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CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

Primary Purpose

Diabetes Mellitus, Type 2

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
linagliptin
glimepiride
linagliptin placebo
glimepiride placebo
Sponsored by
Boehringer Ingelheim
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Diabetes Mellitus, Type 2

Eligibility Criteria

40 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion criteria:

  1. Type 2 diabetes
  2. Elevated glycosylated haemoglobin (HbA1c): 6.5 - 8.5%, inclusive, if treatment naïve or mono-/dual therapy with metformin and/or an alpha-glucosidase inhibitor; 6.5 - 7.5%, inclusive, if treatment with sulphonylurea/glinide in mono- or dual (with metformin OR an alpha-glucosidase inhibitor) therapy)
  3. Pre-existing cardiovascular disease OR specified diabetes end-organ damage OR age => 70 years OR two or more specified cardiovascular risk factor
  4. BMI =< 45kg/m²
  5. age between >= 40 and =< 85 years
  6. signed and dated written International Conference of Harmonisation( ICF)
  7. stable anti-diabetic background for at least 8 wks before study start

Exclusion criteria:

  1. Type 1 diabetes
  2. Treatment with other antidiabetic drugs (e.g. rosiglitazone, pioglitazone, Glucagon-like peptide 1 (GLP-1) analogue/agonists, Dipeptidyl-peptidase IV (DPP-IV) inhibitors or any insulin) prior to informed consent (previous short term use of insulin (up to two weeks) is allowed if taken at least 8 weeks prior informed consent)
  3. treatment with any anti-obesity drug less than 3 months before ICF
  4. uncontrolled hyperglycemia
  5. previous or planned bariatric surgery or intervention
  6. current or planned system corticoid treatment
  7. change in thyroid hormones treatment
  8. acute liver disease or impaired hepatic function
  9. pre-planned coronary artery revascularization within 6 months of ICF
  10. known hypersensitivity to any of the components
  11. Inappropriateness of glimepiride treatment for renal safety issues according to local prescribing information
  12. congestive heart failure class III or IV
  13. acute or chronic metabolic acidosis
  14. hereditary galactose intolerance
  15. alcohol or drug abuse
  16. participation in another trail with IMP given 2 months before Investigational Medicinal/Medical Product (IMP) start
  17. pre-menopausal women who are nursing or pregnant or of child-bearing potential and not willing to use acceptable method of birth control
  18. patients considered reliable by the investigator
  19. acute coronary syndrome =< 6 wks before ICF
  20. stroke or Transient Ischemic Attack (TIA) =< 3 months prior to ICF

