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A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication

Primary Purpose

Type 2 Diabetes

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Dapagliflozin

Placebo matching Dapagliflozin

About this trial

This is an interventional treatment trial for Type 2 Diabetes focused on measuring Diabetes Mellitus, Type 2, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders, Metabolic Diseases, Angiotensin Receptor Inhibitors, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cardiovascular Agents, Pharmacological Actions

Eligibility Criteria

18 Years - 89 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Written informed consent
Males and females, 18 to 89 years old, with type 2 diabetes with inadequate glycemic control HbA1c between 7-10.5% and uncontrolled hypertension Systolic Blood Pressure (SBP) 140-165 and Diastolic Blood Pressure (DBP) 85-105
Subjects must have a mean 24 hr blood pressure ≥ 130/80 determined by Ambulatory Blood Pressure Monitoring (ABPM) within 1 week prior to Day 1 visit
Stable dose of oral antidiabetic agent (OAD) for at least 6 weeks [12 wks for Thiazolidinedione (TZD)] or a stable daily dose of insulin, as a monotherapy or in combination with another OAD, for 8 weeks, and a stable dose of ACEI or ARB and 1 additional antihypertensive medication for at least 4 weeks
C-peptide ≥ 0.8 ng/mL
Body Mass Index ≤ 45.0 kg/m2
Serum creatinine < 1.50 mg/dL for men or < 1.40 mg/dL for women

Exclusion Criteria:

Aspartate aminotransferase (AST) and /or Alanine aminotransferase (ALT) > 3.0*upper limit of normal (ULN)
Serum total bilirubin ≥ 1.5*ULN
Creatinine kinase > 3*ULN
Symptoms of severely uncontrolled diabetes
History of malignant or accelerated hypertension
Currently unstable or serious cardiovascular, renal, hepatic, hematological, oncological, endocrine, psychiatric, or rheumatic diseases

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Dapagliflozin 10 mg

Placebo matching Dapagliflozin

Arm Description

Dapagliflozin 10 mg tablets

Placebo tablets matching dapagliflozin tablets

Outcomes

Primary Outcome Measures

Adjusted Mean Change From Baseline in Seated Systolic Blood Pressure for 12 Week Double-Blind Treatment Period - Randomized Participants

Systolic blood pressure (SBP) was measured in millimeters of mercury (mmHg) on Day -1, Day 1, Weeks 2, 4, 8, and 12 of the Double Blind Period. Blood pressure (BP) values were obtained after the participant was seated for quietly for 10 minutes; a mean of 3 replicate measurements was taken at least 1 minute apart. However, if the 3 consecutive seated BP readings were not within 8 mm Hg of each other, an additional 2 BP readings were obtained (total = 5) and incorporated into the calculated mean. BP was measured in both arms. If the BP was higher in one arm than the other, then this arm was used; if no difference, the participant's dominant arm was used for all future BP measurements. Baseline was defined as the last assessment prior to the start date and time of the first dose of the double-blind study medication. Participants refrained from ingestion of caffeine, alcohol, or nicotine at least 10 hours prior to their visit and having their BP measured.

Adjusted Mean Change From Baseline in Hemoglobin A1c (HbA1c) for 12 Week Double-Blind Treatment Period - Randomized Participants

Adjusted mean change in glycosylated hemoglobin ( HbA1c) from baseline at Week 12 was calculated. HbA1c was measured as percent of hemoglobin by a central laboratory. Baseline was defined as the last assessment prior to the start date and time of the first dose of the double-blind study medication. HbA1c values were obtained at enrollment and lead-in (Day -28) periods, and at Day 1, Weeks 4, 8, and 12, in the double-blind period.

Secondary Outcome Measures

Adjusted Mean Change From Baseline in 24-hour Ambulatory Systolic Blood Pressure at Week 12 Last Observation Carried Forward (LOCF)

Ambulatory 24 hour (hr) blood pressure monitoring (ABPM) was performed at baseline, which was during the lead-in period (between Day -7 and Day -1 prior to randomization) and 1 week prior to the Week 12 visit/end of treatment visit. If no Week 12 measurement was available, the last available earlier post-baseline measurement was used (LOCF) for analysis. Initiation of the 24-hr ABPM began between 6am and 11am to ensure trough BP measurements were obtained.The ABPM units were calibrated, and used per the manufacturer's and central ABPM vendor instructions. BP was measured in mmHg. Participants had to have a mean 24-hour ABPM ≥ 130/80 mmHg prior to randomization. All medication was withheld on the morning of the study visit and brought to the visit site by the participant. Once the ABPM cuff was in place, all morning medication was taken while at the site.

Adjusted Mean Change From Baseline in Seated Diastolic Blood Pressure (DBP) for 12 Week Double-Blind Treatment Period - Randomized Participants

Diastolic BP was measured in millimeters of mercury (mmHg) on Day -1, Day 1, Weeks 2, 4, 8, and 12 of the Double Blind Period. Diastolic BP values were obtained after the participant was seated for quietly for 10 minutes; a mean of 3 replicate measurements was taken at least 1 minute apart. However, if the 3 consecutive seated BP readings were not within 8 mm Hg of each other, an additional 2 BP readings were obtained (total = 5) and incorporated into the calculated mean. BP was measured in both arms. If the pressure was higher in one arm than the other, then this arm was used; if no difference, the participant's dominant arm was used for all future BP measurements. Baseline was defined as the last assessment prior to the start date and time of the first dose of the double-blind study medication. Participants refrained from ingestion of caffeine, alcohol, or nicotine at least 10 hours prior to their visit and having their BP measured.

Adjusted Mean Change From Baseline in 24-hr Ambulatory Diastolic Blood Pressure at Week 12 (LOCF)

Ambulatory 24 hour (hr) BP monitoring (ABPM) was performed at baseline, which was during the lead-in period (between Day -7 and Day -1 prior to randomization) and 1 week prior to the Week 12 visit/end of treatment visit. If no Week 12 measurement was available, the last available earlier post-baseline measurement was used (LOCF). Initiation of the 24-hr ABPM began between 6am and 11am to ensure trough BP measurements were obtained. The ABPM units were calibrated, and used per the manufacturer's and central ABPM vendor instructions. BP was measured in mmHg. Participants had to have a mean 24-hour ABPM ≥ 130/80 mmHg prior to randomization. All medication was withheld on the morning of the study visit and brought to the visit site by the participant. Once the ABPM cuff was in place, all morning medication was taken while at the site.

