lambton
ZIP/Postal Code
NSW2305
Country
Australia
Facility Name
Investigator Site 6108
City
So Australia
Country
Australia
Facility Name
Investigator Site 6119
City
South Port
ZIP/Postal Code
4215QLD
Country
Australia
Facility Name
Investigator Site 2069
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 2T9
Country
Canada
Facility Name
Investigator Site 2065
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Facility Name
Investigator Site 2064
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6L 5X8
Country
Canada
Facility Name
Investigator Site 2073
City
Red Deer
State/Province
Alberta
ZIP/Postal Code
T4N 4E7
Country
Canada
Facility Name
Investigator Site 2059
City
Kelowna
State/Province
British Columbia
ZIP/Postal Code
V1Y 1E4
Country
Canada
Facility Name
Investigator Site 2068
City
New Westminister
State/Province
British Columbia
ZIP/Postal Code
v3L3W4
Country
Canada
Facility Name
Investigator Site 2066
City
Surrey
State/Province
British Columbia
ZIP/Postal Code
V3V 1Z2
Country
Canada
Facility Name
Investigator Site 2057
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6Z1Y6
Country
Canada
Facility Name
Investigator Site 2063
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R4R2
Country
Canada
Facility Name
Investigator Site 2070
City
Saint John
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3V6
Country
Canada
Facility Name
Investigator Site 2048
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
Facility Name
Investigator Site 2072
City
Sydney
State/Province
Nova Scotia
ZIP/Postal Code
B1P1P3
Country
Canada
Facility Name
Investigator Site 2067
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L2X2
Country
Canada
Facility Name
Investigator Site 2075
City
Kitchener
State/Province
Ontario
ZIP/Postal Code
N2M 1B2
Country
Canada
Facility Name
Investigator Site 2058
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
Facility Name
Investigator Site 2004
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 8C3
Country
Canada
Facility Name
Investigator Site 2008
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1E4B9
Country
Canada
Facility Name
Investigator Site 2030
City
Thunder Bay
State/Province
Ontario
ZIP/Postal Code
P7B7C7
Country
Canada
Facility Name
Investigator Site 2011
City
Toronto
State/Province
Ontario
ZIP/Postal Code
J6V2H2
Country
Canada
Facility Name
Investigator Site 2012
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B1W8
Country
Canada
Facility Name
Investigator Site 2074
City
Laval
State/Province
Quebec
ZIP/Postal Code
H7M 3L9
Country
Canada
Facility Name
Investigator Site 2020
City
Lévis
State/Province
Quebec
ZIP/Postal Code
G6V 4Z5
Country
Canada
Facility Name
Investigator Site 2009
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Facility Name
Investigator Site 2052
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2W1T8
Country
Canada
Facility Name
Investigator Site 2001
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3H2R9
Country
Canada
Facility Name
Investigator Site 2071
City
St. Jerome
State/Province
Quebec
ZIP/Postal Code
J7Z5T3
Country
Canada
Facility Name
Investigator Site 2006
City
Terrebonne
State/Province
Quebec
ZIP/Postal Code
J6V2H2
Country
Canada
Facility Name
Investigator Site 2053
City
Quebec
ZIP/Postal Code
G1R 2J6
Country
Canada
Facility Name
Investigator Site 2007
City
Quebec
ZIP/Postal Code
G1V4G5
Country
Canada
Facility Name
Investigator Site 2010
City
Saint John
ZIP/Postal Code
NBE2L4L2
Country
Canada
Facility Name
Investigator Site 4212
City
Jihlavska
State/Province
Brno
ZIP/Postal Code
62500
Country
Czech Republic
Facility Name
Investigator Site 4201
City
Usti nad Labem