Sites / Locations

  • North Alabama Research Center, LLC
  • Alabama Internal Medicine, PC
  • Cahaba Research, Inc.
  • Internal Medicine Center, LLC
  • Diagnostic and Medical Clinic
  • Extended Arm Physicians, Inc.
  • Office of Dr. Terence T. Hart MD
  • Advanced Clinical Research
  • Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
  • Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
  • Genova Clinical Research
  • Quality of Life Medical & Research Center
  • Northeast Arkansas Baptist Clinic
  • Medical Investigations, Inc
  • Aureus Research, Inc
  • Desert Oasis Healthcare
  • Edinger Medical Group and Research Center
  • Clinical Trials of St. Jude Heritage Med. Group
  • Long Beach Center for Clinical Research
  • Office of Dr. Richard S. Cherlin
  • Providence Clinical Research
  • Chaparral Medical Group, Inc
  • ARI Clinical Trials, Inc
  • San Diego Sports Medicine and Family Health Center
  • West Coast Research, LLC
  • University of California Los Angeles
  • Metabolic Institute of America
  • Matrix Research Institute
  • Orange County Research Center
  • Westlake Medical Research
  • Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
  • Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
  • East Coast Medical Associates
  • Todd Kazdan, DO Family Practice
  • Century Clinical Research, Inc
  • Doral Research Center
  • Riverside Clinical Research
  • Alan Graff, MD, PA
  • M & O Clinical Research, LLC
  • Eastern Research
  • Research in Miami Inc
  • Jacksonville Impotence Treatment Center
  • East Coast Institute for Research, LLC
  • Care Partners Clinical Research LLC
  • Precision Clinical Research, LLC
  • Veritas Research Corporation
  • APF Research, LLC
  • Swiss Medical Research
  • University of Miami
  • South Miami Clinical Research
  • Well Pharma Medical Research
  • Advanced Pharma CR, LLC
  • AppleMed Research Group, LLC
  • Kendall South Medical Center, Inc
  • Suncoast Clinical Research, Inc.
  • Advanced Research Institute, Inc
  • Sunshine Research Center
  • Diabetes and Endocrine Center of Orlando
  • Suncoast Clinical Research
  • Misal Khan, MD FRCS, ED, PA
  • Iconic Clinical Trials
  • Gulf Region Clinical Research Institute
  • St. John's Center for Clinical Research
  • Metabolic Research Institute
  • PMI Health Research Group
  • Atlanta Diabetes Associates
  • Albert F. Johary MD, PC
  • Georgia Clinical Research, LLC
  • Hayden Lake Family Physicians
  • Boise Kidney and Hypertension Institute
  • Suburban Clinical Research
  • Cedar-Crosse Research Center
  • John H. Stroger Jr. Hospital of Cook Country
  • Apex Medical Research
  • Pharmakon Inc
  • American Health Network
  • Investigators Research Group, LLC
  • American Health Network of Indiana, LLC
  • Mapleton Medical Center
  • American Health Network, LLC
  • McKinley Research, LLC
  • American Health Network of Indiana, LLC
  • MCM Clinical Research, LLC
  • Kentucky Diabetes Endocrinology Center
  • Four Rivers Clinical Research, Inc
  • Crescent City Clinical Research
  • Acadia Clinical Research, LLC
  • Office of Dr. Stephen R. Smith, MD
  • Endocrine and Metabolic Consultants
  • Tristan Medical Enterprises, PC dba Regeneris
  • ClinSite, LLC
  • Apex Medical Research, AMR Inc
  • Westside Family Medical Center, PC
  • Tri City Medical Centers, PC
  • KMED Research
  • Tri-County Research, Inc
  • Medical Research Associates
  • Oakland Medical Research Center
  • Park Nicollet Institute
  • The Center for Clinical Trials, Inc.
  • Mercy Health Research
  • Quality Clinical Research
  • Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
  • Clinical Research of South Nevada
  • Palm Medical Research Center
  • Atco Medical Associates, PC
  • Summit Medical Group
  • USMA Clinical Research
  • Central Jersey Medical Research
  • Albany Medical Center / Albany Medical College
  • Endocrine Associates of Long Island, PC
  • Southgate Medical Group/ Southgate Medical Park
  • OnSite Clinical Solutions, LLC
  • Kernodle Clinic West
  • The University of North Carolina at Chapel Hill
  • Internal Medicine Research
  • Gaffney Health Services
  • Durham Internal Medicine Associates
  • Sentara Family Medicine
  • PMG Research of Raleigh, LLC
  • Carolina Research Center, Inc
  • Piedmont Healthcare
  • PMG Research of Wilmington, LLC
  • Community Health Care of Manchester
  • Community Medical Associates, LLC
  • Harrison Community Research Center
  • Medical Frontiers, LLC
  • Genoa Medical Center
  • Office of Dr. Craig S. Thompson, MD, LLC
  • RAS Health Limited
  • Advanced Medical Research, LLC
  • Pharmacotherapy Research Associates, Inc
  • Infinity Research Group, LLC
  • Castlerock Clinical Research Consultants, LLC
  • Oregon Medical Group
  • Harleysville Medical Associates
  • Detweiler Family Medicine & Associates, PC
  • Temple University School of Medicine
  • Warminster Medical Associates, PC
  • New England Center for Clinical Research, Inc
  • Hartwell Research Group, LLC
  • Paris View Family Practice
  • Mountain View Clinical Research
  • South Carolina Nephrology and Hypertension Center, Inc
  • Carolina Diabetes & Kidney Center
  • PMG Research of Bristol
  • University Diabetes and Endocrine Consultants
  • University of Tennessee
  • Trinity Clinical Research, LLC
  • KRK Medical Research
  • Austin Center for Clinical Research
  • Punzi Medical Center
  • Dallas Diabetes and Endocrine Center
  • Baylor Endocrine Center
  • University of Texas Southwestern Medical Center
  • Jacon Medical Research Associates, LLC
  • JVC Family Medicine
  • Clinical Trial Network
  • Endocrine and Psychiastry Center
  • Pioneer Research Solutions, Inc.
  • Midland Clinical Research Center
  • Hill Country Medical Associates
  • Naidu Clinic
  • The Methodist Hospital d/b/a HMRI CCAT at Pearland
  • Village Health Partners
  • Sun Research Institute
  • Northeast Clinical Research of San Antonio, LLC
  • Kenneth Otah and Associates
  • PHS Clinical Trials
  • Highland Clinical Research
  • Burke Internal Medicine and Research
  • Ettrick Health Center
  • Manassas Clinical Research Center
  • Clinical Research Partners, LLC
  • Richmond Family Practice
  • Larry D Stonesifer, MD Inc., PS
  • Premier Clinical Research
  • Instituto de Investigaciones Clínicas de Bahía Blanca
  • CIPREC
  • CENUDIAB
  • Instituto Médico Especializado
  • Consultorios Asociados de Endocrinología e Invest Clínica
  • IPAC - Clínica Privada Caraffa SRL
  • Instituto Cardiovascular de Corrientes Juana Francisca Cabra
  • Ilaim-Ceom
  • Hospital Italiano de La Plata
  • CIPADI
  • Instituto de Investigaciones Clinicas de Rosario
  • Instituto de Hematología y Medicina Clínica Dr. Rubén Davoli
  • Hospital San Bernardo
  • Investigaciones Clinicas Tucuman
  • Instituto de Investigaciones Biomédicas
  • Centro de Investigaciones Clínicas del Litoral
  • Royal Brisbane & Women's Hospital-Endocrinology
  • Logan Hospital
  • Royal Adelaide Hospital
  • Eastern Clinical Research Unit
  • Royal Melbourne Hospital
  • Blankenberge - PRAC Vileyn, Geert
  • Bonheiden - HOSP Imelda
  • De Pinte - PRAC Hollanders, Geert
  • Retie - PRAC De Vos, Axel
  • Deurne - PRAC Heyvaert, Frank
  • Deurne - PRAC Verelst, Joost
  • Genk - PRAC Vernijns, J.
  • Gozée - PRAC De Meulemeester, Marc
  • Hasselt - PRAC Vantroyen, Daniel
  • Herent - PRAC Denolf, Bart
  • Linkebeek - PRAC Maury, Olivier
  • Moorsel - PRAC Van Mulders, N.
  • Natoye - PRAC Balthazar, Y.
  • Tremelo - PRAC Vermeersch, Lode
  • Hospital Universitário João de Barros Barreto
  • Universidade Federal do Paraná
  • Hospital Geral de Goiânia Alberto Rassi
  • Centro de Pesquisas Clínicas Ltda
  • Centro de Estudos em Diabetes e Hipertensão
  • Irmandade Santa Casa de Misericordia de Porto Alegre
  • Centro de Pesquisas em Diabetes
  • Instituto Estadual de Diabetes e Endocrinologia
  • Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
  • Instituto de Molestias Cardiovasculares - IMC
  • Hospital das Clinicas da FMUSP
  • Hospital do Rim e Hipertensão - UNIFESP
  • Univ.Multiprofile Hospital "Dr. Georgy Stranski" EAD, Pleven
  • Multiprofile Hospital for Active Treatment
  • Multiprofile Hospital for Active Treatment "Zaritza Johanna"
  • Military Medical Academy, Clin. Endocrinology & Metab. Dis.
  • MHAT Prof Stoyan Kirkovich AD
  • IUCPQ (Laval University)
  • First Line Medical Services Ltd.
  • Topsail Road Medical Clinic
  • Cambridge Cardiac Care Inc.
  • Hamilton Medical Research Group
  • SKDS Research Incorporated
  • Wilderman Medical Clinic
  • St. Michael's Hospital
  • Albion Finch Medical Centre
  • Kings County Medical Centre
  • Dynamik Research
  • Consulta Privada Maria Loreto Aguirre Coveña
  • Hospital de Servicios Médicos Godoy Ltda
  • Centro Medico Antulawen
  • Hospital Naval Almirante Nef
  • BioMelab
  • Centro Cientifico Asistencial Jose Luis Accini
  • Fundacion del Caribe de Investigacion Biomedica
  • Endocare Research Institute
  • Dexa Diabetes Servicios Médicos Ltda
  • UNIENDO Unidad Integral de Endocrinologia
  • Centro cardiovascular Aristides
  • centro de Diagnostico Cardiologico para la Investigacion Bio
  • Fundacion Cardiovascular de Colombia
  • Fundación Oftalmologica de Santander
  • Fundación Centro de Investigaciones Biomédicas Riescard
  • Internal & Diabetology Ambulance, Jablonec nad Nisou
  • Diabetology & Internal Ambulance
  • Internal & Diabetology Ambulance Dr. Vrkoc, Ostrava
  • Cardiology ambulance, Plzen
  • ResTrial s.r.o.
  • Diebetology internal Ambulance
  • Internal & Diabetology Ambulance, Prostejov
  • Hospital Strakonice, Internal Department
  • Diabetesklinikka, Mehiläinen Töölö
  • Lääkärikeskus Ite
  • Lääkärikeskus Aava Kerava
  • Kokkolan Lääkärikeskus
  • IteLasaretti
  • Terveystalo Oulu, Diapolis
  • TYKS
  • CAB Hell M, MG, Behren Les Forbach
  • HOP Haut Levèque, Diabéto, Pessac
  • CAB Lemarie B, MG, Bourg des Cptes
  • CAB Cadinot Dr D, Broglie
  • CAB Breton Dr Nicolas
  • CAB Ferrier R, MG, Cannes
  • CAB Jordan E, MG, Carbonne
  • CAB Merlin P, MG Castets
  • CAB Fonteny R, MG, Chartres
  • CAB Fournier P, MG, Chartres
  • CAB Martocq G, MG, Cournonterral
  • HOP, Fort de France, Fort de France
  • CAB Le Mouel S, MG, Hinx
  • CAB Pholsena, MG, La Réunion
  • CAB Bismuth M
  • CAB Zimmermann D
  • CAB Mainetti P, MG, Maintenon
  • CAB Barucq F, MG, Orthez
  • CAB Mostephai M
  • CAB Cassagnes JL, MG, Palau Del Vidre
  • CAB Mercey Y, MG, St Genies des Fontaines
  • Hop St Dié des Vosges, Diabéto, St Dié des Vosges
  • CAB Bonneau D, MG, Thouars
  • CAB Morel H, MG, Tilly sur Seulles
  • Unimed Ajara LLC, Private Practice
  • Central Hospital LTD 'Gormedi', Gori
  • L&J Clinic, Kutaisi
  • EC Cardiology Clinic,Tbilisi
  • National Center for Diabetes Research Ltd., Tbilisi
  • National Institute of Endocrinology, Tbilisi
  • Zhordania Institute of Human Reproduction, Tbilisi
  • Medical Centre Medelite Ltd., Tbilisi
  • Chemotherapy & Immunotherapy Clinic 'Medulla', Tbilisi
  • JSC 'Curatio'
  • Universitätsklinikum Aachen, AöR
  • Studienzentrum Klausmann
  • Gemeinschaftspraxis, Asslar
  • Diabetes Schwerpunktpraxis
  • Praxis Dr. Naumburger, Berlin
  • emovis GmbH
  • Praxis Dr. Rieker, Berlin
  • IFG Institut für Gesundheitsförderung GmbH
  • MVZ DaVita Dormagen GmbH
  • Praxis Dr. Busch, Dortmund
  • GWT-TUD GmbH
  • Praxis Dr. Schlecht, Eisenach
  • ZKS Südbrandenburg GmbH
  • Praxis Dr. Huptas, Essen
  • Praxis Dr. Schmidt, Flörsheim
  • Institut für Stoffwechselforschung, Frankfurt
  • Praxis Dr. Groeneveld, Furth im Wald
  • Praxis Dr. Kohlhas, Gebhardshain
  • Praxis Dr. Samer, Haag
  • Klinische Forschung Management & Services GmbH
  • Diabetologische Schwerpunktpraxis
  • Praxis Dr. Burkhardt, Hamburg
  • Diabeteszentrum Alstertal, Hamburg
  • Praxis Dr. Herrmann, Hatten
  • Dünnwaldpraxis, Köln
  • Praxis Dr. Klein, Künzing
  • Praxis Dr. Nischik, Leipzig
  • Praxis Dr. Kropp, Lübeck
  • PFÜTZNER Science & Health Institute GmbH
  • Diabetologische Schwerpunktpraxis
  • Praxis Dr. Böckmann
  • Praxis Dr. Hilgenberg
  • Praxis Dr. Naudts, Rodgau
  • Praxis Dr. Hirschhäuser
  • Praxis Dr. Segner, St. Ingberg
  • Praxis Dr. Herrmann
  • Praxis Dr. Dietlein
  • Praxis Dr. Sauter
  • Schwerpunktpraxis Diabetologie
  • General Hospital of Athens Evangelismos
  • General University Hospital "Attikon"
  • Univ. Gen. Hosp. of Ioannina
  • General Hospital "Amalia Fleming"
  • General Hospital of Nikaia
  • University General Hospital of Thessaloniki AHEPA
  • General Hopsital of Thessaloniki "Ippokrateio"
  • Kliniki Thermi
  • Alice Ho Miu Ling Nethersole Hospital
  • Prince of Wales Hospital
  • Queen Mary Hospital
  • Imre Magyar Hospital, Ajka
  • Lausmed Kft. Outpatient Unit of Internal Medicine
  • Karolyi Sandor Hospital, Budapest
  • Bekes County Pandy Kalman Hospital
  • Erzsebet Hospital, Hodmezövasarhely
  • Dr. Samuel Diosszilagyi Hospital and Outpatient Clinic, Mako
  • TaNa Med Kft.
  • Grof Esterhazy Hospital and Outpatient Clinic
  • Tolna County Balassa Janos Hospital
  • Shree Krishna Hospital and Heart Care Centre, Ahmedabad
  • CIIGMA Institute of Medical Sciences Pvt Ltd
  • MS Ramaiah Memorial Hospital,
  • Diabetes care and research centre
  • Manipal Hospital
  • Bangalore Diabetes Centre (BDC)- Medisys Clinical Research
  • Belgaum Diabetes Centre, Belgaum
  • Swamy Diabetes Centre
  • Apollo Hospitals
  • M V Hospital For Diabetes and Diabetes Research Centre
  • Dr. Mohans Diabetes Speciality Centre
  • Kovai Diabetes Speciality Centre & Hospital
  • TOTALL Diabetes Hormone Institute
  • Diabetes Thyroid and Endocrine Centre
  • Diamed Clinical Research Services Pvt. Ltd.
  • Grant Medical Foundation, Ruby Hall Clinic
  • K.G.N. Diabetes and Endocrine Centre
  • Global Hospital- Superspeciality & Transplant Centre
  • RHIDEM
  • Sunil's Diabetes care and Research Centre
  • Jahingir Clinical Development Centre
  • Deshmukh Clinic
  • Diabetes Care Center
  • Yalamanchi Hospitals & Research Centres Pvt Ltd.
  • The Red House Family Practice
  • Connolly Hospital Blanchardstown
  • The Palms GP Surgery
  • Fethard-on-Sea Medical Practice
  • Barzilai Medical Center
  • Rambam Medical Center
  • Edith Wolfson Medical Center, Diabetic Unit, Holon
  • Hadassah Medical Center, Ein-Karem
  • Western Galilee Hospital
  • The Chaim Sheba Medical Center Tel Hashomer
  • Sourasky Medical Center
  • Ospedale "SS. Trinità"
  • Policlinico Universitario Mater Domini, Universita di Catanzaro
  • Policlinico San Martino
  • Ospedale di Guastalla
  • A.O.U.Policlinico G.Martino
  • Fondazione Centro San Raffaele del Monte Tabor
  • Ospedale S. Pertini
  • Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
  • IRCCS Gruppo Multimedica
  • Daishinkai Medical Corporation Ookuma Hospital
  • Chibanishi General Hospital
  • New Tokyo Heart Clinic
  • Kashinoki I.M. Clinic, Fukushima, I.M.
  • Japan Community Health care Organization Nihonmatsu Hospital
  • Iwase General Hospital
  • Iryohojinshadan Sasaki Clinic
  • Takasagoseibu Hospital
  • Kanagawa Cardiovascular and Respiratory Center
  • Jinnouchi Clinic Diabetes Care Center
  • Kumamoto Rosai Hospital
  • Koga General Hospital
  • Saitama Medical Cooperative Association Hanyu General Hospital
  • Nihon University Itabashi Hospital
  • Korea University Ansan Hospital
  • Inje University Busan Paik Hospital
  • Keimyung University Dongsan Medical Center
  • National Health Insurance Service Ilsan Hospital
  • Dongguk University Ilsan Hospital
  • Inje University Ilsan Paik Hospital
  • Chonbuk National University Hospital
  • Pusan National Univ. Hosp
  • Seoul National University Bundang Hospital
  • Korea University Anam Hospital
  • Korea University Guro Hospital
  • Kangdong Sacred Heart Hospital
  • Ajou University Hospital
  • Wonju Severance Christian Hosp
  • Pusan National University Yangsan Hospital
  • Monash University
  • Hospital University Sains Malaysia
  • Hospital Kuala Lumpur
  • University Malaya Medical Centre
  • Hospital Tengku Ampuan Afzan
  • Hospital Melaka
  • Penang Medical College
  • Hospital Taiping
  • Hospital General de Acapulco
  • Centro de Investigacion Cardiometabolica de Aguascalientes
  • Instituto Nacional de Cardiologia Ignacio Chavez
  • Unidad de Investigacion Clinica Cardiometabolica de Occident
  • Hospital Universitario Dr Jose Eleuterio Gonzalez
  • Huisartspraktijk Emmers
  • FlevoResearch
  • Academisch Medisch Centrum (AMC)
  • Rode Kruis Ziekenhuis Beverwijk
  • Andromed Breda
  • Noordwest Ziekenhuisgroep, location Den Helder
  • Andromed Eindhoven
  • Andromed Noord
  • Vasculair Onderzoek Centrum
  • Maastricht Universitair Medisch Centrum
  • Andromed Rotterdam
  • Rotterdam Research Institute
  • Ikazia Ziekenhuis
  • Antonius Ziekenhuis
  • Andromed Oost
  • Andromed Leiden-Zoetermeer
  • Christchurch Hospital
  • RMC Medical Research Ltd
  • P3 Research, Wellington
  • P3 Research, Promed House
  • Bodø Legesenter AS, avd. for med. studier
  • Medi 3 Innlandet AS, avd Elverum
  • Vestre Viken HF, Bærum sykehus
  • M3 Helse AS
  • Bylegene SA
  • Heiaklinikken
  • Rådhuset Spesialistsenter
  • Sandvika Spesialistsenter
  • Grålum Legesenter
  • Forusakutten - Kolibri Medical, Avd. Stavanger
  • Medi 3 AS
  • Instituto Delgado de Investigacion Medica
  • Clinica San Pedro
  • Hospital Nacional Dos de Mayo
  • Clinica Internacional
  • Centro de Investigaciones Médicas METABOLICARE SAC
  • Clinica San Gabriel
  • Centro De Especialidades Medicas Santa Maria S.A.C
  • Clinica San Judas Tadeo
  • Center for Diabetes Care
  • Mary Mediatrix Medical Center
  • Philippine General Hospital
  • University of Santo Tomas Hospital
  • Manila Doctors Hospital
  • Asian Hospital & Medical Center
  • St. Luke's Medical Center
  • Quirino Memorial Medical Center
  • Cardinal Santos Medical Center
  • Surigao Health Specialists
  • Hospital Fernando Fonseca, EPE
  • CHLO, EPE - Hospital de Santa Cruz
  • CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
  • Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã
  • Hospital Distrital Figueira da Foz, EPE
  • Hospital da Luz
  • Centro Hospitalar São João,EPE
  • Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
  • SC Diabol SRL, Brasov
  • Nicodiab SRL, Bucharest
  • SC Medical Centre "Sanatatea Ta" SRL, Bucharest
  • Consultmed SRL, Iasi
  • Emergency County Clinical Hospital, Sibiu
  • Private Practice Dr. Remus Gagiu
  • LLC Clinic of new technologies of medicine
  • City Clinical Hospital No. 6 of MoH of Udmurt Republic
  • City Clinical Hospital No. 4, Moscow
  • City Clinical Hospital No. 13, Moscow
  • State Institution "Central Clinical Hospital of RAS", Moscow
  • City Clinical Hospital No. 61, Moscow
  • State Healthcare Institution, Regional hospital #2
  • Limited Liability Company "CENTER DIABET", Samara
  • MMU City Outpatient Clinic no. 20, Saratov
  • Clinical Medical Center Zvezdara, Belgrade
  • Clinical Centre Nis
  • General Hospital Pancevo
  • General Hospital Subotica, Internal Medicine
  • Clinical Hospital Center Zemun
  • DIASTYLE s.r.o., Diabetology Outpatient Department
  • ENDIAMED s.r.o., Dolny Kubin
  • CELL B s.r.o.
  • DIA-KONTROL s.r.o.
  • Funkystuff s.r.o., Nove Zamky
  • Diabetologicka ambulancia MUDr. Lucia Gajdosikova s.r.o.
  • MEDIVASA s.r.o., Outpatient Clinic, Zilina
  • Dr. P. Patel
  • Dr. E. L. Janari
  • Dr. Vawda
  • Parklands Medical Centre
  • Dr. Jurgens
  • Dr. H. Makan
  • Dr. D. R. Lakha, Johannesburg
  • Greenacres Hospital
  • Dr. M. Seeber
  • Vergelegen Medi-Clinic
  • C.A.P. Sardenya
  • CAP Les Corts
  • CAP Casanova
  • CAP Burjassot 1
  • C.S. Natahoyo
  • Hospital Universitari de Girona Doctor Josep Trueta
  • CAP Florida
  • Hospital de Bellvitge
  • CAP La Roca
  • Hospital General Universitario Gregorio Marañón
  • C.S. El Cristo
  • C.S. Colloto
  • C.S. Vallobin-La Florida
  • ABS Pineda de Mar
  • Hospital de l'Esperit Sant
  • CAP Tàrrega
  • CS Ingeniero Joaquin Benlloch
  • Hospital Clínico de Valencia
  • CTC Sahlgrenska Universitetssjukhuset
  • Sjukhuset, Härnösand
  • Avonova Hälsa AB
  • Skånes universitetssjukhus, Malmö
  • Dalecarlia Clinical Research Center
  • Södra Dalarnas vårdcentral, Hedemora
  • Näsets Läkargrupp
  • Vårdcentralen Silentzvägen
  • S3 Clinical Research Centers
  • Allgemeine Medizin
  • FMH endocrinologia diabetologia
  • Inselspital Bern
  • Dr. Pietro Gerber
  • Chang-Hua Christian Hospital
  • Kaohsiung Medical University Chung-Ho Memorial Hospital
  • E-Da Hospital
  • Far Eastern Memorial Hospital
  • Taichung Veterans General Hospital
  • China Medical University Hospital
  • NCKUH
  • National Taiwan University Hospital
  • Shih-Kong Wu Ho-Shu Memorial Hospital
  • Taipe Veterans General Hospital
  • Cheng Hsin General Hospital
  • Tri-Service General Hospital
  • Cardinal Tien Hospital
  • Taipei Medical University-Shuang Ho Hospital
  • Mackay Memorial Hospital
  • HOP Fattouma Bourguiba, Mint, Monastir
  • HOP Hédi Chaker, Endo, Sfax
  • HOP Farhat Hached, Mint, Sousse
  • HOP Habib Thameur, Mint, Tunis
  • Donetsk Regional Clinical Hosp, Therapy Department
  • Ivano-Frankivsk City Central Clinical Hospital
  • City Clinical Hospital No. 17, Kharkov
  • City Clinical Hospital No. 27, Kharkiv
  • Clinic for Cardiology "Sertse i sudyny", Kiev
  • City Clinical Hospital No. 1, Kiev
  • Poliklinika #2, Kyiv
  • City Hospital No. 5, Lvov
  • Odeska zaliznichna likarnya, Odessa
  • Vinnitsia Regional Endocrinology Dispensary
  • Crouch Oak Family Practice
  • Ash Vale Health Centre, Aldershot
  • Birmingham Heartlands Hospital
  • Hathaway Medical Centre
  • University Hospital of North Durham
  • St Mary's Surgery
  • Gloucestershire Royal Hospital
  • James Paget University Hospital
  • Morriston Hospital
  • Royal Cornwall Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

linagliptin

glimepiride 1-4 mg QD

Arm Description

patient to receive linagliptin or glimepiride placebo over encapsulated tablet Quaque die (QD)

patient to receive glimepiride 1-4 mg or linagliptin placebo tablet Quaque die (QD)

Outcomes

Primary Outcome Measures

The First 3-point Major Adverse Cardiovascular Events (3P-MACE)
The first occurrence of any of the following Clinical Event Committee (CEC) confirmed adjudicated components of the primary composite endpoint: CV death (including fatal stroke and fatal myocardial infarction (MI)), non-fatal MI (excluding silent MI), or nonfatal stroke is presented.

