Study to Asses Efficacy of Intralymphatic Immunotherapy (ILIT)

The purpose of the study is to try a new route for specific immunotherapy (SIT). The current treatment form for SIT is subcutaneously (SCIT), which is a long treatment with up to 50 injections subcutaneously in the upper arm. The investigators believe that there is additional effect if the allergen is injected directly into the lymph node, since it is here, the allergen presentation is happening. The trial has been performed in Switzerland with significant effect of only three injections of grass-allergen into a lymph node (Clinicaltrials.gov; NCT00470457). The investigators would like to see what happens if the the dose is doubled, so the patients will receive 6 injections all in all, with the same amount of allergen as the earlier study (1000 SQ-U). Also the outcome measurements is slightly different as the patients will note their symptoms in a diary. The patients will be divided into three groups using allocation: 1 group with 6 injections of allergen 1 group with 3 injections of allergen and 3 injections of placebo 1 group with 6 injections of placebo. The trial will be double blinded.

3 injections of grass-allergen. Every dose will be 1000 SQ-U. Also 3 injections of placebo (physiological saline)

The patients will fill out a diary during the grasspollen-season before and after treatment. Also they will fill out a form for the general status of the season passed.

Inclusion Criteria: grass pollen allergy through at least 2 seasons positive skin prick test positive Specific IgE of at least 2. (CAP) Signed informed consent for females a negative pregnancy test. Exclusion Criteria: out of age limits rhinoconjunctivitis all year round. uncontrolled seasonal asthma patients treated with steroids continuously or beta-blockers. pregnancy and breastfeeding HIV, Hepatitis B+c, and other immunological diseases. psychiatric disease treatment with SCIT or SLIT within the last 5 years participation in other clinical trials within the last 3 months.