Adjusted Mean Change From Baseline in Serum Uric Acid at Week 12 in Double-Blind Treatment Period - Randomized Participants

Adjusted mean change in serum uric acid from baseline at Week 12 was calculated. Serum uric acid was measured in milligrams per deciliter (mg/dL) by a central laboratory. Baseline was defined as the last assessment prior to the start date and time of the first dose of the double-blind study medication. Serum uric acid measurements were obtained at qualification and lead-in (Day -28) periods, and at Day 1, Weeks 4, 8, and 12, in the double-blind period but only the change from baseline at Week 12 was considered a secondary endpoint and is presented.

Number of Participants With Deaths,Serious Adverse Events (SAEs), Adverse Events (AEs), Hypoglycemia Events, Discontinuation Due to AEs, SAEs and Hypoglycemia, During the 12 Week Double Blind Period, Including Data After Rescue

Medical Dictionary for Regulatory Activities (MedDRA), version 15.1 AE=any new unfavorable symptom, sign, or disease or worsening of a preexisting condition that may not have a causal relationship with treatment. SAE=a medical event that at any dose results in death, persistent or significant disability/incapacity, or drug dependency/abuse; is life-threatening, an important medical event, or a congenital anomaly/birth defect; or requires or prolongs hospitalization. Related=having certain, probable, possible, or missing relationship to study drug as per the investigator. Events captured from baseline to last double blind dose plus 4 days for AEs, plus 30 days for SAEs during the Double Blind 12 Week Period. Only hypoglycemia reported as an SAE is included in AE/SAE categories . All reported hypoglycemia events within 4 days of last day of treatment are included as hypoglycemic events.

Number of Participants With Marked Chemistry Laboratory Abnormalities in 12 Week Double Blind Treatment Period, Including Data After Rescue

Samples obtained: Day 1, Weeks 4, 8,12 in Double Blind Period. Baseline: last assessment prior to start of first dose of double-blind treatment. Pretreatment (PreRX); grams per deciliter (g/dL); upper limit of normal (ULN); milliequivalent per liter (mEq/L); greater than (>) less than (<); Units per liter (U/L), Marked abnormality Low (High): hemoglobin <6 (>18 females or >20 males) g/dL; creatinine (>=1.5*preRX, >=2.5 mg/dL); glucose < 54 or (> 350) mg/dL; albumin <= 2 or (> 6) g/dL; creatine kinase >5*ULN; albumin/creatinine ratio (>1800 mg/G); calcium <7.5 (>1 and >0.5 from PreRX) mg/dL; bicarbonate <=13 meq/dL; potassium <=2.5 (>6) meq/L; magnesium <1 (>4) mEq/L; sodium < 130 mEq/L (>150 mEq/L; phosphorus (>=5.6 mg/dL age 17-65, >=5.1 is >=66 years); Albumin/creatinine ratio (>1800 mg/g). Note: Hepatic tests are presented separately in next outcome measure.

Number of Participants With Elevated Liver Laboratory Tests in Participants Treated With Double Blind 10 mg Dapagliflozin or Placebo , Including Data After Rescue

Laboratories were obtained at Day 1, Weeks 4, 8 and 12 in the Double Blind Period. Baseline: last assessment prior to start of first dose of double-blind treatment. Includes laboratory values measured after the first date of double-blind treatment and up to and including the last day of double blind treatment plus 30 days. Upper limit of normal (ULN);, alanine aminotransferase (ALT); aspartate aminotransferase (AST); alkaline phosphatase (ALP). Marked abnormality (High): AST and ALT (>3*ULN); ALP (>1.5*ULN); bilirubin (>1.5*ULN). Participants with abnormally elevated liver laboratory tests were followed 30 days after the last dose of study drug.

Number of Participants With Normal or Abnormal Electrocardiogram Summary Tracing at Week 12 (LOCF), Including Data After Rescue

12-Lead electrocardiograms (ECGs) were performed at Enrollment, Day 1 of Double Blind Period and Week 12/End of treatment visit (last observation carried forward) on participants who were supine. ECGs were assessed by the investigator as normal or abnormal. Baseline (BL) was Day 1 prior to dosing or last observation prior to dosing.

Proportion of Participants With Orthostatic Hypotension at Baseline and Week 12, Including Data After Rescue

Orthostatic hypotension was defined as a decrease from supine to standing of > 20 mmHg in systolic BP or >10 mmHg in diastolic BP. Proportion was calculated from number of participants with orthostatic hypotension (n) divided by the number of treated participants (N). n/N presented as a percent (%). Baseline was Day 1 of the double blind Period. Measurements for orthostatic hypotension were taken on Day 1 and at Week 12 visit and does not reflect AEs reported by the investigator.

Full Information

NCT ID

NCT01195662

First Posted

September 3, 2010

Last Updated

November 10, 2016

Sponsor

AstraZeneca

Collaborators

Bristol-Myers Squibb

1. Study Identification

Unique Protocol Identification Number

NCT01195662

Brief Title

A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication

Official Title

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Dapagliflozin in Subjects With Type 2 Diabetes With Inadequately Controlled Hypertension on an Angiotensin-Converting Enzyme (ACE) Inhibitor or Angiotensin Receptor Blocker (ARB) and an Additional Antihypertensive Medication

Study Type

Interventional

2. Study Status

Record Verification Date

December 2015

Overall Recruitment Status

Completed

Study Start Date

October 2010 (undefined)

Primary Completion Date

February 2013 (Actual)

Study Completion Date

February 2013 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

Collaborators

Bristol-Myers Squibb

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The purpose of this study is to learn if BMS-512148 (Dapagliflozin), after 12 weeks, can improve (decrease) blood pressure in patients with type 2 diabetes with uncontrolled hypertension who are on an Angiotensin-converting enzyme inhibitor (ACEI) or an Angiotensin Receptor Blocker (ARB).The safety of this treatment will also be studied

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Type 2 Diabetes

Keywords

Diabetes Mellitus, Type 2, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders, Metabolic Diseases, Angiotensin Receptor Inhibitors, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cardiovascular Agents, Pharmacological Actions

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigator

Allocation

Randomized

Enrollment

2245 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Dapagliflozin 10 mg

Arm Type

Experimental

Arm Description

Dapagliflozin 10 mg tablets

Arm Title

Placebo matching Dapagliflozin

Arm Type

Placebo Comparator

Arm Description

Placebo tablets matching dapagliflozin tablets

Intervention Type

Drug

Intervention Name(s)

Dapagliflozin

Other Intervention Name(s)

BMS-512148, Farxiga™

Intervention Description

Tablets, Oral, 10 mg, once daily, Up to 12 weeks

Intervention Type

Drug

Intervention Name(s)

Placebo matching Dapagliflozin

Intervention Description

Tablets, Oral, 0 mg, once daily, Up to 12 weeks

Primary Outcome Measure Information:

Title

Adjusted Mean Change From Baseline in Seated Systolic Blood Pressure for 12 Week Double-Blind Treatment Period - Randomized Participants

Description

Time Frame

Baseline to Week 12

Title

Adjusted Mean Change From Baseline in Hemoglobin A1c (HbA1c) for 12 Week Double-Blind Treatment Period - Randomized Participants

Description

Time Frame

Baseline to Week 12

Secondary Outcome Measure Information:

Title

Adjusted Mean Change From Baseline in 24-hour Ambulatory Systolic Blood Pressure at Week 12 Last Observation Carried Forward (LOCF)

Description

Time Frame

Baseline, Week 12

Title

Adjusted Mean Change From Baseline in Seated Diastolic Blood Pressure (DBP) for 12 Week Double-Blind Treatment Period - Randomized Participants

Description

Time Frame

Baseline to Week 12

Title

Adjusted Mean Change From Baseline in 24-hr Ambulatory Diastolic Blood Pressure at Week 12 (LOCF)

Description

Time Frame

Baseline, Week 12

Title

Adjusted Mean Change From Baseline in Serum Uric Acid at Week 12 in Double-Blind Treatment Period - Randomized Participants

Description

Time Frame

Baseline, Week 12

Title

Description

Time Frame

Baseline to last dose of 12 weeks of double blind medication plus 30 days if SAE or plus 4 days if AE/hypoglycemic event

Title

Number of Participants With Marked Chemistry Laboratory Abnormalities in 12 Week Double Blind Treatment Period, Including Data After Rescue

Description

Time Frame

Baseline (Day 1) to last dose double blind medication (Week 12) plus 4 days

Title

Number of Participants With Elevated Liver Laboratory Tests in Participants Treated With Double Blind 10 mg Dapagliflozin or Placebo , Including Data After Rescue

Description

Time Frame

Baseline (Day 1) to last dose double blind medication (Week 12) Plus 30 days

Title

Number of Participants With Normal or Abnormal Electrocardiogram Summary Tracing at Week 12 (LOCF), Including Data After Rescue

Description

Time Frame

Baseline, Week 12

Title

Proportion of Participants With Orthostatic Hypotension at Baseline and Week 12, Including Data After Rescue

Description

Time Frame

Baseline (Day 1), Week 12

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

89 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Written informed consent Males and females, 18 to 89 years old, with type 2 diabetes with inadequate glycemic control HbA1c between 7-10.5% and uncontrolled hypertension Systolic Blood Pressure (SBP) 140-165 and Diastolic Blood Pressure (DBP) 85-105 Subjects must have a mean 24 hr blood pressure ≥ 130/80 determined by Ambulatory Blood Pressure Monitoring (ABPM) within 1 week prior to Day 1 visit Stable dose of oral antidiabetic agent (OAD) for at least 6 weeks [12 wks for Thiazolidinedione (TZD)] or a stable daily dose of insulin, as a monotherapy or in combination with another OAD, for 8 weeks, and a stable dose of ACEI or ARB and 1 additional antihypertensive medication for at least 4 weeks C-peptide ≥ 0.8 ng/mL Body Mass Index ≤ 45.0 kg/m2 Serum creatinine < 1.50 mg/dL for men or < 1.40 mg/dL for women Exclusion Criteria: Aspartate aminotransferase (AST) and /or Alanine aminotransferase (ALT) > 3.0*upper limit of normal (ULN) Serum total bilirubin ≥ 1.5*ULN Creatinine kinase > 3*ULN Symptoms of severely uncontrolled diabetes History of malignant or accelerated hypertension Currently unstable or serious cardiovascular, renal, hepatic, hematological, oncological, endocrine, psychiatric, or rheumatic diseases

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Bristol-Myers Squibb

Organizational Affiliation

Bristol-Myers Squibb

Official's Role

Study Director

Facility Information:

Facility Name

University Of Alabama At Birmingham

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35294

Country

United States

Facility Name

Medical Affiliated Research Center, Inc.

City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35801

Country

United States

Facility Name

Wilmax Clinical Research, Inc.

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36608

Country

United States

Facility Name

43rd Medical Associates

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85051

Country

United States

Facility Name

Central Phoenix Medical Center

City

Tempe

State/Province

Arizona

ZIP/Postal Code

85282

Country

United States

Facility Name

Clinical Research Advantage, Inc./Mesa Family Med Ctr, Pc

City

Tempe

State/Province

Arizona

ZIP/Postal Code

85282

Country

United States

Facility Name

Clinical Research Advantage/Desert Clinical Research

City

Tempe

State/Province

Arizona

ZIP/Postal Code

85282

Country

United States

Facility Name

Visions Clinical Research - Tucson

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85712

Country

United States

Facility Name

Eclipse Clinical Research

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85745

Country

United States

Facility Name

Aureus Research, Inc.

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72211

Country

United States

Facility Name

Preferred Research Partners, Inc.

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72211

Country

United States

Facility Name

Cmp Research

City

Anaheim

State/Province

California

ZIP/Postal Code

92805

Country

United States

Facility Name

Catalina Research Institute, Llc

City

Chino

State/Province

California

ZIP/Postal Code

91710

Country

United States

Facility Name

Southland Clinical Research Center, Inc.

City

Fountain Valley

State/Province

California

ZIP/Postal Code

92708

Country

United States

Facility Name

Marin Endocrine Care & Research, Inc.

City

Greenbrae

State/Province

California

ZIP/Postal Code

94904

Country

United States

Facility Name

Del Rosario Medical Clinic, Inc.

City

Huntington Park

State/Province

California

ZIP/Postal Code

90255

Country

United States

Facility Name

Time Clinical Research Inc.

City

Huntington Park

State/Province

California

ZIP/Postal Code

90255

Country

United States

Facility Name

Clinica Medica San Miguel

City

Los Angeles

State/Province

California

ZIP/Postal Code

90015

Country

United States

Facility Name

American Institute Of Research

City

Los Angeles

State/Province

California

ZIP/Postal Code

90017

Country

United States

Facility Name

Randall G. Shue, D.O.

City

Los Angeles

State/Province

California

ZIP/Postal Code

90023

Country

United States

Facility Name

Mcs Clinical Trials

City

Los Angeles

State/Province

California

ZIP/Postal Code

90057

Country

United States

Facility Name

National Research Inst

City

Los Angeles

State/Province

California

ZIP/Postal Code

90057

Country

United States

Facility Name

Diabetes Medical Center Of California

City

Northridge

State/Province

California

ZIP/Postal Code

91325

Country

United States

Facility Name

Valley Clinical Trials

City

Northridge

State/Province

California

ZIP/Postal Code

91325

Country

United States

Facility Name

Lucita M. Cruz,Md.,Inc.