Secondary Outcome Measures

The First 4-point (4P)- MACE
The first key secondary endpoint was time to first occurrence of any of the following adjudicated components of the composite endpoint: CV death (including fatal stroke and fatal MI), non-fatal stroke, non-fatal MI (excluding silent MI), or hospitalisation for unstable angina pectoris.
Percentage of Participants Taking Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, Without >2% Weight Gain, and Without Moderate/Severe Hypoglycaemic Episodes During Maintenance Phase
The second key secondary endpoint was a composite endpoint of treatment sustainability, defined as the percentage of patients taking trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, without >2% weight gain, and without moderate/severe hypoglycaemic episodes during maintenance phase.
Percentage of Participants Who Were on Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, and Without >2% Weight Gain During Maintenance Phase
The third key secondary endpoint was a composite endpoint of treatment sustainability, defined as percentage of patients who were on trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, and without >2% weight gain during maintenance phase.
Percentage of Participants With the Occurrence of at Least One Event of 3P-MACE
Percentage of participants occurrence of at least one of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI) and non-fatal stroke is presented as secondary CV endpoint.
Percentage of Participants With the Occurrence of at Least One Event of 4P -MACE
Percentage of participants occurrence of at least one of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI), non-fatal stroke, and hospitalisation for unstable angina pectoris is presented as secondary CV endpoint.
Percentage of Participants With Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events
Percentage of participants with occurrence of any of the following components of the composite endpoint of all adjudication-confirmed events of: CV death (including fatal stroke and fatal MI) non-fatal MI non-fatal stroke hospitalisation for unstable angina pectoris TIA hospitalisation for heart failure hospitalisation for coronary revascularisation procedures (CABG, PCI)
Time to First Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events
Time to first occurrence of any of the following components of the composite endpoint of all adjudication-confirmed events of: CV death (including fatal stroke and fatal MI) non-fatal MI non-fatal stroke hospitalisation for unstable angina pectoris Transient ischaemic attack (TIA) hospitalisation for heart failure hospitalisation for coronary revascularisation procedures (CABG, PCI)
Change From Baseline to Final Visit in Hemoglobin A1c (HbA1c)
Change from baseline to final visit in HbA1c is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Change From Baseline to Final Visit in Fasting Plasma Glucose (FPG)
Change from baseline to final visit in fasting plasma glucose (FPG) is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Change From Baseline to Final Visit Fasting Total Cholesterol, Low-density Lipoprotein (LDL) Cholesterol and High-density Lipoprotein (HDL) Cholesterol
Change from baseline to final visit in total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Change From Baseline to Final Visit in Triglycerides
Change from baseline to final visit in triglycerides is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Change From Baseline to Final Visit in Creatinine
Change from baseline to final visit in creatinine is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Change From Baseline to Final Visit in Estimated Glomerular Filtration Rate (eGFR)
Change from baseline to final visit in eGFR is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Change From Baseline to Final Visit in Urine Albumin Creatinine Ratio (UACR)
Change from baseline to final visit in UACR is presented as secondary diabetes-related endpoint. Least square mean is adjusted geometric mean (gMean) ratio. The Final Visit value referred to the last value obtained on-treatment.
Percentage of Participants With Transition in Albuminuria Classes
Percentage of patients with transition in albuminuria classes is presented as secondary endpoint. Data for last value on treatment (LVOT) to baseline (base) is presented.
Change From Baseline of Insulin Secretion Rate (ISR) at Fixed Glucose Concentration at 208 Weeks
The endpoint change from baseline of ISR at fixed glucose concentration at 208 weeks as derived from a 3-hour meal tolerance test is Beta-cell function sub-study endpoint.
Percentage of Participants With Occurrence of Accelerated Cognitive Decline at End of Follow-up
Occurrence of accelerated cognitive decline based on regression based index (RBI) score at end of follow-up (a dichotomous outcome measure; presence or absence of accelerated cognitive decline) is Cognition sub-study endpoint.
Continuous Glucose Monitoring (CGM) Sub-study: Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Milligrams/ Deciliter) to End of Study
Baseline data for the continuous glucose monitoring sub-study was collected and analyzed. However, the participant number was far less than original planned. The study was stopped early around week 64 (V9) due to recruitment issues and data were not pre-specified to be analyzed and reported at week 64 time point as target was with an estimated time point of 432 weeks for primary or secondary end points. Thus this endpoint was not analysed and only the baseline data collected were analysed and the results are reported in this CGM substudy endpoint.
CGM Sub-study : Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Millimoles/ Litre) to End of Study
Baseline data for the continuous glucose monitoring sub-study was collected and analyzed. However, the participant number was far less than original planned. The study was stopped early around week 64 (V9) due to recruitment issues and data were not pre-specified to be analyzed and reported at week 64 time point as target was with an estimated time point of 432 weeks for primary or secondary end points. Thus this endpoint was not analysed and only the baseline data collected were analysed and the results are reported in this CGM substudy endpoint.

Full Information

First Posted
November 17, 2010
Last Updated
December 19, 2019
Sponsor
Boehringer Ingelheim
Collaborators
Eli Lilly and Company
search

1. Study Identification

Unique Protocol Identification Number
NCT01243424
Brief Title
CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes
Official Title
A Multicentre, International, Randomised, Parallel Group, Double Blind Study to Evaluate Cardiovascular Safety of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk.
Study Type
Interventional

2. Study Status

Record Verification Date
December 2019
Overall Recruitment Status
Completed
Study Start Date
November 11, 2010 (Actual)
Primary Completion Date
August 21, 2018 (Actual)
Study Completion Date
August 21, 2018 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Boehringer Ingelheim
Collaborators
Eli Lilly and Company

4. Oversight

5. Study Description

Brief Summary
The aim of the study is to investigate the longterm impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type 2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Diabetes Mellitus, Type 2

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
6103 (Actual)

8. Arms, Groups, and Interventions

Arm Title
linagliptin
Arm Type
Experimental
Arm Description
patient to receive linagliptin or glimepiride placebo over encapsulated tablet Quaque die (QD)
Arm Title
glimepiride 1-4 mg QD
Arm Type
Active Comparator
Arm Description
patient to receive glimepiride 1-4 mg or linagliptin placebo tablet Quaque die (QD)
Intervention Type
Drug
Intervention Name(s)
linagliptin
Intervention Description
linagliptin tablets 5mg QD
Intervention Type
Drug
Intervention Name(s)
glimepiride
Intervention Description
glimepiride over-encapsulated tablet 1-4 mg QD
Intervention Type
Drug
Intervention Name(s)
linagliptin placebo
Intervention Description
linagliptin placebo
Intervention Type
Drug
Intervention Name(s)
glimepiride placebo
Intervention Description
glimepiride placebo
Primary Outcome Measure Information:
Title
The First 3-point Major Adverse Cardiovascular Events (3P-MACE)
Description
The first occurrence of any of the following Clinical Event Committee (CEC) confirmed adjudicated components of the primary composite endpoint: CV death (including fatal stroke and fatal myocardial infarction (MI)), non-fatal MI (excluding silent MI), or nonfatal stroke is presented.
Time Frame
From randomization until individual day of trial completion, up to 432 weeks
Secondary Outcome Measure Information:
Title
The First 4-point (4P)- MACE
Description
The first key secondary endpoint was time to first occurrence of any of the following adjudicated components of the composite endpoint: CV death (including fatal stroke and fatal MI), non-fatal stroke, non-fatal MI (excluding silent MI), or hospitalisation for unstable angina pectoris.
Time Frame
From randomization until individual day of trial completion, up to 432 weeks
Title
Percentage of Participants Taking Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, Without >2% Weight Gain, and Without Moderate/Severe Hypoglycaemic Episodes During Maintenance Phase
Description
The second key secondary endpoint was a composite endpoint of treatment sustainability, defined as the percentage of patients taking trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, without >2% weight gain, and without moderate/severe hypoglycaemic episodes during maintenance phase.
Time Frame
From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)
Title
Percentage of Participants Who Were on Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, and Without >2% Weight Gain During Maintenance Phase
Description
The third key secondary endpoint was a composite endpoint of treatment sustainability, defined as percentage of patients who were on trial medication at trial end, maintained glycaemic control (HbA1c ≤7.0%) without need for rescue medication, and without >2% weight gain during maintenance phase.
Time Frame
From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)
Title
Percentage of Participants With the Occurrence of at Least One Event of 3P-MACE
Description
Percentage of participants occurrence of at least one of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI) and non-fatal stroke is presented as secondary CV endpoint.
Time Frame
From randomization until individual day of trial completion, up to 432 weeks
Title
Percentage of Participants With the Occurrence of at Least One Event of 4P -MACE
Description
Percentage of participants occurrence of at least one of the following adjudicated components of CV death (including fatal stroke and fatal MI), non-fatal MI (excluding silent MI), non-fatal stroke, and hospitalisation for unstable angina pectoris is presented as secondary CV endpoint.
Time Frame
From randomization until individual day of trial completion, up to 432 weeks
Title
Percentage of Participants With Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events
Description
Percentage of participants with occurrence of any of the following components of the composite endpoint of all adjudication-confirmed events of: CV death (including fatal stroke and fatal MI) non-fatal MI non-fatal stroke hospitalisation for unstable angina pectoris TIA hospitalisation for heart failure hospitalisation for coronary revascularisation procedures (CABG, PCI)
Time Frame
From start of the treatment until 7 days after the end of treatment, up to 433 weeks
Title
Time to First Occurrence of Any of the Components of the Composite Endpoint of All Adjudication-confirmed Events
Description
Time to first occurrence of any of the following components of the composite endpoint of all adjudication-confirmed events of: CV death (including fatal stroke and fatal MI) non-fatal MI non-fatal stroke hospitalisation for unstable angina pectoris Transient ischaemic attack (TIA) hospitalisation for heart failure hospitalisation for coronary revascularisation procedures (CABG, PCI)
Time Frame
From start of the treatment until 7 days after the end of treatment, up to 433 weeks
Title
Change From Baseline to Final Visit in Hemoglobin A1c (HbA1c)
Description
Change from baseline to final visit in HbA1c is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Change From Baseline to Final Visit in Fasting Plasma Glucose (FPG)
Description
Change from baseline to final visit in fasting plasma glucose (FPG) is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Change From Baseline to Final Visit Fasting Total Cholesterol, Low-density Lipoprotein (LDL) Cholesterol and High-density Lipoprotein (HDL) Cholesterol
Description
Change from baseline to final visit in total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Change From Baseline to Final Visit in Triglycerides
Description
Change from baseline to final visit in triglycerides is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Change From Baseline to Final Visit in Creatinine
Description
Change from baseline to final visit in creatinine is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Change From Baseline to Final Visit in Estimated Glomerular Filtration Rate (eGFR)
Description
Change from baseline to final visit in eGFR is presented as secondary diabetes-related endpoint. Least square mean is adjusted mean. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Change From Baseline to Final Visit in Urine Albumin Creatinine Ratio (UACR)
Description
Change from baseline to final visit in UACR is presented as secondary diabetes-related endpoint. Least square mean is adjusted geometric mean (gMean) ratio. The Final Visit value referred to the last value obtained on-treatment.
Time Frame
Baseline and week 432
Title
Percentage of Participants With Transition in Albuminuria Classes
Description
Percentage of patients with transition in albuminuria classes is presented as secondary endpoint. Data for last value on treatment (LVOT) to baseline (base) is presented.
Time Frame
Baseline and week 432
Title
Change From Baseline of Insulin Secretion Rate (ISR) at Fixed Glucose Concentration at 208 Weeks
Description
The endpoint change from baseline of ISR at fixed glucose concentration at 208 weeks as derived from a 3-hour meal tolerance test is Beta-cell function sub-study endpoint.
Time Frame
Baseline and week 208
Title
Percentage of Participants With Occurrence of Accelerated Cognitive Decline at End of Follow-up
Description
Occurrence of accelerated cognitive decline based on regression based index (RBI) score at end of follow-up (a dichotomous outcome measure; presence or absence of accelerated cognitive decline) is Cognition sub-study endpoint.
Time Frame
433 weeks
Title
Continuous Glucose Monitoring (CGM) Sub-study: Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Milligrams/ Deciliter) to End of Study
Description
Baseline data for the continuous glucose monitoring sub-study was collected and analyzed. However, the participant number was far less than original planned. The study was stopped early around week 64 (V9) due to recruitment issues and data were not pre-specified to be analyzed and reported at week 64 time point as target was with an estimated time point of 432 weeks for primary or secondary end points. Thus this endpoint was not analysed and only the baseline data collected were analysed and the results are reported in this CGM substudy endpoint.
Time Frame
Baseline
Title
CGM Sub-study : Change From Baseline in the Inter-quartile Range of Diurnal Glucose Variability (Millimoles/ Litre) to End of Study
Description
Baseline data for the continuous glucose monitoring sub-study was collected and analyzed. However, the participant number was far less than original planned. The study was stopped early around week 64 (V9) due to recruitment issues and data were not pre-specified to be analyzed and reported at week 64 time point as target was with an estimated time point of 432 weeks for primary or secondary end points. Thus this endpoint was not analysed and only the baseline data collected were analysed and the results are reported in this CGM substudy endpoint.
Time Frame
Baseline

