Efficacy and Safety of Sub-tenon Ranibizumab for Recurrent Pterygia
Primary Purpose
Pterygium
Status
Completed
Phase
Phase 1
Locations
United States
Study Type
Interventional
Intervention
Ranibizumab
Sponsored by
About this trial
This is an interventional treatment trial for Pterygium focused on measuring Pterygium
Eligibility Criteria
Inclusion Criteria:
Patients with actively growing pterygia, either surgical recurrences, or non-surgical primary lesions.
Exclusion Criteria:
- Pregnancy
- History of CVA
- Monocular patients
- Minors
Sites / Locations
- University of New Mexico Health Science Center
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Ranibizumab treatment
Arm Description
Patients will receive a sub-tenons injection of Ranibizumab 0.5mg, to be repeated twice with 30 day intervals between each dose.
Outcomes
Primary Outcome Measures
Safety
The following safety criteria will be monitored: subjective complaints, objective signs of inflammation, intraocular pressure, tear film and ocular surface integrity.
Secondary Outcome Measures
Regression of pterygium
Regression of the lesion will be determined by measurement if the horizontal extension of the lesion relative to the limbus, and by photographic comparison incorporating software analysis
Full Information
NCT ID
NCT01169909
First Posted
July 23, 2010
Last Updated
May 13, 2016
Sponsor
University of New Mexico
Collaborators
Genentech, Inc.
1. Study Identification
Unique Protocol Identification Number
NCT01169909
Brief Title
Efficacy and Safety of Sub-tenon Ranibizumab for Recurrent Pterygia
Official Title
The Use of Ranibizumab to Control Pterygium Growth in Recurrences and in Non-surgical Primary Lesions.
Study Type
Interventional
2. Study Status
Record Verification Date
May 2016
Overall Recruitment Status
Completed
Study Start Date
August 2010 (undefined)
Primary Completion Date
July 2014 (Actual)
Study Completion Date
July 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of New Mexico
Collaborators
Genentech, Inc.
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Ranibizumab, an effective antineovascular drug, will be studied for safety and efficacy in pterygium, a neovascular disorder of the ocular surface.
Detailed Description
Ptergyia are chronic fibrovascular lesions of the ocular surface. This study is designed to look for a signal of efficacy when the lesions are in a phase of active vascular growth. This phase is most often caught in a newly recurring pterygia post-operatively.
Patients identified with actively growing lesions, will be offered local injections directly beneath the lesions. They will be examined for any adverse side effects and regression of the lesion.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pterygium
Keywords
Pterygium
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 1
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
10 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Ranibizumab treatment
Arm Type
Experimental
Arm Description
Patients will receive a sub-tenons injection of Ranibizumab 0.5mg, to be repeated twice with 30 day intervals between each dose.
Intervention Type
Drug
Intervention Name(s)
Ranibizumab
Intervention Description
Subtenon injections of Ranibizumab 0.5mg will be given, and repeated twice with 30 day intervals between each dose. Note, after an amendment in February 2011, this dose was increased to 2mg with the same schedule.
Primary Outcome Measure Information:
Title
Safety
Description
The following safety criteria will be monitored: subjective complaints, objective signs of inflammation, intraocular pressure, tear film and ocular surface integrity.
Time Frame
Within the first 30 days after injection
Secondary Outcome Measure Information:
Title
Regression of pterygium
Description
Regression of the lesion will be determined by measurement if the horizontal extension of the lesion relative to the limbus, and by photographic comparison incorporating software analysis
Time Frame
Within 30 days after drug injection
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Patients with actively growing pterygia, either surgical recurrences, or non-surgical primary lesions.
Exclusion Criteria:
Pregnancy
History of CVA
Monocular patients
Minors
Facility Information:
Facility Name
University of New Mexico Health Science Center
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87106
Country
United States
12. IPD Sharing Statement
Learn more about this trial
Efficacy and Safety of Sub-tenon Ranibizumab for Recurrent Pterygia
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