State/Province
Labem
ZIP/Postal Code
40113
Country
Czech Republic
Facility Name
Investigator Site 4216
City
Liberec
State/Province
Stare Mesto
ZIP/Postal Code
46063
Country
Czech Republic
Facility Name
Investigator Site 4210
City
Brno
ZIP/Postal Code
656 91
Country
Czech Republic
Facility Name
Investigator Site 4206
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czech Republic
Facility Name
Investigator Site 4208
City
Jihlava
ZIP/Postal Code
58633
Country
Czech Republic
Facility Name
Investigator Site 4214
City
Mlada Boleslav
ZIP/Postal Code
29350
Country
Czech Republic
Facility Name
Investigator Site 4218
City
Nymburk
ZIP/Postal Code
288 02
Country
Czech Republic
Facility Name
Investigator 4218
City
Nymburk
ZIP/Postal Code
425/9
Country
Czech Republic
Facility Name
Investigator Site 4207
City
Olomouc
ZIP/Postal Code
755 20
Country
Czech Republic
Facility Name
Investigator Site 4209
City
Ostrava
ZIP/Postal Code
70852
Country
Czech Republic
Facility Name
Investigator Site 4205
City
Plzen
ZIP/Postal Code
30599
Country
Czech Republic
Facility Name
Investigator Site 4204
City
Praha 2
ZIP/Postal Code
12802
Country
Czech Republic
Facility Name
Investigator Site 4217
City
Praha 5
ZIP/Postal Code
150 06
Country
Czech Republic
Facility Name
Investigator Site 4213
City
Praha
ZIP/Postal Code
10034
Country
Czech Republic
Facility Name
Investigator Site 4220
City
Praha
ZIP/Postal Code
6
Country
Czech Republic
Facility Name
Investigator Site 4202
City
Usti nad Labem
ZIP/Postal Code
401 13
Country
Czech Republic
Facility Name
Investigator Site 4203
City
Znojmo
ZIP/Postal Code
66902
Country
Czech Republic
Facility Name
Investigator Site 9502
City
Tbilisi
ZIP/Postal Code
0102
Country
Georgia
Facility Name
Investigator Site 9508
City
Tbilisi
ZIP/Postal Code
0102
Country
Georgia
Facility Name
Investigator Site 9504
City
Tbilisi
ZIP/Postal Code
0141
Country
Georgia
Facility Name
Investigator Site 9509
City
Tbilisi
ZIP/Postal Code
0144
Country
Georgia
Facility Name
Investigator Site 9510
City
Tbilisi
ZIP/Postal Code
0144
Country
Georgia
Facility Name
Investigator Site 9501
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Investigator Site 9505
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Investigator Site 9506
City
Tbilisi
ZIP/Postal Code
0164
Country
Georgia
Facility Name
Investigator Site 9503
City
Tbilisi
ZIP/Postal Code
0179
Country
Georgia
Facility Name
Investigator Site 9507
City
Tbilisi
ZIP/Postal Code
0186
Country
Georgia
Facility Name
Investigator Site 4921
City
Warendorf
State/Province
Am Krankenhaus
ZIP/Postal Code
48231
Country
Germany
Facility Name
Investigator Site 4932
City
Bad Friedrichshall
ZIP/Postal Code
74177
Country
Germany
Facility Name
Investigator Site 4930
City
Bad Nauheim
ZIP/Postal Code
61231
Country
Germany
Facility Name
Investigator Site 4928
City
Berlin
ZIP/Postal Code
12559
Country
Germany
Facility Name
Investigator Site 4904
City
Bielefeld
ZIP/Postal Code
336 04
Country
Germany
Facility Name
Investigator Site 4905
City
Bonn
ZIP/Postal Code
53105
Country
Germany
Facility Name
Investigator Site 4923
City
Dortmund
ZIP/Postal Code
44137
Country
Germany
Facility Name
Investigator Site 4912
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
Investigator Site 4907
City
Goettingen
ZIP/Postal Code
37075
Country
Germany
Facility Name
Investigator Site 4922
City
Hamburg
ZIP/Postal Code
21075
Country
Germany
Facility Name
Investigator Site 4929
City
Kassel
ZIP/Postal Code
34121
Country
Germany
Facility Name
Investigator Site 4911
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Investigator Site 4901
City
Limburg
ZIP/Postal Code
65549
Country