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion criteria: Type 2 diabetes Elevated glycosylated haemoglobin (HbA1c): 6.5 - 8.5%, inclusive, if treatment naïve or mono-/dual therapy with metformin and/or an alpha-glucosidase inhibitor; 6.5 - 7.5%, inclusive, if treatment with sulphonylurea/glinide in mono- or dual (with metformin OR an alpha-glucosidase inhibitor) therapy) Pre-existing cardiovascular disease OR specified diabetes end-organ damage OR age => 70 years OR two or more specified cardiovascular risk factor BMI =< 45kg/m² age between >= 40 and =< 85 years signed and dated written International Conference of Harmonisation( ICF) stable anti-diabetic background for at least 8 wks before study start Exclusion criteria: Type 1 diabetes Treatment with other antidiabetic drugs (e.g. rosiglitazone, pioglitazone, Glucagon-like peptide 1 (GLP-1) analogue/agonists, Dipeptidyl-peptidase IV (DPP-IV) inhibitors or any insulin) prior to informed consent (previous short term use of insulin (up to two weeks) is allowed if taken at least 8 weeks prior informed consent) treatment with any anti-obesity drug less than 3 months before ICF uncontrolled hyperglycemia previous or planned bariatric surgery or intervention current or planned system corticoid treatment change in thyroid hormones treatment acute liver disease or impaired hepatic function pre-planned coronary artery revascularization within 6 months of ICF known hypersensitivity to any of the components Inappropriateness of glimepiride treatment for renal safety issues according to local prescribing information congestive heart failure class III or IV acute or chronic metabolic acidosis hereditary galactose intolerance alcohol or drug abuse participation in another trail with IMP given 2 months before Investigational Medicinal/Medical Product (IMP) start pre-menopausal women who are nursing or pregnant or of child-bearing potential and not willing to use acceptable method of birth control patients considered reliable by the investigator acute coronary syndrome =< 6 wks before ICF stroke or Transient Ischemic Attack (TIA) =< 3 months prior to ICF
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Boehringer Ingelheim
Organizational Affiliation
Boehringer Ingelheim
Official's Role
Study Chair
Facility Information:
Facility Name
North Alabama Research Center, LLC
City
Athens
State/Province
Alabama
ZIP/Postal Code
35611
Country
United States
Facility Name
Alabama Internal Medicine, PC
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35235
Country
United States
Facility Name
Cahaba Research, Inc.
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35242
Country
United States
Facility Name
Internal Medicine Center, LLC
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Diagnostic and Medical Clinic
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36695
Country
United States
Facility Name
Extended Arm Physicians, Inc.
City
Montgomery
State/Province
Alabama
ZIP/Postal Code
36106
Country
United States
Facility Name
Office of Dr. Terence T. Hart MD
City
Tuscumbia
State/Province
Alabama
ZIP/Postal Code
35674
Country
United States
Facility Name
Advanced Clinical Research
City
Pell City
State/Province
Alaska
ZIP/Postal Code
35128
Country
United States
Facility Name
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
City
Mesa
State/Province
Arizona
ZIP/Postal Code
85203
Country
United States
Facility Name
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
City
Mesa
State/Province
Arizona
ZIP/Postal Code
85213
Country
United States
Facility Name
Genova Clinical Research
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85704
Country
United States
Facility Name
Quality of Life Medical & Research Center
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85712
Country
United States
Facility Name
Northeast Arkansas Baptist Clinic
City
Jonesboro
State/Province
Arkansas
ZIP/Postal Code
72404
Country
United States
Facility Name
Medical Investigations, Inc
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Aureus Research, Inc
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72211
Country
United States
Facility Name
Desert Oasis Healthcare
City
Bermuda Dunes
State/Province
California
ZIP/Postal Code
92203
Country
United States
Facility Name
Edinger Medical Group and Research Center
City
Fountain Valley
State/Province
California
ZIP/Postal Code
92708
Country
United States
Facility Name
Clinical Trials of St. Jude Heritage Med. Group
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
Country
United States
Facility Name
Long Beach Center for Clinical Research
City
Long Beach
State/Province
California
ZIP/Postal Code
90807
Country
United States
Facility Name
Office of Dr. Richard S. Cherlin
City
Los Gatos
State/Province
California
ZIP/Postal Code
95032
Country
United States
Facility Name
Providence Clinical Research
City
North Hollywood
State/Province
California
ZIP/Postal Code
91606
Country
United States
Facility Name
Chaparral Medical Group, Inc
City
Pomona
State/Province
California
ZIP/Postal Code
91767
Country
United States
Facility Name
ARI Clinical Trials, Inc
City
Redondo Beach
State/Province
California
ZIP/Postal Code
90277
Country
United States
Facility Name
San Diego Sports Medicine and Family Health Center
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
West Coast Research, LLC
City
San Ramon
State/Province
California
ZIP/Postal Code
94582
Country
United States
Facility Name
University of California Los Angeles
City
Sylmar
State/Province
California
ZIP/Postal Code
91342
Country
United States
Facility Name
Metabolic Institute of America
City
Tarzana
State/Province
California
ZIP/Postal Code
91356
Country
United States
Facility Name
Matrix Research Institute
City
Tustin
State/Province
California
ZIP/Postal Code
92780
Country
United States
Facility Name
Orange County Research Center
City
Tustin
State/Province
California
ZIP/Postal Code
92780
Country
United States
Facility Name
Westlake Medical Research
City
Westlake Village
State/Province
California
ZIP/Postal Code
91361
Country
United States
Facility Name
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80920
Country
United States
Facility Name
East Coast Medical Associates
City
Boca Raton
State/Province
Florida
ZIP/Postal Code
33433
Country
United States
Facility Name
Todd Kazdan, DO Family Practice
City
Davie
State/Province
Florida
ZIP/Postal Code
33314
Country
United States
Facility Name
Century Clinical Research, Inc
City
Daytona Beach
State/Province
Florida
ZIP/Postal Code
32117
Country
United States
Facility Name
Doral Research Center
City
Doral
State/Province
Florida
ZIP/Postal Code
33172
Country
United States
Facility Name
Riverside Clinical Research
City
Edgewater
State/Province
Florida
ZIP/Postal Code
32132
Country
United States
Facility Name
Alan Graff, MD, PA
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33309
Country
United States
Facility Name
M & O Clinical Research, LLC
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Eastern Research
City
Hialeah
State/Province
Florida
ZIP/Postal Code
33013
Country
United States
Facility Name
Research in Miami Inc
City
Hialeah
State/Province
Florida
ZIP/Postal Code
33013
Country
United States
Facility Name
Jacksonville Impotence Treatment Center
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32223
Country
United States
Facility Name
East Coast Institute for Research, LLC
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32258
Country
United States
Facility Name
Care Partners Clinical Research LLC
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32277
Country
United States
Facility Name
Precision Clinical Research, LLC
City
Lauderdale Lakes
State/Province
Florida
ZIP/Postal Code
33319
Country
United States
Facility Name
Veritas Research Corporation
City
Miami
State/Province
Florida
ZIP/Postal Code
33126
Country
United States
Facility Name
APF Research, LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33134
Country
United States
Facility Name
Swiss Medical Research
City
Miami
State/Province
Florida
ZIP/Postal Code
33135
Country
United States
Facility Name
University of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
South Miami Clinical Research
City
Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Well Pharma Medical Research
City
Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Advanced Pharma CR, LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33147
Country
United States
Facility Name
AppleMed Research Group, LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33155
Country
United States
Facility Name
Kendall South Medical Center, Inc
City
Miami
State/Province
Florida
ZIP/Postal Code
33185
Country
United States
Facility Name
Suncoast Clinical Research, Inc.
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34652
Country
United States
Facility Name
Advanced Research Institute, Inc
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34653
Country
United States
Facility Name
Sunshine Research Center
City
Opa-locka
State/Province
Florida
ZIP/Postal Code
33054
Country
United States
Facility Name
Diabetes and Endocrine Center of Orlando
City
Orlando
State/Province
Florida
ZIP/Postal Code
32803
Country
United States
Facility Name
Suncoast Clinical Research
City
Palm Harbor
State/Province
Florida
ZIP/Postal Code
34684
Country
United States
Facility Name
Misal Khan, MD FRCS, ED, PA
City
Panama City
State/Province
Florida
ZIP/Postal Code
32401
Country
United States
Facility Name
Iconic Clinical Trials
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33024
Country
United States
Facility Name
Gulf Region Clinical Research Institute
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32514
Country
United States
Facility Name
St. John's Center for Clinical Research
City
Ponte Vedra Beach
State/Province
Florida
ZIP/Postal Code
32081
Country
United States
Facility Name
Metabolic Research Institute
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Facility Name
PMI Health Research Group
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30312
Country
United States
Facility Name
Atlanta Diabetes Associates
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30318
Country
United States
Facility Name
Albert F. Johary MD, PC
City
Dunwoody
State/Province
Georgia
ZIP/Postal Code
30338
Country
United States
Facility Name
Georgia Clinical Research, LLC
City
Snellville
State/Province
Georgia
ZIP/Postal Code
30078
Country
United States
Facility Name
Hayden Lake Family Physicians
City
Hayden Lake
State/Province
Idaho
ZIP/Postal Code
83835
Country
United States
Facility Name
Boise Kidney and Hypertension Institute
City
Meridian
State/Province
Idaho
ZIP/Postal Code
83642
Country
United States
Facility Name
Suburban Clinical Research
City
Bolingbrook
State/Province
Illinois
ZIP/Postal Code
60490
Country
United States
Facility Name
Cedar-Crosse Research Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60607
Country
United States
Facility Name
John H. Stroger Jr. Hospital of Cook Country
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Apex Medical Research
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60616
Country
United States
Facility Name
Pharmakon Inc
City
Evergreen Park
State/Province
Illinois
ZIP/Postal Code
60805
Country
United States
Facility Name
American Health Network
City
Avon
State/Province
Indiana
ZIP/Postal Code
46123
Country
United States
Facility Name
Investigators Research Group, LLC
City
Brownsburg
State/Province
Indiana
ZIP/Postal Code
46112
Country
United States
Facility Name
American Health Network of Indiana, LLC
City
Franklin
State/Province
Indiana
ZIP/Postal Code
46131
Country
United States
Facility Name
Mapleton Medical Center
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46205
Country
United States
Facility Name
American Health Network, LLC
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46254
Country
United States
Facility Name
McKinley Research, LLC
City
Mishawaka
State/Province
Indiana
ZIP/Postal Code
46545
Country
United States
Facility Name
American Health Network of Indiana, LLC
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47304
Country
United States
Facility Name
MCM Clinical Research, LLC
City
Florence
State/Province
Kentucky
ZIP/Postal Code
41042
Country
United States
Facility Name
Kentucky Diabetes Endocrinology Center
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
Four Rivers Clinical Research, Inc
City
Paducah
State/Province
Kentucky
ZIP/Postal Code
42003
Country
United States
Facility Name
Crescent City Clinical Research
City
Metairie
State/Province
Louisiana
ZIP/Postal Code
70006
Country
United States
Facility Name
Acadia Clinical Research, LLC
City
Bangor
State/Province
Maine
ZIP/Postal Code
04401
Country
United States
Facility Name
Office of Dr. Stephen R. Smith, MD
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21234
Country
United States
Facility Name
Endocrine and Metabolic Consultants
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20852
Country
United States
Facility Name
Tristan Medical Enterprises, PC dba Regeneris
City
North Attleboro
State/Province
Massachusetts
ZIP/Postal Code
02760
Country
United States
Facility Name
ClinSite, LLC
City
Canton
State/Province
Michigan
ZIP/Postal Code
48187
Country
United States
Facility Name
Apex Medical Research, AMR Inc
City
Flint
State/Province
Michigan
ZIP/Postal Code
48504
Country
United States
Facility Name
Westside Family Medical Center, PC
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49009
Country
United States
Facility Name
Tri City Medical Centers, PC
City
Livonia
State/Province
Michigan
ZIP/Postal Code
48152
Country
United States
Facility Name
KMED Research
City
Saint Clair Shores
State/Province
Michigan
ZIP/Postal Code
48081
Country
United States
Facility Name
Tri-County Research, Inc
City
Sterling Heights
State/Province
Michigan
ZIP/Postal Code
48310
Country
United States
Facility Name
Medical Research Associates