City

Norwalk

State/Province

California

ZIP/Postal Code

90650

Country

United States

Facility Name

Sds Clinical Trials

City

Orange

State/Province

California

ZIP/Postal Code

92868

Country

United States

Facility Name

Bayview Research Group, Llc

City

Paramount

State/Province

California

ZIP/Postal Code

90723

Country

United States

Facility Name

San Diego Managed Care Group

City

Poway

State/Province

California

ZIP/Postal Code

92064

Country

United States

Facility Name

Integrated Research Group, Inc.

City

Riverside

State/Province

California

ZIP/Postal Code

92506

Country

United States

Facility Name

Quality Control Research, Inc

City

Sacramento

State/Province

California

ZIP/Postal Code

95842

Country

United States

Facility Name

Wetlin Research Associates, Inc.

City

San Diego

State/Province

California

ZIP/Postal Code

92120

Country

United States

Facility Name

Crest Clinical Trials, Inc.

City

Santa Ana

State/Province

California

ZIP/Postal Code

92701

Country

United States

Facility Name

Neurological Research Institute

City

Santa Monica

State/Province

California

ZIP/Postal Code

90404

Country

United States

Facility Name

Orrin M. Troum, Md And Medical Associates

City

Santa Monica

State/Province

California

ZIP/Postal Code

90404

Country

United States

Facility Name

Torrance Clinical Research

City

Torrance

State/Province

California

ZIP/Postal Code

90505

Country

United States

Facility Name

Orange County Research Center

City

Tustin

State/Province

California

ZIP/Postal Code

92780

Country

United States

Facility Name

University Clinical Investigators, Inc.

City

Tustin

State/Province

California

ZIP/Postal Code

92780

Country

United States

Facility Name

Chase Medical Research, Llc

City

Waterbury

State/Province

Connecticut

ZIP/Postal Code

06708

Country

United States

Facility Name

Christiana Care Health Services, Inc

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Zasa Clinical Research

City

Boynton Beach

State/Province

Florida

ZIP/Postal Code

33472

Country

United States

Facility Name

Bradenton Research Center, Inc.

City

Bradenton

State/Province

Florida

ZIP/Postal Code

34205

Country

United States

Facility Name

Innovative Research Of West Florida, Inc

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33756

Country

United States

Facility Name

Clinical Research Of South Florida

City

Coral Gables

State/Province

Florida

ZIP/Postal Code

33134

Country

United States

Facility Name

Avail Clinical Research, Llc

City

Deland

State/Province

Florida

ZIP/Postal Code

32720

Country

United States

Facility Name

International Research Associates, Llc

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33012

Country

United States

Facility Name

Palm Springs Research Institute

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33012

Country

United States

Facility Name

The Community Research Of South Florida

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33016

Country

United States

Facility Name

Central Florida Internists

City

Kissimmee

State/Province

Florida

ZIP/Postal Code

34741

Country

United States

Facility Name

Newphase Clinical Trials, Inc.

City

Miami Beach

State/Province

Florida

ZIP/Postal Code

33140

Country

United States

Facility Name

Ocean Blue Medical Research Center, Inc.

City

Miami Springs

State/Province

Florida

ZIP/Postal Code

33166

Country

United States

Facility Name

Flcri Global Research, Llc

City

Miami

State/Province

Florida

ZIP/Postal Code

33125

Country

United States

Facility Name

Clinical Research Of Miami, Inc.

City

Miami

State/Province

Florida

ZIP/Postal Code

33126

Country

United States

Facility Name

Pharmax Research Clinic, Inc.

City

Miami

State/Province

Florida

ZIP/Postal Code

33126

Country

United States

Facility Name

Apf Research, Llc

City

Miami

State/Province

Florida

ZIP/Postal Code

33135

Country

United States

Facility Name

Community Research Foundation, Inc.

City

Miami

State/Province

Florida

ZIP/Postal Code

33155

Country

United States

Facility Name

Baptist Diabetes Associates, Pa

City

Miami

State/Province

Florida

ZIP/Postal Code

33156

Country

United States

Facility Name

Suncoast Clinical Research, Inc.

City

New Port Richey

State/Province

Florida

ZIP/Postal Code

34652

Country

United States

Facility Name

Florida Institute For Clinical Research, Llc

City

Orlando

State/Province

Florida

ZIP/Postal Code

32822

Country

United States

Facility Name

Michele A. Morrison Internal Medicine, Inc.

City

Pembroke Pines

State/Province

Florida

ZIP/Postal Code

33026

Country

United States

Facility Name

Medsol Clinical Research Center

City

Port Charlotte

State/Province

Florida

ZIP/Postal Code

33952

Country

United States

Facility Name

Meridien Research

City

Tampa

State/Province

Florida

ZIP/Postal Code

33606

Country

United States

Facility Name

Perimeter Institute For Clinical Research

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30338

Country

United States

Facility Name

Bainbridge Medical Associates

City

Bainbridge

State/Province

Georgia

ZIP/Postal Code

39819

Country

United States

Facility Name

River Birch Research Alliance, Llc

City

Blue Ridge

State/Province

Georgia

ZIP/Postal Code

30513

Country

United States

Facility Name

In-Quest Medical Research, Llc

City

Duluth

State/Province

Georgia

ZIP/Postal Code

30096

Country

United States

Facility Name

Middle Georgia Drug Study Center, Llc

City

Perry

State/Province

Georgia

ZIP/Postal Code

31069

Country

United States

Facility Name

Cedar Crosse Research Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60607

Country

United States

Facility Name

So. Illinois Clin Res Ctr @ Div Of Kevin L Pritchett Md, Pc

City

O?Fallon

State/Province

Illinois

ZIP/Postal Code

62269

Country

United States

Facility Name

Springfield Diabetes And Endocrine Center

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62704

Country

United States

Facility Name

American Health Network Of Indiana Llc

City

Avon

State/Province

Indiana

ZIP/Postal Code

46123

Country

United States

Facility Name

Investigators Research Group, Llc

City

Brownsburg

State/Province

Indiana

ZIP/Postal Code

46112

Country

United States

Facility Name

American Health Network Of In Llc

City

Franklin

State/Province

Indiana

ZIP/Postal Code

46131

Country

United States

Facility Name

Laporte County Institute For Clinical Research, Inc.