Germany
Facility Name
Investigator Site 4927
City
Lubeck
ZIP/Postal Code
23538
Country
Germany
Facility Name
Investigator Site 4908
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
Facility Name
Investigator Site 4902
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Investigator Site 4917
City
Munchen
Country
Germany
Facility Name
Investigator Site 4925
City
Nauen
ZIP/Postal Code
14641
Country
Germany
Facility Name
Investigator Site 4915
City
Regensburg
ZIP/Postal Code
93053
Country
Germany
Facility Name
Investigator Site 4906
City
Ulm
ZIP/Postal Code
89081
Country
Germany
Facility Name
Investigator Site 3626
City
Pecs
State/Province
Baranya Megye
ZIP/Postal Code
H-7624
Country
Hungary
Facility Name
Investigator Site 3606
City
Szekesfehervar
State/Province
Fejer Megye
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Investigator Site 3602
City
Budapest
State/Province
Gaal Jozsef
Country
Hungary
Facility Name
Investigator Site 3605
City
Debrecen
State/Province
Hajdu-Bihar
ZIP/Postal Code
4012
Country
Hungary
Facility Name
Investigator Site 3614
City
Semmelweis
State/Province
Kistarcsa
ZIP/Postal Code
2143
Country
Hungary
Facility Name
Investigator Site 3616
City
Budapest
State/Province
Pest Megye
ZIP/Postal Code
1076
Country
Hungary
Facility Name
Investigator Site 3612
City
Budapest
State/Province
Pest Megye
ZIP/Postal Code
1097
Country
Hungary
Facility Name
Investigator Site 3607
City
Szolnok
State/Province
Szolnok Megye
ZIP/Postal Code
5000
Country
Hungary
Facility Name
Investigator Site 3603
City
Zalaegerszeg
State/Province
Zala Megye
ZIP/Postal Code
H-8900
Country
Hungary
Facility Name
Investigator Site 3625
City
Balatonfured
ZIP/Postal Code
8203
Country
Hungary
Facility Name
Investigator Site 3604
City
Budapest
ZIP/Postal Code
1096
Country
Hungary
Facility Name
Investigator Site 3622
City
Budapest
ZIP/Postal Code
1106
Country
Hungary
Facility Name
Investigator Site 3619
City
Eger
ZIP/Postal Code
3300
Country
Hungary
Facility Name
Investigator Site 3624
City
Hodmezovasarhely
ZIP/Postal Code
6800
Country
Hungary
Facility Name
Investigator Site 3629
City
Sopron
ZIP/Postal Code
9400
Country
Hungary
Facility Name
Investigator Site 3623
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
Facility Name
Investigator Site 9110
City
Hyderabad
State/Province
Andhra Pradesh
ZIP/Postal Code
500082
Country
India
Facility Name
Investigator Site 9109
City
Secunderabad
State/Province
Andhra Pradesh
ZIP/Postal Code
500003
Country
India
Facility Name
Investigator Site 9119
City
Secunderabad
State/Province
Andhra Pradesh
ZIP/Postal Code
500003
Country
India
Facility Name
Investigator Site 9105
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110076
Country
India
Facility Name
Investigator Site 9104
City
Ahmedabad
State/Province
Gujarat
ZIP/Postal Code
380 014
Country
India
Facility Name
Investigator Site 9111
City
Ahmedabad
State/Province
Gujarat
ZIP/Postal Code
380052
Country
India
Facility Name
Investigator Site 9108
City
Ahmedabad
State/Province
Gujarat
ZIP/Postal Code
380060
Country
India
Facility Name
Investigator Site 9117
City
Surat
State/Province
Gujarat
ZIP/Postal Code
395007
Country
India
Facility Name
Investigator Site 9115
City
Vadodara
State/Province
Gujarat
ZIP/Postal Code
390 015
Country
India
Facility Name
Investigator Site 9102
City
Vadodara
State/Province
Gujarat
ZIP/Postal Code
390007
Country
India
Facility Name
Investigator Site 9114
City
Bangalore
State/Province
Karanataka
ZIP/Postal Code
560 0034
Country
India
Facility Name
Investigator Site 9121
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560 052
Country
India
Facility Name
Investigator Site 9113