City
Traverse City
State/Province
Michigan
ZIP/Postal Code
49684
Country
United States
Facility Name
Oakland Medical Research Center
City
Troy
State/Province
Michigan
ZIP/Postal Code
48085
Country
United States
Facility Name
Park Nicollet Institute
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55416
Country
United States
Facility Name
The Center for Clinical Trials, Inc.
City
Biloxi
State/Province
Mississippi
ZIP/Postal Code
39531
Country
United States
Facility Name
Mercy Health Research
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Quality Clinical Research
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
Facility Name
Clinical Research of South Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89121
Country
United States
Facility Name
Palm Medical Research Center
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89148
Country
United States
Facility Name
Atco Medical Associates, PC
City
Atco
State/Province
New Jersey
ZIP/Postal Code
08004
Country
United States
Facility Name
Summit Medical Group
City
Clifton
State/Province
New Jersey
ZIP/Postal Code
07012
Country
United States
Facility Name
USMA Clinical Research
City
Elizabeth
State/Province
New Jersey
ZIP/Postal Code
07201
Country
United States
Facility Name
Central Jersey Medical Research
City
Elizabeth
State/Province
New Jersey
ZIP/Postal Code
07202
Country
United States
Facility Name
Albany Medical Center / Albany Medical College
City
Albany
State/Province
New York
ZIP/Postal Code
12206
Country
United States
Facility Name
Endocrine Associates of Long Island, PC
City
Smithtown
State/Province
New York
ZIP/Postal Code
11787
Country
United States
Facility Name
Southgate Medical Group/ Southgate Medical Park
City
West Seneca
State/Province
New York
ZIP/Postal Code
14224
Country
United States
Facility Name
OnSite Clinical Solutions, LLC
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
Kernodle Clinic West
City
Burlington
State/Province
North Carolina
ZIP/Postal Code
27215
Country
United States
Facility Name
The University of North Carolina at Chapel Hill
City
Chapel Hill
State/Province
North Carolina
ZIP/Postal Code
27517
Country
United States
Facility Name
Internal Medicine Research
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Gaffney Health Services
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28205
Country
United States
Facility Name
Durham Internal Medicine Associates
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27704
Country
United States
Facility Name
Sentara Family Medicine
City
Elizabeth City
State/Province
North Carolina
ZIP/Postal Code
27909
Country
United States
Facility Name
PMG Research of Raleigh, LLC
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27609
Country
United States
Facility Name
Carolina Research Center, Inc
City
Shelby
State/Province
North Carolina
ZIP/Postal Code
28150
Country
United States
Facility Name
Piedmont Healthcare
City
Statesville
State/Province
North Carolina
ZIP/Postal Code
28625
Country
United States
Facility Name
PMG Research of Wilmington, LLC
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
Community Health Care of Manchester
City
Akron
State/Province
Ohio
ZIP/Postal Code
44319
Country
United States
Facility Name
Community Medical Associates, LLC
City
Austintown
State/Province
Ohio
ZIP/Postal Code
44515
Country
United States
Facility Name
Harrison Community Research Center
City
Cadiz
State/Province
Ohio
ZIP/Postal Code
43907
Country
United States
Facility Name
Medical Frontiers, LLC
City
Carlisle
State/Province
Ohio
ZIP/Postal Code
45005
Country
United States
Facility Name
Genoa Medical Center
City
Genoa
State/Province
Ohio
ZIP/Postal Code
43430
Country
United States
Facility Name
Office of Dr. Craig S. Thompson, MD, LLC
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
RAS Health Limited
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
Advanced Medical Research, LLC
City
Maumee
State/Province
Ohio
ZIP/Postal Code
43537
Country
United States
Facility Name
Pharmacotherapy Research Associates, Inc
City
Zanesville
State/Province
Ohio
ZIP/Postal Code
43701
Country
United States
Facility Name
Infinity Research Group, LLC
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73103
Country
United States
Facility Name
Castlerock Clinical Research Consultants, LLC
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74136
Country
United States
Facility Name
Oregon Medical Group
City
Eugene
State/Province
Oregon
ZIP/Postal Code
97401
Country
United States
Facility Name
Harleysville Medical Associates
City
Harleysville
State/Province
Pennsylvania
ZIP/Postal Code
19438
Country
United States
Facility Name
Detweiler Family Medicine & Associates, PC
City
Lansdale
State/Province
Pennsylvania
ZIP/Postal Code
19446
Country
United States
Facility Name
Temple University School of Medicine
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
Warminster Medical Associates, PC
City
Warminster
State/Province
Pennsylvania
ZIP/Postal Code
18974
Country
United States
Facility Name
New England Center for Clinical Research, Inc
City
Cranston
State/Province
Rhode Island
ZIP/Postal Code
02920
Country
United States
Facility Name
Hartwell Research Group, LLC
City
Anderson
State/Province
South Carolina
ZIP/Postal Code
29621
Country
United States
Facility Name
Paris View Family Practice
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29601
Country
United States
Facility Name
Mountain View Clinical Research
City
Greer
State/Province
South Carolina
ZIP/Postal Code
29651
Country
United States
Facility Name
South Carolina Nephrology and Hypertension Center, Inc
City
Orangeburg
State/Province
South Carolina
ZIP/Postal Code
29118
Country
United States
Facility Name
Carolina Diabetes & Kidney Center
City
Sumter
State/Province
South Carolina
ZIP/Postal Code
29150
Country
United States
Facility Name
PMG Research of Bristol
City
Bristol
State/Province
Tennessee
ZIP/Postal Code
37620
Country
United States
Facility Name
University Diabetes and Endocrine Consultants
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37411
Country
United States
Facility Name
University of Tennessee
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38163
Country
United States
Facility Name
Trinity Clinical Research, LLC
City
Tullahoma
State/Province
Tennessee
ZIP/Postal Code
37388
Country
United States
Facility Name
KRK Medical Research
City
Arlington
State/Province
Texas
ZIP/Postal Code
76012
Country
United States
Facility Name
Austin Center for Clinical Research
City
Austin
State/Province
Texas
ZIP/Postal Code
78758
Country
United States
Facility Name
Punzi Medical Center
City
Carrollton
State/Province
Texas
ZIP/Postal Code
75006
Country
United States
Facility Name
Dallas Diabetes and Endocrine Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230
Country
United States
Facility Name
Baylor Endocrine Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
University of Texas Southwestern Medical Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-8858
Country
United States
Facility Name
Jacon Medical Research Associates, LLC
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
JVC Family Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77040
Country
United States
Facility Name
Clinical Trial Network
City
Houston
State/Province
Texas
ZIP/Postal Code
77074
Country
United States
Facility Name
Endocrine and Psychiastry Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77095
Country
United States
Facility Name
Pioneer Research Solutions, Inc.
City
Houston
State/Province
Texas
ZIP/Postal Code
77099
Country
United States
Facility Name
Midland Clinical Research Center
City
Midland
State/Province
Texas
ZIP/Postal Code
79707
Country
United States
Facility Name
Hill Country Medical Associates
City
New Braunfels
State/Province
Texas
ZIP/Postal Code
78130
Country
United States
Facility Name
Naidu Clinic
City
Odessa
State/Province
Texas
ZIP/Postal Code
79761
Country
United States
Facility Name
The Methodist Hospital d/b/a HMRI CCAT at Pearland
City
Pearland
State/Province
Texas
ZIP/Postal Code
77584
Country
United States
Facility Name
Village Health Partners
City
Plano
State/Province
Texas
ZIP/Postal Code
75024
Country
United States
Facility Name
Sun Research Institute
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78215
Country
United States
Facility Name
Northeast Clinical Research of San Antonio, LLC
City
Schertz
State/Province
Texas
ZIP/Postal Code
78154
Country
United States
Facility Name
Kenneth Otah and Associates
City
Sugar Land
State/Province
Texas
ZIP/Postal Code
77478
Country
United States
Facility Name
PHS Clinical Trials
City
Midvale
State/Province
Utah
ZIP/Postal Code
84047
Country
United States
Facility Name
Highland Clinical Research
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84124
Country
United States
Facility Name
Burke Internal Medicine and Research
City
Burke
State/Province
Virginia
ZIP/Postal Code
22015
Country
United States
Facility Name
Ettrick Health Center
City
Ettrick
State/Province
Virginia
ZIP/Postal Code
23803
Country
United States
Facility Name
Manassas Clinical Research Center
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20110
Country
United States
Facility Name
Clinical Research Partners, LLC
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23220
Country
United States
Facility Name
Richmond Family Practice
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23220
Country
United States
Facility Name
Larry D Stonesifer, MD Inc., PS
City
Federal Way
State/Province
Washington
ZIP/Postal Code
98003
Country
United States
Facility Name
Premier Clinical Research
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Instituto de Investigaciones Clínicas de Bahía Blanca
City
Bahía Blanca
ZIP/Postal Code
B8000FTD
Country
Argentina
Facility Name
CIPREC
City
Caba
ZIP/Postal Code
C1119ACN
Country
Argentina
Facility Name
CENUDIAB
City
Caba
ZIP/Postal Code
C1440AAD
Country
Argentina
Facility Name
Instituto Médico Especializado
City
Capital Federal
ZIP/Postal Code
C1405BCH
Country
Argentina
Facility Name
Consultorios Asociados de Endocrinología e Invest Clínica
City
Capital Federal
ZIP/Postal Code
C1425AGC
Country
Argentina
Facility Name
IPAC - Clínica Privada Caraffa SRL
City
Cordoba
ZIP/Postal Code
X5008KKF
Country
Argentina
Facility Name
Instituto Cardiovascular de Corrientes Juana Francisca Cabra
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
Facility Name
Ilaim-Ceom
City
Córdoba
ZIP/Postal Code
X5000BNB
Country
Argentina
Facility Name
Hospital Italiano de La Plata
City
La Plata
ZIP/Postal Code
B1900AWT
Country
Argentina
Facility Name
CIPADI
City
Mendoza
ZIP/Postal Code
M5500EVJ
Country
Argentina
Facility Name
Instituto de Investigaciones Clinicas de Rosario
City
Rosario
ZIP/Postal Code
S2000CVD
Country
Argentina
Facility Name
Instituto de Hematología y Medicina Clínica Dr. Rubén Davoli
City
Rosario
ZIP/Postal Code
S2000CXP
Country
Argentina
Facility Name
Hospital San Bernardo
City
Salta
ZIP/Postal Code
A4406CLA
Country
Argentina
Facility Name
Investigaciones Clinicas Tucuman
City
San Miguel de Tucumán
ZIP/Postal Code
T4000ICL
Country
Argentina
Facility Name
Instituto de Investigaciones Biomédicas
City
Santa Fe
ZIP/Postal Code
S3000FNF
Country
Argentina
Facility Name
Centro de Investigaciones Clínicas del Litoral
City
Santa Fe
ZIP/Postal Code
S3000SWO
Country
Argentina
Facility Name
Royal Brisbane & Women's Hospital-Endocrinology
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Facility Name
Logan Hospital
City
Meadowbrook
State/Province
Queensland
ZIP/Postal Code
4131
Country
Australia
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Eastern Clinical Research Unit
City
East Ringwood
State/Province
Victoria
ZIP/Postal Code
3135
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Blankenberge - PRAC Vileyn, Geert
City
Blankenberge
ZIP/Postal Code
8370
Country
Belgium
Facility Name
Bonheiden - HOSP Imelda
City
Bonheiden
ZIP/Postal Code
2820
Country
Belgium
Facility Name
De Pinte - PRAC Hollanders, Geert
City
De Pinte
ZIP/Postal Code
9840
Country
Belgium
Facility Name
Retie - PRAC De Vos, Axel
City
Dessel
ZIP/Postal Code
2480
Country
Belgium
Facility Name
Deurne - PRAC Heyvaert, Frank
City
Deurne
ZIP/Postal Code
2100
Country
Belgium
Facility Name
Deurne - PRAC Verelst, Joost
City
Deurne
ZIP/Postal Code
2100
Country
Belgium
Facility Name
Genk - PRAC Vernijns, J.
City
Genk
ZIP/Postal Code
3600
Country
Belgium
Facility Name
Gozée - PRAC De Meulemeester, Marc
City
Gozée
ZIP/Postal Code
6534
Country
Belgium
Facility Name
Hasselt - PRAC Vantroyen, Daniel
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Facility Name
Herent - PRAC Denolf, Bart
City
Herent
ZIP/Postal Code
3020
Country
Belgium
Facility Name
Linkebeek - PRAC Maury, Olivier
City
Linkebeek
ZIP/Postal Code
1630
Country
Belgium
Facility Name
Moorsel - PRAC Van Mulders, N.
City
Moorsel
ZIP/Postal Code
9310
Country
Belgium
Facility Name
Natoye - PRAC Balthazar, Y.
City
Natoye
ZIP/Postal Code
5360
Country
Belgium
Facility Name
Tremelo - PRAC Vermeersch, Lode
City
Tremelo
ZIP/Postal Code
3210
Country
Belgium
Facility Name
Hospital Universitário João de Barros Barreto
City
Belém
ZIP/Postal Code
66073-000
Country
Brazil
Facility Name
Universidade Federal do Paraná
City
Curitiba
ZIP/Postal Code
80060-900
Country
Brazil
Facility Name
Hospital Geral de Goiânia Alberto Rassi
City
Goiânia
ZIP/Postal Code
74043-110
Country
Brazil
Facility Name
Centro de Pesquisas Clínicas Ltda
City
Higienópolis
ZIP/Postal Code
01244-030
Country
Brazil
Facility Name
Centro de Estudos em Diabetes e Hipertensão
City
Joaquim Távora
ZIP/Postal Code
60115-282
Country
Brazil
Facility Name
Irmandade Santa Casa de Misericordia de Porto Alegre
City
Porto Alegre
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Centro de Pesquisas em Diabetes
City
Porto Alegre
ZIP/Postal Code
90035-170
Country
Brazil
Facility Name
Instituto Estadual de Diabetes e Endocrinologia
City
Río de Janeiro
