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Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

Primary Purpose

Heart Failure, Cardiomyopathy

Status

Completed

Phase

Phase 4

Locations

United States

Study Type

Interventional

Intervention

carvedilol

About this trial

This is an interventional diagnostic trial for Heart Failure focused on measuring beta blockers, heart failure, contractility, remodeling

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Patients 18 years of age or older.
Man or nonpregnant women (only women who are postmenopausal, surgically sterile or practicing an acceptable method of contraception)
Patients with dilated nonischemic cardiomyopathy with LVEF< 35% and NYHA Class III-IVa heart failure
Patients on standard stable medical therapy with Ace inhibitors (or hydralazine and nitrates or Angiotensin II Receptor blockers if Ace-intolerant), diuretics and or digoxin for at least 1 month prior to enrollment in the study.
Heart failure symptoms have to be present for at least 3 months
Written informed consent

Exclusion Criteria:

Ischemic heart disease documented by cardiac catheterization with any coronary obstructive lesion > 50% stenosis, history of myocardial infarction, coronary artery bypass surgery , percutaneous coronary angioplasty or stenting
Uncorrected primary valvular disease, obstructive or restrictive cardiomyopathy.
Systolic blood pressure >170 or <85 mm Hg or diastolic blood pressure >100 mm Hg; heart rate <50 bpm.
Sick sinus syndrome or advanced heart block (unless treated by a pacemaker), symptomatic or sustained ventricular tachycardia not controlled by antiarrhythmic drugs or an implantable defibrillator
Cor pulmonale, obstructive pulmonary disease requiring oral bronchodilator or steroid therapy
Active malignancy, or a systemic or terminal disease that would limit physical function or survival during the trial
Active and known drug or alcohol dependence or any factors that will interfere with the study conduct or interpretation of results.
Clinically important hepatic or renal disease; or any condition other than heart failure that could limit survival
Platelet count <100 000 mm3 or white blood cell count <3000 mm3, INR (international normalized ratio) >1.7
Current treatment with beta-blocker, beta-agonist, verapamil, chronic cyclic or continuous inotropic therapy, or use of an investigational drug within 30 days of entry into the challenge phase
History of drug sensitivity or adverse reactions to beta-blockers
Unwillingness to cooperate or give written informed consent, pregnant or lactating women

Sites / Locations

Michael E. DeBakey Veterans Affairs Medical Center

Outcomes

Primary Outcome Measures

Load independent measure of contractility: Left ventricular velocity of circumferential shortening to left ventricular end systolic stress ratio

Mean velocity of circumferential fiber shortening (VCF) will be derived as = Left Ventricular Fractional shortening / Ejection Time.Left ventricular (LV) end-systolic stress will be calculated as = ([1.35 × P × LV endsysolic diameter]/(4 × LV posterior wall thickness in systole × (1+LV posterior wall thickness in systole /LV endsysolic diameter)))

Secondary Outcome Measures

Left ventricular end diastolic and end systolic volumes, left ventricular end systolic stress, effective arterial elastance

Full Information

NCT ID

NCT01261065

First Posted

December 15, 2010

Last Updated

December 15, 2010

Sponsor

Michael E. DeBakey VA Medical Center

1. Study Identification

Unique Protocol Identification Number

NCT01261065

Brief Title

Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

Official Title

Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

Study Type

Interventional

2. Study Status

Record Verification Date

December 2010

Overall Recruitment Status

Completed

Study Start Date

December 2001 (undefined)

Primary Completion Date

October 2005 (Actual)

Study Completion Date

October 2005 (Actual)

3. Sponsor/Collaborators

Name of the Sponsor

Michael E. DeBakey VA Medical Center

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The overall hypothesis of this application is that the improvement in LV ejection performance following treatment with betablockers is due, at least in part, to improvement in intrinsic myocardial contractility.