City
Indore
State/Province
Madhya Pradesh
ZIP/Postal Code
452008
Country
India
Facility Name
Investigator Site 9101
City
Nagpur
State/Province
Maharashtra
ZIP/Postal Code
440012
Country
India
Facility Name
Investigator Site 9103
City
Lucknow
State/Province
Uttar Pradesh
ZIP/Postal Code
226003
Country
India
Facility Name
Investigator Site 9118
City
Kolkata
State/Province
West Bengal
ZIP/Postal Code
7000020
Country
India
Facility Name
Investigator Site 9107
City
Kolkata
State/Province
West Bengal
ZIP/Postal Code
700027
Country
India
Facility Name
Investigator Site 3921
City
Brescia
State/Province
Via L Bissolati
ZIP/Postal Code
57
Country
Italy
Facility Name
Investigator Site 3908
City
Cecina
ZIP/Postal Code
57023
Country
Italy
Facility Name
Investigator Site 3912
City
Colleferro
ZIP/Postal Code
00034
Country
Italy
Facility Name
Investigator Site 3910
City
Ferrara
ZIP/Postal Code
44121
Country
Italy
Facility Name
Investigator Site 3916
City
Massa
ZIP/Postal Code
54100
Country
Italy
Facility Name
Investigator Site 3906
City
Milano
ZIP/Postal Code
20138
Country
Italy
Facility Name
Investigator Site 3901
City
Monza
ZIP/Postal Code
20052
Country
Italy
Facility Name
Investigator Site 3907
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
Investigator Site 3920
City
Novara
ZIP/Postal Code
28100
Country
Italy
Facility Name
Investigator Site 3918
City
Roma
ZIP/Postal Code
00135
Country
Italy
Facility Name
Investigator Site 3902
City
Rome
ZIP/Postal Code
00168
Country
Italy
Facility Name
Investigator Site 3909
City
Rome
ZIP/Postal Code
00189
Country
Italy
Facility Name
Investigator Site 3903
City
Rozzano (MI)
ZIP/Postal Code
20089
Country
Italy
Facility Name
Investigator Site 3904
City
Siena
ZIP/Postal Code
53100
Country
Italy
Facility Name
Investigator Site 8205
City
Busan
ZIP/Postal Code
602-715
Country
Korea, Republic of
Facility Name
Investigator Site 8206
City
Busan
ZIP/Postal Code
602-739
Country
Korea, Republic of
Facility Name
Investigator Site 8202
City
Cheongju
ZIP/Postal Code
361-711
Country
Korea, Republic of
Facility Name
Investigator Site 8214
City
Daegu
ZIP/Postal Code
700-712
Country
Korea, Republic of
Facility Name
Investigator Site 8213
City
Daejeon
ZIP/Postal Code
301-723
Country
Korea, Republic of
Facility Name
Investigator Site 8203
City
Gwangju
ZIP/Postal Code
501-757
Country
Korea, Republic of
Facility Name
Investigator Site 8204
City
Gyeonggi-do
ZIP/Postal Code
480-717
Country
Korea, Republic of
Facility Name
Investigator Site 8210
City
Kangwon-do
ZIP/Postal Code
220-701
Country
Korea, Republic of
Facility Name
Investigator Site 8209
City
Seoul
ZIP/Postal Code
130-702
Country
Korea, Republic of
Facility Name
Investigator Site 8215
City
Seoul
ZIP/Postal Code
130-709
Country
Korea, Republic of
Facility Name
Investigator Site 8212
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Investigator Site 8207
City
Seoul
ZIP/Postal Code
135-720
Country
Korea, Republic of
Facility Name
Investigator Site 8201
City
Seoul
ZIP/Postal Code
152-703
Country
Korea, Republic of
Facility Name
Investigator Site 8208
City
Suwon
ZIP/Postal Code
442-723
Country
Korea, Republic of
Facility Name
Investigator Site 8211
City
Suwon
ZIP/Postal Code
443-721
Country
Korea, Republic of
Facility Name
Investigator Site 9603
City
Bir Hassan
State/Province
Jnah
Country
Lebanon
Facility Name
Investigator Site 9601
City
Beirut
ZIP/Postal Code
BEI
Country
Lebanon
Facility Name
Investigator Site 9603
City
Beirut
Country
Lebanon
Facility Name
Investigator Site 3126
City
Nieuwegein
State/Province
CM
ZIP/Postal Code
3435
Country
Netherlands
Facility Name
Investigator Site 3129
City
