Efficacy of Two Prophylactic Schedules (Prulifloxacin Versus Phosphomycin)

Epidemiological studies showed that 20-30% of patients with uncomplicated urinary tract infections risked recurrent infection. Urinary tract infection causes marked discomfort for the patient, has a negative impact upon quality of life, and is associated with high social and health costs in terms of specialist appointments, laboratory and instrumental tests and prescriptions . Although diverse cycles of antibiotic therapy and prophylaxis have been proposed, doubts persist about the most efficacious pharmacological agents, duration of prophylaxis , the incidence of adverse effects and relapse when antibiotic therapy is suspended. Aims of the study: To compare the efficacy of two prophylactic schedules (Prulifloxacin vs Phosphomycin): in reducing the number of urinary tract infection episodes during prophylaxis in reducing the number of urinary tract infection episodes after prophylaxis in improving the patient's quality of life . To assess : Tolerability of antibiotic prophylaxis The incidence of resistance to antibiotic therapy

Inclusion Criteria: Female patients Age over 18 years old No allergies to the drugs to be prescribed No counter-indications to this drug therapy Urine culture shows responsiveness to drugs at recruitment of patient History of urinary tract infections with at least three episodes in the previous year or two in the past six months Exclusion Criteria: Lack of tolerability of prescribed drugs