Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome (AUSC)
Adrenal Tumour With Mild Hypercortisolism
About this trial
This is an interventional treatment trial for Adrenal Tumour With Mild Hypercortisolism focused on measuring mild hypercortisolism, adrenal tumour, surgical procedures, elective, indication
Eligibility Criteria
Inclusion Criteria:
Adrenal tumour with biochemical mild hypercortisolism defined as pathological dexamethasone suppression test (cortisol > 50 nmol/L at 8.00 am after 1 mg dexamethasone at 10 pm, plus one of the following criteria
- Low or suppressed adrenocorticotropic hormone (ACTH)
- Low or suppressed dehydroepiandrosterone (DHEA)
- No or pathological circadian rhythm of cortisol
Exclusion Criteria:
- Increased levels of 24 hours urinary excretion of cortisol
- Pregnancy or lactation
- Inability to understand information or to comply with scheduled follow-up
- Mild hypercortisolism with bilateral adrenal tumours, without a gradient (lateralization on venous sampling)
Sites / Locations
- Århus University Hospital
- Haukeland University Hospital
- Sahlgrenska University Hospital
- Skåne University Hospital-Lund, Department of Surgery
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Follow-up
Surgery
Patients who are diagnosed with biochemically mild hypercortisolism (so-called subclinical Cushing´s syndrome), who are followed only.
Patients diagnosed with adrenal tumour and with biochemically mild hypercortisolism (so-called subclinical Cushing´s syndrome), operated with adrenalectomy