Goes
State/Province
RA
ZIP/Postal Code
4462
Country
Netherlands
Facility Name
Investigator Site 3120
City
Amstelveen
ZIP/Postal Code
1186 AM
Country
Netherlands
Facility Name
Investigator Site 3128
City
Amsterdam
ZIP/Postal Code
1081 HV
Country
Netherlands
Facility Name
Investigator Site 3117
City
Amsterdam
ZIP/Postal Code
1091 AC
Country
Netherlands
Facility Name
Investigator Site 3125
City
Amsterdam
Country
Netherlands
Facility Name
Investigator Site 3136
City
Breda
ZIP/Postal Code
4818
Country
Netherlands
Facility Name
Investigator Site 3130
City
Delft
ZIP/Postal Code
2625 AD
Country
Netherlands
Facility Name
Investigator Site 3108
City
Den Helder
ZIP/Postal Code
1782 GZ
Country
Netherlands
Facility Name
Investigator Site 3105
City
Deventer
ZIP/Postal Code
7416 SE
Country
Netherlands
Facility Name
Investigator Site 3102
City
Ede
ZIP/Postal Code
6716RP
Country
Netherlands
Facility Name
Investigator Site 3134
City
Heerlen
ZIP/Postal Code
6419 PC
Country
Netherlands
Facility Name
Investigator Site 3109
City
Hoogeveen
ZIP/Postal Code
7909 AA
Country
Netherlands
Facility Name
Investigator Site 3101
City
Leeuwarden
Country
Netherlands
Facility Name
Investigator Site 3118
City
Leiden
ZIP/Postal Code
2333 ZA
Country
Netherlands
Facility Name
Investigator Site 3112
City
Purmerend
ZIP/Postal Code
1447 TC
Country
Netherlands
Facility Name
Investigator Site 3107
City
Roosendaal
ZIP/Postal Code
4708 AE
Country
Netherlands
Facility Name
Investigator Site 3104
City
Rotterdam
ZIP/Postal Code
3011 TD
Country
Netherlands
Facility Name
Investigator Site 3106
City
Rotterdam
ZIP/Postal Code
3045 PM
Country
Netherlands
Facility Name
Investigator Site 3123
City
Rotterdam
ZIP/Postal Code
3075 EA
Country
Netherlands
Facility Name
Investigator Site 3131
City
Schiedam
ZIP/Postal Code
3118 JH
Country
Netherlands
Facility Name
Investigator Site 3135
City
Sneek
ZIP/Postal Code
8601 ZK
Country
Netherlands
Facility Name
Investigator Site 3103
City
Tilburg
ZIP/Postal Code
5022 CG
Country
Netherlands
Facility Name
Investigator Site 3116
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
Investigator Site 3124
City
Venlo
ZIP/Postal Code
5912 BL
Country
Netherlands
Facility Name
Investigator Site 3113
City
Zaandam
ZIP/Postal Code
1502 DV
Country
Netherlands
Facility Name
Investigator Site 6402
City
Takapuna
State/Province
Auckland
ZIP/Postal Code
0622
Country
New Zealand
Facility Name
Investigator Site 6405
City
Christchurch
ZIP/Postal Code
8011
Country
New Zealand
Facility Name
Investigator Site 6404
City
Dunedin
ZIP/Postal Code
9054
Country
New Zealand
Facility Name
Investigator Site 6401
City
Hamilton
ZIP/Postal Code
3240
Country
New Zealand
Facility Name
Investigator Site 6406
City
Wellington
ZIP/Postal Code
6021
Country
New Zealand
Facility Name
Investigator Site 4825
City
Wroc³aw
State/Province
Dolnoslaskie
ZIP/Postal Code
53-114
Country
Poland
Facility Name
Investigator Site 4804
City
Inowroclaw
State/Province
Kujawsko-pomorskie
ZIP/Postal Code
88-100
Country
Poland
Facility Name
Investigator Site4819
City
Pulawy
State/Province
Podkarpackie
ZIP/Postal Code
24-100
Country
Poland
Facility Name
Investigator Site 4828
City
Gdansk
State/Province
Pomorskie
ZIP/Postal Code
80-952
Country
Poland
Facility Name
Investigator Site 4809
City
Bialystok
ZIP/Postal Code
15-276
Country
Poland
Facility Name
Investigator Site 4813
City
Bialystok
ZIP/Postal Code
15-276
Country
Poland
Facility Name
Investigator Site 4801
City
Bytom
ZIP/Postal Code
41-902
Country
Poland
Facility Name
Investigator Site 4816
City
Stalowa Wola
ZIP/Postal Code
37-450
Country
Poland
Facility Name
Investigator Site 4827
City
Szczecin