Detailed Description

The immediate specific objectives of this application are two-fold: (1) to determine whether the observed improvement in LV ejection performance is due to alterations in intrinsic cardiac myocardial contractility and (2) to determine whether changes in LV contractile reserve following an infusion of intravenous milrinone can be used to predict a salutary response to beta-blockers. The immediate specific objectives of this proposal will be addressed in the following two Specific Aims: In Specific Aim 1, we will determine whether the observed improvement in LV ejection fraction following treatment with beta-blockers is due to changes in intrinsic myocardial contractility, as opposed to changes in LV remodeling (i.e. reduction in LV volume) or changes in LV loading conditions. Changes in LV function will be evaluated using proven indexes, one an ejection phase index: the relation of end-systolic stress (ESS) to the mean velocity of fiber shortening (VCF), considered a relatively load independent measure of contractility. Changes in LV structure will be evaluated using echocardiography. In Specific Aim 2, we will determine whether the salutary response to beta-blockers can be predicted by measuring "contractile reserve", defined as a change in contractility determined by the relation of the mean velocity of fiber shortening (VCF) to end-systolic stress (ESS) in response to intravenous milrinone infusion at the cardiac catheterization lab prior to the institution of beta-blockade. The response to treatment with beta-blockers will be assessed by measurement of LV ejection fraction and LV end-diastolic volume by echocardiography after 6 months of treatment with beta-blockers, and these measurements will be correlated with the respective changes in contractile reserve measurement at baseline.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Heart Failure, Cardiomyopathy

Keywords

beta blockers, heart failure, contractility, remodeling

7. Study Design

Primary Purpose

Diagnostic

Study Phase

Phase 4

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

55 (Actual)

8. Arms, Groups, and Interventions

Intervention Type

Drug

Intervention Name(s)

carvedilol

Other Intervention Name(s)

coreg

Intervention Description

Patients with heart failure and LVEF < 35 % were treated with maximally tolerated dose of carvedilol for a period of six months. Target dose was 25 mg bid or 37.5 mg bid if patient's baseline weight > 80 kg.

Primary Outcome Measure Information:

Title

Load independent measure of contractility: Left ventricular velocity of circumferential shortening to left ventricular end systolic stress ratio

Description

Time Frame

6 months

Secondary Outcome Measure Information:

Title

Left ventricular end diastolic and end systolic volumes, left ventricular end systolic stress, effective arterial elastance

Time Frame

6 months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Patients 18 years of age or older. Man or nonpregnant women (only women who are postmenopausal, surgically sterile or practicing an acceptable method of contraception) Patients with dilated nonischemic cardiomyopathy with LVEF< 35% and NYHA Class III-IVa heart failure Patients on standard stable medical therapy with Ace inhibitors (or hydralazine and nitrates or Angiotensin II Receptor blockers if Ace-intolerant), diuretics and or digoxin for at least 1 month prior to enrollment in the study. Heart failure symptoms have to be present for at least 3 months Written informed consent Exclusion Criteria: Ischemic heart disease documented by cardiac catheterization with any coronary obstructive lesion > 50% stenosis, history of myocardial infarction, coronary artery bypass surgery , percutaneous coronary angioplasty or stenting Uncorrected primary valvular disease, obstructive or restrictive cardiomyopathy. Systolic blood pressure >170 or <85 mm Hg or diastolic blood pressure >100 mm Hg; heart rate <50 bpm. Sick sinus syndrome or advanced heart block (unless treated by a pacemaker), symptomatic or sustained ventricular tachycardia not controlled by antiarrhythmic drugs or an implantable defibrillator Cor pulmonale, obstructive pulmonary disease requiring oral bronchodilator or steroid therapy Active malignancy, or a systemic or terminal disease that would limit physical function or survival during the trial Active and known drug or alcohol dependence or any factors that will interfere with the study conduct or interpretation of results. Clinically important hepatic or renal disease; or any condition other than heart failure that could limit survival Platelet count <100 000 mm3 or white blood cell count <3000 mm3, INR (international normalized ratio) >1.7 Current treatment with beta-blocker, beta-agonist, verapamil, chronic cyclic or continuous inotropic therapy, or use of an investigational drug within 30 days of entry into the challenge phase History of drug sensitivity or adverse reactions to beta-blockers Unwillingness to cooperate or give written informed consent, pregnant or lactating women

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Biykem Bozkurt, MD

Organizational Affiliation

Michael E.DeBakey VA Medical Center, Baylor College of Medicine

Official's Role

Principal Investigator

Facility Information:

Facility Name

Michael E. DeBakey Veterans Affairs Medical Center

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

12. IPD Sharing Statement

Learn more about this trial

Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

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