Comparative Analysis of BioXtra on Xerostomia (BioXtra)
Radiation-Induced Xerostomia
About this trial
This is an interventional supportive care trial for Radiation-Induced Xerostomia focused on measuring Xerostomia, Radiotherapy of head and neck, BioXtra
Eligibility Criteria
Inclusion Criteria:
- complaint of xerostomia after head and neck radiotherapy
- patient must have given written informed consent
Exclusion Criteria:
- age under 18 years
- history of any treatment for cancer in the last 3 months
- recurrence of cancer and end stage of it
- diabetes mellitus
- sjogren syndrome or other medical causes of xerostomia
- drug therapy which might induce xerostomia
- refusal of cooperation or consent
Sites / Locations
- Qazvin University of Medical Sciences
Arms of the Study
Arm 1
Other
bioxtra spray and mouth rinse
Drug: BioXtra spray or mouth rinse Patients had been xerostomia due to radiation of head and neck were selected for the study. Gender, age, medical history, VAS, dichotomous questionnaire of xerostomia , and other treatment used for this disease were recorded. Local ethical committee approval was obtained before the trial started and all patients gave written informed consent. Patients were randomly divided into two groups .First group received BioXtra spray and second group used BioXtra mouth rinse for 2 weeks and then 1 weeks wash -out period and for other 2 weeks drugs is switched . Each patients was examined at the beginning of the therapy ,and then 2 weeks after therapy and 35 days after first visit.