ZIP/Postal Code
70-111
Country
Poland
Facility Name
Investigator Site 4812
City
Warszawa
ZIP/Postal Code
00-685
Country
Poland
Facility Name
Investigator Site 4815
City
Warszawa
ZIP/Postal Code
01-809
Country
Poland
Facility Name
Investigator Site 4806
City
Warszawa
ZIP/Postal Code
02-507
Country
Poland
Facility Name
Investigator Site 4823
City
Warszawa
ZIP/Postal Code
04-628
Country
Poland
Facility Name
Investigator Site 4824
City
Wroclaw
ZIP/Postal Code
50-367
Country
Poland
Facility Name
Investigator Site 7026
City
Barnaui
ZIP/Postal Code
656099
Country
Russian Federation
Facility Name
Investigator Site 7021
City
Chelyabinsk
Country
Russian Federation
Facility Name
Investigator Site 7001
City
Ekaterinburg
ZIP/Postal Code
620109
Country
Russian Federation
Facility Name
Investigator Site 7023
City
Irkutsk
ZIP/Postal Code
664079
Country
Russian Federation
Facility Name
Investigator Site 7020
City
Kazan
ZIP/Postal Code
420101
Country
Russian Federation
Facility Name
Investigator Site 7002
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
Investigator Site 7017
City
Krasnoyarsk
Country
Russian Federation
Facility Name
Investigator Site 7024
City
Kursk
ZIP/Postal Code
305035
Country
Russian Federation
Facility Name
Investigator Site 7007
City
Leningrad
Country
Russian Federation
Facility Name
Investigator Site 7003
City
Moscow
ZIP/Postal Code
111539
Country
Russian Federation
Facility Name
Investigator Site 7015
City
Moscow
ZIP/Postal Code
119620
Country
Russian Federation
Facility Name
Investigator Site 7019
City
Moscow
ZIP/Postal Code
121552
Country
Russian Federation
Facility Name
Investigator Site 7018
City
Murmansk
ZIP/Postal Code
183047
Country
Russian Federation
Facility Name
Investigator Site 7004
City
Novosibirsk
ZIP/Postal Code
630008
Country
Russian Federation
Facility Name
Investigator Site 7027
City
Novosibirsk
Country
Russian Federation
Facility Name
Investigator Site 7022
City
Orenburg
ZIP/Postal Code
460040
Country
Russian Federation
Facility Name
Investigator Site 7016
City
Rostov-on-Don
ZIP/Postal Code
344068
Country
Russian Federation
Facility Name
Investigator Site 7005
City
Samara
ZIP/Postal Code
443070
Country
Russian Federation
Facility Name
Investigator Site 7006
City
Saratov
ZIP/Postal Code
410054
Country
Russian Federation
Facility Name
Investigator Site 7028
City
Saratov
Country
Russian Federation
Facility Name
Investigator Site 7008
City
St. Petersburg
ZIP/Postal Code
198205
Country
Russian Federation
Facility Name
Investigator Site 7010
City
St. Petersburg
Country
Russian Federation
Facility Name
Investigator Site 7013
City
St. Petersburg
Country
Russian Federation
Facility Name
Investigator Site 7025
City
St. Petersburg
Country
Russian Federation
Facility Name
Investigator Site 7009
City
St.Petersburg
ZIP/Postal Code
191015
Country
Russian Federation
Facility Name
Investigator Site 7011
City
Tomsk
ZIP/Postal Code
634012
Country
Russian Federation
Facility Name
Investigator Site 7012
City
Tyumen
ZIP/Postal Code
625026
Country
Russian Federation
Facility Name
Investigator Site 3404
City
Oviedo
State/Province
Asturias
ZIP/Postal Code
33006
Country
Spain
Facility Name
Investigator Site 3432
City
Badalona
State/Province
Barcelona
ZIP/Postal Code
08916
Country
Spain
Facility Name
Investigator Site 3420
City
Coslada
State/Province
Madrid
ZIP/Postal Code
28820
Country
Spain
Facility Name
Investigator Site 3419
City
Fuenlabrada
State/Province
Madrid
ZIP/Postal Code
28942
Country
Spain
Facility Name
Investigator Site 3413
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Investigator Site 3411
City
Lorca
State/Province
Murcia
ZIP/Postal Code
30800