City

Michigan City

State/Province

Indiana

ZIP/Postal Code

46360

Country

United States

Facility Name

American Health Network Of In Llc

City

Muncie

State/Province

Indiana

ZIP/Postal Code

47304

Country

United States

Facility Name

Medical Development Centers, Llc

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70808

Country

United States

Facility Name

Omega Clinical Research, Llc

City

Metairie

State/Province

Louisiana

ZIP/Postal Code

70006

Country

United States

Facility Name

Acadia Clinical Research, Llc

City

Bangor

State/Province

Maine

ZIP/Postal Code

04401

Country

United States

Facility Name

Alternative Primary Care

City

Silver Spring

State/Province

Maryland

ZIP/Postal Code

20910

Country

United States

Facility Name

Hci-Metromedic Walk-In Medical Office

City

New Bedford

State/Province

Massachusetts

ZIP/Postal Code

02740

Country

United States

Facility Name

Neurocare, Inc.

City

Newton

State/Province

Massachusetts

ZIP/Postal Code

02459

Country

United States

Facility Name

Atlantic Clinical Trials, Llc

City

Watertown

State/Province

Massachusetts

ZIP/Postal Code

02472

Country

United States

Facility Name

Providence Park Clinical Research

City

Novi

State/Province

Michigan

ZIP/Postal Code

48374

Country

United States

Facility Name

The Center For Clinical Trials

City

Biloxi

State/Province

Mississippi

ZIP/Postal Code

39531

Country

United States

Facility Name

Phillips Medical Services, Pllc

City

Jackson

State/Province

Mississippi

ZIP/Postal Code

39209

Country

United States

Facility Name

Jefferson City Medical Group

City

Jefferson City

State/Province

Missouri

ZIP/Postal Code

65109

Country

United States

Facility Name

Kcumb Dybedal Clinical Research Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64106

Country

United States

Facility Name

Clin Research Advantage, Inc. James Meli, Do Family Pracice

City

Henderson

State/Province

Nevada

ZIP/Postal Code

89014

Country

United States

Facility Name

Office Of Ted Thorp, Md

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89102

Country

United States

Facility Name

Independent Clinical Researchers@ Wolfson Medical Center

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89103

Country

United States

Facility Name

Clinical Research Advantage, Inc.

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89128

Country

United States

Facility Name

Palm Medical Research Center

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89148

Country

United States

Facility Name

Comprehensive Clinical Research

City

Berlin

State/Province

New Jersey

ZIP/Postal Code

08009

Country

United States

Facility Name

Premier Research

City

Trenton

State/Province

New Jersey

ZIP/Postal Code

08611

Country

United States

Facility Name

Medex Healthcare Research, Inc.

City

New York

State/Province

New York

ZIP/Postal Code

10022

Country

United States

Facility Name

Digiovanna Institute For Medical Education & Research

City

North Massapequa

State/Province

New York

ZIP/Postal Code

11758

Country

United States

Facility Name

Southgate Medical Group

City

West Seneca

State/Province

New York

ZIP/Postal Code

14224

Country

United States

Facility Name

Diabetes & Endocrinology Consultants

City

Morehead City

State/Province

North Carolina

ZIP/Postal Code

28557

Country

United States

Facility Name

Burke Primary Care

City

Morganton

State/Province

North Carolina

ZIP/Postal Code

28655

Country

United States

Facility Name

Lillestol Research

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58103

Country

United States

Facility Name

Community Health Care, Inc.

City

Canal Fulton

State/Province

Ohio

ZIP/Postal Code

44614

Country

United States

Facility Name

Community Research

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45227

Country

United States

Facility Name

Parsons Avenue Medical Clinical

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43207

Country

United States

Facility Name

Clinical Research Source, Inc

City

Perrysburg

State/Province

Ohio

ZIP/Postal Code

43551

Country

United States

Facility Name

Sooner Clinical Research

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73112

Country

United States

Facility Name

Integris Family Care Yukon

City

Yukon

State/Province

Oklahoma

ZIP/Postal Code

73099

Country

United States

Facility Name

Willamette Valley Clinical Studies

City

Eugene

State/Province

Oregon

ZIP/Postal Code

97404

Country

United States

Facility Name

Southeastern Pa Medical Institute

City

Broomall

State/Province

Pennsylvania

ZIP/Postal Code

19008

Country

United States

Facility Name

Abington Memorial Hos/Feasterville Family Health Care Center

City

Feasterville

State/Province

Pennsylvania

ZIP/Postal Code

19053

Country

United States

Facility Name

The Clinical Trial Center, Llc

City

Jenkintown

State/Province

Pennsylvania

ZIP/Postal Code

19046

Country

United States

Facility Name

Arcuri Clinical Research Llc

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19142

Country

United States

Facility Name

Philadelphia Health Associates - Adult Medicine

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19146

Country

United States

Facility Name

Research Across America

City

Reading

State/Province

Pennsylvania

ZIP/Postal Code

19606

Country

United States

Facility Name

Pish Medical Associates

City

Uniontown

State/Province

Pennsylvania

ZIP/Postal Code

15401

Country

United States

Facility Name

Greater Providence Clinical Research, Llc

City

Warwick

State/Province

Rhode Island

ZIP/Postal Code

02888

Country

United States

Facility Name

Medical Research South

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29407

Country

United States

Facility Name

Southeastern Research Associates, Inc.

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

North Myrtle Beach Family Practice

City

North Myrtle Beach

State/Province

South Carolina

ZIP/Postal Code

29582

Country

United States

Facility Name

Pawleys Pediatrics And Adult Medicine

City

Pawleys Island

State/Province

South Carolina

ZIP/Postal Code

29585

Country

United States

Facility Name

Hillcrest Clinical Reseach, Llc

City

Simpsonville

State/Province

South Carolina

ZIP/Postal Code

29681

Country

United States

Facility Name

Palmetto Clinical Research

City

Summerville

State/Province

South Carolina

ZIP/Postal Code

29485

Country

United States

Facility Name

Southwind Medical Specialists

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38125

Country

United States

Facility Name

Tn Medical Research

City

Spring Hill

State/Province

Tennessee

ZIP/Postal Code

37174

Country

United States

Facility Name

Arlington Family Research Center, Inc.

City

Arlington

State/Province

Texas

ZIP/Postal Code

76012

Country

United States

Facility Name

3rd Coast Research Associates

City

Corpus Christi

State/Province

Texas

ZIP/Postal Code

78414

Country

United States

Facility Name

Krk Medical Research

City

Dallas

State/Province

Texas

ZIP/Postal Code

75230

Country

United States

Facility Name

Research Institute Of Dallas

City

Dallas

State/Province

Texas

ZIP/Postal Code

75231

Country

United States

Facility Name

Internal Medicine Clinical Reaseach

City

Dallas

State/Province

Texas

ZIP/Postal Code

75235

Country

United States

Facility Name

Renaissance Clinical Research And Hypertension Pllc

City

Dallas

State/Province

Texas

ZIP/Postal Code

75235

Country

United States

Facility Name

Sergio F. Rovner, M.D.

