The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children
Primary Purpose
HIV Infections, Varicella-zoster Virus
Status
Completed
Phase
Phase 4
Locations
Thailand
Study Type
Interventional
Intervention
VZV vaccination
Sponsored by
About this trial
This is an interventional prevention trial for HIV Infections focused on measuring varicella-zoster virus vaccine, varicella-zoster virus antibody, immunogenicity, safety and efficacy, HIV-infected children, Assess protective VZV Antibody, Adverse events from VZV vaccine
Eligibility Criteria
Inclusion Criteria:
- HIV-infected children.
- Aged between 1 to 15 years.
- CD4 T lymphocyte percentage ≥ 15% or ≥ 200 cell/ml within 6 months at time of enrollment.
- Written informed consent was obtained from each child's parent or guardian before enrollment.
- HIV-infected children who age more than 7 years old sign assent.
Exclusion Criteria:
- History of clinical varicella or zoster.
- History of exposure to VZV within 1 month before study entry.
- Received varicella vaccine.
- Received immunoglobulin or blood product within 3 months before study entry.
- Using oral steroid or immunosuppressive drugs within 3 months before study entry.
- History of hypersensitivity to vaccine component (Neomycin).
Sites / Locations
- Department of Pediatrics, Chulalongkorn University
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
1
Arm Description
Receive 1 course of VZV vaccine : 2 doses of vaccines with 3 months apart.
Outcomes
Primary Outcome Measures
Proportion of children with protective VZV Antibody in HIV infected children after 2 doses of VZV vaccine.
Secondary Outcome Measures
Adverse events from VZV vaccine.
Compare proportion of children who developed VZV antibody by baseline characteristics e.g. immune status, age, gender.
Full Information
NCT ID
NCT01138215
First Posted
June 4, 2010
Last Updated
July 15, 2020
Sponsor
The HIV Netherlands Australia Thailand Research Collaboration
Collaborators
Chulalongkorn University
1. Study Identification
Unique Protocol Identification Number
NCT01138215
Brief Title
The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children
Official Title
The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children
Study Type
Interventional
2. Study Status
Record Verification Date
July 2020
Overall Recruitment Status
Completed
Study Start Date
June 2009 (undefined)
Primary Completion Date
August 2009 (Actual)
Study Completion Date
August 2009 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
The HIV Netherlands Australia Thailand Research Collaboration
Collaborators
Chulalongkorn University
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
To study about the immunogenicity, safety and efficacy of varicella-zoster virus vaccine in HIV-infected children.
Detailed Description
VZV causes two clinical diseases, primary infection results in varicella (chickenpox) after which virus latent in dorsal root ganglion. Reactivation of VZV results in herpes zoster (shingles) about years or decades. Immunocompetent children, varicella generally mild self limiting illness. In HIV infected children, VZV is often more severe illness with progressive varicella characterized by continuing eruption of lesions and high fever persist into second weeks, as well as encephalitis, hepatitis and pneumonia can developed. Zoster in immunocompromised patient become disseminated with lesions appearing outsides primary dermatomes and with visceral complications and can cause recurrences of herpes zoster. VZV illness in patients with immunodeficiency disorders require admission to hospital and the use of antiviral drugs. Sometimes, antiviral drug fails in immunocompromised children. Passive immunization with varicella zoster-immunoglobulin (VZIG), administered within three days of exposure, is effective in preventing disease or in reducing severity of illness in susceptible immunocompromised persons. About half of the cases of varicella in immunocompromised children occur without a recognised exposure to VZV. Both severe and fatal varicella has been documented despite appropriate immunoprophylaxis withVZIG. Furthermore, VZIG is expensive and short supply. These limitations make passive immunization a less than optimum strategy for preventing chickenpox. Permanent protection provided by administering the vaccine to high-risk persons would be preferable.
Sartori AM., University of Sao Paolo in Sep 2004 found that after give two doses of the varicella vaccine in 41 susceptible HIV-infected childrens in CDC class N1 or A1. Seroconversion occurred in 53% and 60% of vaccines after one and two doses, respectively. No significant fall in CD4 T lymphocytes or increase in HIV viral load at eight weeks after vaccination.