ZIP/Postal Code
20211-340
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
City
Santa Cecília
ZIP/Postal Code
01221-020
Country
Brazil
Facility Name
Instituto de Molestias Cardiovasculares - IMC
City
São José do Rio Preto
ZIP/Postal Code
15015-210
Country
Brazil
Facility Name
Hospital das Clinicas da FMUSP
City
São Paulo
ZIP/Postal Code
05403-900
Country
Brazil
Facility Name
Hospital do Rim e Hipertensão - UNIFESP
City
Vila Clementino
ZIP/Postal Code
04025-011
Country
Brazil
Facility Name
Univ.Multiprofile Hospital "Dr. Georgy Stranski" EAD, Pleven
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
Facility Name
Multiprofile Hospital for Active Treatment
City
Sofia
ZIP/Postal Code
1431
Country
Bulgaria
Facility Name
Multiprofile Hospital for Active Treatment "Zaritza Johanna"
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Facility Name
Military Medical Academy, Clin. Endocrinology & Metab. Dis.
City
Sofia
ZIP/Postal Code
1606
Country
Bulgaria
Facility Name
MHAT Prof Stoyan Kirkovich AD
City
Stara Zagora
ZIP/Postal Code
6000
Country
Bulgaria
Facility Name
IUCPQ (Laval University)
City
Quebec
State/Province
Migration Data
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
First Line Medical Services Ltd.
City
St. John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1E 2C2
Country
Canada
Facility Name
Topsail Road Medical Clinic
City
St. John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1E 2E2
Country
Canada
Facility Name
Cambridge Cardiac Care Inc.
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
Facility Name
Hamilton Medical Research Group
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8M 1K7
Country
Canada
Facility Name
SKDS Research Incorporated
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 5G8
Country
Canada
Facility Name
Wilderman Medical Clinic
City
Thornhill
State/Province
Ontario
ZIP/Postal Code
L4J 1W3
Country
Canada
Facility Name
St. Michael's Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5C 2T2
Country
Canada
Facility Name
Albion Finch Medical Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M9V 4B4
Country
Canada
Facility Name
Kings County Medical Centre
City
Montague
State/Province
Prince Edward Island
ZIP/Postal Code
C0A 1R0
Country
Canada
Facility Name
Dynamik Research
City
Pointe Claire
State/Province
Quebec
ZIP/Postal Code
H9R 3J1
Country
Canada
Facility Name
Consulta Privada Maria Loreto Aguirre Coveña
City
Providencia
ZIP/Postal Code
7500010
Country
Chile
Facility Name
Hospital de Servicios Médicos Godoy Ltda
City
Providencia
Country
Chile
Facility Name
Centro Medico Antulawen
City
Temuco
Country
Chile
Facility Name
Hospital Naval Almirante Nef
City
Viña del Mar
Country
Chile
Facility Name
BioMelab
City
Barranquilla
Country
Colombia
Facility Name
Centro Cientifico Asistencial Jose Luis Accini
City
Barranquilla
Country
Colombia
Facility Name
Fundacion del Caribe de Investigacion Biomedica
City
Barranquilla
Country
Colombia
Facility Name
Endocare Research Institute
City
Bogota
Country
Colombia
Facility Name
Dexa Diabetes Servicios Médicos Ltda
City
Bogotá
Country
Colombia
Facility Name
UNIENDO Unidad Integral de Endocrinologia
City
Bogotá
Country
Colombia
Facility Name
Centro cardiovascular Aristides
City
Cartagena
Country
Colombia
Facility Name
centro de Diagnostico Cardiologico para la Investigacion Bio
City
Cartagena
Country
Colombia
Facility Name
Fundacion Cardiovascular de Colombia
City
El Bosque
Country
Colombia
Facility Name
Fundación Oftalmologica de Santander
City
El Bosque
Country
Colombia
Facility Name
Fundación Centro de Investigaciones Biomédicas Riescard
City
Tolima
Country
Colombia
Facility Name
Internal & Diabetology Ambulance, Jablonec nad Nisou
City
Jablonec nad Nisou
ZIP/Postal Code
466 01
Country
Czechia
Facility Name
Diabetology & Internal Ambulance
City
Olomouc-Lazce
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Internal & Diabetology Ambulance Dr. Vrkoc, Ostrava
City
Ostrava
ZIP/Postal Code
702 00
Country
Czechia
Facility Name
Cardiology ambulance, Plzen
City
Plzen
ZIP/Postal Code
301 00
Country
Czechia
Facility Name
ResTrial s.r.o.
City
Praha 8
ZIP/Postal Code
181 00
Country
Czechia
Facility Name
Diebetology internal Ambulance
City
Praha
ZIP/Postal Code
101 00
Country
Czechia
Facility Name
Internal & Diabetology Ambulance, Prostejov
City
Prostejov
ZIP/Postal Code
796 01
Country
Czechia
Facility Name
Hospital Strakonice, Internal Department
City
Strakonice
ZIP/Postal Code
386 29
Country
Czechia
Facility Name
Diabetesklinikka, Mehiläinen Töölö
City
Helsinki
ZIP/Postal Code
00260
Country
Finland
Facility Name
Lääkärikeskus Ite
City
Joensuu
ZIP/Postal Code
80100
Country
Finland
Facility Name
Lääkärikeskus Aava Kerava
City
Kerava
ZIP/Postal Code
04200
Country
Finland
Facility Name
Kokkolan Lääkärikeskus
City
Kokkola
ZIP/Postal Code
67100
Country
Finland
Facility Name
IteLasaretti
City
Kuopio
ZIP/Postal Code
FI-70100
Country
Finland
Facility Name
Terveystalo Oulu, Diapolis
City
Oulu
ZIP/Postal Code
FI-90100
Country
Finland
Facility Name
TYKS
City
Turku
ZIP/Postal Code
FI-20520
Country
Finland
Facility Name
CAB Hell M, MG, Behren Les Forbach
City
Behren Les Forbach
ZIP/Postal Code
57460
Country
France
Facility Name
HOP Haut Levèque, Diabéto, Pessac
City
Bordeaux
ZIP/Postal Code
33075
Country
France
Facility Name
CAB Lemarie B, MG, Bourg des Cptes
City
Bourg des Comptes
ZIP/Postal Code
35890
Country
France
Facility Name
CAB Cadinot Dr D, Broglie
City
Broglie
ZIP/Postal Code
27270
Country
France
Facility Name
CAB Breton Dr Nicolas
City
Béziers
ZIP/Postal Code
34500
Country
France
Facility Name
CAB Ferrier R, MG, Cannes
City
Cannes
ZIP/Postal Code
06400
Country
France
Facility Name
CAB Jordan E, MG, Carbonne
City
Carbonne
ZIP/Postal Code
31390
Country
France
Facility Name
CAB Merlin P, MG Castets
City
Castets
ZIP/Postal Code
40260
Country
France
Facility Name
CAB Fonteny R, MG, Chartres
City
Chartres
ZIP/Postal Code
28000
Country
France
Facility Name
CAB Fournier P, MG, Chartres
City
Chartres
ZIP/Postal Code
28000
Country
France
Facility Name
CAB Martocq G, MG, Cournonterral
City
Cournonterral
ZIP/Postal Code
34660
Country
France
Facility Name
HOP, Fort de France, Fort de France
City
Fort De France
ZIP/Postal Code
97261
Country
France
Facility Name
CAB Le Mouel S, MG, Hinx
City
Hinx
ZIP/Postal Code
40180
Country
France
Facility Name
CAB Pholsena, MG, La Réunion
City
La Reunion
ZIP/Postal Code
97410
Country
France
Facility Name
CAB Bismuth M
City
Labarthe sur Leze
ZIP/Postal Code
31860
Country
France
Facility Name
CAB Zimmermann D
City
Louvigne De Bie
ZIP/Postal Code
35680
Country
France
Facility Name
CAB Mainetti P, MG, Maintenon
City
Maintenon
ZIP/Postal Code
28130
Country
France
Facility Name
CAB Barucq F, MG, Orthez
City
Orthez
ZIP/Postal Code
64300
Country
France
Facility Name
CAB Mostephai M
City
Orthez
ZIP/Postal Code
64300
Country
France
Facility Name
CAB Cassagnes JL, MG, Palau Del Vidre
City
Palau Del Vidre
ZIP/Postal Code
66690
Country
France
Facility Name
CAB Mercey Y, MG, St Genies des Fontaines
City
Saint Genies Des Fontaines
ZIP/Postal Code
66740
Country
France
Facility Name
Hop St Dié des Vosges, Diabéto, St Dié des Vosges
City
St Dié des Vosges Cedex
ZIP/Postal Code
88187
Country
France
Facility Name
CAB Bonneau D, MG, Thouars
City
Thouars
ZIP/Postal Code
79100
Country
France
Facility Name
CAB Morel H, MG, Tilly sur Seulles
City
Tilly sur Seulles
ZIP/Postal Code
14250
Country
France
Facility Name
Unimed Ajara LLC, Private Practice
City
Batumi
ZIP/Postal Code
6004
Country
Georgia
Facility Name
Central Hospital LTD 'Gormedi', Gori
City
Gori
ZIP/Postal Code
1400
Country
Georgia
Facility Name
L&J Clinic, Kutaisi
City
Kutaisi
ZIP/Postal Code
4600
Country
Georgia
Facility Name
EC Cardiology Clinic,Tbilisi
City
Tbilisi
ZIP/Postal Code
0144
Country
Georgia
Facility Name
National Center for Diabetes Research Ltd., Tbilisi
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
National Institute of Endocrinology, Tbilisi
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Zhordania Institute of Human Reproduction, Tbilisi
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
Facility Name
Medical Centre Medelite Ltd., Tbilisi
City
Tbilisi
ZIP/Postal Code
0177
Country
Georgia
Facility Name
Chemotherapy & Immunotherapy Clinic 'Medulla', Tbilisi
City
Tbilisi
ZIP/Postal Code
0186
Country
Georgia
Facility Name
JSC 'Curatio'
City
Zugdidi
ZIP/Postal Code
2100
Country
Georgia
Facility Name
Universitätsklinikum Aachen, AöR
City
Aachen
ZIP/Postal Code
52074
Country
Germany
Facility Name
Studienzentrum Klausmann
City
Aschaffenburg
ZIP/Postal Code
63739
Country
Germany
Facility Name
Gemeinschaftspraxis, Asslar
City
Asslar
ZIP/Postal Code
35614
Country
Germany
Facility Name
Diabetes Schwerpunktpraxis
City
Bad Nauheim
ZIP/Postal Code
61231
Country
Germany
Facility Name
Praxis Dr. Naumburger, Berlin
City
Berlin
ZIP/Postal Code
10409
Country
Germany
Facility Name
emovis GmbH
City
Berlin
ZIP/Postal Code
10629
Country
Germany
Facility Name
Praxis Dr. Rieker, Berlin
City
Berlin
ZIP/Postal Code
10789
Country
Germany
Facility Name
IFG Institut für Gesundheitsförderung GmbH
City
Berlin
ZIP/Postal Code
12621
Country
Germany
Facility Name
MVZ DaVita Dormagen GmbH
City
Dormagen- Hackenbroich
ZIP/Postal Code
41540
Country
Germany
Facility Name
Praxis Dr. Busch, Dortmund
City
Dortmund
ZIP/Postal Code
44137
Country
Germany
Facility Name
GWT-TUD GmbH
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Praxis Dr. Schlecht, Eisenach
City
Eisenach
ZIP/Postal Code
99817
Country
Germany
Facility Name
ZKS Südbrandenburg GmbH
City
Elsterwerda
ZIP/Postal Code
04910
Country
Germany
Facility Name
Praxis Dr. Huptas, Essen
City
Essen
ZIP/Postal Code
45307
Country
Germany
Facility Name
Praxis Dr. Schmidt, Flörsheim
City
Flörsheim
ZIP/Postal Code
65439
Country
Germany
Facility Name
Institut für Stoffwechselforschung, Frankfurt
City
Frankfurt
ZIP/Postal Code
60322
Country
Germany
Facility Name
Praxis Dr. Groeneveld, Furth im Wald
City
Furth im Wald
ZIP/Postal Code
93437
Country
Germany
Facility Name
Praxis Dr. Kohlhas, Gebhardshain
City
Gebhardshain
ZIP/Postal Code
57580
Country
Germany
Facility Name
Praxis Dr. Samer, Haag
City
Haag
ZIP/Postal Code
83527
Country
Germany
Facility Name
Klinische Forschung Management & Services GmbH
City
Hamburg
ZIP/Postal Code
20253
Country
Germany
Facility Name
Diabetologische Schwerpunktpraxis
City
Hamburg
ZIP/Postal Code
21073
Country
Germany
Facility Name
Praxis Dr. Burkhardt, Hamburg
City
Hamburg
ZIP/Postal Code
22335
Country
Germany
Facility Name
Diabeteszentrum Alstertal, Hamburg
City
Hamburg
ZIP/Postal Code
22391
Country
Germany
Facility Name
Praxis Dr. Herrmann, Hatten
City
Kirchhatten
ZIP/Postal Code
26209
Country
Germany
Facility Name
Dünnwaldpraxis, Köln
City
Köln
ZIP/Postal Code
51069
Country
Germany
Facility Name
Praxis Dr. Klein, Künzing
City
Künzing
ZIP/Postal Code
94550
Country
Germany
Facility Name
Praxis Dr. Nischik, Leipzig
City
Leipzig
ZIP/Postal Code
04109
Country
Germany
Facility Name
Praxis Dr. Kropp, Lübeck
City
Lübeck
ZIP/Postal Code
23554
Country
Germany
Facility Name
PFÜTZNER Science & Health Institute GmbH
City
Mainz
ZIP/Postal Code
55128
Country
Germany
Facility Name
Diabetologische Schwerpunktpraxis
City
Münster
ZIP/Postal Code
48153
Country
Germany
Facility Name
Praxis Dr. Böckmann
City
Neumünster
ZIP/Postal Code
24534
Country
Germany
Facility Name
Praxis Dr. Hilgenberg
City
Rehburg-Loccum
ZIP/Postal Code
31547
Country
Germany
Facility Name
Praxis Dr. Naudts, Rodgau
City
Rodgau/Dudenhofen
ZIP/Postal Code
63110
Country
Germany
Facility Name
Praxis Dr. Hirschhäuser
City
Saarbrücken
ZIP/Postal Code
66121
Country
Germany
Facility Name
Praxis Dr. Segner, St. Ingberg
City
Saint Ingbert / Oberwürzbach
ZIP/Postal Code
66386
Country
Germany
Facility Name
Praxis Dr. Herrmann
City
Schwabenheim
ZIP/Postal Code
55270
Country
Germany
Facility Name
Praxis Dr. Dietlein
City
Stadtbergen
ZIP/Postal Code
86391
Country
Germany
Facility Name
Praxis Dr. Sauter
City
Wangen
ZIP/Postal Code
88239
Country
Germany
Facility Name
Schwerpunktpraxis Diabetologie
City
Zwenkau
ZIP/Postal Code
04442
Country
Germany
Facility Name
General Hospital of Athens Evangelismos
City
Athens
ZIP/Postal Code
10676
Country
Greece
Facility Name
General University Hospital "Attikon"
City
Haidari, Athens
ZIP/Postal Code
12410
Country
Greece
Facility Name
Univ. Gen. Hosp. of Ioannina
City
Ioannina
ZIP/Postal Code
45500
Country
Greece
Facility Name
General Hospital "Amalia Fleming"
City
Melissia, Athens
ZIP/Postal Code
15127
Country
Greece
Facility Name
General Hospital of Nikaia
City
Nikaia
ZIP/Postal Code
18484
Country
Greece
Facility Name
University General Hospital of Thessaloniki AHEPA
City
Thessaloniki
ZIP/Postal Code
54636
Country
Greece
Facility Name
General Hopsital of Thessaloniki "Ippokrateio"
City
Thessaloniki
ZIP/Postal Code
54642
Country
Greece
Facility Name
Kliniki Thermi
City
Thessaloniki
ZIP/Postal Code
57001
Country
Greece
Facility Name
Alice Ho Miu Ling Nethersole Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Prince of Wales Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Queen Mary Hospital
City
Hong Kong
Country
Hong Kong
Facility Name
Imre Magyar Hospital, Ajka
City
Ajka
ZIP/Postal Code
8400
Country
Hungary
Facility Name
Lausmed Kft. Outpatient Unit of Internal Medicine
City
Baja
ZIP/Postal Code
6500
Country
Hungary
Facility Name
Karolyi Sandor Hospital, Budapest
City
Budapest
ZIP/Postal Code
1041
Country
Hungary
Facility Name
Bekes County Pandy Kalman Hospital
City
Gyula
ZIP/Postal Code
5700
Country
Hungary
Facility Name
Erzsebet Hospital, Hodmezövasarhely
City
Hódmezövásárhely
ZIP/Postal Code
6800
Country
Hungary
Facility Name
Dr. Samuel Diosszilagyi Hospital and Outpatient Clinic, Mako
City
Mako
ZIP/Postal Code
6900
Country
Hungary
Facility Name
TaNa Med Kft.
City
Mosonmagyarovar
ZIP/Postal Code
9200
Country
Hungary
Facility Name
Grof Esterhazy Hospital and Outpatient Clinic