City

El Paso

State/Province

Texas

ZIP/Postal Code

79925

Country

United States

Facility Name

Pioneer Research Solutions, Inc.

City

Houston

State/Province

Texas

ZIP/Postal Code

77008

Country

United States

Facility Name

Village Family Practice

City

Houston

State/Province

Texas

ZIP/Postal Code

77024

Country

United States

Facility Name

Dependable Clinical Research, Llc

City

Houston

State/Province

Texas

ZIP/Postal Code

77074

Country

United States

Facility Name

Southwest Clinical Trials

City

Houston

State/Province

Texas

ZIP/Postal Code

77074

Country

United States

Facility Name

Bellaire Medical Care Group

City

Houston

State/Province

Texas

ZIP/Postal Code

77081

Country

United States

Facility Name

Excel Clinical Research, Llc

City

Houston

State/Province

Texas

ZIP/Postal Code

77081

Country

United States

Facility Name

Hill Country Medical Associates

City

New Braunfels

State/Province

Texas

ZIP/Postal Code

78130

Country

United States

Facility Name

North Hills Medical Research, Inc.

City

North Richland Hills

State/Province

Texas

ZIP/Postal Code

76180

Country

United States

Facility Name

Med-Olam Clinical Research

City

Pasadena

State/Province

Texas

ZIP/Postal Code

77504

Country

United States

Facility Name

Lisa E. Medwedeff, Md, Pa

City

Plano

State/Province

Texas

ZIP/Postal Code

75024

Country

United States

Facility Name

Sun Research Institute

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78215

Country

United States

Facility Name

Abbott Clinical Research Group, Inc.

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78224

Country

United States

Facility Name

Covenant Clinical Research, Pa

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Innovative Clinical Trials

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Breco Research, Ltd

City

Sugarland

State/Province

Texas

ZIP/Postal Code

77479

Country

United States

Facility Name

Exodus Healthcare Network

City

Magna

State/Province

Utah

ZIP/Postal Code

84044

Country

United States

Facility Name

Wasatch Endocrinology And Diabetes Specialists

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84102

Country

United States

Facility Name

Wasatch Clinical Research

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84107

Country

United States

Facility Name

Alexandria Health Care Center

City

Alexandria

State/Province

Virginia

ZIP/Postal Code

22314

Country

United States

Facility Name

Millennium Clinical Trials Llc

City

Arlington

State/Province

Virginia

ZIP/Postal Code

22203

Country

United States

Facility Name

Burke Internal Medicine And Research

City

Burke

State/Province

Virginia

ZIP/Postal Code

22015

Country

United States

Facility Name

Manassas Clinical Research Center

City

Manassas

State/Province

Virginia

ZIP/Postal Code

20110

Country

United States

Facility Name

Hampton Roads Center For Clinical Research, Inc.

City

Suffolk

State/Province

Virginia

ZIP/Postal Code

23435

Country

United States

Facility Name

Larry D. Stonesifer, Md

City

Federal Way

State/Province

Washington

ZIP/Postal Code

98003

Country

United States

Facility Name

Sound Medical Research

City

Port Orchard

State/Province

Washington

ZIP/Postal Code

98366

Country

United States

Facility Name

Clinical Investigation Specialists, Inc.