Saro H. Armenian, University of Southern California in Nov 2005 administrated single dose of live varicella vaccine to 10 HIV infected children. After vaccination, positive VZV-LPA response was detected in 50% of patients at week 2 and 100% at week 4, remained positive in 90% at week 52. VZV IgG was detected in 11% at week 2, 67% at week 8, only 33% at week 52.
Myron J. Levin, University of Colorado in June 2006-2008 study about the safety and immunogenicity of vaccine in varicella-zoster virus (VZV) naive, HIV-infected children with moderate symptoms and/or more pronounced past or current decreases in CD4+ T cell counts. Recipients (97 children) were stratified into 3 groups : group I - CDC category 1 and immunologic category 1 (least affected group of HIV-infected children), group II - CDC category A, B, or N and immunologic category 2 (CD4% = 15-24), group III : CDC category C and/or immunologic category 3, but at least 3 months prior to vaccination, had achieved clinical category A or N and equivalent of immunologic category 1 (CD4% = 25). After 2 doses of vaccines , 79% of children developed VZV-specific antibody and/or CMI 2 months after vaccine and 83% were responders 1 year after vaccination. Bekker V., Emma Children's Hospital, Netherland in Nov 2006 administered 2 doses of varicella vaccine to 15 VZV-seronegative HIV-1 infected children (total lymphocyte counts > 700 lymphocytes/microl) and 6 HIV-negative VZV-seronegative. Only 60% of the HIV-1 infected children had VZV-specific Ab after two immunizations, where as 100% of the siblings seroconverted.
Thai HIV infected children usually start antiretroviral late due to limited access to care with more severe suppressed of immune status than children in developed countries. Moreover, VZV vaccine is not in the country guideline and still expensive. We would like to provide VZV prevention for this group of children and to evaluate the VZV antibody response in Thai HIV children after VZV vaccination.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
HIV Infections, Varicella-zoster Virus
Keywords
varicella-zoster virus vaccine, varicella-zoster virus antibody, immunogenicity, safety and efficacy, HIV-infected children, Assess protective VZV Antibody, Adverse events from VZV vaccine
7. Study Design
Primary Purpose
Prevention
Study Phase
Phase 4
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
60 (Actual)
8. Arms, Groups, and Interventions
Arm Title
1
Arm Type
Experimental
Arm Description
Receive 1 course of VZV vaccine : 2 doses of vaccines with 3 months apart.
Intervention Type
Biological
Intervention Name(s)
VZV vaccination
Intervention Description
Dose : 0.5 ml Route : subcutaneous injection (SC)
Primary Outcome Measure Information:
Title
Proportion of children with protective VZV Antibody in HIV infected children after 2 doses of VZV vaccine.
Time Frame
1 month after vaccine completion
Secondary Outcome Measure Information:
Title
Adverse events from VZV vaccine.
Time Frame
1 month after completion of vaccine
Title
Compare proportion of children who developed VZV antibody by baseline characteristics e.g. immune status, age, gender.
Time Frame
1 month after completion of vaccine
10. Eligibility
Sex
All
Minimum Age & Unit of Time
1 Year
Maximum Age & Unit of Time
15 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
HIV-infected children.
Aged between 1 to 15 years.
CD4 T lymphocyte percentage ≥ 15% or ≥ 200 cell/ml within 6 months at time of enrollment.
Written informed consent was obtained from each child's parent or guardian before enrollment.
HIV-infected children who age more than 7 years old sign assent.
Exclusion Criteria:
History of clinical varicella or zoster.
History of exposure to VZV within 1 month before study entry.
Received varicella vaccine.
Received immunoglobulin or blood product within 3 months before study entry.
Using oral steroid or immunosuppressive drugs within 3 months before study entry.
History of hypersensitivity to vaccine component (Neomycin).
Facility Information:
Facility Name
Department of Pediatrics, Chulalongkorn University
City
Bangkok
ZIP/Postal Code
10330
Country
Thailand
12. IPD Sharing Statement
Links:
URL
http://www.hivnat.org
Description
HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT)
Learn more about this trial
The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children
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