City
Papa
ZIP/Postal Code
8500
Country
Hungary
Facility Name
Tolna County Balassa Janos Hospital
City
Szekszard
ZIP/Postal Code
7100
Country
Hungary
Facility Name
Shree Krishna Hospital and Heart Care Centre, Ahmedabad
City
Ahmedabad
ZIP/Postal Code
380052
Country
India
Facility Name
CIIGMA Institute of Medical Sciences Pvt Ltd
City
Aurangabad
ZIP/Postal Code
431001
Country
India
Facility Name
MS Ramaiah Memorial Hospital,
City
Bangalore, Karnataka
ZIP/Postal Code
560054
Country
India
Facility Name
Diabetes care and research centre
City
Bangalore
ZIP/Postal Code
560010
Country
India
Facility Name
Manipal Hospital
City
Bangalore
ZIP/Postal Code
560017
Country
India
Facility Name
Bangalore Diabetes Centre (BDC)- Medisys Clinical Research
City
Bangalore
ZIP/Postal Code
560043
Country
India
Facility Name
Belgaum Diabetes Centre, Belgaum
City
Belgaum
ZIP/Postal Code
590001
Country
India
Facility Name
Swamy Diabetes Centre
City
Chennai
ZIP/Postal Code
600 028
Country
India
Facility Name
Apollo Hospitals
City
Chennai
ZIP/Postal Code
600010
Country
India
Facility Name
M V Hospital For Diabetes and Diabetes Research Centre
City
Chennai
ZIP/Postal Code
600013
Country
India
Facility Name
Dr. Mohans Diabetes Speciality Centre
City
Chennai
ZIP/Postal Code
600086
Country
India
Facility Name
Kovai Diabetes Speciality Centre & Hospital
City
Coimbatore
ZIP/Postal Code
641009
Country
India
Facility Name
TOTALL Diabetes Hormone Institute
City
Indore
ZIP/Postal Code
452010
Country
India
Facility Name
Diabetes Thyroid and Endocrine Centre
City
Jaipur
ZIP/Postal Code
302 006
Country
India
Facility Name
Diamed Clinical Research Services Pvt. Ltd.
City
Jaipur
ZIP/Postal Code
302016
Country
India
Facility Name
Grant Medical Foundation, Ruby Hall Clinic
City
Maharashtra
ZIP/Postal Code
411001
Country
India
Facility Name
K.G.N. Diabetes and Endocrine Centre
City
Mumbai, Maharastra
ZIP/Postal Code
400008
Country
India
Facility Name
Global Hospital- Superspeciality & Transplant Centre
City
Mumbai
ZIP/Postal Code
400012
Country
India
Facility Name
RHIDEM
City
Mumbai
ZIP/Postal Code
400014
Country
India
Facility Name
Sunil's Diabetes care and Research Centre
City
Nagpur
ZIP/Postal Code
440 010
Country
India
Facility Name
Jahingir Clinical Development Centre
City
Pune
ZIP/Postal Code
411001
Country
India
Facility Name
Deshmukh Clinic
City
Pune
ZIP/Postal Code
411030
Country
India
Facility Name
Diabetes Care Center
City
Thiruvananthapuram
ZIP/Postal Code
695 010
Country
India
Facility Name
Yalamanchi Hospitals & Research Centres Pvt Ltd.
City
Vijayawada
ZIP/Postal Code
520 002
Country
India
Facility Name
The Red House Family Practice
City
Co. Cork
ZIP/Postal Code
CORK
Country
Ireland
Facility Name
Connolly Hospital Blanchardstown
City
Dublin
ZIP/Postal Code
15
Country
Ireland
Facility Name
The Palms GP Surgery
City
Gorey
ZIP/Postal Code
Wexford
Country
Ireland
Facility Name
Fethard-on-Sea Medical Practice
City
Wexford
ZIP/Postal Code
Wexford
Country
Ireland
Facility Name
Barzilai Medical Center
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
Facility Name
Rambam Medical Center
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Facility Name
Edith Wolfson Medical Center, Diabetic Unit, Holon
City
Holon
ZIP/Postal Code
58100
Country
Israel
Facility Name
Hadassah Medical Center, Ein-Karem
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Western Galilee Hospital
City
Nahariya
ZIP/Postal Code
22100
Country
Israel
Facility Name
The Chaim Sheba Medical Center Tel Hashomer
City
Tel Hashomer
ZIP/Postal Code
52621
Country
Israel
Facility Name
Sourasky Medical Center
City
Tel-Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Ospedale "SS. Trinità"
City
Cagliari
ZIP/Postal Code
09100
Country
Italy
Facility Name
Policlinico Universitario Mater Domini, Universita di Catanzaro
City
Catanzaro
ZIP/Postal Code
88100
Country
Italy
Facility Name
Policlinico San Martino
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
Ospedale di Guastalla
City
Guastalla (RE)
ZIP/Postal Code
42016
Country
Italy
Facility Name
A.O.U.Policlinico G.Martino
City
Messina
ZIP/Postal Code
98125
Country
Italy
Facility Name
Fondazione Centro San Raffaele del Monte Tabor
City
Milano
ZIP/Postal Code
20132
Country
Italy
Facility Name
Ospedale S. Pertini
City
Roma
ZIP/Postal Code
00100
Country
Italy
Facility Name
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
City
Roma
ZIP/Postal Code
00189
Country
Italy
Facility Name
IRCCS Gruppo Multimedica
City
Sesto San Giovanni (MI)
ZIP/Postal Code
20099
Country
Italy
Facility Name
Daishinkai Medical Corporation Ookuma Hospital
City
Aichi, Nagoya
ZIP/Postal Code
462-0825
Country
Japan
Facility Name
Chibanishi General Hospital
City
Chiba, Matsudo
ZIP/Postal Code
270-2251
Country
Japan
Facility Name
New Tokyo Heart Clinic
City
Chiba, Matsudo
ZIP/Postal Code
271-0077
Country
Japan
Facility Name
Kashinoki I.M. Clinic, Fukushima, I.M.
City
Fukushima, Date
ZIP/Postal Code
960-0418
Country
Japan
Facility Name
Japan Community Health care Organization Nihonmatsu Hospital
City
Fukushima, Nihonmatsu
ZIP/Postal Code
964-8501
Country
Japan
Facility Name
Iwase General Hospital
City
Fukushima, Sukagawa
ZIP/Postal Code
962-8503
Country
Japan
Facility Name
Iryohojinshadan Sasaki Clinic
City
Hyogo, Amagasaki
ZIP/Postal Code
660-0827
Country
Japan
Facility Name
Takasagoseibu Hospital
City
Hyogo, Takasago
ZIP/Postal Code
676-0812
Country
Japan
Facility Name
Kanagawa Cardiovascular and Respiratory Center
City
Kanagawa, Yokohama
ZIP/Postal Code
236-0051
Country
Japan
Facility Name
Jinnouchi Clinic Diabetes Care Center
City
Kumamoto, Kumamoto
ZIP/Postal Code
862-0976
Country
Japan
Facility Name
Kumamoto Rosai Hospital
City
Kumamoto, Yatsushiro
ZIP/Postal Code
866-8533
Country
Japan
Facility Name
Koga General Hospital
City
Miyazaki, Miyazaki
ZIP/Postal Code
880-0041
Country
Japan
Facility Name
Saitama Medical Cooperative Association Hanyu General Hospital
City
Saitama, Hanyu
ZIP/Postal Code
348-0045
Country
Japan
Facility Name
Nihon University Itabashi Hospital
City
Tokyo, Itabashi-ku
ZIP/Postal Code
173-8610
Country
Japan
Facility Name
Korea University Ansan Hospital
City
Ansan
ZIP/Postal Code
15355
Country
Korea, Republic of
Facility Name
Inje University Busan Paik Hospital
City
Busan
ZIP/Postal Code
614-735
Country
Korea, Republic of
Facility Name
Keimyung University Dongsan Medical Center
City
Daegu
ZIP/Postal Code
700-712
Country
Korea, Republic of
Facility Name
National Health Insurance Service Ilsan Hospital
City
Goyang
ZIP/Postal Code
410-719
Country
Korea, Republic of
Facility Name
Dongguk University Ilsan Hospital
City
Goyang
ZIP/Postal Code
410-773
Country
Korea, Republic of
Facility Name
Inje University Ilsan Paik Hospital
City
Goyang
ZIP/Postal Code
411-706
Country
Korea, Republic of
Facility Name
Chonbuk National University Hospital
City
Jeonju
ZIP/Postal Code
561-712
Country
Korea, Republic of
Facility Name
Pusan National Univ. Hosp
City
Pusan
ZIP/Postal Code
602-739
Country
Korea, Republic of
Facility Name
Seoul National University Bundang Hospital
City
Seongnam
ZIP/Postal Code
463-707
Country
Korea, Republic of
Facility Name
Korea University Anam Hospital
City
Seoul
ZIP/Postal Code
02841
Country
Korea, Republic of
Facility Name
Korea University Guro Hospital
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Facility Name
Kangdong Sacred Heart Hospital
City
Seoul
ZIP/Postal Code
134-701
Country
Korea, Republic of
Facility Name
Ajou University Hospital
City
Suwon
ZIP/Postal Code
443-380
Country
Korea, Republic of
Facility Name
Wonju Severance Christian Hosp
City
Wonju
ZIP/Postal Code
220-701
Country
Korea, Republic of
Facility Name
Pusan National University Yangsan Hospital
City
Yangsan
ZIP/Postal Code
626-770
Country
Korea, Republic of
Facility Name
Monash University
City
Johor Bahru, Johor
ZIP/Postal Code
80100
Country
Malaysia
Facility Name
Hospital University Sains Malaysia
City
Kota Bharu
ZIP/Postal Code
16150
Country
Malaysia
Facility Name
Hospital Kuala Lumpur
City
Kuala Lumpur
ZIP/Postal Code
50586
Country
Malaysia
Facility Name
University Malaya Medical Centre
City
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
Facility Name
Hospital Tengku Ampuan Afzan
City
Kuantan
ZIP/Postal Code
25100
Country
Malaysia
Facility Name
Hospital Melaka
City
Melaka
ZIP/Postal Code
75400
Country
Malaysia
Facility Name
Penang Medical College
City
Penang
ZIP/Postal Code
10450
Country
Malaysia
Facility Name
Hospital Taiping
City
Taiping
ZIP/Postal Code
34000
Country
Malaysia
Facility Name
Hospital General de Acapulco
City
Acapulco
ZIP/Postal Code
39570
Country
Mexico
Facility Name
Centro de Investigacion Cardiometabolica de Aguascalientes
City
Aguascalientes
ZIP/Postal Code
20234
Country
Mexico
Facility Name
Instituto Nacional de Cardiologia Ignacio Chavez
City
Distrito Federal
ZIP/Postal Code
14080
Country
Mexico
Facility Name
Unidad de Investigacion Clinica Cardiometabolica de Occident
City
Guadalajara
ZIP/Postal Code
44150
Country
Mexico
Facility Name
Hospital Universitario Dr Jose Eleuterio Gonzalez
City
Monterrey
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Huisartspraktijk Emmers
City
's-hertogenbosch
ZIP/Postal Code
5235 KG
Country
Netherlands
Facility Name
FlevoResearch
City
Almere
ZIP/Postal Code
1311 RL
Country
Netherlands
Facility Name
Academisch Medisch Centrum (AMC)
City
Amsterdam
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Rode Kruis Ziekenhuis Beverwijk
City
Beverwijk
ZIP/Postal Code
1942 LE
Country
Netherlands
Facility Name
Andromed Breda
City
Breda
ZIP/Postal Code
4811 SW
Country
Netherlands
Facility Name
Noordwest Ziekenhuisgroep, location Den Helder
City
Den Helder
ZIP/Postal Code
1782 GZ
Country
Netherlands
Facility Name
Andromed Eindhoven
City
Eindhoven
ZIP/Postal Code
5611 NV
Country
Netherlands
Facility Name
Andromed Noord
City
Groningen
ZIP/Postal Code
9711 SG
Country
Netherlands
Facility Name
Vasculair Onderzoek Centrum
City
Hoorn
ZIP/Postal Code
1624 NP
Country
Netherlands
Facility Name
Maastricht Universitair Medisch Centrum
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
Andromed Rotterdam
City
Rotterdam
ZIP/Postal Code
3039 BD
Country
Netherlands
Facility Name
Rotterdam Research Institute
City
Rotterdam
ZIP/Postal Code
3039 BD
Country
Netherlands
Facility Name
Ikazia Ziekenhuis
City
Rotterdam
ZIP/Postal Code
3083 AN
Country
Netherlands
Facility Name
Antonius Ziekenhuis
City
Sneek
ZIP/Postal Code
8601 ZK
Country
Netherlands
Facility Name
Andromed Oost
City
Velp
ZIP/Postal Code
6883 ES
Country
Netherlands
Facility Name
Andromed Leiden-Zoetermeer
City
Zoetermeer
ZIP/Postal Code
2724 EK
Country
Netherlands
Facility Name
Christchurch Hospital
City
Christchurch
ZIP/Postal Code
4710
Country
New Zealand
Facility Name
RMC Medical Research Ltd
City
Dunedin
ZIP/Postal Code
9012
Country
New Zealand
Facility Name
P3 Research, Wellington
City
Newtown Wellington NZ
ZIP/Postal Code
6021
Country
New Zealand
Facility Name
P3 Research, Promed House
City
Tauranga
ZIP/Postal Code
3110
Country
New Zealand
Facility Name
Bodø Legesenter AS, avd. for med. studier
City
Bodø
ZIP/Postal Code
N-8001
Country
Norway
Facility Name
Medi 3 Innlandet AS, avd Elverum
City
Elverum
ZIP/Postal Code
N-2408
Country
Norway
Facility Name
Vestre Viken HF, Bærum sykehus
City
Gjettum
ZIP/Postal Code
N-1346
Country
Norway
Facility Name
M3 Helse AS
City
Hamar
ZIP/Postal Code
N-2317
Country
Norway
Facility Name
Bylegene SA
City
Jessheim
ZIP/Postal Code
N-2050
Country
Norway
Facility Name
Heiaklinikken
City
Lierskogen
ZIP/Postal Code
N-3420
Country
Norway
Facility Name
Rådhuset Spesialistsenter
City
Oslo
ZIP/Postal Code
N-0160
Country
Norway
Facility Name
Sandvika Spesialistsenter
City
Sandvika
ZIP/Postal Code
N-1337
Country
Norway
Facility Name
Grålum Legesenter
City
Sarpsborg
ZIP/Postal Code
N-1727
Country
Norway
Facility Name
Forusakutten - Kolibri Medical, Avd. Stavanger
City
Stavanger
ZIP/Postal Code
N-4005
Country
Norway
Facility Name
Medi 3 AS
City
Ålesund
ZIP/Postal Code
N-6002
Country
Norway
Facility Name
Instituto Delgado de Investigacion Medica
City
Arequipa
ZIP/Postal Code
LIMA 54
Country
Peru
Facility Name
Clinica San Pedro
City
Huacho
Country
Peru
Facility Name
Hospital Nacional Dos de Mayo
City
Lima
ZIP/Postal Code
01
Country
Peru
Facility Name
Clinica Internacional
City
Lima
ZIP/Postal Code
LIMA 1
Country
Peru
Facility Name
Centro de Investigaciones Médicas METABOLICARE SAC
City
Lima
ZIP/Postal Code
Lima 27
Country
Peru
Facility Name
Clinica San Gabriel
City
Lima
ZIP/Postal Code
Lima 32
Country
Peru
Facility Name
Centro De Especialidades Medicas Santa Maria S.A.C
City
Piura
Country
Peru
Facility Name
Clinica San Judas Tadeo
City
San Miguel
ZIP/Postal Code
32
Country
Peru
Facility Name
Center for Diabetes Care
City
Iloilo
ZIP/Postal Code
5000
Country
Philippines
Facility Name
Mary Mediatrix Medical Center
City
Lipa City, Batangas
ZIP/Postal Code
4217
Country
Philippines
Facility Name
Philippine General Hospital
City
Manila
ZIP/Postal Code
1000
Country
Philippines
Facility Name
University of Santo Tomas Hospital
City
Manila
ZIP/Postal Code
1008
Country
Philippines
Facility Name
Manila Doctors Hospital
City
Manila
ZIP/Postal Code
1011
Country
Philippines
Facility Name
Asian Hospital & Medical Center
City
Muntinlupa
ZIP/Postal Code
1781
Country
Philippines
Facility Name
St. Luke's Medical Center
City
Quezon City
ZIP/Postal Code
1102
Country
Philippines
Facility Name
Quirino Memorial Medical Center
City
Quezon City
ZIP/Postal Code
1109
Country
Philippines
Facility Name
Cardinal Santos Medical Center
City
San Juan
ZIP/Postal Code
1503
Country
Philippines
Facility Name
Surigao Health Specialists
City
Surigao
ZIP/Postal Code
8400
Country
Philippines
Facility Name
Hospital Fernando Fonseca, EPE
City
Amadora
ZIP/Postal Code
2700-276
Country
Portugal
Facility Name
CHLO, EPE - Hospital de Santa Cruz
City
Carnaxide
ZIP/Postal Code
2799-523
Country
Portugal
Facility Name
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