City

Kenosha

State/Province

Wisconsin

ZIP/Postal Code

53142

Country

United States

Facility Name

Local Institution

City

Camperdown

State/Province

New South Wales

ZIP/Postal Code

2050

Country

Australia

Facility Name

Local Institution

City

Heidelberg

State/Province

Victoria

ZIP/Postal Code

3081

Country

Australia

Facility Name

Local Institution

City

Nedlands

State/Province

Western Australia

ZIP/Postal Code

6009

Country

Australia

Facility Name

Local Institution

City

Kelowona

State/Province

British Columbia

ZIP/Postal Code

V1Y 3G8

Country

Canada

Facility Name

Local Institution

City

Victoria

State/Province

British Columbia

ZIP/Postal Code

V8V 3N7

Country

Canada

Facility Name

Local Institution

City

Monction

State/Province

New Brunswick

ZIP/Postal Code

E1G 1A7

Country

Canada

Facility Name

Local Institution

City

Brampton

State/Province

Ontario

ZIP/Postal Code

L6T 3J1

Country

Canada

Facility Name

Local Institution

City

Granby

State/Province

Quebec

ZIP/Postal Code

J2G 8Z9

Country

Canada

Facility Name

Local Institution

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H2R 1V6

Country

Canada

Facility Name

Local Institution

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7K 3H3

Country

Canada

Facility Name

Local Institution

City

Armenia

State/Province

Quindio

ZIP/Postal Code

0000

Country

Colombia

Facility Name

Local Institution

City

Bucaramanga

State/Province

Santander

ZIP/Postal Code

0000

Country

Colombia

Facility Name

Local Institution

City

Barranquilla

ZIP/Postal Code

0000

Country

Colombia

Facility Name

Local Institution

City

Barranquilla

Country

Colombia

Facility Name

Local Institution

City

Bogota

ZIP/Postal Code

0000

Country

Colombia

Facility Name

Local Institution

City

Beroun

ZIP/Postal Code

266 01

Country

Czech Republic

Facility Name

Local Institution

City

Cheb

ZIP/Postal Code

350 02

Country

Czech Republic

Facility Name

Local Institution

City

Havirov

ZIP/Postal Code

736 01

Country

Czech Republic

Facility Name

Local Institution

City

Krnov

ZIP/Postal Code

794 01

Country

Czech Republic

Facility Name

Local Institution

City

Liberec

ZIP/Postal Code

460 01

Country

Czech Republic

Facility Name

Local Institution

City

Ostrava

ZIP/Postal Code

702 00

Country

Czech Republic

Facility Name

Local Institution

City

Prague 1

ZIP/Postal Code

116 94

Country

Czech Republic

Facility Name

Local Institution

City

Praha 4

ZIP/Postal Code

149 00

Country

Czech Republic

Facility Name

Local Institution

City

Copenhagen

ZIP/Postal Code

DK 2400

Country

Denmark

Facility Name

Local Institution

City

Frederiksberg

ZIP/Postal Code

2000

Country

Denmark

Facility Name

Local Institution

City

Gentofte

ZIP/Postal Code

2820

Country

Denmark

Facility Name

Local Institution

City

Slagelse

ZIP/Postal Code

4200

Country

Denmark

Facility Name

Local Institution

City

Helsinki

ZIP/Postal Code

09200

Country

Finland

Facility Name

Local Institution

City

Kerava

ZIP/Postal Code

04200

Country

Finland

Facility Name

Local Institution

City

Kokkola

ZIP/Postal Code

67100

Country

Finland

Facility Name

Local Institution

City

Oulu

ZIP/Postal Code

90100

Country

Finland

Facility Name

Local Institution

City

Aschaffenburg

State/Province

Bavaria

ZIP/Postal Code

63739

Country

Germany

Facility Name

Local Institution

City

Augsburg

State/Province

Bavaria

ZIP/Postal Code

86150

Country

Germany

Facility Name

Local Institution

City

Duisburg

State/Province

Nordrhein-Westfalen

ZIP/Postal Code

47051

Country

Germany

Facility Name

Local Institution

City

Bad Kreuznach

ZIP/Postal Code

55545

Country

Germany

Facility Name

Local Institution

City

Berlin

ZIP/Postal Code

10787

Country

Germany

Facility Name

Local Institution

City

Dortmund

ZIP/Postal Code

44137

Country

Germany

Facility Name

Local Institution

City

Dresden

ZIP/Postal Code

01307

Country

Germany

Facility Name

Local Institution

City

Karlsruhe

ZIP/Postal Code

76199

Country

Germany

Facility Name

Local Institution

City

Kothen

ZIP/Postal Code

06366

Country

Germany

Facility Name

Local Institution

City

Kronshagen

ZIP/Postal Code

24119

Country

Germany

Facility Name

Local Institution

City

Langenfeld

ZIP/Postal Code

40764

Country

Germany

Facility Name

Local Institution

City

Lueneburg

ZIP/Postal Code

21339

Country

Germany

Facility Name

Local Institution

City

Magdeburg

ZIP/Postal Code

39112

Country

Germany

Facility Name

Local Institution

City

Mainz

ZIP/Postal Code

55116

Country

Germany

Facility Name

Local Institution

City

Mannheim

ZIP/Postal Code

68161

Country

Germany

Facility Name

Local Institution

City

Saarbruecken

ZIP/Postal Code

66121

Country

Germany

Facility Name

Local Institution

City

Wuestensachsen

ZIP/Postal Code

36115

Country

Germany

Facility Name

Local Institution

City

Gyongyos

State/Province

Heves

ZIP/Postal Code

3200

Country

Hungary

Facility Name

Local Institution

City

Budapest

ZIP/Postal Code

1134

Country

Hungary

Facility Name

Local Institution

City

Budapest

ZIP/Postal Code

H-1171

Country

Hungary

Facility Name

Local Institution

City

Eger

ZIP/Postal Code

3300

Country

Hungary

Facility Name

Local Institution

City

Kisvarda

ZIP/Postal Code

4600

Country

Hungary

Facility Name

Local Institution

City

Miskolc

ZIP/Postal Code

3530

Country

Hungary

Facility Name

Local Institution

City

Nyiregyhaza

ZIP/Postal Code

4400

Country

Hungary

Facility Name

Local Institution

City

Satoraljaujhely

ZIP/Postal Code

3980

Country

Hungary

Facility Name

Local Institution

City

Sopron

ZIP/Postal Code

9400

Country

Hungary

Facility Name

Local Institution

City

Szeged

ZIP/Postal Code

6720

Country

Hungary

Facility Name

Local Institution

City

Szekszard

ZIP/Postal Code

H-7100

Country

Hungary

Facility Name

Local Institution

City

Hyderabad

State/Province

Andhra Pradesh

ZIP/Postal Code

5000 18

Country

India

Facility Name

Local Institution

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560 043

Country

India

Facility Name

Local Institution

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560043

Country

India

Facility Name

Local Institution

City

Bangalore

State/Province

Karnataka

ZIP/Postal Code

560092

Country

India

Facility Name

Local Institution

City

Mangalore

State/Province

Karnataka

ZIP/Postal Code

575001

Country

India

Facility Name

Local Institution

City

Belgaum

State/Province

Karnatka

ZIP/Postal Code

590010

Country

India

Facility Name

Local Institution

City

Indore

State/Province

Madhya Pradesh

ZIP/Postal Code

452010

Country

India

Facility Name

Local Institution

City

Nagpur

State/Province

Maharashtra

ZIP/Postal Code

440010

Country

India

Facility Name

Local Institution

City

Nagpur

State/Province

Maharashtra

ZIP/Postal Code

440012

Country

India

Facility Name

Local Institution

City

Nagpur

State/Province

Maharashtra

ZIP/Postal Code

440033

Country

India

Facility Name

Local Institution

City

Delhi

State/Province

New Delhi

ZIP/Postal Code

110007

Country

India

Facility Name

Local Institution

City

Jaipur

State/Province

Rajasthan

ZIP/Postal Code

202023

Country

India

Facility Name

Local Institution

City

Chennai

State/Province

Tamil Nadu

ZIP/Postal Code

600013

Country

India

Facility Name

Local Institution

City

Coimbatore

State/Province

Tamil Nadu

ZIP/Postal Code

641 018

Country

India

Facility Name

Local Institution

City

Madurai

State/Province

Tamilnadu

ZIP/Postal Code