Country
Spain
Facility Name
Investigator Site 3416
City
Pamplona
State/Province
Navarra
ZIP/Postal Code
31008
Country
Spain
Facility Name
Investigator Site 3408
City
Vigo
State/Province
Pontevedra
ZIP/Postal Code
36211
Country
Spain
Facility Name
Investigator Site 3410
City
Vigo
State/Province
Pontevedra
ZIP/Postal Code
36214
Country
Spain
Facility Name
Investigator Site 3425
City
Galdakao
State/Province
Vizcaya
ZIP/Postal Code
48960
Country
Spain
Facility Name
Investigator Site 3435
City
Albacete
ZIP/Postal Code
02006
Country
Spain
Facility Name
Investigator Site 3428
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
Investigator Site 3418
City
Barcelona
ZIP/Postal Code
08906
Country
Spain
Facility Name
Investigator Site 3406
City
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
Investigator Site 3407
City
Huelva
ZIP/Postal Code
21005
Country
Spain
Facility Name
Investigator Site 3430
City
Leganes
ZIP/Postal Code
28911
Country
Spain
Facility Name
Investigator Site 3402
City
Lleida
ZIP/Postal Code
25198
Country
Spain
Facility Name
Investigator Site 3409
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Investigator Site 3423
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Investigator Site 3401
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Investigator Site 3415
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Investigator Site 3421
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Investigator Site 3431
City
Pontevedra
ZIP/Postal Code
36071
Country
Spain
Facility Name
Investigator Site 3424
City
Reus
ZIP/Postal Code
43206
Country
Spain
Facility Name
Investigator Site 3414
City
Santa Cruz de Tenerife
ZIP/Postal Code
38010
Country
Spain
Facility Name
Investigator Site 3434
City
Sevilla
ZIP/Postal Code
41009
Country
Spain
Facility Name
Investigator Site 3422
City
Utrera
ZIP/Postal Code
41710
Country
Spain
Facility Name
Investigator Site 3403
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Investigator Site 3809
City
Dnipropetrovsk
ZIP/Postal Code
49006
Country
Ukraine
Facility Name
Investigator Site 3807
City
Ivano-Frankivsk
ZIP/Postal Code
76014
Country
Ukraine
Facility Name
Investigator Site 3806
City
Kharkiv
ZIP/Postal Code
61002
Country
Ukraine
Facility Name
Investigator Site 3802
City
Kharkiv
ZIP/Postal Code
61018
Country
Ukraine
Facility Name
Investigator Site 3803
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Investigator Site
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Investigator Site 3810
City
Kharkiv
Country
Ukraine
Facility Name
Investigator Site 3801
City
Kiev
ZIP/Postal Code
02175
Country
Ukraine
Facility Name
Investigator Site 3805
City
Kiev
Country
Ukraine
Facility Name
Investigator Site 3808
City
Kiev
Country
Ukraine
Facility Name
Investigator Site 3811
City
Lviv
Country
Ukraine
Facility Name
Investigator Site 3813
City
Odessa
ZIP/Postal Code
65014
Country
Ukraine
Facility Name
Investigator Site 3815
City
Odessa
Country
Ukraine
Facility Name
Investigator Site 3814
City
Poltava
ZIP/Postal Code
36039
Country
Ukraine

12. IPD Sharing Statement

Citations:
PubMed Identifier
24247616
Citation
Nicholls SJ, Kastelein JJ, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig W, Jukema JW, Nambi V, Wright RS, Menon V, Lincoff AM, Nissen SE; VISTA-16 Investigators. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. JAMA. 2014 Jan 15;311(3):252-62. doi: 10.1001/jama.2013.282836.
Results Reference
derived

Learn more about this trial

VISTA-16 Trial: Evaluation of Safety and Efficacy of Short-term A-002 Treatment in Subjects With Acute Coronary Syndrome

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