City
Coimbra
ZIP/Postal Code
3000-075
Country
Portugal
Facility Name
Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã
City
Covilhã
ZIP/Postal Code
6200-251
Country
Portugal
Facility Name
Hospital Distrital Figueira da Foz, EPE
City
Figueira da Foz
ZIP/Postal Code
3094-001
Country
Portugal
Facility Name
Hospital da Luz
City
Lisboa
ZIP/Postal Code
1500-650
Country
Portugal
Facility Name
Centro Hospitalar São João,EPE
City
Porto
ZIP/Postal Code
4202-451
Country
Portugal
Facility Name
Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
City
Santa Maria da Feira
ZIP/Postal Code
4520-211
Country
Portugal
Facility Name
SC Diabol SRL, Brasov
City
Brasov
ZIP/Postal Code
500365
Country
Romania
Facility Name
Nicodiab SRL, Bucharest
City
Bucharest
ZIP/Postal Code
010507
Country
Romania
Facility Name
SC Medical Centre "Sanatatea Ta" SRL, Bucharest
City
Bucharest
ZIP/Postal Code
020614
Country
Romania
Facility Name
Consultmed SRL, Iasi
City
Iasi
ZIP/Postal Code
700547
Country
Romania
Facility Name
Emergency County Clinical Hospital, Sibiu
City
Sibiu
ZIP/Postal Code
550245
Country
Romania
Facility Name
Private Practice Dr. Remus Gagiu
City
Tirgoviste
ZIP/Postal Code
130083
Country
Romania
Facility Name
LLC Clinic of new technologies of medicine
City
Dzerzhinsky
ZIP/Postal Code
140091
Country
Russian Federation
Facility Name
City Clinical Hospital No. 6 of MoH of Udmurt Republic
City
Izhevsk
ZIP/Postal Code
436000
Country
Russian Federation
Facility Name
City Clinical Hospital No. 4, Moscow
City
Moscow
ZIP/Postal Code
115093
Country
Russian Federation
Facility Name
City Clinical Hospital No. 13, Moscow
City
Moscow
ZIP/Postal Code
115280
Country
Russian Federation
Facility Name
State Institution "Central Clinical Hospital of RAS", Moscow
City
Moscow
ZIP/Postal Code
117333
Country
Russian Federation
Facility Name
City Clinical Hospital No. 61, Moscow
City
Moscow
ZIP/Postal Code
119048
Country
Russian Federation
Facility Name
State Healthcare Institution, Regional hospital #2
City
Rostov-na-Donu
ZIP/Postal Code
344029
Country
Russian Federation
Facility Name
Limited Liability Company "CENTER DIABET", Samara
City
Samara
ZIP/Postal Code
443067
Country
Russian Federation
Facility Name
MMU City Outpatient Clinic no. 20, Saratov
City
Saratov
ZIP/Postal Code
410018
Country
Russian Federation
Facility Name
Clinical Medical Center Zvezdara, Belgrade
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical Centre Nis
City
Nis
ZIP/Postal Code
18000
Country
Serbia
Facility Name
General Hospital Pancevo
City
Pancevo
ZIP/Postal Code
26000
Country
Serbia
Facility Name
General Hospital Subotica, Internal Medicine
City
Subotica
ZIP/Postal Code
24000
Country
Serbia
Facility Name
Clinical Hospital Center Zemun
City
Zemun
ZIP/Postal Code
11080
Country
Serbia
Facility Name
DIASTYLE s.r.o., Diabetology Outpatient Department
City
Banska Bystrica
ZIP/Postal Code
974 01
Country
Slovakia
Facility Name
ENDIAMED s.r.o., Dolny Kubin
City
Dolny Kubin
ZIP/Postal Code
026 01
Country
Slovakia
Facility Name
CELL B s.r.o.
City
Levice
ZIP/Postal Code
934 01
Country
Slovakia
Facility Name
DIA-KONTROL s.r.o.
City
Levice
ZIP/Postal Code
934 01
Country
Slovakia
Facility Name
Funkystuff s.r.o., Nove Zamky
City
Nove Zamky
ZIP/Postal Code
940 01
Country
Slovakia
Facility Name
Diabetologicka ambulancia MUDr. Lucia Gajdosikova s.r.o.
City
Povazska Bystrica
ZIP/Postal Code
017 01
Country
Slovakia
Facility Name
MEDIVASA s.r.o., Outpatient Clinic, Zilina
City
Zilina
ZIP/Postal Code
010 01
Country
Slovakia
Facility Name
Dr. P. Patel
City
Cape Town
ZIP/Postal Code
7764
Country
South Africa
Facility Name
Dr. E. L. Janari
City
Cape Town
ZIP/Postal Code
7965
Country
South Africa
Facility Name
Dr. Vawda
City
Durban
ZIP/Postal Code
4091
Country
South Africa
Facility Name
Parklands Medical Centre
City
Durban
ZIP/Postal Code
4091
Country
South Africa
Facility Name
Dr. Jurgens
City
Krugersdorp
ZIP/Postal Code
1739
Country
South Africa
Facility Name
Dr. H. Makan
City
Lenasia
ZIP/Postal Code
1827
Country
South Africa
Facility Name
Dr. D. R. Lakha, Johannesburg
City
Lenasia
ZIP/Postal Code
2033
Country
South Africa
Facility Name
Greenacres Hospital
City
Port Elizabeth
ZIP/Postal Code
6045
Country
South Africa
Facility Name
Dr. M. Seeber
City
Pretoria
ZIP/Postal Code
0083
Country
South Africa
Facility Name
Vergelegen Medi-Clinic
City
Somerset West
ZIP/Postal Code
7130
Country
South Africa
Facility Name
C.A.P. Sardenya
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
CAP Les Corts
City
Barcelona
ZIP/Postal Code
08028
Country
Spain
Facility Name
CAP Casanova
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Facility Name
CAP Burjassot 1
City
Burjassot
ZIP/Postal Code
46100
Country
Spain
Facility Name
C.S. Natahoyo
City
Gijon
ZIP/Postal Code
33212
Country
Spain
Facility Name
Hospital Universitari de Girona Doctor Josep Trueta
City
Girona
ZIP/Postal Code
17007
Country
Spain
Facility Name
CAP Florida
City
L'Hospitalet de Llobregat
ZIP/Postal Code
08905
Country
Spain
Facility Name
Hospital de Bellvitge
City
L'Hospitalet de Llobregat
ZIP/Postal Code
08907
Country
Spain
Facility Name
CAP La Roca
City
La Roca Del Vallés (Barcelona)
ZIP/Postal Code
08430
Country
Spain
Facility Name
Hospital General Universitario Gregorio Marañón
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
C.S. El Cristo
City
Oviedo
ZIP/Postal Code
33006
Country
Spain
Facility Name
C.S. Colloto
City
Oviedo
ZIP/Postal Code
33010
Country
Spain
Facility Name
C.S. Vallobin-La Florida
City
Oviedo
ZIP/Postal Code
33012
Country
Spain
Facility Name
ABS Pineda de Mar
City
Pineda de Mar
ZIP/Postal Code
08397
Country
Spain
Facility Name
Hospital de l'Esperit Sant
City
Santa Coloma De Gramanet
ZIP/Postal Code
08923
Country
Spain
Facility Name
CAP Tàrrega
City
Tàrrega
ZIP/Postal Code
25300
Country
Spain
Facility Name
CS Ingeniero Joaquin Benlloch
City
Valencia
ZIP/Postal Code
46006
Country
Spain
Facility Name
Hospital Clínico de Valencia
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
CTC Sahlgrenska Universitetssjukhuset
City
Göteborg
ZIP/Postal Code
413 45
Country
Sweden
Facility Name
Sjukhuset, Härnösand
City
Härnösand
ZIP/Postal Code
87182
Country
Sweden
Facility Name
Avonova Hälsa AB
City
Järfälla
ZIP/Postal Code
177 30
Country
Sweden
Facility Name
Skånes universitetssjukhus, Malmö
City
Malmö
ZIP/Postal Code
20502
Country
Sweden
Facility Name
Dalecarlia Clinical Research Center
City
Rättvik
ZIP/Postal Code
795 30
Country
Sweden
Facility Name
Södra Dalarnas vårdcentral, Hedemora
City
Rättvik
ZIP/Postal Code
79530
Country
Sweden
Facility Name
Näsets Läkargrupp
City
Skanör
ZIP/Postal Code
239 33
Country
Sweden
Facility Name
Vårdcentralen Silentzvägen
City
Uddevalla
ZIP/Postal Code
451 50
Country
Sweden
Facility Name
S3 Clinical Research Centers
City
Vällingby
ZIP/Postal Code
162 68
Country
Sweden
Facility Name
Allgemeine Medizin
City
Basel
ZIP/Postal Code
4057
Country
Switzerland
Facility Name
FMH endocrinologia diabetologia
City
Bellinzona
ZIP/Postal Code
6500
Country
Switzerland
Facility Name
Inselspital Bern
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
Dr. Pietro Gerber
City
Lugano
ZIP/Postal Code
6900
Country
Switzerland
Facility Name
Chang-Hua Christian Hospital
City
Changhua
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Kaohsiung Medical University Chung-Ho Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Facility Name
E-Da Hospital
City
Kaohsiung
ZIP/Postal Code
824
Country
Taiwan
Facility Name
Far Eastern Memorial Hospital
City
New Taipei City
ZIP/Postal Code
220
Country
Taiwan
Facility Name
Taichung Veterans General Hospital
City
Taichung,
ZIP/Postal Code
40705
Country
Taiwan
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Facility Name
NCKUH
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Shih-Kong Wu Ho-Shu Memorial Hospital
City
Taipei
ZIP/Postal Code
111
Country
Taiwan
Facility Name
Taipe Veterans General Hospital
City
Taipei
ZIP/Postal Code
11217
Country
Taiwan
Facility Name
Cheng Hsin General Hospital
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Facility Name
Tri-Service General Hospital
City
Taipei
ZIP/Postal Code
114
Country
Taiwan
Facility Name
Cardinal Tien Hospital
City
Taipei
ZIP/Postal Code
23137
Country
Taiwan
Facility Name
Taipei Medical University-Shuang Ho Hospital
City
Taipei
ZIP/Postal Code
235
Country
Taiwan
Facility Name
Mackay Memorial Hospital
City
Taipei
ZIP/Postal Code
25160
Country
Taiwan
Facility Name
HOP Fattouma Bourguiba, Mint, Monastir
City
Monastir
ZIP/Postal Code
5000
Country
Tunisia
Facility Name
HOP Hédi Chaker, Endo, Sfax
City
Sfax
ZIP/Postal Code
3029
Country
Tunisia
Facility Name
HOP Farhat Hached, Mint, Sousse
City
Sousse
ZIP/Postal Code
4000
Country
Tunisia
Facility Name
HOP Habib Thameur, Mint, Tunis
City
Tunis
ZIP/Postal Code
1008
Country
Tunisia
Facility Name
Donetsk Regional Clinical Hosp, Therapy Department
City
Donetsk
ZIP/Postal Code
83003
Country
Ukraine
Facility Name
Ivano-Frankivsk City Central Clinical Hospital
City
Ivano-Frankivsk
ZIP/Postal Code
76000
Country
Ukraine
Facility Name
City Clinical Hospital No. 17, Kharkov
City
Kharkiv
ZIP/Postal Code
61037
Country
Ukraine
Facility Name
City Clinical Hospital No. 27, Kharkiv
City
Kharkov
ZIP/Postal Code
61002
Country
Ukraine
Facility Name
Clinic for Cardiology "Sertse i sudyny", Kiev
City
Kiev
ZIP/Postal Code
01032
Country
Ukraine
Facility Name
City Clinical Hospital No. 1, Kiev
City
Kiev
ZIP/Postal Code
02091
Country
Ukraine
Facility Name
Poliklinika #2, Kyiv
City
Kyiv
ZIP/Postal Code
02002
Country
Ukraine
Facility Name
City Hospital No. 5, Lvov
City
Lvov
ZIP/Postal Code
73013
Country
Ukraine
Facility Name
Odeska zaliznichna likarnya, Odessa
City
Odesa
ZIP/Postal Code
65039
Country
Ukraine
Facility Name
Vinnitsia Regional Endocrinology Dispensary
City
Vinnitsa
ZIP/Postal Code
21010
Country
Ukraine
Facility Name
Crouch Oak Family Practice
City
Addlestone
ZIP/Postal Code
KT15 2BH
Country
United Kingdom
Facility Name
Ash Vale Health Centre, Aldershot
City
Ash Vale, Aldershot
ZIP/Postal Code
GU12 5BA
Country
United Kingdom
Facility Name
Birmingham Heartlands Hospital
City
Birmingham
ZIP/Postal Code
B9 5SS
Country
United Kingdom
Facility Name
Hathaway Medical Centre
City
Chippenham
ZIP/Postal Code
SN14 6GT
Country
United Kingdom
Facility Name
University Hospital of North Durham
City
Durham
ZIP/Postal Code
DH1 5TW
Country
United Kingdom
Facility Name
St Mary's Surgery
City
Ely
ZIP/Postal Code
CB7 4HF
Country
United Kingdom
Facility Name
Gloucestershire Royal Hospital
City
Gloucester
ZIP/Postal Code
GL1 3NN
Country
United Kingdom
Facility Name
James Paget University Hospital
City
Great Yarmouth
ZIP/Postal Code
NR31 6LA
Country
United Kingdom
Facility Name
Morriston Hospital
City
Swansea
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
Facility Name
Royal Cornwall Hospital
City
Truro
ZIP/Postal Code
TR1 3LJ
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
36116359
Citation
Verhagen C, Janssen J, Minderhoud CA, van den Berg E, Wanner C, Passera A, Johansen OE, Biessels GJ. Chronic kidney disease and cognitive decline in patients with type 2 diabetes at elevated cardiovascular risk. J Diabetes Complications. 2022 Oct;36(10):108303. doi: 10.1016/j.jdiacomp.2022.108303. Epub 2022 Aug 31.
Results Reference
derived
PubMed Identifier
34895804
Citation
Verhagen C, Janssen J, Biessels GJ, Johansen OE, Exalto LG. Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males: CAROLINA-COGNITION study. Nutr Metab Cardiovasc Dis. 2022 Feb;32(2):355-364. doi: 10.1016/j.numecd.2021.10.013. Epub 2021 Oct 27.
Results Reference
derived
PubMed Identifier
33559704
Citation
Biessels GJ, Verhagen C, Janssen J, van den Berg E, Wallenstein G, Zinman B, Espeland MA, Johansen OE. Effects of linagliptin vs glimepiride on cognitive performance in type 2 diabetes: results of the randomised double-blind, active-controlled CAROLINA-COGNITION study. Diabetologia. 2021 Jun;64(6):1235-1245. doi: 10.1007/s00125-021-05393-8. Epub 2021 Feb 9.
Results Reference
derived
PubMed Identifier
31536101
Citation
Rosenstock J, Kahn SE, Johansen OE, Zinman B, Espeland MA, Woerle HJ, Pfarr E, Keller A, Mattheus M, Baanstra D, Meinicke T, George JT, von Eynatten M, McGuire DK, Marx N; CAROLINA Investigators. Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial. JAMA. 2019 Sep 24;322(12):1155-1166. doi: 10.1001/jama.2019.13772. Erratum In: JAMA. 2019 Dec 3;322(21):2138.
Results Reference
derived
PubMed Identifier
30811335
Citation
Janssen J, van den Berg E, Zinman B, Espeland MA, Geijselaers SLC, Mattheus M, Johansen OE, Biessels GJ. HbA1c, Insulin Resistance, and beta-Cell Function in Relation to Cognitive Function in Type 2 Diabetes: The CAROLINA Cognition Substudy. Diabetes Care. 2019 Jan;42(1):e1-e3. doi: 10.2337/DC18-0914. No abstract available.
Results Reference
derived
PubMed Identifier
29334906
Citation
Biessels GJ, Janssen J, van den Berg E, Zinman B, Espeland MA, Mattheus M, Johansen OE; CAROLINA(R) investigators. Rationale and design of the CAROLINA(R) - cognition substudy: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus. BMC Neurol. 2018 Jan 15;18(1):7. doi: 10.1186/s12883-018-1014-7.
Results Reference
derived
PubMed Identifier
25780262
Citation
Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle HJ. Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA(R)). Diab Vasc Dis Res. 2015 May;12(3):164-74. doi: 10.1177/1479164115570301. Epub 2015 Mar 15.
Results Reference
derived
PubMed Identifier
30736150
Citation
Chilton R. Linagliptin versus glimepiride add-on for the long-term treatment of Type 2 diabetes mellitus. Expert Rev Endocrinol Metab. 2013 Jul;8(4):345-349. doi: 10.1586/17446651.2013.811849.
Results Reference
derived
Links:
URL
http://trials.boehringer-ingelheim.com/
Description
Related Info

Learn more about this trial

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

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