625020

Country

India

Facility Name

Local Institution

City

Chennai Tamilnadu

ZIP/Postal Code

6000081

Country

India

Facility Name

Local Institution

City

Hyderabad

ZIP/Postal Code

500063

Country

India

Facility Name

Local Institution

City

Nagpur

ZIP/Postal Code

440012

Country

India

Facility Name

Local Institution

City

Trivandrum

ZIP/Postal Code

695011

Country

India

Facility Name

Local Institution

City

Dublin 15

State/Province

Dublin

Country

Ireland

Facility Name

Local Institution

City

Galway

Country

Ireland

Facility Name

Local Institution

City

Torreon

State/Province

Coahuila

ZIP/Postal Code

27000

Country

Mexico

Facility Name

Local Institution

City

Mexico City

State/Province

Distrito Federal

ZIP/Postal Code

03300

Country

Mexico

Facility Name

Local Institution

City

Mexico City

State/Province

Distrito Federal

ZIP/Postal Code

07760

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44100

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44130

Country

Mexico

Facility Name

Local Institution

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44670

Country

Mexico

Facility Name

Local Institution

City

Cuautla

State/Province

Morelos

ZIP/Postal Code

62744

Country

Mexico

Facility Name

Local Institution

City

Monterrey

State/Province

Nuevo Leon

ZIP/Postal Code

64000

Country

Mexico

Facility Name

Local Institution

City

Monterrey

State/Province

Nuevo Leon

ZIP/Postal Code

64460

Country

Mexico

Facility Name

Local Institution

City

Culiacan

State/Province

Sinaloa

ZIP/Postal Code

80020

Country

Mexico

Facility Name

Local Institution

City

Merida

State/Province

Yucatan

ZIP/Postal Code

97070

Country

Mexico

Facility Name

Local Institution

City

Chihuahua

ZIP/Postal Code

31217

Country

Mexico

Facility Name

Local Institution

City

Del. Benito Juarez

ZIP/Postal Code

03100

Country

Mexico

Facility Name

Local Institution

City

Delegacion Tlalpan

ZIP/Postal Code

14000

Country

Mexico

Facility Name

Local Institution

City

Distrito Federal

ZIP/Postal Code

07020

Country

Mexico

Facility Name

Local Institution

City

San Luis Potosi

ZIP/Postal Code

78200

Country

Mexico

Facility Name

Local Institution

City

Bialystok

ZIP/Postal Code

15-404

Country

Poland

Facility Name

Local Institution

City

Bialystok

ZIP/Postal Code

15-879

Country

Poland

Facility Name

Local Institution

City

Chrzanow

ZIP/Postal Code

32-500

Country

Poland

Facility Name

Local Institution

City

Elblag

ZIP/Postal Code

82-300

Country

Poland

Facility Name

Local Institution

City

Gdansk

ZIP/Postal Code

80-847

Country

Poland

Facility Name

Local Institution

City

Gdynia

ZIP/Postal Code

81-384

Country

Poland

Facility Name

Local Institution

City

Kamieniec Zabkowicki

ZIP/Postal Code

57-230

Country

Poland

Facility Name

Local Institution

City

Katowice

ZIP/Postal Code

40-748

Country

Poland

Facility Name

Local Institution

City

Kielce

ZIP/Postal Code

25-364

Country

Poland

Facility Name

Local Institution

City

Krakow

ZIP/Postal Code

30-015

Country

Poland

Facility Name

Local Institution

City

Krakow

ZIP/Postal Code

31-159

Country

Poland

Facility Name

Local Institution

City

Lodz

ZIP/Postal Code

90-242

Country

Poland

Facility Name

Local Institution

City

Lodz

ZIP/Postal Code

92-525

Country

Poland

Facility Name

Local Institution

City

Lublin

ZIP/Postal Code

20-044

Country

Poland

Facility Name

Local Institution

City

Ostroda

ZIP/Postal Code

14-100

Country

Poland

Facility Name

Local Institution

City

Poznan

ZIP/Postal Code

61-251

Country

Poland

Facility Name

Local Institution

City

Warsaw

ZIP/Postal Code

02-097

Country

Poland

Facility Name

Local Institution

City

Warsaw

ZIP/Postal Code

02-507

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

01-192

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

01-337

Country

Poland

Facility Name

Local Institution

City

Warszawa

ZIP/Postal Code

01-868

Country

Poland

Facility Name

Local Institution

City

Wroclaw

ZIP/Postal Code

50-088

Country

Poland

Facility Name

Local Institution

City

Wroclaw

ZIP/Postal Code

50-349

Country

Poland

Facility Name

Local Institution

City

Zabrze

ZIP/Postal Code

41-800

Country

Poland

Facility Name

Local Institution

City

Fajard

ZIP/Postal Code

00738

Country

Puerto Rico

Facility Name

Local Institution

City

Ponce

ZIP/Postal Code

00717

Country

Puerto Rico

Facility Name

Local Institution

City

San Juan

ZIP/Postal Code

00920

Country

Puerto Rico

Facility Name

Local Institution

City

Oradea

State/Province

Bihor

ZIP/Postal Code

410169

Country

Romania

Facility Name

Local Institution

City

Oradea

State/Province

Jud. Bihor

ZIP/Postal Code

410469

Country

Romania

Facility Name

Local Institution

City

Timisoara

State/Province

Jud. Timis

ZIP/Postal Code

300125

Country

Romania

Facility Name

Local Institution

City

Targu Mures

State/Province

Mures

ZIP/Postal Code

540098

Country

Romania

Facility Name

Local Institution

City

Targu Mures

State/Province

Mures

ZIP/Postal Code

540142

Country

Romania

Facility Name

Local Institution

City

Ploiesti

State/Province

Prahova

ZIP/Postal Code

100163

Country

Romania

Facility Name

Local Institution

City

Ploiesti

State/Province

Prahova

ZIP/Postal Code

100342

Country

Romania

Facility Name

Local Institution

City

Timisoara

State/Province

Timis

ZIP/Postal Code

300456

Country

Romania

Facility Name

Local Institution

City

Bucuresti

ZIP/Postal Code

010507

Country

Romania

Facility Name

Local Institution

City

Bucuresti

ZIP/Postal Code

010719

Country

Romania

Facility Name

Local Institution

City

Bucuresti

ZIP/Postal Code

020475

Country

Romania

Facility Name

Local Institution

City

Bucuresti

ZIP/Postal Code

020725

Country

Romania

Facility Name

Local Institution

City

Cluj-Napoca

ZIP/Postal Code

400006

Country

Romania

Facility Name

Local Institution

City

Satu Mare

ZIP/Postal Code

440055

Country

Romania

Facility Name

Local Institution

City

Sibiu

ZIP/Postal Code

550245

Country

Romania

Facility Name

Local Institution

City

Sibiu

ZIP/Postal Code

550371

Country

Romania

Facility Name

Local Institution

City

Irvine

State/Province

Ayrshire

ZIP/Postal Code

KA11 1JU

Country

United Kingdom

Facility Name

Local Institution

City

Ely

State/Province

Cambridgeshire

ZIP/Postal Code

CB7 5JD

Country

United Kingdom

Facility Name

Local Institution

City

Birmingham

State/Province

West Midlands

ZIP/Postal Code

B9 5SS

Country

United Kingdom

Facility Name

Local Institution

City

Bath

State/Province

Wiltshire

ZIP/Postal Code

BA2 3HT

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

26620248

Citation

Weber MA, Mansfield TA, Cain VA, Iqbal N, Parikh S, Ptaszynska A. Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Diabetes Endocrinol. 2016 Mar;4(3):211-220. doi: 10.1016/S2213-8587(15)00417-9. Epub 2015 Nov 27. Erratum In: Lancet Diabetes Endocrinol. 2016 Mar;4(3):e3. Lancet Diabetes Endocrinol. 2016 Mar;4(3):e3.

Results Reference

derived

Links:

URL

http://www.bms.com/studyconnect/Pages/home.aspx

Description

BMS clinical trial educational resource

Learn more about this trial

A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication

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A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes With Inadequately Controlled Hypertension on an ACEI or ARB and an Additional Antihypertensive Medication

Type 2 Diabetes

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial